Diagnostics Stewardship in Molecular Microbiology: From at Home testing to NGS, An Issue of the Clinics in Laboratory Medicine

1st Edition, Volume 44-1 - January 30, 2024
Editors: Jennifer Dien Bard, Esther Babady
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 1 9 - 3
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 2 0 - 9

In this issue of Clinics in Laboratory Medicine, guest editors Drs. Jennifer Dien Bard and Esther Babady bring their considerable expertise to the topic of Diagnostics Stewardsh… Read more

Diagnostics Stewardship in Molecular Microbiology: From at Home testing to NGS, An Issue of the Clinics in Laboratory Medicine

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In this issue of Clinics in Laboratory Medicine, guest editors Drs. Jennifer Dien Bard and Esther Babady bring their considerable expertise to the topic of Diagnostics Stewardship in Molecular Microbiology: From At-Home Testing to Next Generation Sequencing. Molecular testing for infectious diseases diagnostics is quickly expanding beyond clinical microbiology laboratories, while higher complexity tests based on next generation sequencing are now available for infectious diseases diagnosis. Diagnostic stewardship, led by microbiology experts in collaboration with clinicians and other healthcare workers, is critical in ensuring responsible and judicious use of these tests. In this issue, top experts in the field address practical challenges and provide guidance for diagnostic stewardship of molecular infectious disease diagnostics tests, from point-of-care to next generation sequencing.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Taking Center Stage: Clinical Laboratory Leading Diagnostic Stewardship Efforts
Key points
Introduction
Components of diagnostic stewardship
Summary
Home and Clinical Laboratory Improvement Amendments–Waived Testing for Infectious Diseases—How Do These Fit in the Testing Landscape?
Key points
Clinical Laboratory Improvement Amendments: Nuts and bolts
Current landscape of Clinical Laboratory Improvement Amendments–waived testing for infectious diseases testing
Home-based infectious disease testing
The only thing constant is change: the evolution of the role of the medical microbiologist and other laboratory specialists in this changing landscape
Point of Care Molecular Testing: Current State and Opportunities for Diagnostic Stewardship
Key points
Introduction
Molecular point-of-care tests
Advantages of performing molecular testing in a point-of-care setting
Current status of diagnostic stewardship and point-of-care testing
Challenges and strategies for success for diagnostic stewardship in the point-of-care setting
Summary
Clinics care points
Preanalytical Challenges of Molecular Microbiology Tests
Key points
Introduction
Discussion
Summary
Clinics care points
Diagnostic Stewardship for Multiplex Respiratory Testing: What We Know and What Needs to Be Done
Key points
Introduction
Upper respiratory panels
Lower respiratory panels
Future directions and summary
Clinics care points
Diagnostic Stewardship for Next-Generation Sequencing Assays in Clinical Microbiology: An Appeal for Thoughtful Collaboration
Key points
Introduction
Currently available tests and their limitations
Discussion
Summary
Clinics care points
Disclosure
The Report Says What?: How the Medical Microbiologist can aid in the Interpretation of Next-Generation Sequencing Results
Key points
Introduction
Applications of next-generation sequencing in clinical microbiology
Resolving contaminants in next-generation sequencing testing
Result reporting algorithms
In-house versus external reference laboratory reporting
Tumor board style discussion of results
Tracking clinical impact
Reimbursement woes
Summary
Is It Possible to Test for Viral Infectiousness?: The Use Case of (SARS-CoV-2)
Key points
Introduction and definitions
Cycle threshold values
Working with the Electronic Health Record and Laboratory Information System to Maximize Ordering and Reporting of Molecular Microbiology Results
Key points
Introduction
The ’digital life cycle’ of a laboratory test
Discussion
Summary
Clinics care points
Present and Future Non-Culture-Based Diagnostics: Stewardship Potentials and Considerations
Key points
Introduction
Transition to molecular-based diagnostics
Decision points for implementing molecular testing
Molecular test use cases
Laboratory network coordination in microbiology
Future directions
Summary
Clinics care points

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Diagnostics Stewardship in Molecular Microbiology: From at Home testing to NGS, An Issue of the Clinics in Laboratory Medicine

Purchase options

Institutional subscription on ScienceDirect

Jennifer Dien Bard

Esther Babady