Functional Nanocomposite Hydrogels

Synthesis, Characterization, and Biomedical Applications

1st Edition - June 22, 2023
Editors: Anuj Kumar, Vijay Kumar Thakur
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 6 3 8 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 6 3 9 - 6

Functional Nanocomposite Hydrogels: Synthesis, Characterization, and Biomedical Applications reviews how the unique properties of nanoscale composite materials make them ideal can… Read more

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Functional Nanocomposite Hydrogels: Synthesis, Characterization, and Biomedical Applications reviews how the unique properties of nanoscale composite materials make them ideal candidates for use in biomedical hydrogels. The book covers a range of key nanocomposite materials for use in biomedical hydrogels, including graphene quantum dot, cellulose and collagen nanocomposites. A wide selection of biomedical applications for functional nanocomposite hydrogels is explored, from drug delivery and cancer therapy, to wound healing and bioimaging. This is a key reference for those working in the fields of biomaterials, nanotechnology, pharmacology, biomedical engineering, and anyone with a particular interest in composites and hydrogels.

To improve the properties of conventional hydrogels, nanoparticles or nanostructures are incorporated into the hydrogel networks, forming a composite hydrogel with specialized functional properties which are tailored to a specific biomedical application.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
1. Fundamental of hydrogels and nanocomposite hydrogels: synthesis, physiochemical characterization, and biomedical applications
Abstract
1.1 Introduction
1.2 Methods of synthesis of various hydrogels
1.3 Characterization of hydrogels
1.4 Biomedical applications of hydrogel and nanocomposite hydrogel
1.5 Conclusion and future prospects
References
Further reading
2. Cellulose-based nanocomposite hydrogels for wound management
Abstract
2.1 Introduction
2.2 Wound-healing process
2.3 Wound dressing and its ideal properties
2.4 Cellulose as a biopolymer for nanocomposite hydrogels
2.5 Cellulose-based nanocomposite hydrogels for wound management
2.6 Conclusion
2.7 Future scope
Acknowledgments
References
3. Lignin nanoparticle–based nanocomposite hydrogels for biomedical applications
Abstract
3.1 Introduction
3.2 Lignin-based hydrogel
3.3 Lignin-based nanoparticles
3.4 Final remarks and future perspectives
References
4. Hydroxyapatite-based hydrogel nanocomposites for bone tissue engineering applications
Abstract
4.1 Introduction
4.2 The concept of tissue engineering
4.3 Types of biomaterials used for orthopedic applications
4.4 What is meant by nanotechnology?
4.5 Hydroxyapatite-based nanocomposites for bone tissue engineering
4.6 Hydrogels
4.7 Hydroxyapatite-based nanocomposite hydrogels for bone tissue engineering
4.8 Conclusions
References
5. Nanoscale bioactive glass/injectable hydrogel composites for biomedical applications
Abstract
5.1 Introduction
5.2 Fabrication techniques for nanoscale bioactive glasses
5.3 General properties of nanoscale bioactive glasses-reinforced injectable hydrogels
5.4 Nanoscale bioactive glasses-reinforced injectable hydrogels for tissue regeneration
5.5 Conclusion and future perspectives
References
6. Graphene oxide-based nanocomposite hydrogels for biosensor applications
Abstract
6.1 Introduction
6.2 Biosensors: an advanced approach and present practices
6.3 Graphene and its oxides: structure and properties
6.4 Hydrogels and their role for various applications
6.5 Construction of a biosensor
6.6 Functionalization and fabrication of graphitic oxide and its nanocomposite in development of biosensor
6.7 Molecular imprinting for developing biosensor
6.8 Graphene and graphitic oxide-based nanocomposite hydrogel biosensors
6.9 Conclusion
Acknowledgment
References
7. Graphene quantum dot-based nanocomposite hydrogels as anticancer drug delivery systems
Abstract
7.1 Introduction
7.2 Graphene quantum dot synthesis and properties
7.3 Graphene quantum dot in drug delivery
7.4 Graphene quantum dot hydrogels
7.5 Conclusion
Acknowledgment
References
8. Periodic mesoporous organosilica-based nanocomposite hydrogels for biomedical applications
Abstract
8.1 Introduction
8.2 Design and assembly of PMO-based nanocomposite hydrogels
8.3 Biomedical application of PMO-based nanocomposite hydrogels
8.4 Conclusion
References
9. POSS-based stimuli-responsive nanocomposite hydrogels for biomedical applications
Abstract
9.1 Hydrogels
9.2 POSS nanochemicals
9.3 PEG–POSS chemical hydrogels
9.4 PNIPAm–POSS physical hydrogels
9.5 Biomedical applications of POSS-based materials
