Drug-Drug Interactions: Scientific and Regulatory Perspectives
- 1st Edition, Volume 43 - October 2, 1997
- Imprint: Academic Press
- Editors: J. Thomas August, Albert Li, Ferid Murad, M. W. Anders, Joseph T. Coyle
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 0 3 2 9 4 4 - 1
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 8 1 3 5 - 4
Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and go… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteDrug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.
- Provides useful references on the science of drug-drug interactions
- Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
- Contains original data from academic and industrial laboratories
- Presents an overview of regulatory agency positions
Professionals in the pharmaceutical industry, health care industry, and governmental regulatory agencies. Students and researchers in the areas of pharmacology, toxicology, pharmacokinetics, and medicine.
J. Collins, Foreword.A.P. Li, Preface.A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.G.L. Kedderis, Pharmacokinetics of Drug Interactions.T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.
- Edition: 1
- Volume: 43
- Published: October 2, 1997
- No. of pages (eBook): 304
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780120329441
- eBook ISBN: 9780080581354
JA
J. Thomas August
Affiliations and expertise
John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.AL
Albert Li
Albert Li, MD, Professor of Paediatrics and Person-in-charge of the Respiratory Service in the Department of Paediatrics at the Chinese University of Hong Kong
Affiliations and expertise
Professor of Paediatrics and Person-in-charge of the Respiratory Service in the Department of Paediatrics at the Chinese University of Hong Kong.FM
Ferid Murad
Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.
Affiliations and expertise
University of Texas Medical School, Houston, U.S.A.MA
M. W. Anders
Affiliations and expertise
University of Rochester; Department of Pharmacology, New York, U.S.A.JC
Joseph T. Coyle
Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
Affiliations and expertise
McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USARead Drug-Drug Interactions: Scientific and Regulatory Perspectives on ScienceDirect