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Fanaroff and Martin's Neonatal-Perinatal Medicine, 2-Volume Set
Diseases of the Fetus and Infant
- 12th Edition - February 19, 2024
- Editors: Richard J. Martin, Avroy A. Fanaroff
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 3 2 6 6 - 0
**Selected for Doody’s Core Titles® 2024 in Pediatrics**A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal… Read more
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Request a sales quote**Selected for Doody’s Core Titles® 2024 in Pediatrics**
A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children’s Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients.
A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children’s Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients.
- Provides up-to-date, evidence-based content throughout, including state-of-the-art coverage of personalized medicine and genetics.
- Contains new chapters on Big Data for the Smallest Patients: What we can learn from neonatal database research; Role of Umbilical Cord Management in Neonatal Resuscitation; Care of Periviable Micropremies: the Japanese perspective; Longer Term Respiratory Outcomes of Prematurity; and Perinatal Palliative Care.
- Features extensive updates throughout, including blood and the hematopoietic system; social and economic contributors to neonatal outcome; fetal growth restriction; diagnostic imaging of the neonate; anesthesia in the neonate; postnatal bacterial infections; neonatal management of congenital heart disease; and retinopathy of prematurity.
- Includes over 600 detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information.
- Provides indexing in both volumes that provides quick access to specific guidance.
- Offers a global perspective with an expanded number of international contributors.
- An ideal resource for clinical practice as well as recommended reading for neonatology board review or maintenance of certification.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Neonatologists, Pediatricians, residents, fellows
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Volume 1
- Part 1. The Field of Neonatal-Perinatal Medicine
- 1. Growth of Neonatal-Perinatal Medicine—A Historical Perspective
- Perinatal Pioneers
- The High-Risk Fetus and Perinatal Obstetrics
- Midwives and Perinatal Care
- Neonatal Resuscitation: Tales of Heroism and Desperations
- Apgar and the Language of Asphyxia
- Foundling Asylums and Infant Care
- Saving Infants to Man the Army
- An Ingenious Contrivance, the Couveuse, and Premature Baby Stations
- Incubators, Baby Shows, and Origins of Neonatal Intensive Care Units
- Supportive Care and Oxygen Therapy
- Ventilatory Care: “Extended Resuscitation”
- Supportive Care: Intravenous Fluid and Blood Transfusions
- Tools and Supplies for Neonatal Intensive Care Units
- Pediatric Surgery: Not for Rabbits Anymore
- Global Neonatal Care
- Medical Errors and “Patient Safety” as a New Discipline
- Controlled Clinical Trials, Evidence-Based Medicine, and Research Networks
- Some Recent Advances and New Frontiers for Research
- Some Famous High-Risk Infants
- Acknowledgments
- 2. Epidemiology for Neonatologists
- Introduction
- Common Epidemiologic Concepts
- Health Statistics and Data Sources
- Birth Data
- Fetal Deaths
- Infant Deaths
- Pregnancy-Related Deaths
- Maternal Morbidity
- Neonatal Morbidity
- 3. Big Data for the Smallest Patients—What We Can Learn From Neonatal Database Research
- Introduction: Neonatal Database Research
- The Scope of Research Using Neonatal Databases
- Interpretation of Neonatal Database Studies
- Statistical Methods
- The Future of Big Data in Neonatology
- 4. Medical Ethics in Neonatal Care
- Introduction
- Principles in Medical Ethics
- Key Terms and Concepts
- Clinical Applications in Specific Moral Problems
- Ethical Responsibilities of Neonatal Physicians
- Acknowledgment
- 5. Improving the Quality, Safety, and Equity of Neonatal Intensive Care for Infants and Families
