Developmental and Fetal Origins of Differences in Monozygotic Twins
From Genetics to Environmental Factors
- 1st Edition - May 15, 2020
- Imprint: Academic Press
- Editors: Alexandra Matias, Isaac Blickstein
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 0 4 7 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 3 0 7 - 1
Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from gene… Read more
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Request a sales quoteDevelopmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.
- Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
- Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
- Features contributions from international experts in twin genetics and developmental biology
Human geneticists; human genomicists; translational researchers in genomic medicine, pediatrics, fetal medicine, obstetrics and gynecology, reproductive biology, epidemiology, public health, bioinformatics, and endocrinology; life science researchers; oncologists; obstetricians; pediatricians; immunologists; bioengineers; developmental biologists
1. Introduction
ALEXANDRA MATIAS
2. Biology of monozygotic twinning
ISAAC BLICKSTEIN
3. Mechanisms of discordance in
monozygotic twins: why and when?
ALEXANDRA MATIAS, SARA SILVA AND
ISAAC BLICKSTEIN
of discordance 62
Conclusion 73
References 73
Further reading 76
4. Monozygotic twins in history:
enlightenment by mythology and
ethnography
GIOVANNI CORSELLO AND ALEXANDRA MATIAS
5. Genetics and epigenetics differences in
monozygotic twins: the vision of the
geneticist
TESSA HOMFRAY
6. Heterokaryotypic monozygotic twins
LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST
7. Differences in placentation in
monochorionic twin pregnancies
SUZANNE F. DE VILLIERS, LISANNE TOLLENAAR
8. Differences in growth: selective
intrauterine growth restriction in
monochorionic twins
MAR BENNASAR AND EDUARD GRATACO´ S
9. Hemoglobin differences at birth in
monochorionic twins
LIANNE VERBEEK AND ENRICO LOPRIORE
10. Differences in amniotic fluid in MZ
twins
RENATO AUGUSTO MOREIRA DE SA´ , PAULO ROBERTO
NASSAR DE CARVALHO AND LUI´SA MOREIRA DE A ´ VILA
11. Twin-reversed arterial perfusion
sequence: different identical twins
LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST
12. Major discordant anomalies in
monozygotic twins: management and
outcome
DANIELA CASATI, STEFANO FAIOLA AND
MARIANO LANNA
13. Congenital heart disease in
monozygotic twins
MANON GIJTENBEEK AND MONIQUE HAAK
14. Spotting the differences in the
first trimester of pregnancy in MZ twins:
the issue of aneuploidies and TTTS
screening
ALEXANDRA MATIAS, MIGUEL PEREIRA MACEDO AND
NUNO MONTENEGRO
15. Noninvasive prenatal screening in
twin pregnancies
SAMANTHA LEONARD AND KIMBERLY MARTIN
16. A new way to look at multiples: the
power of image
HERON WERNER JR, JORGE LOPES AND
MIGUEL PEREIRA MACEDO
17. Differences in monozygotic twins: the
implications of diet and intestinal
microbioma
CARLOS CARDOSO, CLA´ UDIA AFONSO AND
NARCISA M. BANDARRA
18. Differences in development in
monozygotic twins
NANCY L. SEGAL, JOSEPH L. NEDELEC AND
VANESSA A. COSTELLO-HARRIS
19. Monozygotic twins: a personal as
well as a criminal and jurisdictional
approach
MAFALDA GAGLIARDINI GRAC¸ A
20. Monozygotic twin differences in
perceived age
MIKAEL THINGGAARD AND KAARE CHRISTENSEN
21. The environmental differences
between twins in utero and their
importance for downstream development: a
need for standardized monitoring in
obstetric research
JEFFREY M. CRAIG, EMMA K. SUTTON AND
SHAYESTEH JAHANFAR
22. Future perspectives
ISAAC BLICKSTEIN
- Edition: 1
- Published: May 15, 2020
- No. of pages (Paperback): 386
- No. of pages (eBook): 386
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128200476
- eBook ISBN: 9780128203071
AM
Alexandra Matias
Dr. Alexandra Matias is Associate Professor of Obstetrics and Gynecology at Porto Medical School, and Senior Consultant in Obstetrics and Gynecology and Specialist in Fetal Medicine at University Hospital of S. João Porto, Portugal. Dr. Matias completed her PhD in Medicine at the University of Porto with the thesis "Venous return in the evaluation of fetal heart function,” and also completed a Alexander von Humboldt Stiftung Fellowship at the Pharmakologisches Institute in Heidelberg, Germany. She currently advises 6 doctorate and 12 master's degrees in Medicine, and served as the PhD jury president at the Faculty of Medicine of the University of Barcelona. Dr. Matias has published widely in such peer reviewed journals as Twin Research and Human Genetics, Ultrasound in Obstetrics and Gynecology, the Journal of Perinatal Medicine, the Journal of Fetal Diagnosis and Therapy, and the European Journal of Pharmacology.
Affiliations and expertise
Associate Professor of Obstetrics and Gynecology (Porto Medical school) and Senior Consultant in Obstetrics and Gynecology (S. Joao hospital)IB
Isaac Blickstein
Isaac Blickstein is Associate Professor of Obstetrics and Gynaecology, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel
Affiliations and expertise
Associate Professor of Obstetrics and Gynaecology, affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, IsraelRead Developmental and Fetal Origins of Differences in Monozygotic Twins on ScienceDirect