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Cornea, 2-Volume Set

  • 6th Edition - July 24, 2026
  • Latest edition
  • Editors: Mark J. Mannis, Edward J. Holland
  • Language: English

A must-have resource for residents and fellows, comprehensive ophthalmologists, and seasoned cornea specialists, Cornea, 6th Edition, remains the only reference available tha… Read more

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Description

A must-have resource for residents and fellows, comprehensive ophthalmologists, and seasoned cornea specialists, Cornea, 6th Edition, remains the only reference available that synthesizes this vast subspecialty into a single, authoritative compendium. Drs. Mark J. Mannis, Edward J. Holland, and Albert Y. Cheung lead a team of more than 300 global experts to keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management. You’ll find current coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease, all highlighted by more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs for superb visual guidance.

Key features

  • Covers the full spectrum of corneal and external disease as well as ocular surface disease and refractive surgery, including the latest surgical procedures and techniques, diagnostic and imaging technologies, and medical management
  • Contains eight new chapters: Diagnosis and Management of Neuropathic Ocular Pain, Scleral Lenses, DMEK Unfolding Techniques, Descemet’s Stripping Only, Management of Corneal Neovascularization, In-Office Corneal Procedures, Collagen Crosslinking for Pediatric Keratoconus, and Allogeneic Corneal Tissue Addition Surgery
  • Discusses key topics such as neuropathic pain, neurotrophic keratopathy, corneal neovascularization, keratoplasty, DALK, DMEK, PDEK, DSO, cultured endothelial cells, mitomycin intravascular chemoembolization, corneal allogenic intrastromal ring segments, in-office corneal procedures, and more
  • Includes more than 80 video clips of current corneal surgery techniques, including new clips of the application of amniotic membrane, penetrating keratoplasty, Descemet rupture management in DALK, and endothelial keratoplasty, among others
  • Provides key point overviews in each chapter that synthesize crucial information
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish after the publication date

Readership

Cornea specialists and fellows

Table of contents

Video Table of Contents

VOLUME 1: FUNDAMENTALS, DIAGNOSIS AND MANAGEMENT
PART 1 Basic Science: Cornea, Sclera, Ocular Adnexa Anatomy, Physiology, and Pathophysiologic Responses


1. Cornea and Sclera: Anatomy and Physiology

2. The Conjunctiva: Anatomy and Physiology

3. Tear Film

4. Eyelids and the Corneal Surface

5. A Matrix of Pathologic Responses in the Cornea

PART 2 Examining and Imaging the Cornea and External Eye
SECTION 1 Basic Evaluation of the Cornea and External Eye


6. Examination of the Lids

7. Slit Lamp Examination and Photography

8. Tear Film and Corneal Diagnostic Techniques

SECTION 2 Laboratory Investigations

9. Practical Ophthalmic Microbiology for the Detection of Corneal Pathogens

10. Molecular Genetics of Corneal Disease

SECTION 3 Imaging Techniques of the Cornea

11. Keratometry and Topography

12. Corneal Shape Analysis and Biomechanical Assessment

13. Specular Microscopy

14. Clinical Applications of Confocal Microscopy

15. High-Resolution Ultrasound

16. Anterior Segment Optical Coherence Tomography

PART 3 Differential Diagnosis of Selected Problems in Cornea and External Disease

17. Congenital Corneal Opacities Diagnosis and Management

18. Peripheral Corneal Disease

19. Evaluation of the Corneal Ulcer

20. Evaluation of Recurrent Corneal Erosions

21. Corneal Deposits

22. The Red Eye

PART 4 Eye Banking

23. Eye Banking: Structure and Function

24. Medical Standards for Eye Banking

PART 5 The Ocular Adnexa
SECTION 1 Diseases of the Lid: Anatomic Abnormalities


25. Malposition of the Eyelids

SECTION 2 Diseases of the Lid: Tumors, Inflammation and Infection

26. Benign Lid Tumors

27. Malignant Eyelid Tumors

28. Blepharitis: Overview and Classification

29. Eyelid Infections

SECTION 3 Disorders of Tear Production and the Lacrimal System

30. Dry Eye Overview: Classification and Treatment Algorithm

31. Aqueous Tear Deficiency

32. Meibomian Gland Dysfunction and Evaporative Dry Eye Disease

33. Dacryoadenitis, Dacryocystitis, and Canaliculitis

34. Epiphora

PART 6 The Conjunctiva
SECTION 1 Conjunctivitis


35. Conjunctiva: An Overview and Classification

36. Bacterial Conjunctivitis

37. Viral Conjunctivitis

38. Chlamydial Infections

39. Ophthalmia Neonatorum

40. Parinaud Oculoglandular Syndrome

41. Seasonal and Perennial Allergic Conjunctivitis

42. Vernal and Atopic Keratoconjunctivitis

43. Giant Papillary Conjunctivitis

44. Mucous Membrane Pemphigoid

45. Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, and Related Mucocutaneous Diseases

46. Toxic Keratoconjunctivitis

47. Superior Limbic Keratoconjunctivitis

48. Ligneous Conjunctivitis

49. Conjunctivochalasis

SECTION 2 Conjunctival Tumors

50. Epithelial Tumors of the Conjunctiva

51. Medical and Surgical Management of Ocular Surface Squamous Neoplasia

52. Melanocytic Neoplasms of the Conjunctiva

53. Subepithelial Tumors of the Conjunctiva

PART 7 Diseases of the Cornea
SECTION 1 Developmental Abnormalities of the Cornea


