Fundamentals and Biomedical Applications of Chitosan Nanoparticles
- 1st Edition - November 27, 2024
- Editors: Kalim Deshmukh, Jagan Mohan Dodda, Ibrahim M. El-Sherbiny, Emmanuel Rotimi Sadiku
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 4 0 8 8 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 4 0 8 9 - 1
Fundamentals and Biomedical Applications of Chitosan Nanoparticles holistically covers the development and application of chitosan nanoparticles, providing an accessible and inter… Read more
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Request a sales quoteFundamentals and Biomedical Applications of Chitosan Nanoparticles holistically covers the development and application of chitosan nanoparticles, providing an accessible and interdisciplinary resource for both those new to the field and those who wish to deepen their knowledge. The book begins with an introduction to synthesis methods, fundamental chemistry, characterization, and surface functionalization of chitosan nanoparticles, guiding the reader through each stage of development. A wide range of biomedical applications are explored, from vaccine delivery, tumor targeting, tissue engineering, and wound healing and antimicrobial therapy.
This will be a helpful guide for postgraduate students and researchers who are starting out in this field, as well as established researchers in the fields of materials science, nanotechnology, materials chemistry, and bioscience.
- Details the regulatory, toxicological, and clinical considerations of chitosan nanoparticles for biomedical applications
- Describes the various methods of synthesis, surface functionalization, crosslinking, and grafting of chitosan nanoparticles
- Reviews a broad range of biomedical applications of chitosan nanoparticles that will appeal to an interdisciplinary readership
Postgraduate students in the fields of materials science, nanotechnology, and biomedical engineering, and researchers who are new to the field of chitosan nanoparticles, Clinical and pharmaceutical scientists and R&D groups developing novel materials for diagnostic and therapeutic applications.
- Fundamentals and Biomedical Applications of Chitosan Nanoparticles
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- About the editors
- Preface
- 1 Chitosan nanoparticles: Fundamental chemistry, properties, and current research trends in biomedical field
- Abstract
- Keywords
- 1.1 Introduction
- 1.2 Physicochemical properties of chitosan nanoparticles
- 1.3 Intrinsic bioactivities of chitosan nanoparticles
- 1.3.1 Anticancer activity
- 1.3.2 Antidiabetic activity
- 1.3.3 Antioxidant and antiinflammatory activity
- 1.3.4 Antimicrobial activity
- 1.3.5 Biocompatibility, biodegradability, and hemocompatibility
- 1.3.6 Mucoadhesion
- 1.3.7 Penetration and permeation enhancer
- 1.3.8 Wound healing
- 1.4 Synthesis, characterization, and surface modification of chitosan nanoparticles
- 1.5 Recent trends in the application of chitosan nanoparticles
- 1.5.1 Drug delivery
- 1.5.2 Biomedical applications
- 1.6 Challenges and future perspective
- 1.7 Conclusion
- References
- 2 Synthesis methods of chitosan nanoparticles: A review
- Abstract
- Keywords
- 2.1 Introduction
- 2.2 Synthesis methods of chitosan nanoparticles
- 2.2.1 Emulsification and cross-linking
- 2.2.2 Reverse micelles
- 2.2.3 Emulsion-droplet coalescence and emulsion-solvent diffusion
- 2.2.4 Micro-fluidic method
- 2.2.5 Ionic cross-linking or ionic gelation
- 2.2.6 Ionic gelation with radical polymerization
- 2.2.7 Self-assembly
- 2.2.8 Top-down
- 2.2.9 Spray drying
- 2.2.10 Supercritical-CO2-assisted solubilization and atomization
- 2.3 Green synthesis of chitosan nanoparticles
- 2.4 Conclusion and future perspectives
- References
- 3 Spectroscopic and microscopic characterizations of chitosan nanoparticles
- Abstract
- Keywords
- 3.1 Introduction
- 3.2 Characterization techniques