- Overview
- The Case for Improvement
- Brief History of Industrial Quality Improvement
- Definitions and Conceptual Frameworks for Quality
- Data and Methods for Quality Improvement
- Quality and Safety Applied
- Conclusion
- Acknowledgments
- 6. Importance of Simulation in Neonatology
- Introduction
- History of Simulation
- Simulation-Based Training in Health Care
- Simulation in Low-Resourced Areas
- Debriefing
- Simulation-Based Research and In Situ Simulation
- Acknowledgment
- 7. Perinatal and Neonatal Care in Developing Countries
- Global Initiatives to Reduce Infant Mortality Rate and Neonatal Mortality Rate
- Global Burden of Maternal and Neonatal Deaths
- Causes of Global Maternal and Neonatal Mortality
- Burden of Neonatal Sepsis
- Evidence-Based Interventions to Reduce Maternal Mortality Rates, Neonatal Mortality Rates, and Infant Mortality Rates
- The Impact of Progress
- Strategies to Improve Global Perinatal and Neonatal Outcomes
- Summary
- 8. Social and Economic Contributors to Neonatal Outcome in the United States
- Epidemiology of Health Disparities in Neonatal and Perinatal Medicine
- Interventions to Reduce Neonatal Health Outcome Disparities
- Part 2. The Fetus
- 9. Genetic Aspects of Perinatal Disease and Prenatal Diagnosis
- Principles of Inheritance
- Teratogens
- Congenital Anomalies and Ultrasonography
- Role of Prenatal Magnetic Resonance Imaging
- Screening Modalities to Identify Genetic Disorders
- Noninvasive Screening and Diagnosis: Current Controversies
- Screening for Multifactorial Disorders
- Diagnostic Modalities
- Technical Advances in Molecular Cytogenetics
- Future Directions for Prenatal Diagnostic Testing
- Assisted Reproductive Technologies
- Genetic Evaluation and Counseling
- 10. Perinatal Ultrasound
- Ultrasound Equipment
- Fetal Imaging Techniques
- Bioeffects and Safety
- Ethical Considerations
- Applications of Ultrasound Studies
- Pregnancy Evaluation
- Doppler Ultrasound
- Ultrasound-Guided Procedures
- Fetal Well-Being Assessment
- Fetal Anomalies
- Ultrasound Examination for Fetal Abnormalities in the Second or Third Trimester
- Summary
- 11. Estimation of Fetal Well-Being
- Introduction
- Antepartum Fetal Surveillance
- Evaluation of the Intrapartum Fetus
- 12. Surgical Treatment of the Fetus
- Summary
- Fetal Access
- Anesthetic Considerations
- Anomalies Amenable to Fetal Surgery
- Conclusion
- 13. Adverse Exposures to the Fetus
- Exposures Not Concurrent With Pregnancy
- Maternal Exposures Concurrent With Pregnancy
- Pathways of Fetal Exposure
- Fetal Pharmacokinetics
- Specific Exposures
- Conclusion
- 14. Fetal Growth Restriction: A Complex Interplay Between the Intrauterine and Maternal Environment
- Summary
- Definitions and Terminology
- The Health Burden of Fetal Growth Restriction
- Classification of Fetal Growth Restriction
- Etiology of Fetal Growth Restriction
- Pathophysiology
- Antenatal Screening and Prenatal Management
- Prevention
- Postnatal Evaluation of Fetal Growth Restriction
- Postnatal Management
- Long-Term Consequences of Fetal Growth Restriction
- Conclusion
- 15. Developmental Origins of Health and Disease
- Fetal Origins of Adult Disease Concept
- Postnatal Growth and Nutrition
- Mismatch Concept
- Placental Abnormalities and Association With Adult Disease
- Gestational Diabetes and Long-Term Metabolic Effects on Offspring
- Developmental Impact of Toxins, Endocrine Disrupters, and Air Pollution (See Also Chapter 13)
- Epigenetics
- Translation to Neonatology
- Part 3. Pregnancy Disorders and Their Impact on the Fetus
- 16. Hypertensive Disorders of Pregnancy
- Classification of Hypertensive Disorders of Pregnancy
- Epidemiology of Preeclampsia
- Clinical Presentation of Preeclampsia
- Other Hypertensive Disorders of Pregnancy
- Prediction
- Prevention
- 17. Pregnancy Complicated by Diabetes Mellitus
- Gestational Diabetes Mellitus
- Screening and Diagnosis
- Antenatal Management
- Treatment
- Fetal Surveillance
- Timing and Mode of Delivery
- Intrapartum Management