9.6 Conclusions
References
10. Silver nanoparticle-based nanocomposite hydrogels for biomedical applications
Abstract
10.1 Introduction
10.2 Properties of nanocomposites
10.3 Nanomaterials used to build nanocomposite hydrogel
10.4 Synthesis of silver nanoparticle composite hydrogels
10.5 Applications of silver nanocomposite hydrogel in biomedical
10.6 Conclusion and future perspectives
Disclosure of potential conflicts of interest
Acknowledgment
References
11. Collagen-inspired mineral nanocomposite hydrogels for bone tissue regeneration
Abstract
11.1 Introduction to nanocomposite hydrogel
11.2 Properties of collagen- inspired mineral nanocomposites
11.3 Biological absorbability
11.4 Hierarchical pore structure
11.5 Mechanical properties
11.6 Angiogenesis
11.7 Production and oxygen release
11.8 Antimicrobial effect
11.9 Nanocomposite hydrogels are classified based on the type of hydrogel
11.10 Mineral nano−composite hydrogels
11.11 Ceramic-based nanocomposite hydrogels
11.12 Conductive nanocomposite hydrogels
11.13 Black phosphorus-based hydrogels
11.14 Graphene containing hydrogels
11.15 Gold nanoparticle hydrogels
11.16 Collagen in bone tissue engineering
11.17 Synthesis of nanocomposite hydrogels
11.18 Blending method
11.19 In situ precipitation method
11.20 Freeze/thawing method
11.21 Grafting-onto method
11.22 Applications of collagen-based nanocomposite hydrogels
11.23 Conclusions
References
12. Protein-based nanocomposite hydrogels for biomedical applications
Abstract
12.1 Introduction
12.2 Nanocomposite hydrogels with albumin
12.3 Nanocomposite hydrogels with collagen
12.4 Nanocomposite hydrogels with gelatin
12.5 Nanocomposite hydrogels with silk fibroin
12.6 Nanocomposite hydrogels with keratin
12.7 Nanocomposite hydrogels with sericin
12.8 Nanocomposite hydrogels with plant-based proteins
References
13. Starch-based nanocomposite hydrogels for biomedical applications
Abstract
13.1 Introduction
13.2 Starch
13.3 Morphological and Structural Characterizations of starches
13.4 Starch hydrogels
13.5 Starch-based Nanocomposite hydrogels
13.6 Biomedical applications
13.7 Conclusions and future trends
References
14. Chitosan-based nanocomposite hydrogels for biomedical applications
Abstract
14.1 Introduction
14.2 Importance of chitosan hydrogels
14.3 Methods of chitosan-based hydrogel preparation
14.4 Applications of chitosan nanocomposite hydrogels in different biomedical areas
14.5 Conclusion
References
15. Alginate-based nanocomposite hydrogels for antimicrobial and antibiofilm applications
Abstract
15.1 Introduction
15.2 Hydrogels
15.3 Alginates as biomaterials
15.4 Alginate-based nanocomposites
15.5 Antimicrobial applications of alginate-based nanocomposite hydrogels
15.6 Antibiofilm applications of alginate-based nanocomposite hydrogels
15.7 Conclusion and future perspectives
References
16. Dual-cross-linked nanocomposite hydrogels for potential antibacterial applications
Abstract
16.1 Introduction
16.2 Conclusions
Funding
References
17. Conductive adhesive self-healing nanocomposite hydrogels for photothermal therapy in wound healing
Abstract
17.1 Introduction
17.2 Photothermal therapy
17.3 Photothermal hydrogels as wound dressings
17.4 Multifunctional hydrogels: major trends and challenges
17.5 Concluding remarks
References
18. 3D printable nanocomposite hydrogels for biomedical applications
Abstract
18.1 Introduction
18.2 Importance of nanocomposite hydrogels in 3D printing technology
18.3 Biomedical applications of 3D printable nanocomposite hydrogels
18.4 Conclusion
References
19. Thermoresponsive nanocomposite hydrogels: tunable systems for localized cancer theranostics
Abstract
19.1 Introduction
19.2 Thermosensitive hydrogels
19.3 Nanocomposite-thermoresponsive hydrogel for cancer theranostics
19.4 Conclusion
References
20. Nanogels for locoregional drug delivery
Abstract
20.1 Introduction
20.2 Intranasal administration
20.3 Intraocular administration
20.4 Intracranial administration
20.5 Endoscopic administration
20.6 Administration near the bone defects
20.7 Administration around the sciatic nerve
20.8 Dermal administration
20.9 Conclusion
References
21. Environmentally sensitive nanocomposite hydrogels for biomedical applications
Abstract
21.1 Introduction
21.2 Nanocomposite hydrogels design and synthesis
21.3 Biomedical applications of environmentally sensitive nanocomposite hydrogel systems
21.4 Conclusion and future perspective
References
22. Bisphosphonate-based nanocomposite hydrogels for biomedical applications
Abstract
22.1 Introduction
22.2 Bisphosphonate nanocomposites and its importance
22.3 Mechanism of action
22.4 Wound healing
22.5 Conclusion and future prospects
References
Index

