Exosomal RNA

Role in Human Diseases and Therapy

1st Edition - March 29, 2024
Editors: Debalina Bhattacharya, Mainak Mukhopadhyay, Kursad Turksen
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 4 0 0 8 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 4 0 0 7 - 5

Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnosti… Read more

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Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process.

This book also gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One. Exosomal RNA—an introduction
1. Introduction
2. Characteristics of exosomal RNA
3. Importance of exosomal RNAs
4. Role of exosomal RNAs in different diseases
5. Concluding remarks
Chapter Two. Biogenesis of exosome and exosomal RNA and its isolation and physical characterizations
1. Introduction
2. Exosome isolation
3. Characterization of exosomes
4. Conclusion
Chapter Three. Exosomal RNA in cancer progression
1. Introduction
2. Exosomal RNAs in cancer progression
3. Conclusion
Chapter Four. Exosomal RNA as a biomarker in cancer diagnostics and therapy
1. Introduction
2. Exosomal RNA as a biomarker for diagnosis and therapy outcome of common tumor types
3. Conclusion
Chapter Five. Exosomal RNA and autophagy
1. Introduction
2. Exosome biogenesis and composition
3. Overview of autophagy
4. Cross-regulation between exosome biogenesis and autophagy
5. Regulation of autophagy via exosome vice versa
6. RNA sorting into exosomes and novel roles in autophagy
7. Mechanisms for miRNA sorting into exosomes
8. Regulation of exosomal miRNAs and autophagy
9. Regulation of exosomal lncRNAs and autophagy
10. Regulation of exosomal circRNAs and autophagy
11. Conclusion
Chapter Six. Exosomal RNA in type 2 diabetes mellitus and other metabolic diseases
1. Introduction
2. Characteristics features and function of exosomes and exosomal RNA
3. Pathophysiology of insulin resistance, diabetes mellitus, and related metabolic complications
4. Discussion and conclusion
Chapter Seven. Exosomal RNAs in immunological diseases
1. Introduction
2. Function and mechanism of exosomal RNAs in immune response
3. Exosomal RNAs in immune regulation
4. Pathogenesis of autoimmune diseases
5. Role of exosomal RNAs in autoimmune diseases
6. Role of exosomal RNAs in other immunological diseases
7. Conclusion
Chapter Eight. Potential role of exosomal miRNA in disease progression and therapeutics
1. Introduction
2. The cellular interaction and sorting mechanism for exosomal miRNAs
3. The function of the exosome, exosomal miRNAs, and associated challenges
4. Importance of exosomal miRNA
5. Applications of exosomal miRNAs
6. Role of exosomal miRNAs in cardiovascular disease
7. Role of exosomal miRNA in neurodegenerative diseases
8. Role of exosomal miRNAs in brain injury
9. Role of exosomal miRNA in spinal cord injury
10. Role of exosomal miRNA in glioma
11. Conclusions
Chapter Nine. Exosomal RNA in aging-related diseases
1. Introduction
2. Exosomal LncRNA in aging
3. Exosomal miRNA in aging
4. Exosomal circRNA in aging
5. Exosomes in neurological disorders
6. Exosomes in bone-related disorders
7. Exosomes in heart disease
8. Exosomes in metabolic disorders
9. Exosomes in autoimmune disorders
10. Concluding remarks and future directions
Chapter Ten. Exosomal RNA in cardiovascular diseases
1. Role of exosomal RNAs in cardiovascular diseases
2. Conclusion
Chapter Eleven. Exosomal RNA in renal diseases
1. Introduction
2. Concluding remarks
Chapter Twelve. Exosomal RNA in bacterial infections
1. Introduction
2. Alterations in exosomes upon bacterial infection
3. Role of exosomes when pathogens infect
4. The role and delivery of bacterial exosomal RNA during pathogen infections
5. Case studies
6. Bacterial exosomal RNA in therapy development
7. Approaches to studying bacterial exosomal RNAs
8. Conclusions
Chapter Thirteen. Role of exosomal RNA in wound healing and tissue repair
1. Introduction
2. Background of regenerative medicine and tissue engineering
3. Role of different exosomal RNA in wound healing and tissue repair
4. Applications of exosomes
5. Future prospects
6. Conclusion
Chapter Fourteen. The importance of exosomal RNA in major ocular and respiratory diseases
1. Introduction
2. Exosomal mRNA
3. Exosomal miRNA
4. Exosomal lncRNA
5. Exosomal circRNA
6. Exosomal RNAs in ocular diseases
7. Corneal disease
8. Diabetic retinopathy
9. Glaucoma
10. Age-related macular degeneration (AMD)
11. Uveal melanoma
12. Retinoblastoma
13. Optic neuropathy
14. Exosomal miRNA in chronic obstructive pulmonary disease (COPD)
15. Exosomal RNA in respiratory diseases
16. Asthma
17. Lung cancer
18. Pneumonia
19. Pulmonary fibrosis
Index

Debalina Bhattacharya

Debalina Bhattacharya is currently working as an Assistant Professor in the Department of Microbiology, Maulana Azad College, West Bengal, India. Previously, she worked as a postdoctoral fellow in the Department of Biotechnology and Department of Biochemistry, University of Calcutta, West Bengal, India. She holds a PhD in bionanotechnology from Jadavpur University, West Bengal, India. She has been awarded UGC DS Kothari Post-Doctoral Fellowship in 2015 and DST-SERB National Post-Doctoral fellowship in 2018. She has co-authored 24 peer-reviewed research articles and review articles and 17 book chapters.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Maulana Azad College, West Bengal, India

Mainak Mukhopadhyay

Dr. Mainak Mukhopadhyay is currently working as Associate Professor at the Department of Biosciences, JIS University, Kolkata, India. Previously, he worked as a research fellow at ONGC Energy Centre, Delhi, India. He holds a PhD in Bioenergy from the Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, India. He has been awarded the Petrotech Research Fellowship in 2008. In 2016 he was awarded the Early Career Research Award from DST-SERB. In addition to editing two books, he has co-authored 13 peer-reviewed papers, 19 book chapters and filled 3 patents.

Affiliations and expertise

Associate Professor, Department of Biosciences, JIS University, Agarpara, Kolkata, India

Kursad Turksen

Professor Kursad Turksen received his PhD from the University of Toronto in the area of osteoprogenitor biology and cell selection methodologies. He then did postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, USA, studying epidermal biology through the use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently series editor of Stem Cells and Regenerative Medicine (Springer Nature) and Cell Biology and Regenerative Medicine (Springer Nature).

Affiliations and expertise

Senior Scientist, Ottawa Hospital Research Institute, Ottawa