- Postpartum Maternal Management
- Pregestational Diabetes Mellitus
- Implications for the Neonate
- Other Novel Challenges
- Breastfeeding in Women With Gestational Diabetes Mellitus
- 18. Obstetric Management of Prematurity
- Prematurity
- Pathogenesis
- Risk Factors
- Predicting Preterm Labor
- Prevention
- Treatment
- Summary
- Acknowledgments
- 19. Fetal Effects of Autoimmune Disease
- Placental Transfer: General Remarks
- Fetal Thrombocytopenia
- Fetal-Neonatal Consequences of Maternal Antinuclear Antibodies
- Fetal-Neonatal Consequences of Maternal Antiphospholipid Antibodies
- Myasthenia Gravis
- Pemphigoid Gestationis
- Summary
- 20. Multiple Gestation: Fetal and Maternal Considerations
- Epidemiology
- Classification of Twin Pregnancies
- Unusual Twinning
- First Trimester Assessment of Multiple Gestations (11+0 to 13+6 Weeks Scans)
- Congenital Malformations
- Complications of Monochorionic Twins
- Delivery Considerations
- Antenatal Steroids in Twin Pregnancies
- Outcome
- Key Points
- 21. Post-Term Pregnancy
- Defining Post-Term
- Estimated Gestational Age
- Incidence of Post-Term Pregnancy
- Etiology
- Maternal Complications
- Neonatal Risks of Post-Term Pregnancy
- Long-Term Complications of Post-Term Pregnancy
- Management
- 22. Immune and Nonimmune Hydrops Fetalis
- Immune Hydrops Fetalis
- Nonimmune Hydrops Fetalis
- Summary
- 23. Amniotic Fluid Volume
- Amniotic Fluid Dynamics
- Measurement of Amniotic Fluid Volume
- Normal Volume and the Singleton Pregnancy
- Twins and Amniotic Fluid
- Abnormalities of Amniotic Fluid Volume and Their Management
- Management of Fluid Abnormalities in Multifetal Pregnancies
- The Future
- 24. Perinatal Infections and Chorioamnionitis
- Definitions and Epidemiology
- Microbiology
- Diagnosis
- Pathogenesis
- Treatment
- Outcomes
- Areas for Future Investigation
- 25. Placental Pathology
- Optimal Use of Pathology Service
- Structure, Function, and Pathologic Reaction Patterns
- Clinical Correlation
- Summary
- Part 4. The Delivery Room
- 26. Anesthesia for Labor and Delivery
- Labor Pain Characteristics and Challenges
- Techniques That Modify Pain
- Obstetric Nerve Blocks
- Neuraxial Blocks
- Delivery Modes and Anesthetic Techniques
- 27. Physical Examination of the Healthy Newborn
- Routine Examination
- Detailed Neurologic Assessment
- Interpretation of the Neurologic Examination
- Limitations of the Routine Examination
- Health Promotion, Screening, and Prevention
- Discharge
- 28. Birth Injuries
- Injuries to Soft Tissues
- Injuries to the Head
- Injuries to the Neck, Shoulder Girdle, and Chest
- Injuries to the Spine and Spinal Cord
- Injuries to Intra-Abdominal Organs
- Injuries to the Extremities
- Trauma to the Genitalia
- Injuries Related to Intrapartum Fetal Monitoring
- Injuries Related to Trauma During Pregnancy
- 29. Congenital Anomalies
- Summary
- General Clinical Approach
- Epidemiology and Etiology
- Evaluation
- Diagnostic Testing and Indications
- Genetic Counseling
- Educational Resources and Support Organizations
- Acknowledgments
- Part 5. Resuscitation of the Newborn
- 30. Overview and Initial Management of Delivery Room Resuscitation
- Fetus
- Transition at Birth
- Causes of Depression and Asphyxia
- Response to Asphyxia
- Preparation for Resuscitation
- Apgar Score
- Umbilical Cord Blood Gases
- Elements of a Resuscitation
- 31. Role of Positive Pressure Ventilation in Neonatal Resuscitation
- Normal Transition and Initial Spontaneous Breathing
- Delayed Transition and Need for Respiratory Support
- Basics of Positive Pressure Support
- Application of Noninvasive Positive Pressure Support
- Applying Positive Pressure Support
- The First Breaths
- Peak Inflation Pressures and Tidal Volumes
- Positive End-Expiratory Pressure
- Inflation Rate and Duration
- Gas Flow
- 32. Oxygen Therapy in Neonatal Resuscitation
- Use of Oxygen in Perinatal Asphyxia and Resuscitation
- Room Air Versus Pure Oxygen for Resuscitation of the Newborn
- Oxygen Supplementation in the Delivery Room in Extremely Low Gestational Age Neonates
