Drug Hypersensitivity, An Issue of Immunology and Allergy Clinics of North America

1st Edition, Volume 42-2 - April 27, 2022
Editor: Elizabeth Phillips
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 3 7 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 3 8 - 7

In this issue of Immunology & Allergy Clinics, guest editor Dr. Elizabeth J. Phillips brings her considerable expertise to the topic of Drug Hypersensitivity. Top experts i… Read more

Drug Hypersensitivity, An Issue of Immunology and Allergy Clinics of North America

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In this issue of Immunology & Allergy Clinics, guest editor Dr. Elizabeth J. Phillips brings her considerable expertise to the topic of Drug Hypersensitivity. Top experts in the field cover key topics such as perioperative anaphylaxis; telemedicine in drug hypersensitivity; aspirin-exacerbated respiratory disease; pediatric drug allergy; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Recognizing Drug Hypersensitivity in Pigmented Skin
Key points
Background
Defining pigmented skin
Clinical spectrum of cutaneous drug hypersensitivity reactions
Factors that influence clinical presentation and sequelae of cutaneous drug hypersensitivity in pigmented skin
Anatomic sites that warrant special consideration
Strategies that may aid the diagnosis and management of cutaneous drug hypersensitivity in pigmented skin
Summary
Clinics care points
Conflict of interest
Anaphylaxis to Excipients in Current Clinical Practice: Evaluation and Management
Key points
Introduction
Polyethylene-Containing Excipients
Nonpolyethylene-derived excipients
Overall management of excipient allergy
Limitations and barriers to optimal excipient allergy management
Summary
Conflicts of interest
Clinics care points
Mas-Related G Protein–Coupled Receptor-X2 and Its Role in Non-immunoglobulin E–Mediated Drug Hypersensitivity
Key points
Introduction
Drugs that activate human mast cells via Mas-related G protein–coupled receptor-X2
Risk factors for MRGPRX2-mediated drug hypersensitivity
Evaluation of suspected MRGPRX2-mediated drug hypersensitivity
Future directions
Summary
Clinics care points
Hypersensitivity Reactions and Immune-Related Adverse Events to Immune Checkpoint Inhibitors: Approaches, Mechanisms, and Models
Key points
Introduction
Mechanism of action of immune checkpoint inhibitors
Overlap between antitumor and autoimmune responses
Management for immune-related adverse events caused by immune checkpoint inhibitors
Dermatologic immune-related adverse events of immune checkpoint inhibitor therapy
Neurologic immune-related adverse events
Cardiac immune-related adverse events
Gastrointestinal immune-related adverse events
Pneumonitis
Endocrine immune-related adverse events
Renal
Ocular
Drug hypersensitivity reactions related to immune checkpoint inhibitors
Immune checkpoint inhibitor-mediated drug hypersensitivity reactions
Management for drug hypersensitivity reactions to immune checkpoint inhibitors
Comparison between immune-related adverse events and drug hypersensitivity reactions and management strategies
Summary
Clinics care points
Skin Testing Approaches for Immediate and Delayed Hypersensitivity Reactions
Key points
Drug patch tests
Drug skin prick tests
Drug intradermal tests
Negative predictive value of drug skin tests
Drug skin tests and patch tests have to be adapted according to the clinical features and the drug involved
Clinics care points
Telemedicine in Drug Hypersensitivity
Key points
Introduction
Summary
Clinics care points
Pharmacogenomics of Drug Hypersensitivity: Technology and Translation
Key points
Introduction
HLA and immunogenomic contributors to drug hypersensitivity
Examples of HLA associations
Summary
Clinics care points
Advances in the Pathomechanisms of Delayed Drug Hypersensitivity
Key points
Introduction
Molecular mechanisms of delayed drug hypersensitivity
Treatment strategies for delayed drug hypersensitivity
Summary
Clinics care points
A Risk-Based Approach to Penicillin Allergy
Key points
Introduction
Discussion
Risk-based approaches to penicillin allergy testing
Summary
Clinics care points
Disclosure
Allergy to Radiocontrast Dye
Key points
Introduction: prevalence, definitions, and risk factors
Clinical relevance
Current evidence on mechanisms
Testing approach
Discussion
Summary
Clinics care points
The Who, What, Where, When, Why, and How of Drug Desensitization
Key points
Introduction
Classification of hypersensitivity reactions and premise and definitions of desensitization
What are the goals of desensitization?
Who should or should not receive desensitization?
When to perform desensitization?
Where to perform desensitization?
How to perform desensitization?
Summary
Clinics care points
Aspirin-Exacerbated Respiratory Disease: A Unique Case of Drug Hypersensitivity
Key points
Introduction
Discussion
Summary
Clinics care points
Pediatric Drug Allergy
Key points
Introduction
Beta-lactam antibiotics
Non–beta-lactam antibiotics
Nonsteroidal anti-inflammatory drugs
Severe cutaneous adverse reactions in children
Summary
Clinics care points
Disclosure
The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021: A Systematic Review
Key points
Introduction
Materials and methods
Results
Research topics
CDS
Genetic Studies
Discussion
Summary
Clinics care points
Disclosure
Supplementary data

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Drug Hypersensitivity, An Issue of Immunology and Allergy Clinics of North America

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Elizabeth Phillips