- 3.2.1 Spectroscopic techniques for characterization of chitosan nanoparticles
- 3.2.2 Microscopic techniques for characterizations of chitosan nanoparticles
- 3.3 Summary
- References
- 4 Biocompatibility, biodegradability, and toxicity evaluations of chitosan nanoparticles
- Abstract
- Keywords
- 4.1 Introduction
- 4.2 Biocompatibility assessments of CSNPs
- 4.2.1 Cell viability studies
- 4.2.2 Cytotoxicity assays
- 4.2.3 Assessment of inflammatory response
- 4.2.4 Hemocompatibility
- 4.3 In vivo biocompatibility and toxicity assessments
- 4.3.1 Animal models
- 4.3.2 Histopathological examination
- 4.3.3 Organ function tests
- 4.4 Biodegradability studies
- 4.4.1 Degradation kinetics
- 4.4.2 Identification of degradation products
- 4.5 Factors influencing biocompatibility and toxicity
- 4.5.1 Particle size and surface charge
- 4.5.2 Concentration and exposure duration
- 4.6 Regulatory compliance
- 4.7 Future prospects
- 4.8 Conclusions
- References
- 5 Surface functionalization, crosslinking, and grafting of chitosan nanoparticles
- Abstract
- Keywords
- 5.1 Introduction
- 5.2 Chitosan nanoparticles
- 5.2.1 Surface functionalization
- 5.2.2 Grafting of chitosan nanoparticles
- 5.2.3 Crosslinking of chitosan nanoparticles
- 5.2.4 bioactive compounds incorporated with chitosan nanoparticles
- 5.3 Systemic toxicity of chitosan nanoparticles
- 5.3.1 Hemocompatibility
- 5.4 Biomedical applications of functionalized, grafted, and crosslinked chitosan nanoparticles
- 5.4.1 Drug delivery and drug release
- 5.4.2 Tissue engineering
- 5.4.3 Cancer diagnostics and therapy
- 5.4.4 Biosensing
- 5.4.5 Photodynamic therapy
- 5.4.6 Bioimaging
- 5.5 Challenges and future prospects
- 5.6 Conclusions
- References
- 6 Chitosan nanoparticles: A promising tool in nanomedicine
- Abstract
- Keywords
- 6.1 Introduction
- 6.2 Physical, chemical and biological properties of CS and CSNPs
- 6.2.1 Adhesivity of CSNPs
- 6.2.2 Biodegradability and safety of CSNPs
- 6.2.3 Antitumor effect of CSNPs
- 6.3 Surface modification of the CSNPs
- 6.4 Fabrication methods of CSNPs
- 6.4.1 Solvent evaporation and ionic crosslinking
- 6.4.2 Covalent crosslinking
- 6.4.3 Ionotropic gelation
- 6.4.4 Microemulsion method
- 6.4.5 Emulsification solvent diffusion method
- 6.4.6 Polyelectrolyte complex
- 6.5 Transport mechanism of CSNPs
- 6.6 Drug release mechanism from CSNPs
- 6.7 CS based therapeutics delivery system
- 6.7.1 Passive drug delivery system
- 6.7.2 Targeted therapeutics delivery system
- 6.7.3 Theranostics for imaging and drug delivery
- 6.7.4 Delivery of protein, peptide, siRNA, etc.
- 6.8 Toxicological profile of the CSNPs
- 6.9 Metabolism of CSNPs
- 6.10 Preclinical and clinical status of the CSNPs based nanomedicine
- 6.11 Challenges and future prospects
- 6.12 Conclusion
- References
- 7 Chitosan nanoparticles as drug carriers and gene delivery systems: Advances and challenges
- Abstract
- Keywords
- 7.1 Introduction
- 7.2 Latest cancer deliveries developed using chitosan nanoparticles
- 7.2.1 Cancer-targeted chitosan delivered by specific ligands
- 7.2.2 Thiolated chitosan in cancer cell adhesion
- 7.2.3 PEGylated CSNPs
- 7.2.4 Polyphenolic-chitosan nanoassemblies
- 7.3 Chitosan nanoparticles in nonviral gene delivery
- 7.3.1 Chitosan nanoparticles-based siRNA/DNA delivery systems
- 7.3.2 Nucleotides-CSNPs
- 7.3.3 Polypeptide-CSNPs
- 7.4 Current clinical and preclinical investigations
- 7.5 Challenges and future perspective
- 7.6 Conclusion
- References
- 8 Chitosan nanoparticles in vaccine delivery systems
- Abstract
- Keywords
- 8.1 Introduction
- 8.2 Historical timeline of chitosan nanoparticles for vaccine delivery
- 8.3 Natural sources of chitosan
- 8.4 Chemistry of chitin
- 8.5 Preparation of chitosan nanoparticles
- 8.6 Step involved in the preparation of vaccine by chitosan nanoparticles
- 8.6.1 Antigen selection and characterization
- 8.6.2 Chitosan-based vaccine formulation design
