Diffraction and Related Studies, Proceedings of the International Symposium on Biomolecular Structure, Conformation, Function and Evolution, Madras, January 1978, Biomolecular Structure, Conformation, Function, and Evolution

Volume 1 Diffraction and Related StudiesPrefacePresidential AddressBiomolecular structure, conformation, function, and evolutionI. Proteins I.1. Structure and Conformation Multi-Domain Structure of the Dimeric Lectin Wheat Germ Agglutinin Molecular Structure of an Acid Protease from Rhizopus chinensis and its Homology with Other Acid Proteases Structural Comparison of the Flavoenzyme Glutathione Reductase with Other Proteins X-Ray Structure of Lupin Leghemoglobin Stereochemically Restrained Crystallographic Least-Squares Refinement of Macromolecule Structures The Use of an Interactive Computer Graphics System in the Study of Protein Conformations I.2. Folding, Assembly, and Models The Beta Bulge—Its Description, Occurrence, and Importance in Protein Structure On the Size and Stability of Alpha-Helices Prediction of Super-Secondary Structures in Terms of Topology/Packing Diagrams Conformation Wheels of Proteins and Nucleic Acids: A Novel Method of Relating Chemical and Stereochemical Aspects of Monomers to the Primary, Secondary and Tertiary Structures of Polymers Mechanism of Self-Organization of the Tertiary Structure of Globular Proteins The Structure and Assembly of Fibrous Proteins I.3 Structure and Function Conformational Flexibility in Human Immunoglobulins Structure and Function of Carbonic Anhydrases Structural Changes Accompanying Expression of Enzymic Functionality: Interaction of Small Molecules with α-Chymotrypsin Conformational adjustment to substrate binding in crystals of triclinic lysozyme I.4 Structure and Evolution Evolution in the Catalytic Geometry of Enzymes Structural Conservatism in Proteins Over Three Billion Years: Cytochrome with a Touch of Collagen Structural Evidence for Gene Duplication and Fusion in the Evolution of ProteinsII. Nucleic Acids and Constituents II.1 Structure and Conformation Nucleic Acid Principles and Transfer RNA Difference Fourier Refinement of the Structure of Monoclinic Yeast tRNAphe at 2.5 Å Resolution Further Refinement of yeast tRNA Phenylalanine Modified Nucleosides, Conformation of Anticodon Loops of tRNA, and Codon-Anticodon Interaction X-Ray Diffraction Studies on Poly(2-Methyladenylic Acid): Poly(uridlic Acid). An Unusual Double-Stranded RNA Aspects of Less-Favoured Nucleotide Conformations The Possible Conformation of FAD Molecule II.2 Folding, Assembly, and Models A Critical Evaluation of Alternative Conformations for the DNA Molecule A Possible Alternative Structure for DNA Configurational Studies of the Polynucleotides The Concept of Extended Virtual Bond. Probing the Helical Conformations of Nucleic Acids in Supermolecular Structures. Conformations of Poly(Dinucleotide) Helices, Intercatated DNA, and Chromatin DNAIII. Protein-Nucleic Acid Interactions Neutron-Scattering Studies of Chromatin Subunits Protein-Nucleic Acid Non-Specific Interaction: Crystal Structure of a Protamine-tRNA Complex at 5.4 Å Resolution, and a Model for Protamine-DNA Complex X-Ray and Electron Microscopic Studies of Crystals of Core lac Repressor Protein X-Ray Diffraction Studies of Complexes of DNA with Lysine and with Lysinecontaining Peptides Crystallographic Studies of Drug-Nucleic Acid Crystalline Complexes and their Biological Implications Crystal Structure of d(A-T)2 and Sequence Specific DNA-Protein RecognitionIV. Polysaccharides IV.1 Structure and Conformation Mechanism of Complex Formation of the Model Enzyme α-Cyclodextrin The Virtual Bond Method and its Application to Polysaccharide Structures Molecular Conformations of some Plant, Animal, and Microbial Polyuronides The Structures of Cellulose and Chitin Conformational Studies on the Peptide Moiety of Bacterial PeptidoglycanV. Viruses V.1 Structure and Models The Structure of Southern Bean Mosaic Virus at 5 Å Resolution Electron Microscope Analysis of Three-Dimensional Structure of the Tails of some Bacteriophages Bilder: A Computer Graphics Program for Biopolymers and its Application to the Interpretation of the Structure of Tobacco Mosaic Virus Protein Discs at 2.8 Å ResolutionVI. Peptides, Drugs, and Other Biomolecules VI.1 Structure, Conformation, and Function Conformation of Cyclic Dipeptides Structure and Conformation of Cyclic Peptides Structure of Peptides: cis-Peptide Bond, β-Turn, Prolyl Residue Structure and Conformation of Amino-Acid Antagonists X-Ray Studies of Molecular Association Involving some Amino Acids Crystal and Molecular Structure of some New Pharmaceuticals and Fungal Metabolites Structure and Function of Drug Molecules Neutron Diffraction Study of Biological Molecules Using Medium Flux Reactors Application of Synchrotron Radiation for the Study of Polymers