Fundamental Neuroscience for Basic and Clinical Applications
- 6th Edition - November 22, 2024
- Authors: Duane E. Haines, Gregory A. Mihailoff, Mary Alissa Willis
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 0 7 0 3 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 0 7 4 0 - 5
Designed to help you comprehend and retain the challenging material you need to know, Fundamental Neuroscience for Basic and Clinical Applications, Sixth Edition, covers the es… Read more
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Request a sales quoteDesigned to help you comprehend and retain the challenging material you need to know, Fundamental Neuroscience for Basic and Clinical Applications, Sixth Edition, covers the essential neuroscience information needed for coursework, exams, and beyond. Using a rigorous yet clinically-focused approach, it integrates neuroanatomy, pharmacology, and physiology, with separate sections devoted to essential concepts, regional neurobiology, and systems neurobiology.
- Begins with the basic concepts that are needed to understand neuroscience at a fundamental level, followed by regional coverage designed to help prepare you for examinations, and ending with a full section on systems neurobiology as you enter the clinical phase of your education
- Contains new end-of-chapter review questions, as well as thoroughly updated information in every chapter, with an emphasis on new clinical thinking as related to the brain and systems neurobiology
- Features hundreds of correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos
- Pays special attention to the correct use of clinical and anatomical terminology, and provides clinical text and clinical-anatomical correlations
- An eBook version is included with purchase. The eBook allows you to access all of the text and figures, with the ability to search, customize your content, make notes and highlights, and have content read aloud
Evolve Instructor site with an image collection and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
Medical Students
- Cover Image
- Title page
- Copyright
- In Memoriam
- Contributors
- Preface
- Acknowledgments
- Contents
- Section I Essential Concepts 1–5
- CHAPTER 1 Orientation to the Structure and Imaging of the Central Nervous System
- Overview
- Regions of the Central Nervous System
- Functional Systems and Regions
- Concept of Afferent and Efferent
- Posterior (Dorsal), Anterior (Ventral), and Other Directions in the Central Nervous System
- Symptom or Sign?
- Clinical Images of the Brain and Skull
- Review Questions
- Sources and Additional Reading
- CHAPTER 2 The Cell Biology of Neurons and Glia
- Overview
- Structure of Neurons
- Classification of Neurons and Groups of Neurons
- Electrical Properties of Neurons
- Neurons as Information Receivers
- Neurons as Information Transmitters
- Neurotransmitters
- Glia
- Astrocytes
- Control of Local Blood Flow Within the Central Nervous System
- Oligodendrocytes
- Microglia
- Tumors of the Central Nervous System
- Supporting Cells of the Peripheral Nervous System
- Degeneration and Regeneration
- Review Questions
- Sources and Additional Reading
- CHAPTER 3 The Electrochemical Basis of Nerve Function
- Combined Forces of Chemical Gradients and Electrical Potentials
- Graded Potentials
- Action Potentials in the Nerve and in the Neuron
- Regenerative Potentials Using a Single Active Current
- Modifiers of Excitability
- A Syndrome of Periodic Paralysis
- Potassium and the Variety of Neuronal Activity
- Neuronal Activity as Information
- Review Questions
- Sources and Additional Reading
- CHAPTER 4 Chemical Signaling in the Nervous System
- The Synapse: Adaptable to Many Tasks