Anuj Kumar

Dr. Anuj Kumar is a DBT-Ramalingaswami Faculty/Assistant Professor at the School of Materials Science and Technology, Indian Institute of Technology (BHU), Varanasi, India since April 2023. Prior to this position, he was an Assistant Professor (Polymers & Biomaterials) at the School of Chemical Engineering, Yeungnam University (YU), South Korea from 2016 to 2023. He was also a Postdoc at YU (2015-2016) and an Assistant Professor (Chemistry) at DIT University (India) (2014-2015). He received his Ph.D. (Polymer Science and Engineering, 2014), M.Tech. (Fibre Science and Technology, 2009), and M.Sc. (Organic Chemistry, 2006) from IIT Roorkee, IIT Delhi, and CCSU Meerut, India, respectively. He has published more than 85 research/review articles, 03 books, and 11 book chapters (Google Citations: 4673, h-index: 35, i10-index: 66). His research interests are focused on polymer chemistry, lignocellulosic biomass, nanocellulose, biomaterials, 3D bioprinting, micro-fluidics, tissue engineering, cultured meat production, drug delivery, cancer therapy, polymer composites/nanocomposites, functional foods and packaging materials, fibres/bio-textiles hydrogel and paper-based bioelectronics, etc.

Affiliations and expertise

DBT-Ramalingaswami Faculty (Assistant Professor equivalent), School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India

Vijay Kumar Thakur

Vijay Kumar Thakur is currently a Professor in the Biorefining and Advanced Materials Research Centre at SRUC, Edinburgh, U.K. He holds an Adjunct Professor position in the Research School of Polymeric Materials, Jiangsu University, China and is a Visiting Professor at Shiv Nadar University, India, and Visitor at Cranfield University, U.K. He has previously held faculty positions at Cranfield University, U.K., Washington State University, U.S.A., and Nanyang Technological University, Singapore. His research activities span the disciplines of Biorefining, Chemistry, Chemical Engineering, Manufacturing, Materials Science, and Nanotechnology, as well as all aspects of Sustainable and Advanced Materials. He has published over 200 SCI journal articles, 2 patents, 50 books, and 37 book chapters in areas concerning polymers, nanotechnology, and materials science. He sits on the editorial board of several SCI journals (e.g., Nature Scientific Reports, Journal of Renewable Materials, Advances in Polymer Technology, International Journal of Polymer Analysis and Characterization, Polymers for Advanced Technologies, Biomolecules, Nanomaterials, Surfaces and Interfaces, Sustainable Chemistry and Pharmacy, Current Opinion in Green and Sustainable Chemistry, and Nano-Structures & Nano-Objects) as an Editor or Editorial Advisory Board member.

Affiliations and expertise

Professor, Biorefining and Advanced Materials Research Centre,SRUC (Scotland’s Rural College), UK