with Limited Spatial OrderAuthor IndexSubject IndexVolume 2 Physico-Chemical and Theoretical StudiesI. Proteins I.1. Structure and Conformation Solution Conformations by Nuclear Magnetic Resonance Technique: From Peptides to Proteins Dynamic Aspects of Protein Conformation Studied by Nuclear Magnetic Resonance Techniques: Evidence for Hydrophobic Stability Domains in Globularproteins Quantitative Characterization of Protein Conformation in Solution by Vacuum Ultraviolet Circular Dichroism Quantitative Determination of the Secondary Structure of Proteins in Solution by Laser Raman Scattering Influence of the Side Chains on the Conformation of Alternating Poly-D-L-Peptides Structural Analyses of Thrombin and Prothrombin I.2 Foldings Assembly, and Models Kinetic Intermediates and the Pathway of Folding of Ribonucleases A and S Modular Assembly of Proteins Fluctuating Secondary Structure Formation During the First Step of Protein Selforganization Predicted Structure for Haptoglobin Respective Roles of Short- and Long-Range Interactions in Protein Folding A Three-Domain Model for Penicillinase from Staphylococcus aureus Myoglobin as a Model of Protein Folding Prediction of Tertiary Atructures in Globular Proteins: Some Essential Parameters Mechanism of Folding and Disulphide Bond Formation in Globular Proteins: A Proposal for a Unified Theory I.3 Structure and Function Seminalplasmin, a New Protein Inhibitor of Microbial Growth and of Transcription from Bovine Seminalplasma, and Two Other Proteins of Seminalplasma Structural Studies on a Freezing-Point-Depressing Protein and its Synthetic AnalogueII. Nucleic Acids and Constituents II.1 Structure and Conformation Structure and Dynamics of Synthetic RNA and DNA Duplexes and their Complexes with Intercalating (Proflavine) and Groove Binding (Netropsin) Ligands in Solution A Comparative Study of the Spatial Configurations of Nucleic Acid Structures in Aqueous Solution Infrared Spectroscopy of Polynucleotides in D2O and H2O Solution Fluorescence Studies of Intramolecular Stacking in Model Dinucleotides Experimental Approaches to Elucidate the Reasons for the Difference Between DNA and RNA Structural Modification of Ribonucleic Acids II.2 Theoretical and Model Studies Conformation of 6-Azauridine-5'-Monophosphate: A Comparison Between X-Ray Diffraction Studies and Conformational Energy Calculations Theoretical Energy Gradient Study of Ribose and Deoxyribose Analogs Water Environmental Effects on the Tautomeric Equilibria of Bologically Important Model Systems: Quantum-Mechanical Studies Interactions Between Solute and Solvent Molecules in Nucleic Acid Bases Solutions Conformational Analysis of Aminoacyladenylates: A Molecular Orbital InvestigationIII. Biomolecular Interactions Form of DNA in Chromatin and in Nucleosomes Molecular Models of DNA-Basic Protein Complexes Stacking and Hydrogen Bonding Interactions in the Recognition of Nucleic Acid Structure and Base Sequences by Proteins Modelling of DNA-Protein Recognition Conformational Transitions in Complexes of DNA with Cationic Dyes Interaction Between Prolyl Hydroxylase and its Polypeptide SubstrateIV. Ribosomes Structure and Function of Escherichia coli Ribosome Regulation of Protein Synthesis Initiation in Eukaryotic Cells Control of Protein Synthesis by Hemin in Reticulocyte Lysates Metabolic Stability of Protein-RNA Interactions: Studies on in Vivo Exchange and Modifications of Ribosomal Proteins Structural Aspects of Codon-Anticodon Interaction of the Escherichia coli Ribosome Nucleoprotein Organization of Messenger Ribonucleoprotein Complexes of Chick Embryonic MusclesV. Membranes Carrier Mediated Transport of Alkali Metal Cations Across Membranes: Insights Through Theoretical Study of Valinomycin and Analogs Poly(D-trp-L-leu) and Other Poly-D-L-Peptides as Models for Ionic Transport Properties of Gramicidin A Thermodynamics of Model Membrane Systems Studied by Titration Calorimetry Molecular Conformation and Organization of Lipids in Biological Membranes Protein Release from the Internal Surface of the Squid Giant Axon Membrane During Excitation and During Application of Agents which Modify ExcitationVI. Peptides, Drugs, and Other Biomolecules VI.1 Structure, Conformation and Function Mechanism of Penicillin Action: A New Insight The Tetrapeptide, HCO-L-Ala-L-Pro-Gly-Gly-OMe: Conformations and Solvent Effects A Quantitative Model of Biomolecular Solvation A Theoretical Study of the Binding of Sodium to Serine Phosphate Theoretical Insights into Pharmacology Conformational Aspects of the Enkephalin-Opiate Receptor Interaction Quantum Approach to Mechanochemistry Molecular Properties and the Smell of Bitter AlmondVII. Biomolecular Evolution Molecular Phylogeny of Mammalian Globin Chain Sequences Deduced by Using a Parsimony Probe How Many Theories for the Origin of (Proto) Life?Author IndexSubject Index