- Glutamate Receptors: The Tetrameric Excitatory Ionotropic Receptors
- Cys-Loop Receptors: The Pentameric Multifunctional Ionotropic Receptors
- The Biogenic Amines Modulate Synaptic Activity
- Coda
- Review Questions
- Sources and Additional Reading
- CHAPTER 5 Development of the Nervous System
- Overview
- Overview
- Development of the Neural Tube: General Concepts
- Brain Development
- Peripheral Nervous System
- Central Nervous System
- Cellular Events in Brain Development
- Review Questions
- Sources and Additional Reading
- Section II Regional Neurobiology 6–16
- CHAPTER 6 The Ventricles, Choroid Plexus, and Cerebrospinal Fluid
- Overview
- Development
- Ventricles
- Ependyma, Choroid Plexus, and Cerebrospinal Fluid
- Review Questions
- Sources and Additional Reading
- CHAPTER 7 The Meninges
- Overview
- Development of the Meninges
- Overview of the Meninges
- Dura Mater
- Arachnoid Mater
- Meningioma
- Meningeal Hemorrhages
- Sources and Additional Reading
- CHAPTER 8 A Survey of the Cerebrovascular System
- Overview
- Causes of Vascular Compromise
- Internal Carotid System
- Vertebrobasilar System
- Cerebral Arteries and Watershed Infarcts
- Circle of Willis
- Veins and Venous Sinuses of the Brain
- Arteries of the Spinal Cord
- Veins of the Spinal Cord
- Blood-Brain Barrier
- Review Questions
- Sources and Additional Reading
- CHAPTER 9 The Spinal Cord
- Overview
- Development
- Spinal Cord Structure
- Regional Characteristics
- Spinal Nerves
- Spinal Reflexes
- Peripheral Nerve Lesions
- Pathways and Tracts of the Spinal Cord
- Deficits Characteristic of Spinal Cord Lesions
- Review Questions
- Sources and Additional Reading
- CHAPTER 10 An Overview of the Brainstem
- Basic Divisions of the Brainstem
- Ventricular Spaces of the Brainstem
- Cranial Nerve Nuclei and Their Functional Components
- Herniation Syndromes Related to the Brainstem
- Review Questions
- Sources and Additional Reading
- CHAPTER 11 The Medulla Oblongata
- Development
- External Features
- Internal Anatomy of the Medulla
- Internal Vasculature of the Medulla and Medullary Syndromes
- Tonsillar Herniation
- Review Questions
- Sources and Additional Reading
- CHAPTER 12 The Pons and Cerebellum
- Development
- External Features
- Internal Anatomy of the Pons
- Vascular Syndromes of the Pons
- Internal Anatomy of the Cerebellum
- Review Questions
- Sources and Additional Reading
- CHAPTER 13 The Midbrain
- Chapter Outline
- Development
- External Features
- Internal Anatomy of the Midbrain
- Vascular Syndromes of the Midbrain
- Herniation Syndromes Related to the Midbrain
- Review Questions
- Sources and Additional Reading
- CHAPTER 14 A Synopsis of Cranial Nerves of the Brainstem
- Overview
- Motor Cell Columns and Nuclei
- Sensory Cell Columns and Nuclei
- Cranial Nerves of the Medulla Oblongata
- Cranial Nerves of the Pons-Medulla Junction
- Cranial Nerve of the Pons
- Cranial Nerves of the Midbrain
- Review Questions
- Sources and Additional Reading
- CHAPTER 15 The Diencephalon
- Overview
- Development of the Diencephalon
- Basic Organization
- Dorsal Thalamus (Thalamus)
- Internal Capsule
- Hypothalamus
- Ventral Thalamus (Subthalamus)
- Epithalamus
- Vasculature of the Diencephalon
- Review Questions
- Sources and Additional Reading
- CHAPTER 16 The Telencephalon
- Overview
- Development
- Lobes of the Cerebral Cortex
- White Matter of the Cerebral Hemisphere
- Basal Nuclei
- Hippocampus and Amygdala
- Review Questions
- Sources and Additional Reading
- Section III Systems Neurobiology 17–33
- CHAPTER 17 The Somatosensory System I: Tactile Discrimination and Position Sense
- Overview
- Posterior Column–Medial Lemniscal System
- Trigeminal System
