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Extracellular Matrix and The Liver
Approach to Gene Therapy
1st Edition - February 6, 2003
Editors: Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. Friedman
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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary… Read more
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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches.
The chapters are divided into six sections as follows:
Basic Science of Extracellular Matrix
Cells Responsible for Extracellular Matrix Production
Activation Mechanism of Hepatic Cells and Signal Transduction
Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
New Strategies for the treatment of Liver Cirrhosis
Discusses the possibility of gene therapy for liver cirrhosis
Includes information on new aspects of hepatic stellate cells
Written by top experts in basic science and clinical hepatology
Hepatologists, molecular geneticists, gastroenterologists, oncologists, and hematologists
New Insights into the Extracellular Matrix Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates Functions of Proteoglycan/Glycosaminoglycan in Liver SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology Cells Responsible for ECM Production in the Liver Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair Molecular Mechanism of Stellate Cell Activation and ECM Remodeling Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype Knockout Mice of Matrix Metalloproteinase Genes Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis