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Elsevier

DNA Replication Across Taxa

  • 1st Edition, Volume 39 - May 27, 2016
  • Latest edition
  • Editor: Laura Kaguni
  • Language: English

DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.… Read more

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Description

DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.

Key features

  • Contains contributions from leading authorities
  • Informs and updates on all the latest developments in the field of enzymes

Readership

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Table of contents

  • Preface
  • Chapter One: Replication Initiation in Bacteria
    • Abstract
    • 1 Introduction
    • 2 Bacterial Replication Origins
    • 3 Mechanism of Initiation
    • 4 Summary
    • Acknowledgments
  • Chapter Two: The E. coli DNA Replication Fork
    • Abstract
    • 1 Introduction
    • 2 Initiation at oriC, the Origin of Replication
    • 3 The Primosome, DnaB, and DnaG
    • 4 Role of SSB at the Replication Fork
    • 5 The Elongation Stage
    • 6 Concluding Comments
    • Acknowledgments
  • Chapter Three: The Replication System of Bacteriophage T7
    • Abstract
    • 1 Introduction
    • 2 T7-Encoded Proteins Involved in DNA Replication
    • 3 Initiation of DNA Replication at the Chromosomal Origin
    • 4 Replication Intermediates
    • 5 Minimal T7 Replisome
    • 6 Leading-Strand Synthesis
    • 7 Lagging-Strand Synthesis
    • 8 Coordination of Leading- and Lagging-Strand Synthesis
  • Chapter Four: Protein-Primed Replication of Bacteriophage Φ29 DNA
    • Abstract
    • 1 Introduction
    • 2 The Protein-Primed Replication Mechanism
    • 3 In Vivo Compartmentalization of ϕ29 DNA Replication
    • Acknowledgments
  • Chapter Five: Archaeal DNA Replication Origins and Recruitment of the MCM Replicative Helicase
    • Abstract
    • 1 Introduction
    • 2 Origin Recognition in Eukaryotes
    • 3 Recruitment of the Replicative Helicase
    • 4 Archaeal Replication Origin Specification
    • 5 Structure of Archaeal Orc1/Cdc6 Proteins
    • 6 Role of ATP in MCM Loading
    • 7 The Mechanism of MCM Recruitment by Orc1–1
    • 8 Concluding Remarks
    • Acknowledgments
  • Chapter Six: The Eukaryotic Replication Machine
    • Abstract
    • 1 Introduction
    • 2 The CMG Helicase
    • 3 The Polymerase Alpha-Primase
    • 4 The Leading and Lagging Strand DNA Polymerases Epsilon and Delta
    • 5 The PCNA Clamp and RFC Clamp Loader
    • 6 The Eukaryotic Replisome Structure and Function
    • 7 Comparison of Bacterial and Eukaryotic Replisomes
    • 8 Future Perspectives
    • Acknowledgments
  • Chapter Seven: The Many Roles of PCNA in Eukaryotic DNA Replication
    • Abstract
    • 1 Introduction
    • 2 PCNA Structure and Function
    • 3 The Role of PCNA in Normal DNA Replication
    • 4 The Role of PCNA in Translesion Synthesis
    • 5 The Role of PCNA in Error-Free Damage Bypass
    • 6 The Role of PCNA in Break-Induced Replication
    • 7 The Role of PCNA in Mismatch Repair
    • 8 The Role of PCNA in Replication-Coupled Nucleosome Assembly
    • 9 Putting It All Together
    • Acknowledgments
  • Chapter Eight: Animal Mitochondrial DNA Replication
    • Abstract
    • 1 Overview
    • 2 Structure–Function Relationships in mtDNA Replication Proteins
    • 3 Mechanisms of Mitochondrial DNA Replication In Vivo
    • 4 Perspectives
    • Acknowledgments
  • Chapter Nine: Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus
    • Abstract
    • 1 Introduction
    • 2 Nucleic Acid Polymerases Employ General Acid Catalysis
    • 3 Kinetic and Structural Determinants of PV RdRp Fidelity
    • 4 Remote-Site Control of an Active-Site Fidelity Checkpoint
    • 5 RdRp Fidelity Is a Determinant of Viral Virulence
    • 6 RdRp Fidelity Mutants Are Vaccine Candidates
    • 7 Correlated Motions of Functionally Important Motifs of the RdRp may be a Determinant of Nucleotide Incorporation Fidelity
    • 8 Nucleotide Binding-Occluded and Binding-Competent States of the RdRp–RNA Complex as Determinants of Fidelity
    • 9 Conserved, Active-Site Determinants of RdRp Incorporation Fidelity may Exist that can be Targeted for Viral Attenuation
    • Acknowledgments
  • Author Index
  • Subject Index

Product details

  • Edition: 1
  • Latest edition
  • Volume: 39
  • Published: May 27, 2016
  • Language: English

About the editor

LK

Laura Kaguni

Dr. Laurie S. Kaguni works at the Department of Biochemistry and Molecular Biology at Michigan State University.
Affiliations and expertise
Department of Biochemistry & Molecular Biology, Michigan State University, USA

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