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Down Syndrome: From Understanding the Neurobiology to Therapy
- 1st Edition, Volume 197 - May 10, 2012
- Editors: Mara Dierssen, Rafa de la Torre
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 4 - 6 0 2 3 8 - 1
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 5 4 2 9 9 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 5 4 3 0 0 - 4
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (H… Read more
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Request a sales quoteDown syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system.
This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures.
- Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research
- Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
- All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
- Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present and future
- Genomic determinants in the phenotypic variability of Down syndrome
- Intellectual disabilities, neuronal post-transcriptional RNA-metabolism and RNA-binding proteins: three actors for a complex scenario
- Aberrant epigenetic landscape in mental retardation
- Pathways to cognitive deficits in Down syndrome
- Neurological Phenotypes for Down Syndrome across the Lifespan
- Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment
- Perturbation of dendritic protrusions in intellectual disability
- The in vivo Down syndrome genomic library in mouse
- Discoveries in Down Syndrome: Moving Basic Science to Clinical Care
- A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome
- Gene therapy for Down syndrome
Cristina Fillat and Xavier Altafaj
Rafael de la Torre and Mara Dierssen
Audrey Letourneau and Stylianos E. Antonarakis
Barbara Bardoni, Sabiha Abekhoukh, Samantha Zongaro and Mireille Melko
Sanchez-Mut JV, Huertas D. and Esteller M.
Xiaolu Sturgeon, Thanh Le, Md. Mahiuddin Ahmed and Katheleen J. Gardiner
Ira T. Lott, MD
Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández and Lynn Nadel
Josien Levenga and Rob Willemsen
Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal and Véronique Brault
A.M. Kleschevnikov, P.V. Belichenko, A. Salehi and C. Wu
Duane G. Currier, Renita C. Polk and Roger H. Reeves
- No. of pages: 272
- Language: English
- Edition: 1
- Volume: 197
- Published: May 10, 2012
- Imprint: Elsevier
- Paperback ISBN: 9780444602381
- Hardback ISBN: 9780444542991
- eBook ISBN: 9780444543004
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