- Room Air Versus 100% Oxygen—Or Something Else
- 33. Chest Compression, Medications, and Special Problems in Neonatal Resuscitation
- Importance of Effective Ventilation
- Chest Compressions
- Medications
- When to Discontinue Resuscitation Efforts
- Immediate Care After Establishing Adequate Ventilation and Circulation
- Special Problems During Resuscitation
- Screening for Congenital Defects
- 34. Role of Umbilical Cord Management in Neonatal Resuscitation
- Introduction
- Delayed Cord Clamping
- Term Infants
- Concerns Related to Delayed Cord Clamping
- Umbilical Cord Milking
- Cord Management Strategies
- Part 6. The Physical Environment in Neonatal Care
- 35. Thermal Environment of the Intensive Care Nursery
- Heat Exchange Physics
- Thermal Physiology
- Temperature Monitoring
- Thermal Aspects of the Care Environment
- Recommendations for Practice
- 36. Optimization of the Neonatal Intensive Care Unit Environment
- Neurobehavioral Maturation
- Behavioral/Sleep States and Neonatal Intensive Care Unit Environment
- Sensory Functions and Neonatal Intensive Care Unit Environment
- Circadian Rhythm and Neonatal Intensive Care Unit Environment
- Sensory Functions and Pain
- Muscle Tone, Movements, and Reflexes
- Sucking and Swallowing
- Environmental Support of Growth
- Environmental Protection From Infections
- Environmental Support of Parent–Infant Interaction
- Neurobehavioral Assessment Tools
- Neonatal Intensive Care Unit Design
- Health Care Team Perspectives
- Conclusion
- Part 7. Provisions for Neonatal Care
- 37. Neonatal Cardiorespiratory Monitoring
- Summary
- Hemodynamic Monitoring
- Blood Gas Monitoring
- Respiratory Monitoring
- Future Directions
- 38. Diagnostic Imaging of the Neonate
- Introduction
- Digital Radiography, Fluoroscopy, and Computed Tomography
- Ultrasound
- Magnetic Resonance Imaging
- Scintigraphy
- Point-of-Care Ultrasound
- Chest
- Heart
- Abdomen
- Hepatobiliary Tract
- Urinary Tract
- Adrenal Glands
- Brain
- Spine
- Skeletal
- Future Directions
- Acknowledgments
- 39. Anesthesia in the Neonate
- Safety and Challenges of Neonatal Anesthesia
- Preoperative Evaluation and Preparation
- Neonatal Physiology and Specific Anesthetic Concerns
- 40. Care of Periviable Micropreemies: The Japanese Perspective
- Introduction
- Background
- Outcomes
- Care for the Improvement of Outcomes Among Preterm Infants
- Before Delivery
- At Birth
- In the Neonatal Intensive Care Unit
- 41. The Late Preterm Infant
- Definition
- Epidemiology and Trends
- Etiology
- Pathophysiology
- Clinical Outcomes
- Hospitalizations and Rehospitalizations After Discharge
- Long-Term Neurodevelopmental Outcomes
- Management
- 42. Nutritional Support for the Preterm Infant
- Growth in the Neonatal Intensive Care Unit
- Growth and Neurodevelopmental Outcomes
- Nutrient Requirements
- Provision of Nutritional Support
- Acknowledgment
- 43. Support for the Family
- Normal Mother-Infant Attachment
- Formation of Mother-Infant Attachment
- Attachment Challenges With Sick or Premature Infants
- Parental Stress
- Family Engagement
- Parental Mental Health Issues
- Discharge Planning
- Summary
- Acknowledgments
- 44. Perinatal Palliative Care
- What Is Perinatal Palliative Care?
- Providing Perinatal Palliative Care
- Components of Perinatal Palliative Care
- Symptom Management
- Anticipatory Guidance for End of Life
- What the Future Looks Like
- Part 8. Developmental Pharmacology
- 45. Principles of Drug Use in the Fetus and Neonate
- Fetal Drug Disposition
- Neonatal Drug Disposition
- 46. Principles of Drug Use During Lactation
- Passage of Exogenous Compounds From Maternal Blood to Milk
- Delivery of Compounds to and Disposition by the Infant
- Conclusions Concerning Breastfeeding and Maternal Drug Therapy
- 47. Pharmacokinetics in Neonatal Medicine
- Drug Disposition Explains Drug Exposure Over Time: Absorption, Distribution, Metabolism, and Excretion
- Pharmacokinetic Models Describe Concentration of Drug Over Time
