Diagnostic Pathology: Endocrine

SECTION 1: THYROID NONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL

4 Thyroglossal Duct Cyst
Vania Nosé, MD, PhD and Nicole A. Cipriani, MD

8 Ectopic Thyroid
Vania Nosé, MD, PhD

12 Solid Cell Nests
Vania Nosé, MD, PhD

16 Dyshormonogenetic Goiter
Vania Nosé, MD, PhD

INFECTIOUS

22 Acute Thyroiditis
Vania Nosé, MD, PhD

AUTOIMMUNE/INFLAMMATORY

26 Subacute/Granulomatous Thyroiditis
Vania Nosé, MD, PhD

32 Palpation Thyroiditis
Vania Nosé, MD, PhD and Nicole A. Cipriani, MD

34 IgG4-Related Thyroid Disease
Vania Nosé, MD, PhD

38 Riedel Thyroiditis
Vania Nosé, MD, PhD

44 Hashimoto Thyroiditis
Vania Nosé, MD, PhD

52 Graves Disease (Diffuse Hyperplasia)
Suzana Leite, MD and Vania Nosé, MD, PhD

60 Amyloid Goiter
Vania Nosé, MD, PhD

REACTIVE

66 Pigments and Crystals, Thyroid
Nicole A. Cipriani, MD and Vania Nosé, MD, PhD

72 Post-FNA Site Changes, Thyroid
Vania Nosé, MD, PhD and Darcy A. Kerr, MD

NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS

74 Thyroid Follicular Nodular Disease
Vania Nosé, MD, PhD

80 Adenomatous Nodules
Vania Nosé, MD, PhD and Lori A. Erickson, MD

86 Follicular Thyroid Adenoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

94 Follicular Thyroid Adenoma With Papillary
Architecture
Vania Nosé, MD, PhD

98 Oncocytic Thyroid Adenoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD

112 Hyalinizing Trabecular Tumor of Thyroid
Vania Nosé, MD, PhD and Nicole A. Cipriani, MD

118 Follicular Thyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

128 Oncocytic Thyroid Carcinoma
Ying-Hsia Chu, MD and Vania Nosé, MD, PhD

132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

140 Kinase Fusion-Related Thyroid Carcinomas
Ying-Hsia Chu, MD and Vania Nosé, MD, PhD

148 Follicular Cell-Derived Thyroid Carcinoma, High Grade
Nicole A. Cipriani, MD and Vania Nosé, MD, PhD

158 Anaplastic Thyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

168 Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD

182 Classic Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

194 Macrofollicular Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD

200 Diffuse Sclerosing Papillary Thyroid Carcinoma
Nicole A. Cipriani, MD and Vania Nosé, MD, PhD

206 Oncocytic Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD

210 Tall Cell Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

218 Columnar Cell Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

222 Clear Cell Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

224 Solid/Trabecular Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

228 Hobnail Papillary Thyroid Carcinoma
Julie Guilmette, MD, FRCPC and Vania Nosé, MD, PhD

234 Warthin-Like Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD

C-CELL-DERIVED TUMORS

240 C-Cell Hyperplasia
Vania Nosé, MD, PhD and Adam S. Fisch, MD, PhD

246 Medullary Thyroid Carcinoma
Vania Nosé, MD, PhD and Adam S. Fisch, MD, PhD

MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA

256 Mixed Medullary and Follicular Cell-Derived Thyroid Carcinoma
Vania Nosé, MD, PhD and Darcy A. Kerr, MD

THYMIC TUMORS WITHIN THYROID

260 Spindle Epithelial Tumor With Thymus-Like Differentiation
Vania Nosé, MD, PhD

266 Intrathyroid Thymic Carcinoma
Vania Nosé, MD, PhD

SALIVARY GLAND-LIKE THYROID TUMORS

274 Mucoepidermoid Carcinoma of Thyroid
Darcy A. Kerr, MD and Vania Nosé, MD, PhD

278 Secretory Carcinoma of Salivary Gland Type
Darcy A. Kerr, MD and Vania Nosé, MD, PhD

HEMATOLYMPHOID TUMORS

282 Lymphoma, Thyroid
Judith Ferry, MD

288 Follicular Dendritic Cell Sarcoma, Thyroid
Vania Nosé, MD, PhD and Darcy A. Kerr, MD

292 Langerhans Cell Histiocytosis, Thyroid
Vania Nosé, MD, PhD and Dipti P. Sajed, MD, PhD

GERM CELL ORIGIN

296 Benign Thyroid Teratoma
Vania Nosé, MD, PhD

302 Struma Ovarii, Struma Carcinoid, and Malignant Struma Ovarii
Vania Nosé, MD, PhD

EMBRYONAL THYROID TUMORS

310 Thyroblastoma
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

MESENCHYMAL AND STROMAL TUMORS

316 Peripheral Nerve Sheath Tumor, Thyroid
Vania Nosé, MD, PhD and Darcy A. Kerr, MD

