Craniofacial Development

1st Edition, Volume 115 - November 16, 2015
Editor: Yang Chai
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 4 0 8 1 4 1 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 1 6 6 1 1 - 0

Craniofacial Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in th… Read more

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Craniofacial Development
, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

This volume covers research methods in Craniofacial Development, and includes sections on such topics as microRNAs in craniofacial development and epigenetic regulation in craniofacial development.

Preface

Introduction to Craniofacial Development

Acknowledgments

Part 1: Craniofacial Morphogenesis and Regeneration: From Cells to Tissues to Organs

Chapter One: Craniofacial Muscle Development
- Abstract
- 1 Head Muscle Formation and Heterogeneity: Extraocular Muscles, Pharyngeal Mesoderm, and Neck Muscles
- 2 Overlap Between Cardiac and Pharyngeal Muscle Progenitors
- 3 FGF–ERK Signaling During Myogenesis
- 4 Head Muscle Regeneration
Chapter Two: Mandible and Tongue Development
- Abstract
- 1 Early Development of the Mandibular Arch
- 2 Mandibular Bone Development
- 3 Tongue Development
- 4 Evolution of the Mandible and Tongue
- 5 Mechanical Relationship Between the Mandible and Tongue
- 6 Stem Cells in Mandible and Tongue Regeneration
- 7 Conclusion
Chapter Three: Cellular and Molecular Mechanisms of Palatogenesis
- Abstract
- 1 Introduction
- 2 Regulation of Palatal Shelf Growth and Patterning
- 3 Proper Periderm Differentiation Is Critical for Normal Palatogenesis
- 4 Palatal Fusion: Formation and Dissolution of the Intershelf Epithelial Seam by Cell Convergence and Extrusion
- 5 Concluding Remarks
- Acknowledgments
Chapter Four: Genetic Influences on Temporomandibular Joint Development and Growth
- Abstract
- 1 Introduction
- 2 Normal Morphogenesis and Cell Biology of the TMJ
- 3 Genes That Affect Mandibular Condylar Cartilage
- 4 Genes Affecting the Mandibular Fossa
- 5 Genes Affecting the Articular Disc and Joint Cavitation
- 6 Discussion
- Acknowledgments
Chapter Five: Regulatory Mechanisms Driving Salivary Gland Organogenesis
- Abstract
- 1 Introduction
- 2 Regulation of Branching Morphogenesis
- 3 SMG Innervation
- 4 Stem/Progenitor Cells
- 5 Conclusion
- Acknowledgments
Chapter Six: The Development of the Calvarial Bones and Sutures and the Pathophysiology of Craniosynostosis
- Abstract
- 1 Introduction
- 2 Early Development
- 3 Calvarial Suture Development and the Pathophysiology of Craniosynostosis
- Acknowledgments
Chapter Seven: Tissue Interactions Regulating Tooth Development and Renewal
- Abstract
- 1 Introduction
- 2 Epithelial–Mesenchymal Tissue Interactions Regulating Tooth Initiation and Morphogenesis
- 3 Epithelial–Mesenchymal Interactions Regulating Dentin and Enamel Formation
- 4 Epithelial–Mesenchymal Interactions Regulating Stem Cells in Continuously Growing Mouse Incisors
- 5 Concluding Remarks
- Acknowledgments
Chapter Eight: Stem Cells in Tooth Development, Growth, Repair, and Regeneration
- Abstract
- 1 Stem Cells in Tooth Development
- 2 Stem Cells in Dentin Repair: Tertiary Dentinogenesis
- 3 The Continuously Growing Incisor
- Acknowledgments
Chapter Nine: Development and Integration of the Ear
- Abstract
- 1 Function and Anatomy of the Mammalian Ear
- 2 Development of the Pharyngeal Apparatus
- 3 Development of the Middle Ear
- 4 Development of the External Ear
- 5 Development of the Inner Ear
- 6 Mechanism and Defects of Integration During Development
- 7 Conclusion

