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Developmental and Fetal Origins of Differences in Monozygotic Twins

From Genetics to Environmental Factors

1st Edition - May 15, 2020

Editors: Alexandra Matias, Isaac Blickstein

Paperback ISBN:

9 7 8 - 0 - 1 2 - 8 2 0 0 4 7 - 6

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 2 0 3 0 7 - 1

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from… Read more

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Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.

1. Introduction

ALEXANDRA MATIAS

2. Biology of monozygotic twinning

ISAAC BLICKSTEIN

3. Mechanisms of discordance in

monozygotic twins: why and when?

ALEXANDRA MATIAS, SARA SILVA AND

ISAAC BLICKSTEIN

of discordance 62

Conclusion 73

References 73

Further reading 76

4. Monozygotic twins in history:

enlightenment by mythology and

ethnography

GIOVANNI CORSELLO AND ALEXANDRA MATIAS

5. Genetics and epigenetics differences in

monozygotic twins: the vision of the

geneticist

TESSA HOMFRAY

6. Heterokaryotypic monozygotic twins

LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST

7. Differences in placentation in

monochorionic twin pregnancies

SUZANNE F. DE VILLIERS, LISANNE TOLLENAAR

8. Differences in growth: selective

intrauterine growth restriction in

monochorionic twins

MAR BENNASAR AND EDUARD GRATACO´ S

9. Hemoglobin differences at birth in

monochorionic twins

LIANNE VERBEEK AND ENRICO LOPRIORE

10. Differences in amniotic fluid in MZ

twins

RENATO AUGUSTO MOREIRA DE SA´ , PAULO ROBERTO

NASSAR DE CARVALHO AND LUI´SA MOREIRA DE A ´ VILA

11. Twin-reversed arterial perfusion

sequence: different identical twins

LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST

12. Major discordant anomalies in

monozygotic twins: management and

outcome

DANIELA CASATI, STEFANO FAIOLA AND

MARIANO LANNA

13. Congenital heart disease in

monozygotic twins

MANON GIJTENBEEK AND MONIQUE HAAK

14. Spotting the differences in the

first trimester of pregnancy in MZ twins:

the issue of aneuploidies and TTTS

screening

ALEXANDRA MATIAS, MIGUEL PEREIRA MACEDO AND

NUNO MONTENEGRO

15. Noninvasive prenatal screening in

twin pregnancies

SAMANTHA LEONARD AND KIMBERLY MARTIN

16. A new way to look at multiples: the

power of image

HERON WERNER JR, JORGE LOPES AND

MIGUEL PEREIRA MACEDO

17. Differences in monozygotic twins: the

implications of diet and intestinal

microbioma

CARLOS CARDOSO, CLA´ UDIA AFONSO AND

NARCISA M. BANDARRA

18. Differences in development in

monozygotic twins

NANCY L. SEGAL, JOSEPH L. NEDELEC AND

VANESSA A. COSTELLO-HARRIS

19. Monozygotic twins: a personal as

well as a criminal and jurisdictional

approach

MAFALDA GAGLIARDINI GRAC¸ A

20. Monozygotic twin differences in

perceived age

MIKAEL THINGGAARD AND KAARE CHRISTENSEN

21. The environmental differences

between twins in utero and their

importance for downstream development: a

need for standardized monitoring in

obstetric research

JEFFREY M. CRAIG, EMMA K. SUTTON AND

SHAYESTEH JAHANFAR

22. Future perspectives

ISAAC BLICKSTEIN