Electrocardiographic Left Ventricular Hypertrophy
Looking Beyond Left Ventricular Mass
- 1st Edition - November 18, 2025
- Latest edition
- Editors: Ljuba Bachárová, Niraj Varma
- Language: English
Electrocardiographic Left Ventricular Hypertrophy: Looking Beyond Left Ventricular Mass provides an innovative perspective on electrocardiograms (ECGs) usage for evaluation of lef… Read more
Electrocardiographic Left Ventricular Hypertrophy: Looking Beyond Left Ventricular Mass provides an innovative perspective on electrocardiograms (ECGs) usage for evaluation of left ventricular hypertrophy (LVH). It links contemporary research results with clinical practice in order to advance application of this cornerstone technology. Specifically, it highlights how standard ECGs can provide unique information on the cardiac electric field in LVH patients.
This book recognizes and fulfills the urgent need to change the classical diagnostic paradigms of ECG diagnosis in LVH. To do so, it turns attention to so-called false-negative ECG findings that in truth provide valuable information that largely overlooked. When used to their fullest potential, these results can be used for enhanced diagnosis, selection of targeted therapy and cardiovascular risk assessment.
This book recognizes and fulfills the urgent need to change the classical diagnostic paradigms of ECG diagnosis in LVH. To do so, it turns attention to so-called false-negative ECG findings that in truth provide valuable information that largely overlooked. When used to their fullest potential, these results can be used for enhanced diagnosis, selection of targeted therapy and cardiovascular risk assessment.
- Provides an understanding of the underlying electrical phenomena in Left Ventricular Hypertrophy (LVH), along with their diagnostic and prognostic importance
- Presents new insights regarding the electrical properties of hypertrophied myocardium, indicating future research and clinical applications
- Addresses controversies around so-called "false negative" ECG results in LVH diagnosis, thereby preventing the dangers of incorrect evaluation and increased risk of death
Practicing cardiologists and research cardiologists
1. Introduction
Ljuba Bachárová and Niraj Varma
2. Electrocardiographic criteria for left ventricular hypertrophy diagnosis
Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros and Kjell Nikus
3. ST segment strain pattern in left ventricular hypertrophy
Douglas Schocken, MD
4. QT interval dynamics in left ventricular hypertrophy
Emanuela Teresa Locati
5. Epidemiology and prognosis of left ventricular hypertrophy through electrocardiography: from Minnesota Code to artificial intelligence
Antonio Luiz Pinho Ribeiro and Gabriela Miana Paixao
6. Echocardiographic diagnosis of left ventricular hypertrophy and its compatibility with electrocardiographic criteria: the “false negative and false positive” electrocardiography
Beata Uziębło-Życzkowska, Katarzyna Piotrowicz and Paweł Krzesiński
7. Addition of serum biomarkers carboxyterminal propeptide of procollagen type I (PICP) and NT-proBNP levels to electrocardiography criteria for detection of left ventricular hypertrophyl
Miquel Fiol, Antonio Bayes de Luna, Alvaro Alonso, Jordi Salas-Salvado, Estefania Toledo, Elena Fortuny, Josep F. Alberti, Angel Alonso-Gomez and Dora Romaguera
8. The discrepancy between wall thickness, myocardial mass, and ECG appearances in young patients with cardiomyopathies
Ingegerd Östman-Smith, Eva Fernlund, Anna Wålinder Österberg and Frida Dangardt
9. Electrocardiographic and echocardiographic differences in the athlete’s heart: a special category
Katarzyna Piotrowicz, Beata Uziębło-Życzkowska and Paweł Krzesiński
10. Electrocardiographic left ventricular hypertrophy and stroke
Yi-Gang Li and Yan Zhao
11. Evolving left ventricular hypertrophy: heart failure
Larisa G. Tereshchenko
12. How far should blood pressure be lowered in middle-aged and elderly patients with hypertension and ECG-LVH? Experiences from LIFE and VALUE
Julian Eek Mariampillai, Sondre Heimark, Sverre E. Kjeldsen and Richard B. Devereux
13. Surgical approaches in hypertrophic cardiomyopathy treatment
Sergey Dzemeshkevich L.
