Falciparum Malaria
Diagnostic Tools, Therapeutic Advances, and Future Opportunities
- 1st Edition - April 14, 2024
- Imprint: Academic Press
- Editor: Tabish Qidwai
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 2 8 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 8 3 - 0
Falciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug… Read more
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Request a sales quoteFalciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug targets. The book also covers recent progress in the development of vaccines and other approaches for malaria treatment, prevention and control and explores diagnostic tools and biomarkers. Sections examine potential biomarkers and their applications, molecular diagnostic tools, multi-omic approaches for the characterization of therapeutic action of potential new antimalarials, therapeutic advances in falciparum malaria, antimalarial drugs, targeting parasite apicoplast for antimalarial drug discovery, cellular and adjunctive therapies for malaria treatment, and future opportunities.
With contributions from experts in the field, this book is an ideal resource for academics, researchers, graduates and industry engaged in malaria research, its diagnosis, and treatment.
- Reviews current therapeutic strategies of falciparum malaria
- Covers antimalarial drugs, peptides, vaccines and RNAi approaches against malaria
- Explores antimalarial drug targets in parasites
- Discusses biomarkers and new diagnostic tools
Academics and Researchers in parasitology engaged in malaria studies, Advanced undergraduate, post graduate and medical students, Physicians, Biotechnologists, Professionals in pharmaceuticals and global health
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- Part I: Diagnostics and biomarkers in falciparum malaria
- Chapter 1. Molecular mechanism of inflammatory signaling pathway in severe malaria pathogenesis
- Abstract
- 1.1 Introduction
- 1.2 Pathogen-associated molecular patterns during malaria pathogenesis
- 1.3 Immune evasion phenotypes instigate severe malaria pathogenesis
- 1.4 Inflammation hypothesis in malaria pathogenesis
- 1.5 Targets of malaria pathogenesis for suitable combination therapy
- 1.6 Conclusion
- References
- Chapter 2. Exploration of potential biomarkers and their applications for detection of malaria
- Abstract
- 2.1 Introduction
- 2.2 Biomarkers for malaria
- 2.3 Future perspectives and challenges
- References
- Chapter 3. Laboratory diagnosis of malaria: an update
- Abstract
- 3.1 Introduction
- 3.2 Microscopic detection
- 3.3 Malaria rapid diagnosis tests
- 3.4 Nucleic acid amplification tests
- 3.5 Serological tests
- 3.6 Other emerging techniques
- 3.7 Conclusion
- References
- Chapter 4. Molecular diagnostic tools in detection of mixed parasite infections: current scenario and challenges
- Abstract
- 4.1 Introduction
- 4.2 Microscopy
- 4.3 Serology-based methods
- 4.4 Mass spectrometry
- 4.5 PCR-based molecular methods
- 4.6 Recent advances in alternative methods for malaria diagnosis
- 4.7 Discussion
- References
- Chapter 5. Multiomics approaches in the development of therapy against malaria
- Abstract
- 5.1 Introduction
- 5.2 Omics approach
- 5.3 Advantage of multiomics approaches
- 5.4 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Part II: Therapeutic advances in falciparum malaria
- Chapter 6. Antimalarial drugs: discovery, mechanism of action, and drug resistance
- Abstract
- 6.1 Introduction
- 6.2 Antimalarial drugs and their mode of action
- 6.3 Drug resistance to available antimalarials
- 6.4 Limitations and possible solutions
- 6.5 Conclusion
- Acknowledgments
- Declaration
- References
- Chapter 7. Targeting parasite apicoplast for antimalarial drug discovery
- Abstract
- 7.1 Introduction
- 7.2 Current status of antimalarials, their importance and limitations
- 7.3 Apicoplast: a unique organelle of Plasmodium
- 7.4 Drug targets in Plasmodium apicoplast
- 7.5 Bioinformatics-based apicoplast-targeted drug designing
- 7.6 Limitation associated with apicoplast-based antimalarial drug discovery
- 7.7 Future aspects and conclusion
- Acknowledgments
- References
- Chapter 8. Antimicrobial peptides as a new class of antimalarial therapeutic agents
- Abstract
- 8.1 Introduction
- 8.2 Peptide allelism: defense system of prokaryotes to higher organism
- 8.3 Natural antimicrobial peptides: innate defense system in human
- 8.4 Market
- 8.5 Conclusion and future directions
- References
- Chapter 9. Investigation of RNA interference in malaria parasites
- Abstract
- 9.1 Global scenario of malaria
- 9.2 RNA interferences and small RNA(siRNA)
- 9.3 Challenges
- 9.4 Knowledge of siRNA in malaria; past, present, and future
- 9.5 Conclusion
- 9.6 Glossary of common terms
- References
- Chapter 10. Current adjunctive therapy for the treatment of severe and cerebral malaria
- Abstract
- 10.1 Introduction
- 10.2 Pathophysiology and CM and subsequent neurological sequelae
- 10.3 Current treatments for severe malaria and adjunct therapy
- 10.4 The role of adjunctive therapy in severe malaria treatment
- 10.5 Improving anemia and liver function
- 10.6 Novel techniques for adjunctive therapy delivery (preclinical murine models)
- 10.7 Delivering gaseous signaling molecules
- 10.8 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Further reading
- Chapter 11. Cellular therapies for malaria treatment
- Abstract
- 11.1 Introduction
- 11.2 Immunopathogenesis of malaria
- 11.3 Role of mesenchymal stem cells in malaria immunomodulation
- 11.4 Role of mesenchymal stem cells in neurogenesis
- 11.5 Role of mesenchymal stem cells in erythropoiesis
- 11.6 Conclusion
- References
- Chapter 12. Malaria diagnostics and treatment: future opportunities
- Abstract
- 12.1 Introduction
- 12.2 Diagnostics
- 12.3 Treatment of malaria
- 12.4 Prevention
- 12.5 Future treatment strategies of falciparum malaria
- References
- Index
- Edition: 1
- Published: April 14, 2024
- Imprint: Academic Press
- No. of pages: 250
- Language: English
- Paperback ISBN: 9780323953283
- eBook ISBN: 9780323957830
TQ
Tabish Qidwai
Dr. Tabish Qidwai PhD is currently an Associate Professor and part of the Faculty of Biotechnology, IBST, Shriramswaroop Memorial University, Lucknow in India. Dr. Qidai pre-doctoral and doctoral research was at CSIR-CIMAP & UP Technical University Lucknow from 2008-2013. He studied host polymorphism in genes related to Plasmodium falciparum infection in an endemic region of India and later worked on the identification and characterization of antimalarial drug targets in Plasmodium falciparum. His postdoctoral research from 2-14-2018 at Babasaheb Bhimrao Ambedkar University, Lucknow explored compounds as potential antimalarial against Plasmodium falciparum. Dr. Qidwai has published over 30 journal articles, contributed book chapters, and recently published a book on Exploration of Host Genetic Factors associated with Malaria. He is a Life member of Society of Biological Chemists, India, the Indian Biophysical Society, and the Indian Science Congress Association. He is also a Member of the International Association of Engineers (IAENG) and the International Society for Infectious Diseases.
Affiliations and expertise
Associate Professor and part of the Faculty of Biotechnology, IBST, Shriramswaroop Memorial University, Lucknow, IndiaRead Falciparum Malaria on ScienceDirect