- Important Factors That Impact Pharmacokinetics
- 48. Infants of Substance-Using Mothers
- Prenatal and Perinatal Considerations
- Neonatal Considerations
- Marijuana (Cannabinoids)
- Opioids
- Benzodiazepines and Barbiturates
- Cocaine
- Amphetamines
- Part 9. The Immune System
- 49. Developmental Immunology
- Overview of Hematopoiesis
- Innate Immunity
- Acquired Immunity
- Passive Immunity
- Evaluation of Host Defenses in Neonates
- Immunomodulation and Future Directions
- 50. Postnatal Bacterial Infections
- Neonatal Sepsis
- Bacterial Infections by Organ System
- Specific Pathogens
- Acknowledgments
- 51. Fungal and Protozoal Infections of the Neonate
- Definitions
- Microbiology
- Pathogenesis and Pathophysiology
- Prematurity
- Incidence
- Outcomes
- Risk Factors
- Clinical Manifestations
- Treatment
- Prevention
- Conclusions
- Antifungal Prophylaxis Summary
- Invasive Candida Infection Summary
- Aspergillus, Mucormycosis, Malassezia, and Trichosporon Infections in the Neonatal Intensive Care Unit
- Other Fungal Infections
- Protozoal Infections
- Acknowledgment
- Chapter 52. Viral Infections in the Neonate
- Herpesvirus Family
- Paramyxoviruses Family
- Human Immunodeficiency Virus
- Enteroviruses and Parechoviruses
- Hepatitis Viruses
- Parvovirus B19
- Influenza A and B
- Rubella Virus
- Coronavirus: Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome, and Coronavirus Disease 2019 (COVID-19)
- West Nile Virus
- Adenovirus
- Human Papillomavirus
- Zika Virus
- Acknowledgment
- Part 10. The Central Nervous System
- 53. Normal and Abnormal Brain Development
- Neural Induction and Neurulation
- Neuronal Proliferation
- Neuronal Migration and Cortical Lamination
- Central Nervous System Organization
- Brain Vascular Development
- Abnormal Brain Development and Disorders
- 54. Cerebral White Matter Damage and Encephalopathy of Prematurity
- Neuropathology of White Matter Injury
- Models of Encephalopathy of Prematurity: Implications for Pathogenesis
- Neuroimaging of White Matter Injury
- Impairment of Brain Growth and Long-Term Development
- 55. Intracranial Hemorrhage and Stroke in the Neonate
- Summary
- Germinal Matrix Hemorrhage–Intraventricular Hemorrhage
- Perinatal Stroke
- 56. Hypoxic-Ischemic Encephalopathy
- Summary
- Definitions
- Pathophysiology
- Perinatal Hypoxic-Ischemic Brain Damage
- Neuropathology
- Assessment Tools
- Neuroimaging
- Chemical Biomarkers
- Management
- Resuscitation
- Systemic Management
- Brain-Oriented Management
- Specific Neuroprotective Strategies
- Prognostic Factors
- The Association Between Hypoxic-Ischemic Encephalopathy and Less Severe Neurodisability
- Acknowledgment
- 57. Seizures in Neonates
- Pathophysiology of Newborn Seizures—Unique Maturational Features Increasing the Likelihood of Seizures in the Newborn
- Biochemical and Physiologic Consequences of Seizures in the Immature Brain—Implications for the Clinician
- Classification of Seizures in the Newborn
- Seizure Etiology
- Diagnosis
- Prognosis
- Management
- 58. Hypotonia and Neuromuscular Disease in the Neonate
- Diagnosis
- Neonatal Neuromuscular Disorders
- Spinal Muscular Atrophy
- Hereditary Motor and Sensory Neuropathies
- Hereditary Sensory and Autonomic Neuropathies
- Neuromuscular Junction Disorders
- Congenital Muscular Dystrophy
- Congenital Myotonic Dystrophy
- Other Muscular Dystrophies
- Congenital Myopathies
- Metabolic and Multisystem Disorders
- Acknowledgments
- 59. Disorders in Head Shape and Size
- Summary
- Examination of the Head
- The Neonate
- Hydrocephalus
- Hydranencephaly
- Craniosynostosis
- Conclusion
- 60. Spinal Dysraphisms
- Summary
- Introduction
- Embryology
- Pathology
- Prenatal Screening and Prevention
- Cutaneous Stigmata
- Imaging
- Overall Management
- Surgical Treatment
- Conclusion
- 61. Hearing Loss in the Newborn Infant
- Background
- Normal/Typical Hearing and Hearing Loss
- Tests for Hearing Loss
- Early Intervention Services
- Etiology of Hearing Loss
- Risk Factors
