Epigenetics in Health and Disease part B

1st Edition, Volume 198 - May 23, 2023
Editors: Vijai Singh, Indra Mani
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 4 4 4 - 8
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 4 4 5 - 5

Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume pr… Read more

Epigenetics in Health and Disease part B

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Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-dCas9 Systems for Epigenetic Editing for Therapeutic Applications, Epigenetics in heredity disease, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Histone deacetylase (HDACs) Inhibitors: Clinical applications, Early epigenetic markers for precision medicine, Epigenetics of neurological diseases, Epigenetic Regulons in Alzheimer’s disease, and Epigenetics in epilepsy.

Cover
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Applications of bioinformatics in epigenetics
Abstract
1: Introduction
2: Epigenetic data processing and analysis
3: Epigenetics databases
4: In silico tools for epigenetic modification
5: Conclusion and future perspectives
Conflict of interest
References
Chapter Two: CRISPR-dCas9 system for epigenetic editing towards therapeutic applications
Abstract
1: Introduction
2: Approaches of epigenome modification using CRISPR-dCas9
3: Conclusions and future remarks
Acknowledgments
References
Chapter Three: Epigenetic control of heredity
Abstract
1: Introduction
2: Epigenetic inheritance
3: Epigenetic control on gene expression
4: DNA methylation and heredity
5: Histone modifications and heredity
6: Non-coding RNAs and heredity
7: Factors influencing epigenesis, associated diseases and their inheritance
8: Role of epigenetic inheritance in heritability of diseases
9: Conclusions
10: Future perspective
References
Chapter Four: Epigenetics in renal diseases
Abstract
1: Introduction
2: Epigenetic mechanisms in renal diseases
3: Conclusion and future perspectives
Conflict of interest
References
Chapter Five: Epigenetics in cancer development, diagnosis and therapy
Abstract
1: Introduction
2: Epigenetics and cancer development
3: Epigenetics and cancer diagnosis
4: Epigenetics and cancer therapy
5: Conclusion and future direction
Acknowledgments
References
Chapter Six: Microbiota and epigenetics: Health impact
Abstract
1: Introduction
2: Epigenetic processes
3: Interaction among diet, microbiome, and epigenetics
4: Epigenetics and microbiome in the diseased states
5: Therapeutic approaches
6: Conclusion
7: Future perspective
References
Chapter Seven: Histone deacetylase (HDACs) inhibitors: Clinical applications
Abstract
1: Introduction
2: The roles of HDACs in cancer
3: HDAC inhibitors in neurodegenerative diseases
4: HDACi in cardiovascular diseases
5: Conclusions
References
Chapter Eight: Early epigenetic markers for precision medicine
Abstract
1: Introduction
2: What is epigenetics?
3: Epigenetic modifications
4: Role of epigenetics in biological processes
5: Epigenetics in cancer
6: Epigenetic in neurological disorders
7: Conclusions
References
Chapter Nine: Epigenetics of neurological diseases
Abstract
1: Introduction
2: Epigenetic layers and their regulators
3: Epigenetic dysregulation in neurological disorders
4: Therapeutic potential
5: Conclusion
References
Chapter Ten: Epigenetic regulons in Alzheimer's disease
Abstract
1: Introduction
2: Epigenetic mechanisms
3: Environmental factors in the progression of AD
4: Epigenetic mechanisms in Alzheimer's disease (AD)
5: Epigenetic therapeutics in AD
6: Conclusions
References
Chapter Eleven: Epigenetics in epilepsy
Abstract
1: Introduction
2: Epigenetic modifications in epilepsy
3: Therapeutic prospects
4: Conclusion
References
Index

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Indra Mani

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India