Fibroblast Activation Protein Imaging, An Issue of PET Clinics

1st Edition, Volume 18-3 - June 1, 2023
Editors: Frederik L. Giesel, Rodney Hicks, Ken Herrmann
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 8 9 5 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 8 9 6 - 9

In this issue, guest editors bring their considerable expertise to this important… Read more

Fibroblast Activation Protein Imaging, An Issue of PET Clinics

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In this issue, guest editors bring their considerable expertise to this important topic.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
CME Accreditation Page
Preface
Advanced Fibroblast Activation Protein-Ligand Developments: FAP Imaging Agents: A Review of the Structural Requirements
Key points
Introduction
Rationale for fibroblast activation protein-α inhibitor design
Improving retention
Improving delivery
Summary
Clinics care points
Disclosure
Fibroblast Activation Protein Inhibitor PET in Pancreatic Cancer
Key points
Introduction
Fibroblast activation protein inhibitor PET/computed tomography and PET/MR imaging in the diagnosis of pancreatic cancer
Prognostic value of FAPI PET in pancreatic cancer
Increased fibroblast activation protein inhibitor uptake in nonmalignant pancreatic lesions
Summary
Clinics care points
Declaration of interests and source of funding
The Diagnostic Value of Fibroblast Activation Protein Imaging in Hepatocellular Carcinoma and Cholangiocellular Carcinoma
Key points
Background
The diagnostic value and limitations of the standard-of-care imaging with [18F]FDG PET/CT scan
Cancer-associated fibroblast and its role in carcinogenesis of hepatocellular carcinoma and cholangiocellular carcinoma
Fibroblast activation protein overexpression and Fibroblast activation protein ligands in PET imaging
Current state of the research in fibroblast activation protein imaging
Outlook
Clinics care points
Conflict of Interest
Fibroblast Activation Protein Inhibitor PET Imaging in Head and Neck Cancer
Key points
Introduction: overview of head and neck cancers
Normal anatomy and imaging technique
Protocols
Imaging findings/pathology
Clinical applications
Diagnostic criteria
Differential diagnosis
Case study presentation
Clinics care points
Declaration of Interests
Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer
Key points
Introduction
FAPI-PET imaging in colorectal cancer
Summary
Clinics care points
Disclosure
Fibroblast Activation Protein Inhibitor PET/CT in Gastric Cancer
Key points
Introduction
Current status of [18F]fluorodeoxyglucose-PET imaging in gastric cancer
Fibroblast activation protein expression in gastric cancer
Clinical applications of fibroblast activation protein inhibitor-PET in gastric cancer
Summary
Clinics care points
Funding
Disclosure
Current Status of Fibroblast Activation Protein Imaging in Gynecologic Malignancy and Breast Cancer
Key points
Introduction
Summary
Clinics care points
Disclosures
Fibroblast Activation Protein Inhibitor (FAPI)-PET Imaging in Sarcoma
Key points
Introduction
Background
Fibroblast activation protein
Fibroblast activation protein and sarcoma
68Ga-FAPI from bench to bedside in patients with sarcoma
PET imaging in sarcoma and impact of 68Ga-FAPI
Limitations of current data and future perspectives
Summary
Clinics care points
Disclosure
Fibroblast Activation Protein Inhibitor Theranostics: The Case for Use in Sarcoma
Key points
Introduction
Future directions
Discussion
Summary
Clinics care points
Declaration of Interests
Radiation Therapy Planning Using Fibroblast Activation Protein Inhibitor
Key points
Introduction
Standard imaging techniques for radiation oncology
Clinical applications of fibroblast activation protein inhibitor for radiation oncology
Discussion
Summary
Clinics care points
Imaging Fibrosis
Key points
Introduction
Discussion/emerging trends
Retroperitoneal Fibrosis
Using fibroblast activation protein inhibitor to select and monitor antifibrotic therapies
Summary
Clinics care points
Disclosure
Cardiac Applications of Fibroblast Activation Protein Imaging
Key points
Overview
Fibroblast activation protein PET imaging versus established fibrosis-imaging tools
Clinics care points
Funding
Disclosure
Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Considerations
Key points
Introduction
Preclinical Evaluation of Fibroblast Activation Protein Inhibitor in Animal Models
Development of Fibroblast Activation Protein Inhibitor Chemicals
Compound Structure and Biological Affinity
Discussion in the future
Summary
Conflict of interest
Disclosure
Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Combination Treatment
Key points
Introduction
Fibroblast activation protein radioligand therapy
Leveraging responses to DNA damage
Exploiting radioligand therapy-induced immunomodulation
Radiation responses of cancer-associated fibroblasts and their potential utilization in combination therapy
Co-targeting the tumor microenvironment
Discussion and conclusion
Disclosure
Fibroblast Activation Protein Inhibitor Theranostics: Early Clinical Translation
Key points
Overview
Early theranostic application of fibroblast activation protein inhibitor ligands
Further development of theranostic tracer: FAPI-46
Radioligand therapy with FAPI-46
Recent theranostic agent developments
Role of radiochemistry
Future perspectives
Author contribution
Conflicts of interest
Clinics care points
Current State of Clinical Trials and Regulatory Approvals with Fibroblast Activation Protein Targeting Interventions
Key points
Background
Current trials
Future directions
Summary
Clinics care points
Disclosure

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Fibroblast Activation Protein Imaging, An Issue of PET Clinics

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