- 8.6.3 Antigen encapsulation in chitosan nanoparticles
- 8.6.4 Stabilization and control
- 8.7 Mechanism of chitosan nanoparticles in application of vaccine delivery
- 8.8 Future prospects
- 8.9 Conclusions
- References
- 9 Chitosan nanoparticles for antimicrobial applications
- Abstract
- Keywords
- 9.1 Introduction
- 9.2 Antimicrobial activity of chitosan
- 9.2.1 Antibacterial study
- 9.2.2 Antifungal study
- 9.2.3 CSNP antiviral efficacy
- 9.3 Enhancement of antimicrobial activities
- 9.3.1 Enhancement of chitosan antibacterial activity
- 9.3.2 Enhancement of chitosan antifungal activity
- 9.4 Cytotoxicity and degradation of CSNPs
- 9.5 Biomedical applications of CSNPs
- 9.6 Challenges and future perspectives of CSNPs in antimicrobial applications
- 9.6.1 Combination therapies
- 9.6.2 Responsive nanoparticles
- 9.6.3 Biosensors based on chitosan nanoparticles for microbial detection
- 9.7 Conclusions
- References
- 10 Chitosan nanoparticles in tumor imaging and therapy
- Abstract
- Keywords
- 10.1 Introduction
- 10.2 Tumor-targeted delivery of chitosan-based NPs
- 10.3 Passive targeting
- 10.4 Active targeting
- 10.5 Tumor imaging
- 10.5.1 Optical imaging
- 10.5.2 Magnetic resonance imaging
- 10.5.3 Multimodal imaging
- 10.6 Effective tumor therapy using chitosan-based NPs
- 10.6.1 Chemotherapy
- 10.6.2 Gene therapy
- 10.6.3 Photodynamic therapy
- 10.6.4 Photothermal therapy
- 10.6.5 Hyperthermic tumor therapy
- 10.7 Challenges and future perspectives
- 10.8 Conclusion
- References
- 11 Hybrid chitosan nanoparticles for sequential targeting of breast, liver, and brain cancer
- Abstract
- Keywords
- Acknowledgment
- 11.1 Introduction
- 11.2 Synthesis methods of chitosan nanoparticles and hybrid derivatives
- 11.3 Chitosan as a drug delivery nanovehicle
- 11.4 Hybrid chitosan nanoparticles for targeting breast cancer
- 11.5 Hybrid chitosan nanoparticles for targeting liver and lung cancer
- 11.6 Hybrid chitosan nanoparticles for targeting brain cancer
- 11.7 Challenges and future perspectives
- 11.8 Conclusion
- References
- 12 Chitosan nanoparticles in tissue engineering and regenerative medicine
- Abstract
- Keywords
- 12.1 Introduction
- 12.2 Chitosan nanoparticles for bone tissue engineering
- 12.3 Chitosan nanoparticles for cartilage tissue engineering
- 12.4 Chitosan nanoparticles in dentistry
- 12.5 Chitosan nanoparticles in drug and gene delivery
- 12.6 Chitosan nanoparticles for nerve tissue engineering
- 12.7 Chitosan nanoparticles for blood vessel engineering
- 12.8 Chitosan nanoparticles for wounds and burns
- 12.9 Chitosan nanoparticles in ophthalmology
- 12.10 Challenges and future perspectives
- 12.11 Conclusion
- References
- 13 Chitosan nanoparticles in wound healing and dressing application
- Abstract
- Keywords
- 13.1 Introduction
- 13.2 Wound healing and dressing challenges
- 13.2.1 Wound healing process
- 13.2.2 Importance of wound dressings
- 13.3 CSNPs synthesis and characterization
- 13.3.1 Methods of CSNP synthesis
- 13.3.2 Characterization of CSNPs
- 13.4 CSNPs as wound healing agents
- 13.4.1 Antibacterial properties
- 13.4.2 Antifungal properties
- 13.4.3 Antiinflammatory activity
- 13.4.4 Immunomodulatory activity
- 13.5 CSNPs as wound dressing
- 13.5.1 Enhanced drug delivery
- 13.5.2 Sustained release of therapeutics
- 13.5.3 Biodegradability and biocompatibility
- 13.5.4 Adhesive and flexible dressing forms
- 13.6 CSNPs in chronic wound management
- 13.6.1 Diabetic foot ulcers
- 13.6.2 Pressure ulcer
- 13.6.3 Venous leg ulcers
- 13.7 Clinical studies and applications
- 13.7.1 Wound healing
- 13.7.2 In vivo studies
- 13.8 Future perspectives and challenges
- 13.8.1 Future perspectives
- 13.8.2 Challenges
- 13.8.3 Potential applications in tissue engineering
- 13.8.4 Regulatory considerations
- 13.8.5 Overcoming limitations and obstacles
- 13.9 Conclusion
- References
- 14 Applications of chitosan nanoparticles in veterinary medicine and diagnostics
