Fidelity and Quality Control in Gene Expression
- 1st Edition, Volume 86 - January 25, 2012
- Imprint: Academic Press
- Editor: Assen Marintchev
- Language: English
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 6 4 9 8 - 7
The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In ad… Read more
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The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.
- Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation
- Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting
Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists
PrefaceQuality control in aminoacyl-tRNA synthesisI. IntroductionII. Class I aaRS Editing MechanismsIII. Class II aaRS Editing MechanismsIV. Nucleotide Determinants for EditingV. Trans-Editing Factors and Triple SievesVI. Loss of Editing Function in aaRSVII. Mistranslation and Role of Editing in CellAcknowledgmentTermination and post-termination events in eukaryotic translationI. IntroductionII. TerminationIII. Ribosome RecyclingIV. ReinitiationAcknowledgmentsQuality control of mRNA decoding on the bacterial ribosomeI. IntroductionII. Speed and Fidelity of Translation in vivoIII. Substrate Selection During Translation InitiationIV. Fidelity of ElongationV. Termination FidelityVI. ConclusionsAcknowledgmentsControl of gene expression by translational recodingI. IntroductionII. Programmed −1 Ribosomal FrameshiftingIII. Programmed +1 Ribosomal FrameshiftingIV. Selenocysteine and Pyrrolysine: The 21st and 22nd Amino AcidsV. Termination Codon ReadthroughVI. SummaryAcknowledgmentsThe tmRNA ribosome-rescue systemI. IntroductionII. tmRNA–SmpB and the Mechanism of trans-TranslationIII. Degradation of ssrA-Tagged Proteins and Truncated mRNAIV. tmRNA-Independent Ribosome-Rescue PathwaysV. Origins of Nonstop mRNA in BacteriaVI. mRNA Cleavage Resulting from Translational ArrestVII. Other Determinants of tmRNA ActivityVIII. Role of tmRNA in Physiology and the Regulation of Gene ExpressionIX. Concluding RemarksAcknowledgmentsPosttranscriptional recoding by RNA editingI. IntroductionII. Machinery and MechanismIII. Impact of RNA EditingIV. Conclusions and Outlook
- Edition: 1
- Volume: 86
- Published: January 25, 2012
- Imprint: Academic Press
- Language: English
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