- Anterior and Posterior Trigeminothalamic Tracts
- Receptive Field Properties of Cortical Neurons
- Neuroimaging and Functional Localization
- Afferent Cerebellar Pathways
- Acknowledgment
- Review Questions
- Sources and Additional Reading
- CHAPTER 18 The Somatosensory System II: Nociception, Thermal Sense, and Touch
- Overview
- Anterolateral System
- Spinal Trigeminal Pathway: Anterior Trigeminothalamic Tract
- Pain Perception
- Chronic and Neuropathic Pain and the Thalamus
- Control of Pain Transmission
- Imaging of the Pain Pathway
- Acknowledgment
- Review Questions
- Sources and Additional Reading
- CHAPTER 19 Viscerosensory Pathways
- Viscerosensory Receptors
- Viscerosensory Fibers
- Ascending Pathway for Sympathetic Afferents
- Pathways for Parasympathetic Afferents
- Visceral Input to the Reticular Activating System
- Other Visceral Nociceptive Pathways
- Review Questions
- Sources and Additional Reading
- CHAPTER 20 The Visual System
- Overview
- Anatomy of the Eye
- Neural Retina and Pigment Epithelium
- Photoreceptor Cells
- Receptive Fields
- Processing of Visual Input in the Retina
- Retinal Projections
- Visual Fields Correlated with Visual Structures as Seen in Magnetic Resonance Imaging
- Lateral Geniculate Nucleus
- Optic Radiations
- Primary Visual Cortex
- Abnormal Development of Visual Cortex
- Other Visual Cortical Areas
- Review Questions
- Sources and Additional Reading
- CHAPTER 21 The Auditory System
- Overview
- Properties of Sound Waves and Hearing
- Processing of Sound: The Ear
- Weber and Rinne Tests
- Overview of Central Auditory Pathways
- Brainstem Auditory Nuclei and Pathways
- Auditory and Related Association Cortices
- Descending Auditory Pathways
- Middle Ear Reflex
- Acoustic Startle Reflex, Orientation, and Attention
- Review Questions
- Sources and Additional Reading
- CHAPTER 22 The Vestibular System
- Overview
- Peripheral Vestibular Labyrinth
- Vestibular Sensory Receptors
- Semicircular Canals and Otolith Organs
- Vestibular Nuclei
- Vestibuloocular Network
- Vestibulospinal Network
- Vestibulothalamocortical Network
- Dizziness and Vertigo
- Review Questions
- Sources and Additional Reading
- CHAPTER 23 Olfaction and Taste
- Overview
- Olfactory Receptors
- Olfactory Transduction
- Central Olfactory Pathways
- Taste Receptors
- Distribution of Taste Receptors
- Taste Transduction
- Peripheral Taste Pathways
- Central Taste Pathways
- Review Questions
- Sources and Additional Reading
- CHAPTER 24 Motor System I: Peripheral Sensory, Brainstem, and Spinal Influence on Anterior Horn Neurons
- Overview
- Anterior Horn Motor Neurons
- Peripheral Sensory Input to the Anterior (Ventral) Horn
- Brainstem-Spinal Systems: Anatomy and Function
- Functional Role of Brainstem-Spinal Interactions
- Review Questions
- Sources and Additional Reading
- CHAPTER 25 Motor System II: Corticofugal Systems and the Control of Movement
- Overview
- General Features of Motor Deficits
- Corticospinal System
- Corticonuclear System
- Other Corticofugal Systems
- Motor Cortex and the Control of Movement
- Hierarchical Organization Versus Parallel Distributed Processing in the Motor System
- Review Questions
- Sources and Additional Reading
- CHAPTER 26 The Basal Nuclei
- Overview
- Components of the Basal Nuclei
- Direct and Indirect Pathways of Basal Nuclear Activity
- Parallel Circuits of Information Flow Through the Basal Nuclei
- Dysfunction of the Basal Nuclei
- Etiology of Basal Nuclear–Related Disorders
- Review Questions
- Sources and Additional Reading
- CHAPTER 27 The Cerebellum
- Overview
- Basic Structural Features
- Cerebellar Cortex
- Functional Cerebellar Modules
- Cerebellar Influence on Visceromotor Functions
