Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I

1st Edition, Volume 160 - October 23, 2021
Imprint: Academic Press
Editors: Shafiqur Rahman, Richard L Bell
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 8 0 5 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 8 0 6 - 9

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, wi… Read more

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I

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Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Cannabis Exposure During Adolescence: A Uniquely Sensitive Period for Neurobiological Effects, The Stoned-Age: A Systematic Review of the Neurobiological Effects of Adolescent Cannabinoid Exposure on Preclinical Animal Models, Genetic Influences Impacting Nicotine Use and Abuse During Adolescence: Insights from Human and Animal Studies, the Impact of Adolescent Nicotine Exposure on Adulthood Alcohol Consumption: The Role of Neuropeptides, and much more.

Additional chapters cover The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents, The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus, Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol Exposure, Peri-Adolescent Binge Drinking Effects on Hippocampal Neurogenesis, Neuroepigenetic Consequences of Adolescent Ethanol Exposure, Adolescent Neuroimmunity and Its Interaction with Alcohol, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Peri-adolescent addiction as a public health issue
Neurodevelopment during adolescence and emerging adulthood
Adolescent timing in rodents
The addiction cycle
Learning and memory
Chapters in Part I of the special issue
References
Chapter One: The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics
Abstract
1: Introduction
2: Brain maturation during adolescence creates a window of vulnerability for injury
3: Persistent changes in adult brain after adolescent binge alcohol
4: Neuroimmune signaling and epigenetic mechanisms
5: Reversibility of persistent adolescent alcohol pathology: Exercise, anti-inflammatories, and promotion of cholinergic signaling
6: Adolescent alcohol abuse as a possible risk factor for cognitive decline with aging
7: Conclusion
References
Chapter Two: Neuroepigenetic consequences of adolescent ethanol exposure
Abstract
1: Introduction
2: Epigenetic modifications
3: Ethanol's metabolic influence on epigenetics
4: Ethanol-induced epigenetic alterations in the amygdala
5: Ethanol-induced epigenetic alterations in the prefrontal cortex
6: Ethanol-induced epigenetic alterations in the hippocampus
7: Conclusion and future directions
Acknowledgments
References
Chapter Three: Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence
Abstract
1: Epidemiology of alcohol use in adolescence
2: Overview of factors associated with alcohol misuse in adolescence
3: Alcohol use during adolescence: Its effect on brain structure and function
4: Resilience and brain mechanisms
5: Moderators of the pathway to AUD
6: Trajectories of risk and resilience: Integration of findings
7: Conclusions
References
Chapter Four: Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry
Abstract
1: Introduction
2: Cognitive flexibility in humans and animal models
3: Human studies of alcohol exposure on cognitive flexibility
4: Non-human models of alcohol exposure on cognitive flexibility
5: Conclusions
6: Future directions
Funding
References
Chapter Five: Effects of adolescent substance use disorders on central cholinergic function
Abstract
1: General introduction
2: Epidemiological findings on adolescent nicotine use
3: The cholinergic system
4: The cholinergic system and adolescence
5: Observations from preclinical studies on the effects of adolescent nicotine exposure
6: Adolescent nicotine effects on nicotinic acetylcholine receptors
7: Adolescent nicotine effects on choline acetyltransferase
8: Adolescent alcohol use/abuse
9: Adolescent voluntary alcohol drinking and adult alcohol drinking
10: Adolescent voluntary alcohol drinking and the cholinergic system
11: Adolescent intermittent ethanol and adulthood alcohol drinking
12: Adolescent intermittent ethanol and the cholinergic system
13: Adolescent ethanol and the α7 nicotinic receptor in the ventral tegmental area
14: Effects of pharmacological manipulation of the cholinergic system and adolescent ethanol exposure
15: Conclusion
References
Chapter Six: Regulation of glutamate signaling in the extended amygdala by adolescent alcohol exposure
Abstract
1: Introduction
2: Maturation of brain regions during adolescence
3: Glutamatergic transmission during adolescence and alcohol's impact
4: Alcohol and negative affect
5: Central nucleus of the amygdala
6: Bed nucleus of the stria terminalis
7: Nucleus accumbens
8: Stress induced relapse
9: Conclusion
Acknowledgments
References
Chapter Seven: The effects of peri-adolescent alcohol use on the developing hippocampus
Abstract
1: Introduction
2: Hippocampus anatomy and adolescent development
3: The effects of alcohol on the peri-adolescent hippocampus
4: Conclusion
References
Chapter Eight: Consequences of adolescent alcohol use on adult hippocampal neurogenesis and hippocampal integrity
Abstract
1: Alcohol use in adolescence
2: Enhanced susceptibility of adolescents to the consequences of excessive drinking
3: Adult neurogenesis
4: Alcohol and adult neurogenesis in adolescents
5: Conclusions
References
Chapter Nine: The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents
Abstract
1: Introduction
2: Adolescent alcohol and sex: Ethanol intake and sensitivity
3: Adolescent alcohol and sex: Social and non-social affect
4: Adolescent alcohol and sex: Dopamine and reward
5: Adolescent alcohol and sex: Spatial learning and hippocampal physiology
6: Adolescent alcohol and sex: Behavioral flexibility and the prefrontal cortex
7: Adolescent alcohol and sex: Sleep regulation and the basal forebrain
8: Adolescent alcohol and sex: Neuroinflammation and epigenetic alterations
9: Conclusion
Acknowledgments
References
Chapter Ten: Future directions for part I: Substance use disorder in adolescence—A vision for a better future
Future directions and strategies
References