320 Solitary Fibrous Tumor, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD

326 Paraganglioma, Thyroid
Lori A. Erickson, MD and Vania Nosé, MD, PhD

332 Leiomyoma and Leiomyosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD

336 Angiosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD

340 Primary Ewing Sarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD

SECONDARY TUMORS WITHIN THYROID

344 Metastasis to Thyroid Gland
Vania Nosé, MD, PhD and Darcy A. Kerr, MD

TUMORS OF UNCERTAIN HISTOGENESIS

350 Cribriform Morular Thyroid Carcinoma
Vania Nosé, MD, PhD

360 Sclerosing Mucoepidermoid Carcinoma With Eosinophilia
Darcy A. Kerr, MD and Vania Nosé, MD, PhD

MOLECULAR PATHOLOGY OF THYROID NEOPLASMS

366 Molecular Pathology of Thyroid Neoplasms
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF THYROID GLAND

372 Thyroid Carcinoma Protocol
Vania Nosé, MD, PhD and Julie Guilmette, MD, FRCPC

SECTION 2: PARATHYROID GLAND NONNEOPLASTIC

376 Primary Multiglandular Parathyroid Disease
Lori A. Erickson, MD

386 Primary Parathyroid Clear Cell Hyperplasia
Lori A. Erickson, MD

390 Secondary Parathyroid Hyperplasia
Lori A. Erickson, MD

396 Tertiary Parathyroid Hyperplasia
Lori A. Erickson, MD

400 Chronic Parathyroiditis
Lori A. Erickson, MD

NEOPLASTIC

404 Parathyroid Adenoma
Lori A. Erickson, MD and Vania Nosé, MD, PhD

412 Parathyroid Lipoadenoma
Lori A. Erickson, MD

416 Atypical Parathyroid Tumor
Vania Nosé, MD, PhD and Lori A. Erickson, MD

422 Parathyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD

432 Metastasis to Parathyroid Gland
Lori A. Erickson, MD

SECTION 3: ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC

438 Adrenal Heterotopia
Arthur S. Tischler, MD

440 Adrenal Hypoplasia and Malformations
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

444 Adrenal Cytomegaly
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

446 Infectious Disorders, Adrenal Glands
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH

450 Autoimmune Adrenalitis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH

452 Adrenal Amyloidosis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH

456 Incidental Adrenal Nodules
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

460 Adrenal Cysts
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

ADRENAL CORTICAL NEOPLASTIC

466 Adrenocortical Hyperplasia and Adrenocortical Nodular Disease
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

472 Primary Pigmented Nodular Adrenocortical Disease
Vania Nosé, MD, PhD

478 Nonfunctioning Adrenal Cortical Adenoma
Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD

480 Aldosterone-Producing Adenoma
Vania Nosé, MD, PhD and Patricia Nogueira de Sa, MD

486 Cortisol-Secreting Adrenal Cortical Adenoma
Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD

492 Sex Hormone-Producing Adrenal Cortical Adenoma
Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD

494 Oncocytic Adrenal Cortical Adenoma
Vania Nosé, MD, PhD and Peter M. Sadow, MD, PhD

498 Adrenal Cortical Carcinoma
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD

510 Adrenal Cortical Neoplasms in Children
Vania Nosé, MD, PhD

ADRENAL MEDULLA AND PARAGANGLIA

518 Adrenal Medullary Hyperplasia
Vania Nosé, MD, PhD

522 Pheochromocytoma and Paraganglioma
Vania Nosé, MD, PhD, Arthur S. Tischler, MD, and Ying-Hsia Chu, MD

534 Composite Pheochromocytoma and Composite Paraganglioma
Vania Nosé, MD, PhD and Arthur S. Tischler, MD

540 Neuroblastic Tumors of Adrenal Gland
Vania Nosé, MD, PhD

ADRENAL MESENCHYMAL AND STROMAL TUMORS

552 Primary Adrenal Myelolipoma
Vania Nosé, MD, PhD

556 Primary Adrenal Melanoma
Vania Nosé, MD, PhD

560 Primary Adrenal Benign Connective Tissue Tumor
Vania Nosé, MD, PhD

562 Primary Adrenal Angiosarcoma
Vania Nosé, MD, PhD

566 Primary Adrenal Leiomyosarcoma
Vania Nosé, MD, PhD

570 Metastasis to Adrenal Gland
Vania Nosé, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ADRENAL GLAND

574 Adrenal Cortical Carcinoma Protocol
Vania Nosé, MD, PhD

SECTION 4: PITUITARY GLAND
NONNEOPLASTIC

578 Hypophysitis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