- Medical Workup for Hearing Loss and Care Coordination
- Middle Ear Disease
- Communication Options
- Audiologic Devices
- Continued Surveillance
- Stress and Impact on the Family
- 62. Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates
- Medical Problems
- Neurodevelopmental Outcome
- Methodologic Considerations in Neurodevelopmental Outcome Studies
- School-Age Outcome
- Young Adult Outcomes
- Children Born at the Threshold of Viability
- Early Intervention
- Volume 2
- Part 11. The Respiratory System
- 63. Lung Development and Maturation
- A Brief History
- Lung Structural Development
- Fetal Lung Fluid
- Other Disorders of Lung Development
- Lethal Pulmonary Disorders
- Alveolar Macrophages
- Surfactant Metabolism
- Physiologic Effects of Surfactant in the Preterm Lung
- Lung Maturation
- 64. Assessment of Neonatal Pulmonary Function
- Clinical Observations
- Cardiorespiratory Assessment
- Respiratory Function
- Clinical Applications
- 65. Respiratory Distress Syndrome in the Neonate
- Incidence
- Pathophysiology
- Heritability of Respiratory Distress Syndrome
- Prevention: Pharmacologic Acceleration of Pulmonary Maturation
- Clinical Features
- Radiographic Findings
- Treatment
- 66. Assisted Ventilation and Its Complications
- Continuous Positive Airway Pressure and Noninvasive Ventilation
- Indications for Assisted Ventilation
- General Principles of Assisted Ventilation
- Classification of Mechanical Ventilators
- Suggested Ventilatory Management Guidelines
- Monitoring of Ventilated Infants
- Complications of Assisted Ventilation
- 67. Spectrum of Neonatal Respiratory Disorders
- Developmental Diseases
- Acquired Neonatal Pulmonary Diseases
- Extracorporeal Membrane Oxygenation for Respiratory Failure
- Rib Cage Abnormalities
- Phrenic Nerve Injury
- Acknowledgments
- 68. Apnea, Bradycardia, Hypoxemia, and the Foundation of Respiratory Control
- Fetal Breathing
- Postnatal Development of Respiratory Control
- Neonatal Apnea, Bradycardia, and Hypoxemia
- Brief, Resolved, Unexplained Events
- 69. Upper Airway Lesions in the Neonate
- Nasal and Nasopharyngeal Lesions
- Oral and Oropharyngeal Lesions
- Laryngeal Lesions
- Conclusion
- 70. Bronchopulmonary Dysplasia in the Neonate
- Epidemiology of Bronchopulmonary Dysplasia
- Pathogenesis
- Pathology
- Clinical Presentation
- Prediction of Bronchopulmonary Dysplasia
- Pulmonary Function
- Prevention of Bronchopulmonary Dysplasia
- Management of Established Bronchopulmonary Dysplasia
- Infant Stimulation
- Parental Support
- Outcome
- 71. Postneonatal Respiratory Morbidity
- Introduction
- Postneonatal Pulmonary Hypertension
- Prevalence of the Problem
- Reactive Airways Disease in Infants and Children Born Preterm
- Neonatal Effects on Long-Term Adult Lung Function
- Summary
- Part 12. The Cardiovascular System
- 72. Cardiac Embryology
- Introduction
- Overview of Normal Heart Development
- Scientific Basis of Cardiogenesis
- 73. Pulmonary Vascular Development
- Fetal Pulmonary Vascular Development
- Pulmonary Vascular Transition
- Vasoactive Mediators of the Pulmonary Vascular Transition
- Abnormalities of Pulmonary Vascular Development
- Clinical Therapy of Pulmonary Hypertension of the Newborn
- Outcome and Follow-Up
- 74. Prenatal Diagnosis of Congenital Heart Disease
- Introduction
- Historical Perspective
- Overview of Fetal Circulation and Cardiac Adaptation at Birth
- Indications for Fetal Echocardiogram
- Performance of a Fetal Echocardiogram
- Fetal Pathology
- Parental Counseling After Fetal Diagnosis of Congenital Heart Disease
- Impact of Prenatal Diagnosis
- Limitations of Fetal Echocardiograms
- Fetal Therapies
- Novel Approaches to Prenatal Diagnosis of Congenital Heart Disease
- Summary
- 75. Patent Ductus Arteriosus
- Pathogenesis
- Pathophysiology
- Clinical Presentation
- Diagnostic Evaluation
- Management
- 76. Congenital Defects of the Cardiovascular System
- Summary
- Cyanotic Heart Defects: Mixing-Dependent
- Cyanotic Heart Defects: Restricted Pulmonary Blood Flow