- Cerebellum and Motor Learning
- Review Questions
- Sources and Additional Reading
- CHAPTER 28 Visual Motor Systems
- Overview
- Peripheral Structures
- Central Structures
- Targeting Movements
- Reflex Movements
- Acknowledgment
- Review Questions
- Sources and Additional Reading
- CHAPTER 29 Visceral Motor Pathways
- Overview
- Organization of the Visceral Motor System
- Development
- Sympathetic Division
- Parasympathetic Division
- Enteric Nervous System
- Regulation of Visceral Motor Outflow
- Review Questions
- Sources and Additional Reading
- CHAPTER 30 The Hypothalamus
- Overview
- Boundaries of the Hypothalamus
- Hypothalamus and Pituitary
- Divisions of the Hypothalamus
- Feeding Motivation
- Blood Supply of the Hypothalamus
- Hypothalamic Afferent Fibers
- Hypothalamic Efferent Fibers
- Intrinsic Hypothalamic Connections
- Pituitary Tumors
- Hypothalamic Reflexes
- Review Questions
- Sources and Additional Reading
- CHAPTER 31 The Limbic System
- Overview
- Cytoarchitectural Definitions of the Limbic Cortex
- Early Functional Concepts
- Blood Supply to the Limbic System
- Hippocampal Formation
- Limbic System and Memory
- Long-term Potentiation and Memory
- Amygdaloid Complex
- Septal Region
- Nucleus Accumbens
- Limbic System and Behavior
- Temporal Lobe Seizures
- Limbic System and Cognitive Function
- Review Questions
- Sources and Additional Reading
- CHAPTER 32 The Cerebral Cortex
- Overview
- Histology of the Cerebral Cortex
- Layers of the Cerebral Cortex
- Neurotransmitters of the Cerebral Cortex
- Neuron Types in the Cerebral Cortex
- Laminar Organization
- Columnar Organization
- Synopsis of Thalamocortical Relationships
- Blood Supply to the Cerebral Cortex
- Higher Cortical Functions
- Review Questions
- Sources and Additional Reading
- CHAPTER 33 The Neurologic Examination
- Overview
- Evaluation Versus Examination
- Mental Status Examination
- Cranial Nerve Function Testing
- Motor Examination
- Sensory Examination
- Review Questions
- Sources and Additional Reading
- Appendix A Answers to Review Questions
- e-Appendix B Alternate Figure Option for Anatomic and Clinical Orientation
- Index
- No. of pages: 576
- Language: English
- Edition: 6
- Published: November 22, 2024
- Imprint: Elsevier
- Paperback ISBN: 9780443107030
- eBook ISBN: 9780443107405
DH
Duane E. Haines
Dr. Haines is an exceedingly well-respected academic (a former Henry Gray/Elsevier award winner from the American Association of Anatomists and a Distinguished Teacher Award winner from the Association of American Medical Colleges). Though Dr. Haines has retired as Chair of the Department of Anatomy as well as Professor of Neurosurgery at the University of Mississippi, he retains a working relationship with Wake Forest University in Winston-Salem, North Carolina. He travels extensively and continues to speak frequently at meetings both in the US and Internationally.
Affiliations and expertise
Professor, Department of Neurobiology and Anatomy, and Professor of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Professor Emeritus (and Former Chairman); Professor, Departments of Neurology and Neurosurgery, The University of Mississippi Medical Center, Jackson, Mississippi, USAGM
Gregory A. Mihailoff
Professor Emeritus Gregory A. Mihailoff works in the Department of Anatomy at Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona.
Affiliations and expertise
Professor Emeritus, Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona, USAMW
Mary Alissa Willis
Mary Alissa Willis is Vice Chair in the Department of Neurology at Cleveland Clinic Foundation, Cleveland, Ohio.
Affiliations and expertise
Vice Chair, Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio, USA