Genetics of Stem Cells
Part A
- 1st Edition, Volume 111 - September 6, 2012
- Imprint: Academic Press
- Editor: Yaoliang Tang
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 8 4 5 9 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 0 1 7 4 6 - 7
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Request a sales quoteThis special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells.
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine
- Contributors
- Preface
- Chapter 1 Generation of Induced Pluripotent Stem Cells from Somatic Cells
- I Generation of iPSCs
- II Methods of Delivering Transcription Factors into Cells
- III Nongenetic Approaches for Reprogramming
- IV Generation of Human iPSCs from Different Somatic Cell Types
- V Characterization of iPSCs
- VI Conclusion
- Chapter 2 Induced Pluripotent Cells in Cardiovascular Biology
- I Introduction
- II Non-iPS-Cell-Based Therapies and Their Limitations
- III Therapeutic Cloning and Embryonic Stem Cells
- IV Induced Pluripotent Stem cells from Differentiated Somatic Cells
- V Cardiovascular Lineage Differentiation of iPS Cells
- Chapter 3 Reprogramming of Somatic Cells
- I Introduction
- II Reprogramming of Somatic Cells into Pluripotent Stem Cells
- III Future Perspectives
- Chapter 4 Induction of Somatic Cell Reprogramming Using the MicroRNA miR-302
- I Introduction
- II Mechanism of Reprogramming
- III Role of miR-302 in Early Embryogenesis
- IV Dual Role of miR-302: Reprogramming Effector and Tumor Suppressor
- V Balancing Stem Cell Tumorigenicity and Senescence
- VI Conclusion
- Chapter 5 From Ontogenesis to Regeneration
- I Regeneration: From Urodeles and Teleosts to Mammals
- II To the “Heart” of the Problem
- III Lessons from Development
- IV Understanding the Stem Cell “Niche” and Its Roles
- V Recreating the Niche: The Importance of 3D Models
- VI Cardiac Cell Therapy: The Era of Clinical Trials
- VII Concluding Remarks
- Chapter 6 Roles of MicroRNAs and Myocardial Cell Differentiation
- I Introduction
- II Myocardial Differentiation of ES Cells and miRNA
- III Somatic Cell Reprogramming and miRNA
- IV Heart Disease and MicroRNAs
- V Conclusion
- Chapter 7 Wnt Signaling and Cardiac Differentiation
- I Introduction
- II Wnt Signaling
- III Wnt Proteins and Cardiogenesis
- IV Concluding Remarks
- Chapter 8 Cross Talk Between the Notch Signaling and Noncoding RNA on the Fate of Stem Cells
- I Introduction
- II Direct Role of Notch Signaling in Stem Cell Maintenance and Differentiation
- III Cross Talk Between MicroRNA and Notch Signal on Stem Cell Fate (Fig. 2)
- IV Epigenetic Regulation of Stem Cell Fate via Notch Signaling
- V Conclusions
- Chapter 9 Myocardial Regeneration
- I Introduction
- II Is There Cardiomyocyte Regeneration from Endogenous CPCs Post-MI?
- III Paracrine Effects of Transplanted Cells in the Injured Heart
- IV IGF + HGF Administration Can Activate In Situ CPCs to Generate Cardiomyocytes
- V Do Transplanted BM-Derived and/or Transplanted or In Situ CPCs Transdifferentiate into Cardiomyocytes and Vascular Cells?
- VI Do CDCs and/or MSCs Stimulate Endogenous CPCs to Regenerate Cardiomyocytes and Vascular Cells?
- VII Can Differentiated Cardiomyocytes Be Induced to Dedifferentiate and Reenter the Cell Cycle?
- VIII Conclusions and Future Perspectives
- Chapter 10 Role of GATA-4 in Differentiation and Survival of Bone Marrow Mesenchymal Stem Cells
- I Introduction
- II Cytotherapy in Myocardial Infarction
- III Genetic Engineering of MSCs with Cytoprotective Factors
- IV Conclusions
- Chapter 11 Progenitor Cell Mobilization and Recruitment: SDF-1, CXCR4, α4-integrin, and c-kit
- I Introduction
- II Progenitor Cell Mobilization
- III Progenitor Cell Recruitment and Retention
- IV Therapeutic Implications
- V Summary
- Chapter 12 Genetically Manipulated Progenitor/Stem Cells Restore Function to the Infarcted Heart Via the SDF-1α/CXCR4 Signaling Pathway
- I Importance of SDF-1α and CXCR4 Interaction in Ischemic Hearts
- II Role of SDF-1α/CXCR4 as Therapeutic Targets in Heart Disease
- III SDF-1α/CXCR4 as Therapeutic Targets in Vascular Diseases
- IV Role of SDF-1α/CXCR4 in Cell-Based Therapy
- V Genetically Manipulated Cell Patch for Repair of Infarcted Myocardium
- VI Conclusions
- Chapter 13 Genetic Modification of Stem Cells for Cardiac, Diabetic, and Hemophilia Transplantation Therapies
- I Introduction
- II Genetic Engineering
- III The Application of Genetic Modification of Stem Cells
- Chapter 14 Role of Heat Shock Proteins in Stem Cell Behavior
- I Introduction
- II Hsps in the Modulation of SC Self-Renewal
- III Expression Profiles of Hsp in Differentiated SCs
- IV Roles of Hsps in Tissue Genesis
- V Protective Effects of Hsps in Transplanted SCs
- VI Roles of Hsps in SC Aging
- VII Conclusions
- Chapter 15 Preconditioning Approach in Stem Cell Therapy for the Treatment of Infarcted Heart
- I Introduction
- II Stem Cell Therapy and the Heart
- III Stem Cell Survival: Major Determinant of Efficacy of Stem Cell Therapy
- IV Preconditioning: A Strategy to “Prime” the Cells for Improved Survival Under Stress
- V Conclusions
- Index
- Edition: 1
- Volume: 111
- Published: September 6, 2012
- No. of pages (Hardback): 384
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780123984593
- eBook ISBN: 9780124017467
YT
Yaoliang Tang
Affiliations and expertise
MD, Ph.D, FAHA, Vascular Biology Center & Department of Medicine, Medical College of Georgia, Georgia Regents University , Augusta, GA, USARead Genetics of Stem Cells on ScienceDirect