Genetics of Stem Cells

Part A

1st Edition, Volume 111 - September 6, 2012
Editor: Yaoliang Tang
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 3 9 8 4 5 9 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 0 1 7 4 6 - 7

This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem… Read more

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This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells.

Contributors
Preface
Chapter 1 Generation of Induced Pluripotent Stem Cells from Somatic Cells

I Generation of iPSCs
II Methods of Delivering Transcription Factors into Cells
III Nongenetic Approaches for Reprogramming
IV Generation of Human iPSCs from Different Somatic Cell Types
V Characterization of iPSCs
VI Conclusion

Chapter 2 Induced Pluripotent Cells in Cardiovascular Biology

I Introduction
II Non-iPS-Cell-Based Therapies and Their Limitations
III Therapeutic Cloning and Embryonic Stem Cells
IV Induced Pluripotent Stem cells from Differentiated Somatic Cells
V Cardiovascular Lineage Differentiation of iPS Cells

Chapter 3 Reprogramming of Somatic Cells

I Introduction
II Reprogramming of Somatic Cells into Pluripotent Stem Cells
III Future Perspectives

Chapter 4 Induction of Somatic Cell Reprogramming Using the MicroRNA miR-302

I Introduction
II Mechanism of Reprogramming
III Role of miR-302 in Early Embryogenesis
IV Dual Role of miR-302: Reprogramming Effector and Tumor Suppressor
V Balancing Stem Cell Tumorigenicity and Senescence
VI Conclusion

Chapter 5 From Ontogenesis to Regeneration

I Regeneration: From Urodeles and Teleosts to Mammals
II To the “Heart” of the Problem
III Lessons from Development
IV Understanding the Stem Cell “Niche” and Its Roles
V Recreating the Niche: The Importance of 3D Models
VI Cardiac Cell Therapy: The Era of Clinical Trials
VII Concluding Remarks

Chapter 6 Roles of MicroRNAs and Myocardial Cell Differentiation

I Introduction
II Myocardial Differentiation of ES Cells and miRNA
III Somatic Cell Reprogramming and miRNA
IV Heart Disease and MicroRNAs
V Conclusion

Chapter 7 Wnt Signaling and Cardiac Differentiation

I Introduction
II Wnt Signaling
III Wnt Proteins and Cardiogenesis
IV Concluding Remarks

Chapter 8 Cross Talk Between the Notch Signaling and Noncoding RNA on the Fate of Stem Cells

I Introduction
II Direct Role of Notch Signaling in Stem Cell Maintenance and Differentiation
III Cross Talk Between MicroRNA and Notch Signal on Stem Cell Fate (Fig. 2)
IV Epigenetic Regulation of Stem Cell Fate via Notch Signaling
V Conclusions

Chapter 9 Myocardial Regeneration

I Introduction
II Is There Cardiomyocyte Regeneration from Endogenous CPCs Post-MI?
III Paracrine Effects of Transplanted Cells in the Injured Heart
IV IGF + HGF Administration Can Activate In Situ CPCs to Generate Cardiomyocytes
V Do Transplanted BM-Derived and/or Transplanted or In Situ CPCs Transdifferentiate into Cardiomyocytes and Vascular Cells?
VI Do CDCs and/or MSCs Stimulate Endogenous CPCs to Regenerate Cardiomyocytes and Vascular Cells?
VII Can Differentiated Cardiomyocytes Be Induced to Dedifferentiate and Reenter the Cell Cycle?
VIII Conclusions and Future Perspectives

Chapter 10 Role of GATA-4 in Differentiation and Survival of Bone Marrow Mesenchymal Stem Cells

I Introduction
II Cytotherapy in Myocardial Infarction
III Genetic Engineering of MSCs with Cytoprotective Factors
IV Conclusions

Chapter 11 Progenitor Cell Mobilization and Recruitment: SDF-1, CXCR4, α4-integrin, and c-kit

I Introduction
II Progenitor Cell Mobilization
III Progenitor Cell Recruitment and Retention
IV Therapeutic Implications
V Summary

Chapter 12 Genetically Manipulated Progenitor/Stem Cells Restore Function to the Infarcted Heart Via the SDF-1α/CXCR4 Signaling Pathway

I Importance of SDF-1α and CXCR4 Interaction in Ischemic Hearts
II Role of SDF-1α/CXCR4 as Therapeutic Targets in Heart Disease
III SDF-1α/CXCR4 as Therapeutic Targets in Vascular Diseases
IV Role of SDF-1α/CXCR4 in Cell-Based Therapy
V Genetically Manipulated Cell Patch for Repair of Infarcted Myocardium
VI Conclusions

Chapter 13 Genetic Modification of Stem Cells for Cardiac, Diabetic, and Hemophilia Transplantation Therapies

I Introduction
II Genetic Engineering
III The Application of Genetic Modification of Stem Cells

Chapter 14 Role of Heat Shock Proteins in Stem Cell Behavior

I Introduction
II Hsps in the Modulation of SC Self-Renewal
III Expression Profiles of Hsp in Differentiated SCs
IV Roles of Hsps in Tissue Genesis
V Protective Effects of Hsps in Transplanted SCs
VI Roles of Hsps in SC Aging
VII Conclusions

Chapter 15 Preconditioning Approach in Stem Cell Therapy for the Treatment of Infarcted Heart

I Introduction
II Stem Cell Therapy and the Heart
III Stem Cell Survival: Major Determinant of Efficacy of Stem Cell Therapy
IV Preconditioning: A Strategy to “Prime” the Cells for Improved Survival Under Stress
V Conclusions

Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Genetics of Stem Cells

Part A

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Yaoliang Tang