- Cyanotic Heart Defects: Complete Mixing
- Cyanotic Heart Defects: Variable Physiology
- Obstructive Heart Defects
- Shunting Lesions
- Acknowledgments
- 77. Unique Neonatal Cardiovascular Problems
- Cardiac Malposition and Abnormalities of Abdominal Situs
- Arteriovenous Malformations
- Myocardial Diseases: Cardiomyopathy and Myocarditis
- Pericardial Diseases
- Cardiac Tumors
- Vascular Rings and Slings
- Neonatal Marfan Syndrome
- The Premature Infant With Congenital Heart Disease
- Acknowledgments
- 78. Disorders of Cardiac Rhythm and Conduction in Newborns
- Normal Sinus Rhythm and Sinus Node Dysfunction
- Sinus Arrhythmia
- Tachyarrhythmias
- Ventricular Arrhythmias
- Atrioventricular Conduction Disturbances
- 79. Neonatal Management of Congenital Heart Disease
- Introduction
- Miscellaneous Procedures
- Medical Management
- What the Future Holds
- Part 13. The Blood and Hematopoietic System
- 80. The Hemostatic System
- Summary
- Neonatal Platelet Disorders
- Neonatal Coagulation Disorders
- Neonatal Thrombotic Disorders
- 81. Red Blood Cell Disorders in the Fetus and Neonate
- Human Hematopoietic Development
- Red Blood Cells
- Red Blood Cell Disorders
- 82. White Blood Cells and Immune Disorders
- White Blood Cells
- Acknowledgments
- 83. Neoplasms in the Neonate
- Infant Cancer
- Neuroblastoma
- Leukemia
- Teratomas and Other Germ Cell Tumors
- Soft Tissue Sarcomas
- Neonatal Brain Tumors
- 84. Blood Component Therapy for the Neonate
- Special Considerations for Transfusion Therapy in the Neonate
- Risks of Transfusion Therapy
- Donor-Specific Units
- Blood Products
- Factor Concentrates
- Special Topics in Neonatal Transfusion
- Future Directions
- Part 14. The Gastrointestinal Tract
- 85. Development of the Neonatal Gastrointestinal Tract
- Summary
- The Beginning
- Esophagus
- Stomach
- Duodenum, Pancreas, and Biliary System
- Small Intestine
- Colon, Rectum, and Anus
- Acknowledgments
- 86. Gastrointestinal Reflux and Motility in the Neonate
- Definitions
- Physiology of Gastroesophageal Reflux
- Gastroesophageal Reflux Disease
- Summary
- 87. Disorders of Digestion in the Neonate
- Chronic Diarrhea
- Diagnostic Testing for Disorders of Digestion
- Disorders of Digestion, Absorption, and Secretion
- Intestinal Failure
- 88. Selected Gastrointestinal Anomalies in the Neonate
- Thoracic Anomalies
- Esophageal Duplications
- Congenital Diaphragmatic Hernia
- Abdominal Wall Defects
- Gastric Volvulus
- Microgastria
- Gastric Perforation
- Spontaneous Intestinal Perforation
- Pyloric Atresia
- Hypertrophic Pyloric Stenosis
- Duodenal Atresia and Stenosis
- Gastrointestinal Duplications
- Malrotation and Midgut Volvulus
- Meconium Syndromes
- Jejunoileal Atresia and Stenosis
- Hirschsprung Disease
- Anorectal Anomalies
- Acknowledgments
- 89. Neonatal Necrotizing Enterocolitis
- Introduction
- Definition of Necrotizing Enterocolitis
- Epidemiology
- Clinical Features
- Treatment
- Outcomes
- Pathophysiology of Necrotizing Enterocolitis
- Preventive Strategies
- Some Imposters of Necrotizing Enterocolitis
- Summary
- Part 15. Metabolic and Endocrine Disorders
- 90. Disorders of Carbohydrate Metabolism in the Neonate
- Placental Transport of Nutrients: Maternal-Fetal Relationship
- Fetal Hormones Mediating Growth
- Fetal Glucose Metabolism
- Glucose Metabolism After Birth—Transitional Neonatal Hypoglycemia
- Hypoglycemia
- Hyperglycemia
- Diabetes Mellitus in the Newborn
- 91. Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate
- Introduction
- Calcium, Phosphorus, and Magnesium Physiology
- Hormonal Regulation of Mineral Metabolism
- Bone Development
- Clinical Conditions Associated With Calcium Disturbances
- Clinical Conditions Associated With Magnesium Disturbances
- Osteopenia of Prematurity
- Acknowledgments
- 92. Thyroid Disorders in the Neonate
- Physiologic Action of Thyroid Hormones
- Synthesis, Release, Transport, and Metabolism of Thyroid Hormones
- Laboratory Tests Used to Assess Thyroid Function
- Thyroxine-Binding Globulin
- Thyroid Imaging
