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Endotype-based Management of Adult and Pediatric OSA​

  • 1st Edition - June 1, 2027
  • Latest edition
  • Editors: Venkata Koka, Umakanth Katwa, Andrea De Vito
  • Language: English

Endotype-based Management of Adult and Pediatric OSA offers a a detailed exploration of endotype-based diagnosis and personalized treatment strategies for both adult and pediat… Read more

Description

Endotype-based Management of Adult and Pediatric OSA offers a a detailed exploration of endotype-based diagnosis and personalized treatment strategies for both adult and pediatric obstructive sleep apnea. It combines the latest research, innovative technologies, and practical clinical tools to help sleep medicine specialists, pulmonologists, ENT surgeons, and biomedical engineers understand and implement targeted therapies. Designed for clinicians, researchers, and educators, this comprehensive resource aims to advance the field of sleep medicine by promoting a more precise and effective approach to managing sleep apnea based on individual physiological traits.

Key features

  • Highlights new technologies such as advanced polysomnography data analysis, AI algorithms, and imaging techniques, along with discussion of their research and clinical applications in managing OSA
  • Provides a comprehensive understanding of the physiological endotypes of obstructive sleep apnea (OSA) and how this knowledge can be used to develop personalized treatment strategies
  • Includes a list of international experts and researchers from various institutions, ensuring a multidisciplinary and comprehensive perspective on endotype-based management of OSA

Readership

Sleep medicine specialists, pulmonologists, ENT surgeons, dentists, and biomedical engineers involved in the diagnosis and treatment of obstructive sleep apnea in both adult and pediatric populations

Table of contents

1. Decoding Collapsibility: The Anatomical Endotype in OSA

2. Loop Gain Dynamics: Instability as a Therapeutic Target

3. Precision Pharmacotherapy: Targeting Endotypic Pathways

4. REM-Driven OSA: Ventilatory Instability Endotypes

5. Expiratory Biomechanics: Pinching as an Endotypic Marker

6. Hypoxic Burden: Quantifying Endotypic Severity

7. Night-to-night variability in endotype expression: a necessity for multi-night evaluation

8. Endotype Modeling: Bridging Computation and Clinic

9. Surgical Precision: Endotype-Driven Airway Reconstruction

10. DISE Revealed: Endotypic Airflow Signatures

11. Pressure Thresholds: Endotype-Guided Therapy Selection

12. Hypoglossal Nerve Stimulation: Muscle Endotype Optimization

13. Endotype-based patient selection for the success of mandibular advancement in OSA

14. Muscle Endotype for Myofunctional Therapy

15. Rehabilitating Muscle Endotypes by Targeted Exercises; a Dental Perspective

16. Role of DISE and Imaging and AI for Targeted Muscle Exercise Selection and Rehabilitation

17. Pediatric Endotypes: Developmental Challenges in OSA

18. CAP Metrics: Pediatric Arousal Endotype Biomarkers

19. UARS unmasked: Endotypic Profiles of Resistance

20. Multidisciplinary Care: Endotyping in Pediatric Practice

21. Bruxism and OSA: Shared Endotypic Pathways

Product details

  • Edition: 1
  • Latest edition
  • Published: June 1, 2027
  • Language: English

About the editors

Venkata Koka

Editor

Venkata Koka is an otolaryngologist and sleep medicine specialist working as a consultant in sleep medicine in Paris, France. ​

​He obtained diplomas in Sleep Medicine from Paris XI University, ESRS (certified expert somnologist), and WSS (International certification in Sleep Medicine) and worked as a consultant in sleep medicine at Antoine Beclere Hospital, Paris - Saclay University, France.

​He is a member of various sleep societies including the AASM, WSS, ESRS, IPSA, ATS, ​and SFRMS (French sleep society)

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​He is actively involved in academics, teaching, and research activities in sleep medicine and sleep physiology and is also an international speaker in the field of sleep medicine during various courses and workshops. He is an editor in various reputed journals in sleep medicine.

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​He is involved in international multi-institutional studies in the development of new diagnostic tools and is a strong advocator of endotype-targeted treatment in a multi-modality approach in OSA.

Affiliations and expertise
Consultant in Sleep Medicine, Antoine Beclere Hospital, Paris-Saclay University, Paris, France

Umakanth Katwa

Editor

Dr Umakanth Katwa is a pediatric pulmonologist, pediatric sleep specialist, Director of the Sleep Center at Boston Children’s Hospital, and Assistant Professor of Pediatrics at Harvard Medical School in Boston. He did his fellowship training in pediatric pulmonary and sleep medicine at Harvard University in Boston.

He is the director of the Infant Apnea Clinic and co-directs the multidisciplinary sleep apnea and sleep surgery program (PSASS). He has extensive teaching experience and co-directs pediatric sleep medicine courses at Harvard and Tufts Universities. He is a member of the American Academy of Sleep Medicine on Sleep and Respiratory Technologist Education Task Force. His research interests include phenotyping pediatrics OSA, infant sleep apnea, drug-induced sleep endoscopy, and technology integration in sleep evaluation. His current NIH-funded research includes AI-based modeling of sleep study interpretation of pediatric OSA, which is called Complete Artificial Intelligence Based Sleep Report (CAISR) and Quantitative Retrospective Analysis of Sleep Physiology (QRASP). He lectures widely across the world and is involved in teaching sleep to physicians, dentists, and medical students. And has extensively published in several peer-reviewed national and international journals

Affiliations and expertise
Director, Sleep Center, Boston Children's Hospital, Boston, USA; Assistant Professor, Department of Pediatrics, Harvard Medical School, Boston, USA

Andrea De Vito

Editor

Prof Andrea De Vito is an ENT specialist, sleep medicine specialist (PhD), Director of the ENT Unit, and Vice-Director of the Department of Surgery, Forlì and Faenza Hospitals, Health Local Agency of Romagna. He is a member of the Italian Association of Otorhinolaryngology (SIO&ChF), holding the position of head of the scientific board for sleep-disordered breathing. He is the vice-president of the Italian Academy of Roncology. He is involved as an invited speaker in most national and international meetings, and he is the director of the Italian Annual Master in sleep-disordered breathing at its 15th edition. He is involved in many research studies, including OSA phenotyping, upper airway surgical treatment outcomes in OSA patients, and drug-induced sleep endoscopy application in OSA patients. He has published in several peer-reviewed international journals, focusing on OSA pathophysiology and surgical outcomes.

Affiliations and expertise
Director, ENT Unit, Forlì and Faenza Hospitals, Health Local Agency of Romagna, Forlì, Italy