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Epigenetics in Organ Specific Disorders
- 1st Edition, Volume 34 - December 2, 2022
- Editors: Chandra S. Boosani, Ritobrata Goswami
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 9 3 1 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 9 3 2 - 2
**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a found… Read more
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Request a sales quote**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**
Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
- Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities
- Explores organ specific epigenetic mechanisms to enable drug discovery and development
- Features chapter contributions from leading researchers in the field
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, cardiology, neurology, pathology, physiology, and bioinformatics; life science researchers; developmental biologists
1. Introduction to epigenetic mechanisms
2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells
3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases
4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases
5. Histone deacetylases and regulation of gene expression during cell proliferation
6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration
7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins
8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis
9. Epigenetic control over cell division in pathological conditions
10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression
11. Role of histone deacetylases in regulating cell cycle progression
12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators
13. Epigenetic pathways that promote cellular autophagy
14. Epigenetic inducers of Cell growth and survival
15. Microbial compounds as potential inducers of epigenetic mechanisms during infections
16. Current epigenetic drugs and their target proteins with potential use in disease treatment
17. Prospects of epigenetic drugs in combination therapy
2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells
3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases
4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases
5. Histone deacetylases and regulation of gene expression during cell proliferation
6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration
7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins
8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis
9. Epigenetic control over cell division in pathological conditions
10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression
11. Role of histone deacetylases in regulating cell cycle progression
12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators
13. Epigenetic pathways that promote cellular autophagy
14. Epigenetic inducers of Cell growth and survival
15. Microbial compounds as potential inducers of epigenetic mechanisms during infections
16. Current epigenetic drugs and their target proteins with potential use in disease treatment
17. Prospects of epigenetic drugs in combination therapy
- No. of pages: 666
- Language: English
- Edition: 1
- Volume: 34
- Published: December 2, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780128239315
- eBook ISBN: 9780128239322
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Chandra S. Boosani
Dr. Chandra S. Boosani is an Assistant Professor at the Genetics, Epigenetics & Molecular Biology Lab, within the Department of Translational Research, at the College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, U.S.A. His research focuses on developing and testing anticancer proteins, and identifying mechanisms of epigenetic drug action, with emphasis on developing recombinant proteins, drug testing in live mice, and analyzing sequencing data. Dr. Boosani has published in such peer reviewed journals as Seminars in Cancer Biology, Blood, Pharmaceuticals, Gene Regulation and Systems Biology, and Protein Expression and Purification.
Affiliations and expertise
Assistant Professor, Department of Translational Research, College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, USARG
Ritobrata Goswami
Ritobrata Goswami is a Assistant Professor in the School of Bioscience, IIT Kharagpur, West Bengal, India.
Affiliations and expertise
Assistant Professor, School of Bioscience, IIT Kharagpur, West Bengal, IndiaRead Epigenetics in Organ Specific Disorders on ScienceDirect