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Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

1st Edition, Volume 166 - September 11, 2019

Editor: Vladimir N Uversky

Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 6 8 5 1 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 6 8 5 2 - 3

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to in… Read more

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

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"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.