582 Hyperplasia, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

584 Sarcoidosis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD

588 Infarction, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

590 Sheehan Syndrome, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

592 Cystic Lesions of Sellar Region
M.Beatriz S. Lopes, MD, PhD

596 Empty Sella Syndrome
M.Beatriz S. Lopes, MD, PhD

NEOPLASTIC
ANTERIOR NEUROENDOCRINE NEOPLASMS

598 Pituitary Neuroendocrine Tumor/Adenoma
M.Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD

604 Somatotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

608 Lactotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

612 Thyrotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

616 Plurihormonal PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

620 Corticotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

624 Gonadotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

628 Null Cell PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD

630 Metastatic Pituitary Neuroendocrine Tumor
Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD

OTHER ANTERIOR PITUITARY TUMORS

634 Adamantinomatous Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD

636 Papillary Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD

638 Pituitary Blastoma

POSTERIOR PITUITARY NEOPLASMS

642 Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor of Sella
M.Beatriz S. Lopes, MD, PhD

NEURONAL TUMORS

646 Gangliocytoma
M.Beatriz S. Lopes, MD, PhD

650 Neuronal Cell Tumors, Pituitary
M.Beatriz S. Lopes, MD, PhD

OTHER PITUITARY TUMORS

652 Metastasis to Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

654 Mesenchymal and Hematopoietic Tumors, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH PRIMARY PITUITARY TUMORS

658 Protocol for Examination of Specimens From Patients With Primary Pituitary Tumors
Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD

SECTION 5: ENDOCRINE PANCREAS

664 Pancreatic Neuroendocrine Neoplasms
Vania Nosé, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ENDOCRINE PANCREAS

674 Pancreatic Neuroendocrine Carcinoma Protocol
Vania Nosé, MD, PhD

SECTION 6: ENDOCRINE SKIN

678 Merkel Cell Carcinoma
Lori A. Erickson, MD

SECTION 7: FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTED THYROID GLAND

690 DICER1 Syndrome
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD

700 Familial Thyroid Carcinoma
Vania Nosé, MD, PhD

706 McCune-Albright Syndrome
Vania Nosé, MD, PhD

712 Multiple Endocrine Neoplasia Type 2 (MEN2)
Vania Nosé, MD, PhD

720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nosé, MD, PhD

726 PTEN Hamartoma Tumor Syndromes
Vania Nosé, MD, PhD

734 Syndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nosé, MD, PhD

PARATHYROID GLAND

742 Familial Isolated Hyperparathyroidism
Vania Nosé, MD, PhD and Lori A. Erickson, MD

746 Hyperparathyroidism-Jaw Tumor Syndrome
Vania Nosé, MD, PhD and Lori A. Erickson, MD

754 Multiple Endocrine Neoplasia Type 1 (MEN1)
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD

762 Multiple Endocrine Neoplasia Type 4 (MEN4)
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD

ADRENAL GLAND AND PARAGANGLIA

768 Beckwith-Wiedemann Syndrome
Patricia Nogueira de Sa, MD and Vania Nosé, MD, PhD

776 Carney Complex
Vania Nosé, MD, PhD

784 Hereditary Neuroblastoma
Vania Nosé, MD, PhD

788 Hereditary Paraganglioma/Pheochromocytoma Syndromes
Vania Nosé, MD, PhD

796 Multiple Endocrine Neoplasia Type 5,MAX-Related
Vania Nosé, MD, PhD

798 Neurofibromatosis Type 1
Michelle Menon Miyake, MD and Vania Nosé, MD, PhD

806 von Hippel-Lindau Syndrome
Vania Nosé, MD, PhD

814 SDH-Deficient Pheochromocytoma and Paraganglioma
Vania Nosé, MD, PhD and Arthur S. Tischler, MD

PANCREAS

820 Glucagon Cell Hyperplasia and Neoplasia
Vania Nosé, MD, PhD

824 Hereditary and Familial Pancreatic Cancer Syndrome
Daniel C. Chung, MD and Vania Nosé, MD, PhD

828 MAFA-Related Familial Insulinomatosis
Vania Nosé, MD, PhD

830 Pancreatic Neuroendocrine Tumor Syndromes

842 Ectopic (Paraneoplastic) Syndromes
Lori A. Erickson, MD