Current Topics in Cellular Regulation

List of Contributors

Preface

Preface to Volume 6

Contents of Previous Volumes

Role of Proteases in Sporulation

I. Introduction

II. Extracellular Proteases of Bacilli

III. Regulation of Extracellular Protease Synthesis and Sporulation

IV. Protein Turnover during Sporulation

V. The Modification of RNA Polymerase and Aldolase by a Serine Protease

VI. Conclusions

References

Regulatory Properties of Glucose-6-Phosphate Dehydrogenase

I. Introduction

II. General Properties

III. G6PD from Microorganisms

IV. G6PD from Mammalian Cells

V. Concluding Remarks

References

The Behavior of Intact Biochemical Control Systems

I. Introduction

II. Essential Concepts and Techniques Illustrated by the Analysis of a Simple System

III. Natural Selection of Feedback Inhibition Patterns in Biosynthetic Pathways

IV. On the Significance of Feedforward Inhibition in a Biosynthetic Pathway

V. Cascaded Enzymatic Mechanisms

VI. Summary

References

A Possible Role for Kinetic Reaction Mechanism Dependent Substrate and Product Effects in Enzyme Regulation

I. Introduction

II. Product Effects on Enzyme Velocity Responses

III. Product Effects on Cooperative Substrate Binding

IV. Substrate Effects on Enzyme Velocity Responses

V. Simulations and Observations with Actual Systems

VI. Michaelis Constants

VII. Evaluation and Future Developments

References

Control of Biogenesis of Isoprenoid Compounds in Animals

I. The Pathways of Biogenesis

II. Cholesterol

III. Ubiquinone

IV. Bile Acids

V. Steroid Hormones

VI. Concluding Remarks

References

On Allosteric Models

I. Some General Relations

II. A Parent Model

III. The MWC and Induced-Fit Models as Subcases

IV. The Effect of a Second Ligand

V. The Effect of Subunit Heterogeneity

VI. An Example from Trout Hemoglobin

VII. Conclusion

References

Regulation of Uridylic Acid Biosynthesis in Eukaryotic Cells

I. General Pathway for Uridylic Acid Biosynthesis

II. Genetic Control of Enzyme Levels in Fungi

III. The Eukaryotic Enzymes

References

Flip-Flop Mechanisms and Half-Site Enzymes

I. Introduction

II. The Flip-Flop Mechanism. Description of a Model, the Alkaline Phosphatase of Eschenchia coli

III. Half-Site Enzymes

IV. Half-of-the-Sites Reactivity and Flip-Flop Mechanisms for Allosteric Enzymes

V. The Functional and Evolutionary Advantages of Half-Site Enzymes and Flip-Flop Mechanisms

References

Note Added in Proof

Author Index

Subject Index