Cytokines
Molecular Signals in Health and Disease
- 1st Edition - June 1, 2027
- Latest edition
- Editors: Christopher Chang, Jolan Walter
- Language: English
Cytokines: Molecular Signals in Health and Disease offers a detailed guide to cytokines, their molecular mechanisms and impact on disease. The book is divided into four sectio… Read more
Description
Description
This book acts as a comprehensive reference on this significant molecule and its role in cellular function and the development of disease and disorders. It is ideal for researchers in the fields of molecular biology and immunology, and those looking to investigate the significance of cytokines in disease pathogenesis and potential therapeutic intervention.
Key features
Key features
- Explores cytokines at the molecular level
- Considers cytokines in the context of various diseases
- Features chapter outlines, key definitions and learning objectives to aide comprehension
Readership
Readership
Table of contents
Table of contents
1. Introduction
2. Structural and functional classification of cytokines
3. Pro-inflammatory cytokines
4. Anti-inflammatory cytokines
5. Growth factors
6. The interferons
7. Chemokines
8. Cytokine receptors
Section B: Mechanisms of Cytokines in Disease
9. The genetics of cytokines
10. Cytokines and cells
11. Signaling pathways and cascades involving cytokines
12. Cytokine networks
13. Heterodimeric cytokines
14. Tissue specific cytokines
15. The development of anti-cytokine inhibitors in modern medicine
16. Animal models in cytokine research
17. Multi-omics, big data and cytokine heat maps
Section C: Cytokine Related Diseases and Syndromes
18. Primary or familial hemophagocytic lymphohistiocytosis
19. The autoinflammatory and periodic fever syndromes
20. Cytokines in autoimmunity – Macrophage Activation Syndrome
21. Allergic diseases
22. HLH in primary immunodeficiency disorders
23. Unusual or rare diseases involving cytokines
24. Cytokines in cancer
25. Cytokine contributions to diseases in specific organ systems
Section D: Cytokine Release Syndrome
26. History of cytokine release syndromes
27. Recognizing and diagnosing cytokine release syndromes
28. Management and treatment of cytokine release syndrome
29. Risks and benefits of cytokine research
30. Concluding remarks and future prospects
Appendix 1 – Abbreviations
Appendix 2 – Table of known cytokines
Appendix 3 – Resources
Product details
Product details
- Edition: 1
- Latest edition
- Published: June 1, 2027
- Language: English
About the editors
About the editors
Christopher Chang
Dr. Christopher Chang is Chief of Immunology, Allergy and Pediatric Rheumatology at Joe DiMaggio Children's Hospital and Memorial Healthcare System. He holds appointments as Professor of Medicine at the University of California, Davis, Professor of Allergy and Immunology at Nova Southeastern University, and Professor of Pediatrics at Florida Atlantic and Florida International Universities. His research focuses on immunodysregulation, primary immunodeficiencies, autoimmunity, epigenetics, atopic dermatitis, and food allergy, with a special interest in artificial intelligence in medicine. He serves as Medical Director of Pediatric Research at Joe DiMaggio Children's Hospital and is Editor-in-Chief of Clinical Reviews in Allergy and Immunology and the Journal of Evidence-based Integrative Medicine. He is a Fellow of the AAAAI and a Regent of the ACAAI.
Jolan Walter
Dr. Jolan Walter is the Robert A. Good Endowed Chair and Division Chief of Pediatric Allergy/Immunology as well as Associate Professor, of Pediatrics, Medicine & Molecular Biology at the University of South Florida in Tampa. She is also the Division Chief of Pediatric Allergy/Immunology and Director of the Jeffrey Modell Diagnostic & Research Center at Johns Hopkins All Children's Hospital in St. Petersburg, Florida. Dr. Walter’s research focus is understanding disease mechanisms of combined immunodeficiencies, and breach in tolerance in immune dysregulation disorders and cytokines, which leads to autoimmune complications and inflammation as well as improving the precision of diagnosis, disease monitoring and treatment of these disorders. She has authored many peer-reviewed articles, and her research is supported by multiple grants including NIH/R01, institutional grants, and other sponsors such as the Jeffrey Modell Foundation.