Discovery and Development of Antidiabetic Agents from Natural Products

Natural Product Drug Discovery

1st Edition - October 11, 2016
Author: Goutam Brahmachari
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 0 9 4 5 0 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 9 6 9 2 - 5

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the p… Read more

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Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.

Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.

Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.

Dedication
List of Contributors
Editor Biography
Foreword
Preface
Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise
- 1. Introduction
- 2. The Molecule
- 3. Extraction, Purification, and Characterization Data of Andrographolide
- 4. Total Synthesis of Andrographolide
- 5. Antidiabetic Potential of Natural Andrographolide and Its Semisynthetic Derivatives
- 6. Studies on Pharmacokinetics and Metabolism
- 7. Safety Aspects of Andrographolide
- 8. Concluding Remarks
- List of Abbreviations
Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products
- 1. Introduction
- 2. Computer-Aided Drug Design Methods
- 3. Applications of Computation to Glycogen Phosphorylase Inhibitor Design
- 4. Concluding Remarks
- List of Abbreviations
Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources
- 1. Introduction
- 2. Curcumin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
- 3. Mangiferin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
- 4. Arjunolic Acid: Extraction, Identification, and Antidiabetic–Antioxidant Potential
- 5. Concluding Remarks
- Abbreviations
Chapter 4. Glucose Transporter 4 Translocation Activators From Nature
- 1. Introduction
- 2. Plant Formulations With Glucose Transporter 4 Translocation Activity
- 3. Naturally Occurring Compounds With GLUT4 Translocation Activity
- 4. Natural Product Derivatives as GLUT4 Translocation Activators
- 5. Concluding Remarks
- List of Abbreviations
Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature
- 1. Introduction
- 2. Diabetes: Definition and Classification
- 3. Importance of Carbohydrate in Antidiabetic Drug Development
- 4. Glycosidase Inhibitors as Antidiabetic Agents
- 5. Carbohydrate-Based Sodium Glucose Cotransporter 2 Inhibitors
- 6. Other Important Carbohydrate-Based Antidiabetic Agents
- 7. Concluding Remarks
- List of Abbreviations
Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues
- 1. Introduction
- 2. Plant-Derived Sesquiterpene Lactones With Antidiabetic Potential
- 3. Plant Extracts Containing Sesquiterpene Lactone Molecules
- 4. Structure–Activity Relationship of Sesquiterpene Lactones
- 5. Concluding Remarks
- List of Abbreviations
Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds
- 1. Introduction
- 2. Advanced Glycation End Products
- 3. Inhibition of AGEs Accumulation by Natural Products
- 4. The Prevention of Prediabetes by Natural Products
- 5. Concluding Remarks
- List of Abbreviations
Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes
- 1. Introduction
- 2. Immune Modulators
- 3. Other Options for Treatment and Prophylaxis of T1D
- 4. Herbal Formulations in Market
- 5. Advantages of Natural Immunomodulators
- 6. Clinical Trials
- 7. Concluding Remarks
- List of Abbreviations
Chapter 9. α-Glucosidase Enzyme Inhibitors From Natural Products
- 1. Introduction
- 2. Brief Methodology, Characterization, and Identification of α-Glucosidase Inhibitors From Medicinal Plants
- 3. Concluding Remarks
- List of Abbreviations
Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview
- 1. Introduction
- 2. Antidiabetic Indian Medicinal Plants
- 3. Concluding Remarks
Index

Goutam Brahmachari

Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series ‘Natural Product Drug Discovery’. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).

Affiliations and expertise

Goutam Brahmachari, PhDFull Professor, Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India

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