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Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (H… Read more
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Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system.
This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures.
Rafael de la Torre and Mara Dierssen
Audrey Letourneau and Stylianos E. Antonarakis
Barbara Bardoni, Sabiha Abekhoukh, Samantha Zongaro and Mireille Melko
Sanchez-Mut JV, Huertas D. and Esteller M.
Xiaolu Sturgeon, Thanh Le, Md. Mahiuddin Ahmed and Katheleen J. Gardiner
Ira T. Lott, MD
Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández and Lynn Nadel
Josien Levenga and Rob Willemsen
Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal and Véronique Brault
A.M. Kleschevnikov, P.V. Belichenko, A. Salehi and C. Wu
Duane G. Currier, Renita C. Polk and Roger H. Reeves
MD