Endocannabinoids

Chapter One: The Endocannabinoid Signaling System in the CNS: A Primer

• Abstract
• 1 Introduction
• 2 The Endocannabinoids
• 3 Endocannabinoid Receptors
• 4 CB1R and Retrograde Regulation of Synaptic Activity
• 5 Summary
• Acknowledgments

Chapter Two: Evidence for a Role of Adolescent Endocannabinoid Signaling in Regulating HPA Axis Stress Responsivity and Emotional Behavior Development

• Abstract
• 1 Adolescence and Pubertal Maturation
• 2 The Neurobiology of Stress
• 3 Adolescent HPA Axis Development
• 4 The Developmental Influence of Gonadal Hormones on the HPA Axis
• 5 The Endocannabinoid System
• 6 Endocannabinoid System Regulation of the HPA Axis in Adulthood
• 7 Ontogeny of the Endocannabinoid System
• 8 Adolescent HPA Axis Function: A Regulatory Role for the Endocannabinoid System?
• 9 Concluding Remarks
• Acknowledgments

Chapter Three: The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract

• Abstract
• 1 Introduction
• 2 The Enteric Nervous System and the Brain–Gut Axis
• 3 The Endocannabinoid System
• 4 Endocannabinoid Signaling Mechanisms
• 5 Other Receptors, Agonists, and Antagonists
• 6 Endocannabinoid Tone
• 7 Cannabinoid Receptor Metaplasticity in the ENS
• 8 Cannabinoid Receptor Properties
• 9 Enteric Glia
• 10 Neurotransmission in the ENS and GI Tract
• 11 Brain–Gut Axis
• 12 The Endocannabinoid System of the ENS in GI Inflammation
• 13 Summary and Future Directions
• Disclosures

Chapter Four: Endocannabinoid Mechanisms Influencing Nausea

• Abstract
• 1 Endocannabinoids in Acute Nausea
• 2 Endocannabinoids in Anticipatory Nausea
• 3 Conclusions

Chapter Five: Endocannabinoid Regulation of Neuroendocrine Systems

• Abstract
• 1 The Endocannabinoids and Their Receptors
• 2 Cannabinoid Regulation of the Neuroendocrine Stress Response
• 3 Endocannabinoid Regulation of Energy Homeostasis
• 4 Endocannabinoids and Fluid Homeostasis
• 5 Endocannabinoid Regulation of Reproduction

Chapter Six: The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress

• Abstract
• 1 Introduction
• 2 The Endocannabinoid System
• 3 The Endocannabinoid System in the Brain Regulates Pain
• 4 The Modulation of Pain by Stress: Role for the Brain's Endocannabinoid System
• 5 The Role of the Endocannabinoid System in the Rostral Ventromedial Medulla in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
• 6 The Role of the Endocannabinoid System in the Periaquaductal Gray in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
• 7 The Role of the Endocannabinoid System in the Amygdala in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
• 8 The Role of the Endocannabinoid System in the Prefrontal Cortex in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
• 9 Less Characterized Supraspinal Endocannabinoid Mechanisms in Pain Modulation
• 10 Concluding Remarks
• Acknowledgments

Chapter Seven: Endocannabinoid Signaling in Motivation, Reward, and Addiction: Influences on Mesocorticolimbic Dopamine Function

• Abstract
• 1 Introduction
• 2 The Neurobiology of Reward
• 3 The Influence of Endocannabinoid Signaling on Reward
• 4 The Role of the Endocannabinoid System in Motivation
• 5 Drug Addiction and the Endocannabinoid System: A Reciprocal Modulation of Synaptic Plasticity
• 6 Concluding Remarks
• Acknowledgments