Falciparum Malaria

Diagnostic Tools, Therapeutic Advances, and Future Opportunities

1st Edition - April 14, 2024
Editor: Tabish Qidwai
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 2 8 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 7 8 3 - 0

Falciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug… Read more

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Falciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug targets. The book also covers recent progress in the development of vaccines and other approaches for malaria treatment, prevention and control and explores diagnostic tools and biomarkers. Sections examine potential biomarkers and their applications, molecular diagnostic tools, multi-omic approaches for the characterization of therapeutic action of potential new antimalarials, therapeutic advances in falciparum malaria, antimalarial drugs, targeting parasite apicoplast for antimalarial drug discovery, cellular and adjunctive therapies for malaria treatment, and future opportunities.

With contributions from experts in the field, this book is an ideal resource for academics, researchers, graduates and industry engaged in malaria research, its diagnosis, and treatment.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editor
Preface
Part I: Diagnostics and biomarkers in falciparum malaria
Chapter 1. Molecular mechanism of inflammatory signaling pathway in severe malaria pathogenesis
Abstract
1.1 Introduction
1.2 Pathogen-associated molecular patterns during malaria pathogenesis
1.3 Immune evasion phenotypes instigate severe malaria pathogenesis
1.4 Inflammation hypothesis in malaria pathogenesis
1.5 Targets of malaria pathogenesis for suitable combination therapy
1.6 Conclusion
References
Chapter 2. Exploration of potential biomarkers and their applications for detection of malaria
Abstract
2.1 Introduction
2.2 Biomarkers for malaria
2.3 Future perspectives and challenges
References
Chapter 3. Laboratory diagnosis of malaria: an update
Abstract
3.1 Introduction
3.2 Microscopic detection
3.3 Malaria rapid diagnosis tests
3.4 Nucleic acid amplification tests
3.5 Serological tests
3.6 Other emerging techniques
3.7 Conclusion
References
Chapter 4. Molecular diagnostic tools in detection of mixed parasite infections: current scenario and challenges
Abstract
4.1 Introduction
4.2 Microscopy
4.3 Serology-based methods
4.4 Mass spectrometry
4.5 PCR-based molecular methods
4.6 Recent advances in alternative methods for malaria diagnosis
4.7 Discussion
References
Chapter 5. Multiomics approaches in the development of therapy against malaria
Abstract
5.1 Introduction
5.2 Omics approach
5.3 Advantage of multiomics approaches
5.4 Conclusion
Acknowledgment
Conflict of interest
References
Part II: Therapeutic advances in falciparum malaria
Chapter 6. Antimalarial drugs: discovery, mechanism of action, and drug resistance
Abstract
6.1 Introduction
6.2 Antimalarial drugs and their mode of action
6.3 Drug resistance to available antimalarials
6.4 Limitations and possible solutions
6.5 Conclusion
Acknowledgments
Declaration
References
Chapter 7. Targeting parasite apicoplast for antimalarial drug discovery
Abstract
7.1 Introduction
7.2 Current status of antimalarials, their importance and limitations
7.3 Apicoplast: a unique organelle of Plasmodium
7.4 Drug targets in Plasmodium apicoplast
7.5 Bioinformatics-based apicoplast-targeted drug designing
7.6 Limitation associated with apicoplast-based antimalarial drug discovery
7.7 Future aspects and conclusion
Acknowledgments
References
Chapter 8. Antimicrobial peptides as a new class of antimalarial therapeutic agents
Abstract
8.1 Introduction
8.2 Peptide allelism: defense system of prokaryotes to higher organism
8.3 Natural antimicrobial peptides: innate defense system in human
8.4 Market
8.5 Conclusion and future directions
References
Chapter 9. Investigation of RNA interference in malaria parasites
Abstract
9.1 Global scenario of malaria
9.2 RNA interferences and small RNA(siRNA)
9.3 Challenges
9.4 Knowledge of siRNA in malaria; past, present, and future
9.5 Conclusion
9.6 Glossary of common terms
References
Chapter 10. Current adjunctive therapy for the treatment of severe and cerebral malaria
Abstract
10.1 Introduction
10.2 Pathophysiology and CM and subsequent neurological sequelae
10.3 Current treatments for severe malaria and adjunct therapy
10.4 The role of adjunctive therapy in severe malaria treatment
10.5 Improving anemia and liver function
10.6 Novel techniques for adjunctive therapy delivery (preclinical murine models)
10.7 Delivering gaseous signaling molecules
10.8 Conclusion
Acknowledgment
Conflict of interest
References
Further reading
Chapter 11. Cellular therapies for malaria treatment
Abstract
11.1 Introduction
11.2 Immunopathogenesis of malaria
11.3 Role of mesenchymal stem cells in malaria immunomodulation
11.4 Role of mesenchymal stem cells in neurogenesis
11.5 Role of mesenchymal stem cells in erythropoiesis
11.6 Conclusion
References
Chapter 12. Malaria diagnostics and treatment: future opportunities
Abstract
12.1 Introduction
12.2 Diagnostics
12.3 Treatment of malaria
12.4 Prevention
12.5 Future treatment strategies of falciparum malaria
References
Index

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