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Elsevier

Current Approaches to Overcome Therapeutic Resistance of Leukemia

  • 1st Edition - April 1, 2027
  • Latest edition
  • Editors: Zhe-Sheng Chen, Saurabh Kumar Jha, Neha Gupta
  • Language: English

Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukem… Read more

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Description

Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukemia. It explores biological, molecular, and clinical dimensions of resistance, bridging fundamental research with therapeutic innovation. The book examines key resistance mechanisms, including genetic mutations, leukemic stem cells, and tumor microenvironment interactions, alongside emerging insights such as epigenetic regulation, metabolic reprogramming, and immune evasion. It further highlights advanced therapeutic approaches, including immunotherapy, targeted therapies, combination strategies, and AI-driven tools for drug discovery and monitoring. This volume provides students, researchers, and clinicians with foundational and integrated knowledge essential for understanding resistance biology and translating discoveries into clinical practice. It supports evidence-based decision-making and promotes the development of innovative strategies to improve patient outcomes.

Key features

  • Bridges basic research and clinical translation by connecting mechanistic insights with therapeutic and future‑oriented perspectives
  • Integrates emerging therapeutic approaches such as CAR‑T cell therapy, PROTAC‑based strategies, combination therapies, and AI‑enabled drug discovery
  • Analyzes intrinsic and acquired resistance mechanisms, including genetic, epigenetic, metabolic, and microenvironment‑driven processes in leukemia

Readership

MD, DM, and PhD students, clinicians, oncologists, and researchers in oncology, hematology, and cancer biology

Table of contents

Part I: Mechanisms of Resistance

1. The Biology of Resistance in Leukemia: From Cells to Niches

2. Leukemia Drug Resistance: Molecular Insights and Pathways

Part II: Emerging Resistance Mechanisms

3. Leukemia Resistance Unveiled: Stem Cells, Microenvironment, and Evolving Mechanisms

4. Non-Genetic and Epigenetic Rewiring in Leukemia Resistance

5. Epigenetic and Metabolic Drivers of Immune Tolerance and Evasion in Leukemia

Part III: Breaking the Barrier

6. Breaking Resistance in Leukemia: CAR-T, PROTACs, and Beyond

7. Defeating Leukemia Resistance: Emerging Therapeutic Frontiers

Part IV: Clinical Translation and Future Directions

8. Clinical Translation of Leukemia Therapies: AI-Driven Drug Discovery and Liquid Biopsy

9. From Bench to Bedside in Leukemia: AI and Liquid Biopsy in Resistance Management

10. AI-Enabled Immunotherapy in Leukemia: Emerging Approaches to Combat Resistance

Product details

  • Edition: 1
  • Latest edition
  • Published: April 1, 2027
  • Language: English

About the editors

ZC

Zhe-Sheng Chen

Zhe-Sheng Chen, PhD., opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen has over 170 papers published, co-edited Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy book (Elsevier), and holds several patents.
Affiliations and expertise
St. John's University, New York, USA

SJ

Saurabh Kumar Jha

Saurabh Kumar Jha is Assistant Professor at Kalindi College, University of Delhi, India. His research focuses on stem cell biology, neurodegeneration, aging, molecular chaperones, ubiquitin E3 ligases, and biomolecule-based therapeutics. His work investigates the molecular mechanisms underlying neurodegenerative disorders and the development of therapeutic strategies based on stem cells and biologically derived molecules. In addition to his research activities, he contributes to teaching, curriculum development, and the supervision of postgraduate and doctoral students. Jha is actively involved in scientific collaborations, professional societies, and academic conferences, with research interests spanning stem cell biology, neurobiology, and translational biomedical science.
Affiliations and expertise
University of Delhi, India

NG

Neha Gupta

Dr. Neha Gupta is an Assistant Professor in Biotechnology at Jiwaji University, Gwalior, with a Ph.D. in Biotechnology and extensive experience in research and teaching. She has received multiple awards recognizing her research excellence in biological sciences and has held an international research role in microbiology and molecular biology. Her academic background includes teaching, mentoring postgraduate students, and guiding research projects.

Her scholarly contributions include numerous publications, as well as authorship of a patent, a book, and several book chapters. She has actively participated in national and international conferences. Her research focuses on bioactive compounds derived from food, their biological functions, and the application of advanced screening, bioinformatics, and computational approaches.

Affiliations and expertise
Assistant Professor in Biotechnology, Jiwaji University, Gwalior, India