Shafiqur Rahman

Shafiqur Rahman, Ph.D. is Professor of Pharmacology in the Department of Pharmaceutical Sciences at South Dakota State University (SDSU) in Brookings, USA. He received his Ph.D. in Neuropharmacology from the Memorial University of Newfoundland, Canada. Dr. Rahman completed his post-doctoral fellowship in the Department of Psychiatry from Indiana University School of Medicine in Indianapolis in USA. Prior to joining SDSU, he worked as research scientist and faculty at the University of Kentucky in Lexington, USA and the University of Toronto, Canada. Dr. Rahman's research focus is drug discovery in neuropharmacology, i.e. the development of novel therapeutic candidates for the treatment of drug addiction and neuropsychiatric disorders. His research and scholarship has resulted in over 125 publications and 11 edited books/book chapters. Dr. Rahman served as editor, editorial board member and reviewer for numerous Scientific Journals and review panels related to drug addiction, neuropharmacology, and drug discovery research. Dr. Rahman is also a member of several professional societies or organizations, including Society for Neuroscience, American Society for Experimental Neurotherapeutics, and American Society for Pharmacology and Experimental Therapeutics.

Affiliations and expertise

Professor, Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA

Richard L Bell

Dr. Bell received a Bachelor of Arts in General Psychology and Addiction Counseling from Minot State University (Minot, ND) and went on to receive a Master of Science and a Doctor of Philosophy in Applied Biopsychology, with a minor in Biostatistics, from the University of New Orleans (New Orleans, LA). He is presently an Associate Professor of Psychiatry at the Indiana University School of Medicine (Indianapolis, IN). He has been researching the in vivo effects of alcohol for 20 years and has maintained continuous funding from the National Institutes of Health—National Institute on Alcohol Abuse and Alcoholism for close to 15 years. His research during this time has focused on the behavioral genetics of rat lines selectively bred to consume high, vs very low, amounts of ethanol. The high ethanol-consuming rat lines display intakes corresponding with that of a 70 kg male drinking a fifth, or more, of 90-proof whiskey every day. These rat lines display many of the behavioral, physiological, neurochemical and genetic characteristics observed in clinical family history positive (FHP), for alcoholism, individuals; whereas the low ethanol-consuming rat lines serve as an animal model of family history negative (FHN) individuals. Moreover, these high ethanol-consuming rat lines meet established criteria for an animal model of alcoholism. Regarding this, he has written extensively on the genotypic as well as behavioral and neurochemical phenotypic characteristics of these and other major, international selectively bred high vs low ethanol-consuming rat lines. His more recent research has focused on three major areas: (1) innate and ethanol-induced changes in gene expression within subregions of the mesocorticolimbic and extended amygdala reward neurocircuits; (2) the acute as well as chronic behavioral and neurochemical effects of ethanol and/or nicotine exposure during adolescence and emerging adulthood; and (3) differences in the genetic, behavioral and neurochemical effects of binge-like, non-binge-like and relapse-like ethanol drinking and/or nicotine consumption. Scholastically, Dr. Bell has presented his findings to professional and lay audiences locally, nationally and internationally. He has published approximately 120 journal articles and book chapters. He serves as Associate Editor, Review Editor or Reviewer for over 50 international journals. He serves as a grant reviewer for the Veterans Affairs and the National Institutes of Health as well as multiple international academic institutions and is a member of the Research Society on Alcoholism—Animal Research and Ethics Committee.

Affiliations and expertise

Associate Professor, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

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