Part 2: Craniofacial Patterning and Signaling Mechanisms

Chapter Ten: Zebrafish Craniofacial Development: A Window into Early Patterning
- Abstract
- 1 Zebrafish Craniofacial Anatomy
- 2 Imaging Craniofacial Development
- 3 Genetic Analyses of Craniofacial Development
- 4 Future Directions
- 5 Conclusions
Chapter Eleven: Regulation of Jaw Length During Development, Disease, and Evolution
- Abstract
- 1 Introduction: On Being the Right Jaw Size During Development and Evolution
- 2 Part 1: Early Determinants of Jaw Length
- 3 Part 2: Determinates of Jaw Length During Skeletal Differentiation
- 4 Part 3: Determinates of Jaw Length During Late-Stage Growth
Chapter Twelve: Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face
- Abstract
- 1 Introduction
- 2 Relationship Between the Brain and the Face
- 3 Implications for Structural Diseases of the Face
- 4 The Role of Brain–Face Interactions in Generating Evolutionary Variation
- 5 Conclusions
Chapter Thirteen: Developmental Plasticity of Patterned and Regenerating Oral Organs
- Abstract
- 1 Introduction and Background
- 2 The Continuum of Oral Organ Patterning and Regeneration
- 3 The Plasticity of Stem-Based Organ Regeneration
- 4 Cichlids Combine the Features of Renewing and Replacing Oral Organ Systems
- Acknowledgments
Chapter Fourteen: Regulating Craniofacial Development at the 3′ End: MicroRNAs and Their Function in Facial Morphogenesis
- Abstract
- 1 Introduction
- 2 Craniofacial Development: Cell Types and Tissue Interactions
- 3 miRNA Biogenesis, Structure, and Function
- 4 miR-140: The First Individual miRNA Associated with Facial Morphogenesis
- 5 miRNA Function in Craniofacial Development—Lessons from Deletion of Dicer1
- 6 The miR-17~ 92 Family: Complex and Compensating Actions During Vertebrate Development
- 7 miRNA Regulation of Bone and Cartilage Development
- 8 miRNAs and Odontogenesis
- 9 miRNAs and Salivary Gland Development
- 10 miRNAs: A Potential Tool for Correcting Craniofacial Defects
- 11 Summary
Chapter Fifteen: Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation
- Abstract
- 1 Introduction
- 2 Signaling Pathways Regulating Craniofacial Development
- 3 Families of Transcription Factors
- 4 Questions for the Future

Part 3: Disease Models, Human Genetics, Genomics and Dynamic Imaging

Chapter Sixteen: Mouse Models of Rare Craniofacial Disorders
- Abstract
- 1 Introduction
- 2 Ribosomopathies
- 3 Ciliopathies
- 4 Syngnathia
- 5 Conclusions and Perspectives
- Acknowledgments
Chapter Seventeen: From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models
- Abstract
- 1 Models to Uncover Genetics of Cleft Lip and Palate
- 2 Treacher Collins: Proof of Concept of a Nonsurgical Therapeutic for a Craniofacial Syndrome
- 3 RASopathies: Understanding and Developing Treatment for Syndromes of the RAS Pathway
- 4 Craniosynostosis: Pursuing Genetic and Pharmaceutical Alternatives to Surgical Treatment
- 5 XLHED: Developing Treatment Based on Knowledge Gained from Mouse and Canine Models
- 6 Concluding Thoughts
- Acknowledgments
Chapter Eighteen: Signaling Pathways in Craniofacial Development: Insights from Rare Skeletal Disorders
- Abstract
- 1 Rare Skeletal Disorders and Their Classification
- 2 Building the Skeleton
- 3 Signaling Pathways in Skeletal Development and Their Associated Skeletal Disorders
- 4 Hedgehog
- 5 Parathyroid Hormone-Related Protein
- 6 WNT
- 7 NOTCH
- 8 Transforming Growth Factor Beta Superfamily
- 9 Fibroblast Growth Factor
- 10 Future Directions
- Acknowledgments
Chapter Nineteen: Clinical and Genomic Approaches for the Diagnosis of Craniofacial Disorders
- Abstract
- 1 Introduction
- 2 Clinical Evaluation and Dysmorphology
- 3 Chromosomal Aberrations
- 4 Evolution of Copy Number Detection
- 5 Single-Candidate Gene and Panel-Based Testing
- 6 Next-Generation Sequencing
- 7 Whole-Exome Sequencing and Whole-Genome Sequencing
- 8 Future Perspectives
Chapter Twenty: Morphometrics, 3D Imaging, and Craniofacial Development
- Abstract
- 1 Introduction
- 2 Morphometrics and Morphospaces
- 3 Approaches to Morphometrics
- 4 Landmarks and Homology
- 5 Quantifying Variation
- 6 3D Imaging for Morphometrics
- 7 Future Directions—Integrating Molecular and Anatomical Imaging
- Acknowledgments
Chapter Twenty-one: Imaging the Cell and Molecular Dynamics of Craniofacial Development: Challenges and New Opportunities in Imaging Developmental Tissue Patterning
- Abstract
- 1 Introduction
- 2 Challenge of Temporal and Spatial Scales in Imaging of Craniofacial Development
- 3 Perspective

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Yang Chai