Functioning Neuroendocrine Tumors and Paraneoplastic Endocrine Syndromes

Volume 135, Functioning Neuroendocrine Tumors and Paraneoplastic Endocrine Syndromes, provides a comprehensive and contemporary overview of the biology, clinical presentation, diagnosis, and management of hormone-secreting neuroendocrine neoplasms and endocrine paraneoplastic syndromes. Functioning neuroendocrine tumors (NETs) represent a unique group of neoplasms characterized by excessive hormone production, leading to diverse and often complex clinical syndromes that require a multidisciplinary approach. At the same time, paraneoplastic endocrine syndromes, resulting from ectopic hormone secretion by non-endocrine malignancies, remain important diagnostic and therapeutic challenges due to their rarity, heterogeneous manifestations, and significant impact on patient outcomes. This volume integrates recent advances in molecular biology, endocrine physiology, functional imaging, pathology, biomarkers, genetics, and precision medicine to provide an evidence-based approach to these disorders. Chapters cover the epidemiology, pathophysiology, diagnostic algorithms, localization techniques, medical and surgical treatment, peptide receptor radionuclide therapy, targeted therapies, and long-term follow-up of patients with functioning NETs, including insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, ACTH-producing tumors, and other rare hormone-secreting neoplasms. In addition, the volume comprehensively reviews endocrine paraneoplastic syndromes such as ectopic Cushing syndrome, humoral hypercalcemia of malignancy, SIADH, tumor-induced hypoglycemia, and other ectopic hormone secretion syndromes, emphasizing early recognition and optimal multidisciplinary management.