Current Developments in Biotechnology and Bioengineering

Advances in Bioprocess Engineering

1st Edition - August 18, 2022
Editors: Ashok Pandey, Ranjna Sirohi, Christian Larroche, Mohammad Taherzadeh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 1 6 7 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 4 8 3 - 6

Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess sy… Read more

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Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Section I: Engineering consideration in design and scale-up of bioreactors
Chapter 1. Types of bioreactors and important design considerations
Abstract
1.1 Introduction
1.2 Submerged fermentation
1.3 Solid-state fermentation
1.4 Modes of operation
1.5 Submerged fermentation bioreactors
1.6 Factors influencing solid-state fermentation process
1.7 Solid-state fermentation bioreactors
1.8 Conclusions and perspectives
References
Chapter 2. Immobilized cell bioreactors
Abstract
2.1 Introduction
2.2 Cell immobilization technology
2.3 Immobilized cell bioreactors
2.4 Cell immobilized bioreactors and industrial development
2.5 Drawbacks and benefits in immobilization technology
2.6 Conclusions and perspectives
References
Chapter 3. Engineering aspects for scale-up of bioreactors
Abstract
3.1 Introduction
3.2 General aspects of bioreactors’ design and engineering
3.3 Scale-up strategies for submerged bioreactors
3.4 Scale-up of pneumatic bioreactors
3.5 Scale-up of nonsubmerged bioreactors
3.6 Conclusions and perspectives
References
Section II: Control systems, optimization and artificial intelligence in industrial bioprocessing
Chapter 4. Modeling and optimization of bioreactor processes
Abstract
4.1 Introduction
4.2 The traditional approach: bioreactor mechanistic models
4.3 Bioreactor models for Industry 4.0
4.4 Conclusions and perspectives
Acknowledgments
References
Chapter 5. On-line monitoring of process parameters during fermentation
Abstract
5.1 Introduction
5.2 Traditional sensors
5.3 Biosensors
5.4 Spectroscopic sensors
5.5 At-line chromatographic methods with liquid handlers
5.6 Mass spectroscopy
5.7 Particle characterization
5.8 Flow following wireless sensors
5.9 Soft sensors
5.10 Conclusions and perspectives
Acknowledgments
References
Chapter 6. Molecular tools for strain improvement for bioprocesses
Abstract
6.1 Introduction
6.2 Strain improvement for industrial bioprocesses
6.3 Genetic engineering to genome engineering
6.4 Gene shuffling to genome shuffling
6.5 Synthetic genes to synthetic genomes
6.6 Conclusions and perspectives
Acknowledgments
References
Chapter 7. Next generation techniques for anaerobic bioprocess optimization
Abstract
7.1 Introduction
7.2 Strategies prior to operation of continuous anaerobic bioprocess
7.3 Monitoring of anaerobic processes
7.4 Conclusions and perspectives
References
Chapter 8. Computational tools in bioprocessing
Abstract
8.1 Introduction
8.2 Computational flow modeling
8.3 Case studies on modeling of bioprocesses
8.4 Conclusions and perspectives
References
Chapter 9. Electrotechnologies for bioprocessing applications
Abstract
9.1 Introduction
9.2 Theoretical aspects
9.3 Power microwaves and interaction with biomaterials
9.4 Ohmic heating
9.5 Conclusions and perspectives
References
Chapter 10. Machine learning for agri-food processes: learning from data, human knowledge, and interactions
Abstract
10.1 Introduction
10.2 A Long-Short-Term Memory network model for biscuit baking
10.3 Prediction of grape berries quality for decision making
10.4 Machine learning user interactions to understand how agronomy experts explore model simulations
10.5 Conclusions and perspectives
Acknowledgments
References
Further reading
Section III: Advanced upstream processing
Chapter 11. Application of design of experiments in bioprocessing: process analysis, optimization, and reliability
Abstract
11.1 Introduction
11.2 Experimental strategies
11.3 Simple comparative experiments
11.4 Statistical analysis
11.5 Regression models
11.6 Screening of potential variables
11.7 Response surface methodology and optimization approach
11.8 Factorial design
11.9 Design of experiments
11.10 Conclusions and perspectives
References
Chapter 12. Advances in gas fermentation processes
Abstract
12.1 Introduction
12.2 Gas fermentation
12.3 Microorganisms and biochemistry of gas fermentation
12.4 Parameters influencing gas fermentation
12.5 Bioreactors for gas fermentation
12.6 Gas electrofermentation
12.7 Life-cycle analysis of gas fermentation processes
12.8 Commercialization of gas fermentation technology
12.9 Conclusions and perspectives
References
Chapter 13. Advances in downstream processing techniques
Abstract
13.1 Introduction
13.2 Conventional downstream processes and their limitations
13.3 Advances in downstream processing approaches
13.4 Conclusions and perspectives
References
Chapter 14. Factors influencing microbial growth and its kinetics
Abstract
14.1 Introduction
14.2 Microbial growth in batch culture
14.3 Stoichiometry of microbial growth
14.4 Microbial growth models
14.5 Factors affecting microbial growth kinetics
14.6 Substrate utilization during microbial growth
14.7 Conclusions and perspectives
References
Section IV: Advanced downstream processing
Chapter 15. Media preparation and sterilization in bioprocesses
Abstract
15.1 Introduction
15.2 Bioprocesses and classifications
15.3 Microbial contaminations in bioprocesses: why and how?
15.4 Sterilization methods
15.5 Media preparation
15.6 Conclusions and perspectives
Acknowledgment
References
Chapter 16. Cell disruption and product isolation
Abstract
16.1 Introduction
16.2 Cell disruption
16.3 Product isolation
16.4 High value–added products
16.5 Conclusions and perspectives
Acknowledgments
References
Further reading
Chapter 17. Unit operations for extraction and purification of biological products
Abstract
17.1 Introduction
17.2 Precipitation
17.3 Aqueous two-phase systems
17.4 Chromatography
17.5 Crystallization
17.6 Drying
17.7 Conclusions and perspectives
References
Index

Ashok Pandey

Professor Ashok Pandey is currently Executive Director, Centre for Energy and Environmental Sustainability-India, Lucknow. He is HSBS National Innovation Chair (Biotechnology) and is/has been Visiting/Distinguished Professor in many countries. His major research and technological development interests are industrial & environmental biotechnology and energy biosciences, focusing on biomass to biofuels & chemicals, waste to wealth & energy, etc.

Affiliations and expertise

Executive Director Centre for Energy and Environmental Sustainability Lucknow, India

Ranjna Sirohi

Dr. Ranjna Sirohi is currently working as Research Professor in Korea University, Seoul. She obtained B.Tech. degree in Biochemical Engineering and M.Tech. degree in Agricultural Engineering with specialization in Food Biotechnology Engineering. She has worked as Visiting Researcher at the École Polytechnique Fédérale de Lausanne, Switzerland, as Scientist at Centre for Energy and Environment Sustainability, Lucknow and as Senior Project Associate at CSIR-NEERI, Nagpur. She obtained her Ph.D. degree in Process and Food Engineering from G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand. Her major research interests are in the field of Bioprocess Technology - Food & Food Waste Valorisation-Waste to Wealth – Biofuels. She has 65 publications/communications that include 32 research and review papers, 12 book chapters, 7 popular articles and 14 conference proceedings. Dr Sirohi has won several awards and honors that include Research Excellent Award in the international conference on New Horizons in Biotechnology, Trivandrum, India (2019), Best Poster award in 8th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2019), Miri; Sarawak, Malaysia (2019) and Research Excellence Award in International Conference on Bio-Innovation for Environmental and Health Sustainable Developments (BEHSD-2018), Lucknow, India (2018). She is the Life member of Indian Society of Agricultural Engineers (ISAE); the Biotech Research Society, India (BRSI); Indian Science Congress Association (ISCA) and Association of Food Scientists & Technologists, India (AFSTI).

Affiliations and expertise

Research Professor, Department of Chemical and Biological Engineering, Korea University, Seoul, Republic of Korea

Christian Larroche

Prof. Christian Larroche is Director of Polytech Clermont-Ferrand, a graduate school of engineering of University Clermont-Auvergne, France. He is also member of the research laboratory Institut Pascal and of the laboratory of excellence ImobS3 at the same university. He has strong research skills and expertise in the area of applied microbiology and biochemical engineering. He is author of 220 documents, including 114 articles, three patents, 15 book chapters and 24 co-editions of books or journal special issues. He is member of French Society for Process Engineering (SFGP), French Society of Biotechnology and European Federation of Chemical Engineering. He is administrator of IBA-IFIBiop and editor of Bioresource Technology.

Affiliations and expertise

Chemical and Biochemical Engineering Laboratory, Institute Pascal, University Clermont Auvergne, Clermont Ferrand, France

Mohammad Taherzadeh

Mohammad J. Taherzadeh is professor in Biotechnology since 2004 at University of Borås in Sweden. He is also director of Resource Recovery, a research profile with about 50 researchers to convert wastes to energy and value-added products. Prof. Taherzadeh has PhD in Bioscience and MSc and Bsc in Chemical Engineering. He is working on converting wastes and residuals to ethanol, biogas, fish feed and superabsorbents, in which fermentation development using bacteria, yeast and filamentous fungi has a heavy weight. Prof. Taherzadeh has more than 120 publications in scientific peer-reviewed journals, 10 book chapters and two patents about filamentous fungi. Mohammad is the panel chairman of “biotechnology, chemical technology and environmental technology” of Swedish Research Council, and also in the editorial board of Bioresource Technology and BioResources.

Affiliations and expertise

Professor, Swedish Centre for Resource Recovery, University of Boras, Boras, Sweden

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Current Developments in Biotechnology and Bioengineering

Advances in Bioprocess Engineering

Purchase options

Institutional subscription on ScienceDirect

Ashok Pandey

Ranjna Sirohi

Christian Larroche

Mohammad Taherzadeh