Eosinophilic Gastrointestinal Diseases, An Issue of Immunology and Allergy Clinics of North America

1st Edition, Volume 44-2 - April 5, 2024
Editors: Glenn T. Furuta, Dan Atkins
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 0 3 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 0 4 - 9

In this issue of Immunology and Allergy Clinics, guest editors Drs. Glenn T. Furuta and Dan Atkins bring their considerable expertise to the topic of Eosinophilic Gastroint… Read more

Eosinophilic Gastrointestinal Diseases, An Issue of Immunology and Allergy Clinics of North America

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In this issue of Immunology and Allergy Clinics, guest editors Drs. Glenn T. Furuta and Dan Atkins bring their considerable expertise to the topic of Eosinophilic Gastrointestinal Diseases. Top experts provide a multilayered examination of the current state of knowledge in the field, compiling an issue that serves as a convenient reference for the evaluation and management of eosinophilic esophagitis (EoE) and eosinophilic gastrointestinal diseases (EGIDs).

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Pathophysiology of Eosinophilic Esophagitis
Key points
Introduction
Genetic contributions
Early-life environmental exposures
Role of the epithelium in eosinophilic esophagitis pathogenesis
Summary
Clinics care points
Pathophysiology and Clinical Impact of Esophageal Remodeling and Fibrosis in Eosinophilic Esophagitis
Key points
Introduction
Defining esophageal remodeling in eosinophilic esophagitis
Summary
Clinics care points
Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis
Key points
Introduction
Epidemiologic clues
Genetic risk factors
Early life
Later life and environmental exposures
Clinical clues
Summary/future directions
Clinics care points
Clinical Evaluation of the Child with Eosinophilic Esophagitis
Key points
Introduction
Epidemiology
Clinical symptoms
Physical examination
Endoscopic findings
Histologic features and diagnostic criteria
Complications of eosinophilic esophagitis
Treatment
Evaluation of atopic comorbidities
Novel methods for disease monitoring in eosinophilic esophagitis
Relationship with oral immunotherapy
Summary
Recognition and Management of Feeding Dysfunction in the Pediatric Patient with Eosinophilic Esophagitis
Key points
Clinical presentation of feeding dysfunction in children with eosinophilic gastrointestinal disorders
Symptoms suggestive of feeding dysfunction
Assessment
Feeding treatment
Case studies
Summary
Clinics care points
Clinical Evaluation of the Adult with Eosinophilic Esophagitis
Key points
Introduction
Definition
Epidemiologic features and demographic characteristics
Assessment of symptoms in adults with eosinophilic esophagitis
Physical examination of adults with eosinophilic esophagitis
Laboratory analyses
Endoscopic assessment of adults with eosinophilic esophagitis
Particularities of biopsy-sampling in eosinophilic esophagitis
Imaging methods
Esophageal stress tests—the emerging “ergometry” for gastroenterologists to demask and quantify hidden dysphagia?
Natural history, complications, and indications for treatment of adult eosinophilic esophagitis
Outlook
Clinics care points
Endoscopic Features of Eosinophilic Esophagitis
Introduction
Clinics care points
Histopathology of Eosinophilic Esophagitis
Key points
Background
Dietary Management of Eosinophilic Esophagitis
Key points
Introduction
Background
Elemental diet: the most effective modality
Allergy testing–based diet
Empiric elimination diets
Four-food elimination diet and step-up approaches
Randomized trials with diet therapies in eosinophilic esophagitis
How to discuss diet therapy with patients
Nutrition assessment
Implementing diet therapy
Empiric elimination diets
Making dietary therapy work for long-term maintenance
Summary
Clinics care points
Pharmacologic Management of Eosinophilic Esophagitis
Key points
Introduction
Proton pump inhibitors
Potassium-competitive acid blockers
Corticosteroids
Biologics
Summary
Clinics care points
Health-Related Quality of Life in Patients with Eosinophilic Esophagitis
Key points
Introduction
Measurement of health-related quality of life in eosinophilic esophagitis
Determinants of quality of life in adult patients with eosinophilic esophagitis
Impact of treatment on quality of life
Summary
Clinics care points
The Relationship Between Eosinophilic Esophagitis and Immunotherapy
Key points
Introduction
Definitions of immunotherapy
Background
Discussion
Outcomes after discontinuation of oral immunotherapy
Aeroallergens and eosinophilic esophagitis
Proposed options for management
Summary
Clinics care points
Embracing Diversity, Equity, Inclusion, and Accessibility in Eosinophilic Gastrointestinal Diseases
Key points
Introduction
Impact of race, ethnicity, and socioeconomic factors on eosinophilic gastrointestinal diseases
Disparities in rural communities
Future directions: where do we go from here?
Summary
Clinics care points
Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders
Key points
Introduction
Definitions and challenges
Epidemiology
Nomenclature
Allergic etiology
Cellular and molecular pathophysiology
Summary
Clinics care points
Role of Mast Cells in Eosinophilic Gastrointestinal Diseases
Key points
Introduction
Summary
Clinics care points
Associations of Eosinophilic Gastrointestinal Disorders with Other Gastrointestinal and Allergic Diseases
Key points
Introduction
Allergy and eosinophilic gastrointestinal disorders
Other gastrointestinal conditions and eosinophilic gastrointestinal disorders
Summary
Clinics care points
Clinical Presentation of Patients with Eosinophilic Gastrointestinal Diseases beyond Eosinophilic Esophagitis
Key points
Clinical presentation of mucosal subtype of eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis
Clinical presentation of muscular subtype of non-EoE EGIDs
Clinical presentation of subserosal subtype of non-EoE EGIDs
Summary
Clinics care points
Endoscopic Features of Eosinophilic Gastrointestinal Diseases
Key points
Introduction
Endoscopic scores in eosinophilic esophagitis
Endoscopic scores in non-EoE eosinophilic gastrointestinal diseases
The role of endoscopic features in diagnosis and follow-up of eosinophilic gastrointestinal diseases
Endoscopic interventions
The role of endoscopy in eosinophilic esophagitis-like diseases
Area of uncertainty
Future perspective
Histopathology of Eosinophilic Gastrointestinal Diseases Beyond Eosinophilic Esophagitis
Key points
Background
Pathogenesis of eosinophilic gastrointestinal diseases
Histopathologic evaluation of mucosal biopsies for the diagnosis of eosinophilic gastrointestinal disease
Influence of eosinophil-depleting biologic agents on histopathology in eosinophilic gastrointestinal disease
Dietary Management of Non-EoE Eosinophilic Gastrointestinal Diseases
Key points
Background
Current evidence: allergy evaluation of patients with non–eosinophilic esophagitis eosinophilic gastrointestinal diseases
Therapeutic options: diet as a treatment modality
Discussion
Summary
Clinics care points
Pharmacologic Management of Non–Eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases
Key points
Introduction
Corticosteroid treatments
Other non-biologic treatments
Biologic treatments
Summary and future directions
Clinics care points

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Eosinophilic Gastrointestinal Diseases, An Issue of Immunology and Allergy Clinics of North America

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Glenn T. Furuta

Dan Atkins