- Abstract
- Keywords
- 14.1 Introduction
- 14.2 Origins and affordability of chitosan
- 14.3 Methods of preparation of CSNPs
- 14.3.1 Emulsification and cross-linking
- 14.3.2 Microemulsion (reversed micelles)
- 14.3.3 Diffusion of an emulsion solvent
- 14.3.4 Ionic gelation and complexation of polyelectrolytes
- 14.3.5 Radical polymerization and modified ionic gelation
- 14.3.6 Emulsion-droplet coalescence
- 14.3.7 Large-scale production of CSNPs: Spinning disk processing technology (SDP)
- 14.4 Role of nanotechnology in veterinary applications
- 14.5 Veterinary applications of CSNPs
- 14.5.1 Wound treatment
- 14.5.2 Tissue engineering
- 14.5.3 Analgesia
- 14.5.4 Antimicrobial activity
- 14.6 Diagnostics
- 14.6.1 Vaccine
- 14.6.2 Diagnosis of bacterial and mycotic diseases
- 14.7 Prospects, challenges, and future directions
- 14.8 Conclusions
- References
- 15 Chitosan nanoparticles-hydrogel composites for biomedical applications
- Abstract
- Keywords
- 15.1 Introduction
- 15.2 Tissue engineering
- 15.2.1 Skin regeneration
- 15.2.2 Bone regeneration
- 15.2.3 Cardiac tissues regeneration
- 15.3 Genetic engineering
- 15.4 Neural engineering
- 15.5 Pharmaceutical engineering
- 15.5.1 Drug delivery
- 15.5.2 Wound healing
- 15.5.3 Tissue engineering
- 15.5.4 Disease treatment
- 15.6 Medical imaging
- 15.6.1 Magnetic resonance imaging
- 15.6.2 Fluorescence imaging
- 15.6.3 Other imaging techniques
- 15.7 Implants
- 15.7.1 Utilization of chitosan composites for implant scaffolds
- 15.7.2 Postsurgery injectable/implanting chitosan hydrogel for cancer therapy
- 15.8 Concluding remarks and future perspectives
- References
- 16 Regulatory status and toxicological, environmental, and health impacts of chitosan nanoparticles
- Abstract
- Keywords
- Acknowledgments
- 16.1 Introduction
- 16.2 Chitosan
- 16.2.1 Preparation of CS
- 16.2.2 Physicochemical properties of CS
- 16.2.3 Synthesis and characterization of CSNPs
- 16.3 Healthcare impacts
- 16.3.1 Antimicrobial properties of CSNPs
- 16.3.2 Antibiofilm effect of CS/metal oxide nanocomposites
- 16.3.3 Antifungal effect of CSNPs
- 16.3.4 Anticancer effect of CS and CS-based NCs
- 16.3.5 Drug delivery properties of CSNPs
- 16.3.6 Role of nanomaterial-based nanocarriers
- 16.3.7 Various nanocarriers and their uses in drug delivery systems
- 16.4 Environmental impacts
- 16.5 Toxicological impact
- 16.5.1 In vitro and in vivo toxicological impact of CSNPs
- 16.6 Regulatory status
- 16.6.1 Regulatory considerations for CSNPs
- 16.6.2 Regulatory pathways
- 16.6.3 CSNP-mediated medical products
- 16.6.4 Further regulatory considerations
- 16.7 Conclusion
- References
- Index
- No. of pages: 738
- Language: English
- Edition: 1
- Published: November 27, 2024
- Imprint: Woodhead Publishing
- Paperback ISBN: 9780443140884
- eBook ISBN: 9780443140891
KD
Kalim Deshmukh
JM
Jagan Mohan Dodda
IE
Ibrahim M. El-Sherbiny
ES
Emmanuel Rotimi Sadiku
Prof. Rotimi Sadiku, currently a Professor at the Department of Chemical, Metallurgical, and Materials Engineering at Tshwane University of Technology, South Africa, earned his BSc. [Hons] and a PhD from the University of Strathclyde, Glasgow, UK, specializing in Polymer Physics with a focus on Polymer Processing, X-ray Diffraction, Thermal Characteristics, Rheology, and Microscopy of Polymers techniques.
His academic journey includes a role as a Lecturer II at the Federal University of Technology in Nigeria, followed by a Postdoctoral Research Fellowship at the University of Genova/CNR, Italy. Upon returning to Nigeria, he continued his career by joining the Federal University of Technology, where he served as a Senior Lecturer. He also spent a year as a Research Fellow at the KTH Institute of Technology in Stockholm, Sweden. In January 2004, he assumed his current position as a Research Professor at Tshwane University of Technology (TUT), South Africa.