- Congenital Hypothyroidism
- Defects in TSH or Thyroid Hormone Action
- Other Conditions Associated With Congenital Hypothyroidism or Abnormal Thyroid Function Testing in the Neonate
- Transient Disorders of Thyroid Function
- Neonatal Graves Disease
- Familial Abnormalities of Thyroxine-Binding Proteins
- 93. Disorders of Sex Development
- Summary
- Fetal Sexual Determination and Differentiation
- A Clinical Approach to the Infant With Suspected Disorder of Sex Development
- Disorders of Sex Development
- Acknowledgments
- 94. Inborn Errors of Metabolism
- Introduction
- Common Misconceptions
- Screening for Inborn Errors of Metabolism
- The Critically Ill Newborn Infant: Clinical Phenotypes
- The Abnormal Newborn Infant: Laboratory Phenotypes
- Treatment
- Conclusion
- Part 16. Neonatal Jaundice and Liver Disease
- 95. Neonatal Jaundice and Liver Disease
- Bilirubin Metabolism
- “Conjugated” Versus “Direct” Bilirubin
- Equilibrium Between Bilirubin Production and Elimination Processes—The Major Determinant of TB Levels
- Genetic Control of Bilirubin Production
- Genetic Control of Uptake of Bilirubin into the Hepatocyte
- Co-Expression of Genes Modulating the Risk of Neonatal Hyperbilirubinemia
- Bilirubin-Induced Neurologic Disorders
- Newer Methods of Diagnosis
- Conjugated Hyperbilirubinemia
- Acknowledgments
- Part 17. The Kidney and Urinary Tract
- 96. Fluid, Electrolytes, and Acid-Base Homeostasis
- Fluid and Electrolyte Management
- Abdominal Wall Defects
- Acid-Base Management
- 97. The Kidney and Urinary Tract of the Neonate
- Kidney and Urinary Tract Development
- Evaluation of the Neonate With Kidney Disease
- Clinical Problems
- Congenital Anomalies of Kidney and Urinary Tract
- Tumors of the Kidney
- Part 18. The Skin
- 98. The Skin of the Neonate
- The Structural Biology of Fetal and Neonatal Skin
- Disorders and Diseases of Fetal and Neonatal Skin
- Principles of Newborn Skin Care
- Part 19. The Eye
- 99. Examination and Common Problems in the Neonatal Eye
- Neonatal Eye Examination
- Orbital Abnormalities
- Hyperthyroid Exophthalmos
- Eyelid Abnormalities
- Eyelid Lesions
- Eyelash Abnormalities
- Lacrimal Abnormalities
- Globe Abnormalities
- Corneal Abnormalities
- Iris Abnormalities
- Pupil Abnormalities
- Lens Abnormalities
- Retina and Vitreous Diseases
- Congenital Disc Anomalies
- Intraocular Tumors
- Neuromuscular Abnormalities
- Eye Findings in Chromosomal Syndromes
- Eye Findings in Craniofacial Syndromes
- Eye Findings in Neurocutaneous Disorders (Phakomatoses)
- Ocular Trauma
- Neonatal Ocular Infections
- Other Ocular Tumors in Infants
- Ocular Manifestations of Maternal Substance Abuse
- 100. Retinopathy of Prematurity
- Introduction
- Incidence
- Pathogenesis
- Classification
- Clinical Course and Screening
- Therapy
- Recommendations for Examination Schedule
- Acknowledgments
- Part 20. Neonatal Orthopedics
- 101. Musculoskeletal Disorders in Neonates
- Overview of Musculoskeletal Chapters
- Etiology of Congenital Disorders
- Development of Disorders
- In Utero Positioning
- Trauma
- 102. Bone and Joint Infections in Neonates
- Osteomyelitis
- Septic Arthritis
- Acknowledgments
- 103. Congenital Abnormalities of the Upper and Lower Extremities and Spine
- Upper Extremities
- Spine
- Lower Extremities
- Syndromes
- Acknowledgments
- Appendices
- Appendix A. Therapeutic Agents
- Appendix B. Tables of Normal Values
- Index
- No. of pages: 2352
- Language: English
- Edition: 12
- Published: February 19, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780323932660
RM
Richard J. Martin
Affiliations and expertise
Director, Neonatal Research Programs, UH Cleveland Medical Center, Professor, Pediatrics, CWRU School of Medicine, Rainbow Babies and Children’s Hospital, Cleveland, OHAF
Avroy A. Fanaroff
Affiliations and expertise
Emeritus Professor, Pediatrics and Reproductive Biology, Case Western Reserve University School of Medicine; Emeritus Eliza Henry Barnes Chair in Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio