
Current Challenges in Cell Therapy for Neurodegenerative Diseases
- 1st Edition, Volume 166 - November 16, 2022
- Editors: Emma L Lane, Cheney J.G. Drew, Mariah J Lelos
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 8 9 3 7 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 9 3 8 - 1
Cell Transplantation and Gene Therapy in Neurodegenerative Disease, Volume 166 in the International Review of Neurobiology series, highlights new advances in the field with this… Read more

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Request a sales quoteCell Transplantation and Gene Therapy in Neurodegenerative Disease, Volume 166 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors who cover Challenges in translating a cell therapy to GMP, The challenges in developing a cell therapy for Huntington’s disease, Challenges of cell therapies for retinal diseases, Challenges of gene therapy in Huntington’s Disease, Technological advances and barriers to gene therapy, Considerations in the development of cell therapy modulation for spinal cord injury treatment, Challenges of developing glial cell therapy for ALS, and more.
Other chapters in this comprehensive release include Exploring cell and gene therapy in current animal models of Parkinson’s and Huntington’s disease, Considerations for the use of biomaterials to support cell therapy in degenerative disease, Neurosurgical challenges/innovations in cell and gene therapy delivery, Neuroimaging: the challenge of harnessing imaging tools to facilitate cell and gene therapy in neurodegenerative diseases/The contribution and challenges for imaging in advanced therapies of movement disorders, Considerations for clinical trial design for novel advanced therapeutics in neurodegenerative disease, and More than a trial participant: The role of the patient in ATMP development and trials for neurodegenerative disease.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in International Review on Neurobiology serials
- Updated release includes the latest information on Cell Transplantation and Gene Therapy in Neurodegenerative Disease
Undergraduates, graduates, academics, and researchers in the field of gene therapy of neurodegenerative diseases
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Challenges in progressing cell therapies to the clinic for Huntington's disease: A review of the progress made with pluripotent stem cell derived medium spiny neurons
- Abstract
- 1: Introduction
- 2: Derivation of MSN-like cells from hPSCs: What has been shown in vitro and in vivo?
- 3: Evidence for functional recovery following CRT and underlying mechanisms
- 4: Challenges
- 5: Conclusions and authors perspectives
- References
- Chapter Two: Challenges of cell therapies for retinal diseases
- Abstract
- 1: Introduction
- 2: Retinal disorders: Focus on AMD and RP
- 3: Human pluripotent stem cells for retinal cell therapy
- 4: Transposing bench-scale practices to industrialization
- 5: Conclusion
- Funding Statement
- References
- Chapter Three: Cell transplantation to repair the injured spinal cord
- 1: Introduction
- 2: Transplantation for spinal cord repair
- 3: Pro-regenerative transplants: Bridging for spinal cord repair
- 4: Building novel neuronal pathways: Neuronal relays for repair
- 5: Cell transplantation for neuroimmune modulation and neuroprotection
- 6: Considerations for contraindications and adverse effects
- 7: Closing remarks
- References
- Further reading
- Chapter Four: Investigating cell therapies in animal models of Parkinson's and Huntington's disease: Current challenges and considerations
- Abstract
- 1: Introduction
- 2: Challenge 1: Identifying a good model for cell transplantation studies
- 3: Challenge 2: Survival of xenografts in rodent models
- 4: Challenge 3: Assessing the functional efficacy of the graft
- 5: Challenge 4: Creating clinically relevant models
- 6: Discussion
- References
- Chapter Five: Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease
- Abstract
- 1: Using biomaterials to support cell therapies
- 2: Considerations for the use of biomaterials
- 3: Promising biomaterial and cell based therapies for neurodegenerative disease
- 4: Clinical translation
- 5: Conclusion
- References
- Chapter Six: Challenges of translating a cell therapy to GMP
- Abstract
- 1: The history of cell and gene therapy manufacturing
- 2: Characterization of the NSCs
- 3: History and track record
- 4: QC/QA at the UC Davis GMP facility
- References
- Chapter Seven: Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease
- Abstract
- 1: Introduction
- 2: Principles of clinical trial design
- 3: Outcome measures in cell and gene therapy trials in neurodegenerative disease
- 4: Technical and practical factors for consideration in operationalizing the intracranial delivery of cell and gene therapies
- 5: Considerations for the inclusion of participants in trials of cell and gene therapies
- 6: Summary
- References
- Chapter Eight: More than a participant in trials of cell and gene therapy: Hearing the voices of people living with neurodegenerative diseases
- Abstract
- 1: Introduction
- 2: Public and patient perceptions of cell and gene therapy
- 3: The experiences of clinical trial participants with neurodegenerative diseases
- 4: How is the voice of those living with degenerative disease engaged with?
- 5: Factors that contribute to a meaningful patient voice
- 6: The patient voice in clinical delivery
- 7: Conclusion
- Acknowledgments
- The authors
- References
- No. of pages: 324
- Language: English
- Edition: 1
- Volume: 166
- Published: November 16, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780323989374
- eBook ISBN: 9780323989381
EL
Emma L Lane
CD
Cheney J.G. Drew
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