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Extracellular Matrix-derived Implants in Clinical Medicine

  • 1st Edition - May 18, 2016
  • Latest edition
  • Editor: Daniel L Mooradian
  • Language: English

Extracellular Matrix-Derived Implants in Clinical Medicine comprehensively covers the emergence of tissue engineering and regenerative medicine over the past few decades,… Read more

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Description

Extracellular Matrix-Derived Implants in Clinical Medicine

comprehensively covers the emergence of tissue engineering and regenerative medicine over the past few decades, along with discussions of continuous funding and research.

The book provides a state-of-the-art review of this increasingly important technology and how it is translating from bench to bedside. Part One of the book looks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurological, while Part Two examines the challenges in harvesting, processing, and manufacturing of extracellular matrices, with a final section reviewing the international regulatory environment and economics of tissue-based products.

Key features

  • Addresses issues of tissue engineering and regenerative medicine from a biomaterials industry perspective
  • Looks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurological
  • Examines the challenges in harvesting, processing, and manufacturing of extracellular matrices
  • Reviews the international regulatory environment and economics of tissue-based products

Readership

Scientists and engineers working in biomedical engineering, biomaterials and tissue engineering, and regulatory professionals and clinicians

Table of contents

  • Related titles
  • List of contributors
  • Woodhead Publishing Series in Biomaterials
  • 1. Introduction
    • 1.1. Introduction
  • 2. Past and present ECM-based vascular biomaterials
    • 2.1. Introduction
    • 2.2. In the beginning
    • 2.3. Biological grafts
    • 2.4. The “ideal” graft
    • 2.5. Future trends
  • 3. Next generation ECM-based vascular biomaterials
    • 3.1. ECM-derived biomaterials
    • 3.2. Patch angioplasty of the carotid artery
    • 3.3. Future trends
  • 4. Allografts and xenografts in soft tissue repair: Current use and future trends
    • 4.1. Introduction
    • 4.2. Tissue source: physical and biological properties
    • 4.3. The processing of allografts and xenografts
    • 4.4. Current products
    • 4.5. Clinical applications
    • 4.6. Abdominal wall (hernia repair)
    • 4.7. Future trends
  • 5. Extracellular matrix–derived tissues for hard tissue repair
    • 5.1. Introduction
    • 5.2. ECM-derived tissues for bone repair
    • 5.3. Extracellular matrix–derived tissues for dental repair
    • 5.4. Outlook
  • 6. Extracellular matrix-derived tissues for neurological applications
    • 6.1. Background
    • 6.2. Current applications of ECM-derived products in CNS surgery
    • 6.3. Current applications of ECM-derived products in the PNS
    • 6.4. Future and emerging applications of ECM technology for neurological therapies
    • 6.5. Conclusions
  • 7. Sourcing animal and human tissue for implant use
    • 7.1. Introduction
    • 7.2. Tissue sourcing
    • 7.3. Tissue processing, storage and logistics
    • 7.4. Regulatory considerations
    • 7.5. Future innovation
  • 8. Xenograft sourcing and manufacturing, challenges, and opportunities
    • 8.1. Introduction
    • 8.2. Sourcing of raw materials
    • 8.3. Manufacturing issues
    • 8.4. Stability batches and stability testing
    • 8.5. Validation
    • 8.6. Sterilization
    • 8.7. Packaging
    • 8.8. Distribution
    • 8.9. Future trends and challenges
    • Abbreviations
  • 9. Amniotic membrane in clinical medicine: History, current status, and future use
    • 9.1. Historical review
    • 9.2. Basic science
    • 9.3. Cellular properties and benefits
    • 9.4. Procurement of amniotic membrane
    • 9.5. Clinical applications
    • 9.6. Conclusion
  • Index

Product details

  • Edition: 1
  • Latest edition
  • Published: May 18, 2016
  • Language: English

About the editor

DM

Daniel L Mooradian

Dr Daniel L. Mooradian, Senior Fellow & Honeywell James J. Renier Chair in Technology Management, The Technological Leadership Institute, University of Minnesota, USA
Affiliations and expertise
University of Minnesota, Minneapolis, MI, USA

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