Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19, An Issue of the Clinics in Laboratory Medicine

1st Edition, Volume 42-1 - February 17, 2022
Editors: Daimon P. Simmons, Peter H. Schur
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 8 6 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 8 7 - 9

In this issue of Clinics in Laboratory Medicine, guest editors Drs. Daimon P. Simmons and Peter H. Schur bring their considerable expertise to the topic of Detection of SARS-CoV-2… Read more

Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19, An Issue of the Clinics in Laboratory Medicine

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In this issue of Clinics in Laboratory Medicine, guest editors Drs. Daimon P. Simmons and Peter H. Schur bring their considerable expertise to the topic of Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19. Top experts in the field cover key topics such as performance of central lab assays to detect SARS-COV-2 antibodies; alternative methods to detect SARS-CoV-2 antibodies; the role of antibodies in developing vaccines for COVID-19; SARS-COV-2 antibodies after immunization; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Severe Acute Respiratory Syndrome Coronavirus 2 Serology Testing – A Laboratory Primer
Key points
Introduction
Severe acute respiratory syndrome coronavirus 2 humoral response
Severe acute respiratory syndrome coronavirus 2 serology testing landscape
Severe acute respiratory syndrome coronavirus 2 serology assay designs
Evaluation of severe acute respiratory syndrome coronavirus 2 serology assays
Severe acute respiratory syndrome coronavirus 2 serology testing recommendations
Severe acute respiratory syndrome coronavirus 2 serology test reporting and interpretation
Severe acute respiratory syndrome coronavirus 2 antibody testing perspective
Clinics care points
Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review
Key points
Introduction
Key design differences among SARS-CoV-2 high-throughput serologic assays with FDA EUA
Performance characteristics among the commonly used high-throughput SARS-CoV-2 serologic assays
Future outlook for SARS-CoV-2 serologic testing
Summary
Clinics care points
Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology
Key points
Introduction
Study population
Sampling schemes
Sample size determination
Sample choice
Performance characteristics
Impact of emerging variants on the performance of lateral flow assays
Summary
Clinics care points
Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
Key points
Introduction
General principles of a serologic assay
Electrochemical immunoassays
Bioluminescent labels
Label-free optical approaches
Neutralization assays
Future directions
Clinics care points
Suboptimal Humoral Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Viral Variant Generation
Key points
Natural immunity in severe acute respiratory syndrome, Middle East respiratory syndrome rarely generated durable humoral immunity, and the data on coronavirus disease-19 are still emerging
The biology of the germinal center response
The loss of germinal centers in severe coronavirus disease -19
Loss of Bcl-6 expressing follicular helper cells in severe coronavirus disease-19
The loss of germinal centers in animal models of severe intracellular infections
The extrafollicular B cell response in coronavirus disease-19 and its potential contribution to pathology
Summary
Clinics care points
Antibody Dynamics and Durability in Coronavirus Disease-19
Key points
Introduction
Overview of B cell activation and antibody responses
Acute phase antibody responses to severe acute respiratory syndrome coronavirus 2
Durability of severe acute respiratory syndrome coronavirus 2 antibody in convalescent subjects
Summary
Clinics care points
Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
Key points
Background
Discussion
Summary
Clinics care points
Vaccine-Induced Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and the Path to Accelerating Development (Determining a Correlate of Protection)
Key points
Introduction
Severe acute respiratory syndrome coronavirus 2 vaccines and antibody responses
Definition and historical examples of correlates of protection and risks
The path to defining correlate of protection for severe acute respiratory syndrome coronavirus 2 vaccines
Other considerations relating to correlates of protection
Summary
Clinics care points

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Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19, An Issue of the Clinics in Laboratory Medicine

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Daimon P. Simmons

Peter H. Schur