14. Genetic factors influencing clinical phenotype and electrocardiographic features in left ventricular hypertrophy
Elena V. Zaklyazminskaya
15. Artificial intelligence for detecting left ventricular hypertrophy using electrocardiography
Simon W. Rabkin
16. Technical considerations in the automated ECG diagnosis of left ventricular hypertrophy
Paul Kligfield and Fabio Badilini
17. Myocardial hypertrophy and ischemia: mechanisms of electrophysiological abnormalities
Jan Azarov, Olesya Bernikova, Alena Tsvetkova and Ksenia Sedova
18. Effect of volumetric and conductivity changes in the left ventricle on QRS complex morphology in simulations
Jana Svehlikova, Jan Zelinka and Ljuba Bachárová
19. The variety of QRS patterns in left ventricular hypertrophy and their electrophysiological interpretation
Ljuba Bachárová
20. Increased LV mass, electrical remodeling, and surface ECG conduction abnormalities in heart failure: implications for implantable defibrillators and cardiac resynchronization therapy
Niraj Varma
Ljuba Bachárová and Niraj Varma
2. Electrocardiographic criteria for left ventricular hypertrophy diagnosis
Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros and Kjell Nikus
3. ST segment strain pattern in left ventricular hypertrophy
Douglas Schocken, MD
4. QT interval dynamics in left ventricular hypertrophy
Emanuela Teresa Locati
5. Epidemiology and prognosis of left ventricular hypertrophy through electrocardiography: from Minnesota Code to artificial intelligence
Antonio Luiz Pinho Ribeiro and Gabriela Miana Paixao
6. Echocardiographic diagnosis of left ventricular hypertrophy and its compatibility with electrocardiographic criteria: the “false negative and false positive” electrocardiography
Beata Uziębło-Życzkowska, Katarzyna Piotrowicz and Paweł Krzesiński
7. Addition of serum biomarkers carboxyterminal propeptide of procollagen type I (PICP) and NT-proBNP levels to electrocardiography criteria for detection of left ventricular hypertrophyl
Miquel Fiol, Antonio Bayes de Luna, Alvaro Alonso, Jordi Salas-Salvado, Estefania Toledo, Elena Fortuny, Josep F. Alberti, Angel Alonso-Gomez and Dora Romaguera
8. The discrepancy between wall thickness, myocardial mass, and ECG appearances in young patients with cardiomyopathies
Ingegerd Östman-Smith, Eva Fernlund, Anna Wålinder Österberg and Frida Dangardt
9. Electrocardiographic and echocardiographic differences in the athlete’s heart: a special category
Katarzyna Piotrowicz, Beata Uziębło-Życzkowska and Paweł Krzesiński
10. Electrocardiographic left ventricular hypertrophy and stroke
Yi-Gang Li and Yan Zhao
11. Evolving left ventricular hypertrophy: heart failure
Larisa G. Tereshchenko
12. How far should blood pressure be lowered in middle-aged and elderly patients with hypertension and ECG-LVH? Experiences from LIFE and VALUE
Julian Eek Mariampillai, Sondre Heimark, Sverre E. Kjeldsen and Richard B. Devereux
13. Surgical approaches in hypertrophic cardiomyopathy treatment
Sergey Dzemeshkevich L.
14. Genetic factors influencing clinical phenotype and electrocardiographic features in left ventricular hypertrophy
Elena V. Zaklyazminskaya
15. Artificial intelligence for detecting left ventricular hypertrophy using electrocardiography
Simon W. Rabkin
16. Technical considerations in the automated ECG diagnosis of left ventricular hypertrophy
Paul Kligfield and Fabio Badilini
17. Myocardial hypertrophy and ischemia: mechanisms of electrophysiological abnormalities
Jan Azarov, Olesya Bernikova, Alena Tsvetkova and Ksenia Sedova
18. Effect of volumetric and conductivity changes in the left ventricle on QRS complex morphology in simulations
Jana Svehlikova, Jan Zelinka and Ljuba Bachárová
19. The variety of QRS patterns in left ventricular hypertrophy and their electrophysiological interpretation
Ljuba Bachárová
20. Increased LV mass, electrical remodeling, and surface ECG conduction abnormalities in heart failure: implications for implantable defibrillators and cardiac resynchronization therapy
Niraj Varma
- Edition: 1
- Latest edition
- Published: November 18, 2025
- Language: English
LB
Ljuba Bachárová
Ljuba Bacharová, MD, MBA, DSc, is the senior research leader at the International Laser Center CVTI, and a part-time teacher at both the Slovak Medical University and the Medical School at Comenius University in Bratislava (from which she received her medical degree). Following graduation, she dedicated herself to internal medicine and medical informatics. She went on to receive her MBA degree at the Business School at University of Leeds, UK. In 2011, she received a Doctor of Sciences (DSc) for her innovative approach to the ECG diagnosis of left ventricular hypertrophy. Her main research interest is the evaluation of the cardiac electric field, from standard 2-lead ECG to modeling, 3D visualization and multimodal imaging. In 2005 she became the executive editor of the Journal of Electrocardiology, and since 2006, she has spearheaded the International Research Interdisciplinary Schools (IRIS).
Affiliations and expertise
Department of Biophotonics, International Laser Center CVTI, Bratislava, SlovakiaNV
Niraj Varma
Niraj Varma, MD, PhD, FRCP is Professor of Medicine at Cleveland Clinic, USA. After medical school in Oxford and Edinburgh, he received specialist training in Cambridge, UK and Harvard Medical School, USA. In Boston he undertook research work leading to a PhD. He has over 25 years of clinical experience maintaining research projects; e.g. pioneering the first clinical applications of remote monitoring of implantable devices, electrocardiographic imaging (ECGI), and cardiac resynchronization algorithms. His current interests are the effects of heart size (hypertrophy and shape) in heart failure on pacing therapies. He is past president of the
International Society for Holter and Noninvasive Electrocardiology (ISHNE), currently serves on the Digital Health Committee of the Heart Rhythm Society (HRS), and is Deputy Editor of Europace journal.Affiliations and expertise
Cleveland Clinic, Cleveland, OH, United StatesRead Electrocardiographic Left Ventricular Hypertrophy on ScienceDirect