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Essentials of Genomic and Personalized Medicine

  • 1st Edition - September 24, 2009
  • Latest edition
  • Editors: Geoffrey S. Ginsburg, Huntington F Willard
  • Language: English

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving popula… Read more

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Description

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine.

Key features

  • Full color throughout
  • Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field
  • Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practic
  • Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Readership

general practitioners, specialists, and students across medical disciplines, research professionals in human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and related areas

Table of contents

1 Introduction

Section 1 - Basics

2 Organization, Variation and Expression of the Human Genome

3 DNA Sequencing for the Detection of Human Genome Variation

4 Genome-Wide Association Studies and Genotyping Technologies

5 Copy Number Variation and Human Health

6 DNA Methylation Analysis: Providing New Insight into Human Disease

7 DNA Microarrays in Biological Diversity and Patient Care

8 Proteomics: The Deciphering of the Functional Genome

9 Comprehensive Metabolic Analysis for Understanding Disease

Section 2 - Informatics

10 Bioinformatic and Computational Analysis for Genomic Medicine

11 Systems Biology and Systems Medicine

12 Electronic Medical Records in Genomic Medicine Practice and Research

13 Health Information Retrieval for Consumers

Section 3 - Translational

14 Genomics to Health: Challenges and Opportunities

15 Pharmacogenetics and Pharmacogenomics

16 Clinical Implementation of Translational Genomics

17 The Role of Genomics in Enabling Prospective Health

18 From Sequence to Genomic Medicine: Genome Policy Considerations

19 Federal Regulation of Genomic Medicine

20 Economic Issues and Genomic Medicine

21 Public Health Genomics

Section 4 - Clinical (Cardiology)

22 Hypertension

23 Lipiprotein Disorders

24 Myocardial Infarction

25 Acute Coronary Syndromes

26 Heart Failure in the Era of Genomic Medicine

27 Genomic Assessment of Cardiac Transplant Rejection

28 Hypertrophic Cardiomyopathy

29 Arrhythmias

30 Genetics and Genomics in the Management of Hemostasis & Thrombosis

31 Genomics of Congenital Heart Disease

Section 5 - Clinical (Oncology)

32 Genomics in the Management of Lymphomas

33 Genomics in Leukemias

34 Lung Cancer

35 Genomics in the Diagnosis and Management of Breast Cancer

36 Colorectal Cancer

37 Prostate Cancer

38 Genomic Assessment of Ovarian Cancer

39 Genomic Evaluation of Pancreatic Neoplasms

40 Genomic Evaluation of Head and Neck Cancer

41 Genomic Medicine, Evaluation of Brain Tumors and Gliomas

42 Diagnostic - Therapeutic Combinations in the Targeted Therapies for Treatment of Cancer

Section 6 - Clinical (Inflammatory Disease)

43 Genomics in the Evaluation and Management of Rheumatoid Arthritis

44 "Omics" in the Genomic Evaluation of Multiple Sclerosis

45 Genomic Assessment of Inflammatory Bowel Disease

46 Asthma Genomics

47 Genomic Aspects in the Evaluation and Management of Chronic Obstructive Pulmonary Disease

48 Genetics and Genomics of Interstitial Lung Disease

49 Peptic Ulcer Disease

Section 7 – Clinical (Metabolic Disease)

50 Genomics in Pathogenesis of Cirrhosis

51 Genomic Medicine and Obesity

52 Diabetes

Section 8 – Clinical (Neurological Disease)

53 Genetics and Genomics of Dementia

54 Genetics and Genomics of Parkinson’s Disease

55 Genomic Considerations in Opthamology

56 Genomics in the Diagnosis and Management of Depression

Section 9 – Clinical (Infectious Disease)

57 "Genomic Approaches to
the Host Response to Pathogens"

58 Host Genomics and Bacterial Infections

60 Diagnosis, Genomics, and the Management of Hepatitis

Product details

  • Edition: 1
  • Latest edition
  • Published: October 2, 2009
  • Language: English

About the editors

GG

Geoffrey S. Ginsburg

Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.
Affiliations and expertise
Chief Medical and Scientific Officer, All of Us Research Program, National Institutes of Health, Bethesda, Maryland, USA

HW

Huntington F Willard

Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.
Affiliations and expertise
Chief Scientific Officer, Genome Medical, Inc., South San Francisco, CA, USA

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