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Enzymes – Mechanisms, Dynamics and Inhibition
- 1st Edition, Volume 122 - September 18, 2020
- Editors: Christo Christov, Tatyana Karabencheva-Christova
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 7 7 6 2 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 7 7 6 3 - 1
Enzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in t… Read more
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Request a sales quoteEnzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.
- Provides a targeted approach to a very wide audience of specialists, researchers and students
- Contains timely chapters written by well-renowned authorities in their field
- Includes a number of high quality illustrations, figures and tables
Protein chemists, molecular cell biologists, immunologists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One. Mapping enzyme-substrate interactions: its potential to study the mechanism of enzymes
- 1. Why modeling enzyme structure and dynamics
- 2. A method for everybody
- 3. Enzymes mechanism: the potential of mapping enzyme-substrate interactions
- 4. From modeling to engineering
- Chapter Two. Experimental insight into enzyme catalysis and dynamics: A review on applications of state of art spectroscopic methods
- 1. Introduction
- 2. Single molecule detection
- 3. Ultrafast spectroscopy
- 4. Raman and Resonance Raman spectroscopy
- 5. Conclusion
- Chapter Three. Structure, catalytic mechanism, posttranslational lysine carbamylation, and inhibition of dihydropyrimidinases
- 1. Introduction
- 2. Structural mechanisms of Lys carbamylation in dihydropyrimidinase
- 3. Molecular basis of dimer or tetramer formation: different contact residues
- 4. Catalytic mechanism: dynamic loops, tunnel bottleneck, and metal content of dihydropyrimidinases
- 5. Competitive inhibitors of dihydropyrimidinase
- 6. Conclusions
- Chapter Four. Catalytic activity regulation through post-translational modification: the expanding universe of protein diversity
- 1. Introduction
- 2. Post-translational modifications at protein backbones
- 3. Metabolism regulation by post-translational modifications
- 4. AMPylation: new insights to an emerging modification
- 5. Stress responsive post-translational modifications: cysteine oxidation and S-nitrosylation
- 6. Conclusions
- Chapter Five. Current advances on the development of BET inhibitors: insights from computational methods
- 1. Introduction
- 2. In silico methods and computer-aided drug design (CADD)
- 3. Discovery of BETs inhibitors
- 4. Case study: optimizing the coumarin scaffold
- 5. Closing remarks
- Chapter Six. How to make an undruggable enzyme druggable: lessons from ras proteins
- 1. Introduction
- 2. Ras proteins as anti-cancer drug targets
- 3. Identifying and characterizing allosteric ligand binding sites on ras proteins
- 4. Allosteric inhibitors of K-Ras: light at the end of the tunnel?
- 5. Ras membrane binding, lateral segregation, and reorientation
- 6. Ras membrane binding and druggability
- 7. Concluding remarks and implications for other challenging drug targets
- Chapter Seven. In silico tools to study molecular targets of neglected diseases: inhibition of TcSir2rp3, an epigenetic enzyme of Trypanosoma cruzi
- 1. Introduction
- 2. Overview of current in silico approaches used for the study of neglected diseases
- 3. Technological trends applied to CADD
- 4. Novel targets and treatments for NTD
- 5. Case study: In silico study of epigenetic target on Trypanosoma cruzi
- 6. Challenges and emerging problems
- 7. Conclusions
- Chapter Eight. Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits
- 1. Introduction
- 2. The catalytic subunit of PP1 (PP1C)
- 3. The PP1 regulatory subunits
- 4. PP1C interacting sites for regulatory proteins
- 5. PP1C interacting proteins and regulators
- 6. Conclusion
- Chapter Nine. Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s
- 1. P450s
- 2. Physiological roles of P450s
- 3. P450 nomenclature and classes
- 4. Biotechnological applications of P450s
- 5. Concluding remarks
- No. of pages: 330
- Language: English
- Edition: 1
- Volume: 122
- Published: September 18, 2020
- Imprint: Academic Press
- Hardback ISBN: 9780128177624
- eBook ISBN: 9780128177631
CC
Christo Christov
Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK
Affiliations and expertise
Department of Chemistry, Michigan Technological University, Houghton, MI, USATK
Tatyana Karabencheva-Christova
Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.
Affiliations and expertise
Department of Chemistry, Michigan Technological University, Houghton, MI, USARead Enzymes – Mechanisms, Dynamics and Inhibition on ScienceDirect