54. Developmental Corneal Anomalies of Size and Shape

55. Axenfeld-Rieger Syndrome

56. Peters Anomaly

SECTION 2 Corneal Manifestations of Systemic Disease and Therapies

57. Corneal Manifestations of Metabolic Diseases

58. Skeletal and Connective Tissue Disorders With Anterior Segment Manifestations

59. Granulomatosis With Polyangiitis and Other Systemic Inflammatory Diseases

60. Nutritional Disorders

61. Hematologic Diseases and Malignancies

62. Endocrine Disease and the Cornea

63. Dermatologic Disorders and the Cornea

64. Infectious Disease: Ocular Manifestations

65. Ocular Graft-Versus-Host Disease

66. Corneal and Ocular Surface Manifestations of Local Eye Therapies

67. Corneal and Ocular Surface Manifestations of Systemic Eye Therapies

SECTION 3 Corneal Dystrophies, Ectatic Disorders, and Degenerations

68. Corneal Dystrophy Classification

69. Anterior Corneal Dystrophies

70. The Stromal Dystrophies

71. Descemet Membrane and Endothelial Dystrophies

72. Noninflammatory Ectatic Disorders

73. Iridocorneal Endothelial Syndrome

74. Corneal and Conjunctival Degenerations

SECTION 4 Corneal Infections

75. Bacterial Keratitis

76. Nontuberculous Mycobacteria Keratitis

77. Herpes Simplex Keratitis

78. Herpes Zoster Keratitis

79. Less Common Viral Corneal Infections

80. Fungal Keratitis

81. Acanthamoeba and Other Parasitic Corneal Infections

82. Corneal Diseases in the Developing World

SECTION 5 Interstitial Keratitis

83. Syphilitic Keratitis

84. Nonsyphilitic Interstitial Keratitis

SECTION 6 Noninfectious Keratopathy

85. Filamentary Keratitis

86. Superficial Punctate Keratitis of Thygeson

87. Neurotrophic Keratopathy

88. Diagnosis and Management of Neuropathic/Nociplastic Ocular Pain

89. Factitious Keratoconjunctivitis

SECTION 7 Immunologic Disorders of the Cornea

90. Corneal Disease in Rheumatoid Arthritis

91. Corneal Disease Associated With Nonrheumatoid Collagen-Vascular Disease

92. Phlyctenular Keratoconjunctivitis and Marginal Staphylococcal Keratitis

93. Mooren Ulcer

SECTION 8 Corneal Trauma

94. Mechanical Injury

95. Chemical and Thermal Injuries of the Eye

96. Corneal Complications of Intraocular Surgery

97. External Eye Manifestations of Biological and Chemical Warfare

SECTION 9 Contact Lenses

98. Contact Lens Applications in Corneal Disease

99. Scleral Contact Lenses

100. Complications of Contact Lens Wear

PART 8 The Sclera and Anterior Uvea
SECTION 1 Disorders of the Sclera


101. Episcleritis

102. Scleritis

SECTION 2 Anterior Uveitis

103. Classification and Diagnosis of Anterior Uveitis

104. Idiopathic Anterior Uveitis

105. Human Leukocyte Antigen-B27-Associated Uveitis

106. Sarcoidosis

107. Behçet Disease

108. Fuchs Uveitis Syndrome

109. Juvenile Idiopathic Arthritis-Associated Uveitis

VOLUME 2: SURGERY OF THE CORNEA AND CONJUNCTIVA
PART 9 Keratoplasty
SECTION 1 Overview


110. The Evolution of Contemporary Keratoplasty

111. Preoperative Considerations and Decision-Making in Keratoplasty

SECTION 2 Penetrating Keratoplasty

112. Penetrating Keratoplasty: The Fundamentals

113. Intraoperative Complications of Penetrating Keratoplasty

114. Femtosecond-Assisted Keratoplasty

SECTION 3 Penetrating Keratoplasty: Postoperative Management

115. Postoperative Management

116. Diagnosis and Management of Corneal Allograft Rejection

117. Infections After Penetrating Keratoplasty

118. Glaucoma After Corneal Transplantation

SECTION 4 Anterior Lamellar Keratoplasty

119. Indications for Anterior Lamellar Keratoplasty

120. Techniques of Anterior Lamellar Keratoplasty

121. Intraoperative and Postoperative Complications of Anterior Lamellar Keratoplasty

122. Recovery Techniques in Deep Anterior Lamellar Keratoplasty

123. Outcomes of Anterior Lamellar Keratoplasty

SECTION 5 Complex Keratoplasty

124. Pediatric Keratoplasty

125. Keratoplasty in Herpes Simplex Infection

126. Immunologically High-Risk Penetrating Keratoplasty and Large-Diameter Corneal Grafts

SECTION 6 Management of Endothelial Dysfunction

127. Indications and Decision-Making for Endothelial Keratoplasty

128. Eye Bank Preparation of Tissue for Endothelial Keratoplasty

129. Surgical Techniques for Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

130. Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

131. Nanothin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

132. Complications of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

133. Outcomes of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

134. Pre-Descemet Endothelial Keratoplasty

135. Surgical Technique for Descemet Membrane Endothelial Keratoplasty (DMEK)

136. DMEK Graft Unfolding: A Systematic Approach

137. Intraoperative and Postoperative Complications of Descemet Membrane Endothelial Keratoplasty (DMEK)

138. Outcomes of Descemet Membrane Endothelial Keratoplasty (DMEK)

139. Complex Endothelial Keratoplasty

140. Descemet Stripping Only

141. Cultivated Corneal Endothelial Cell Transplantation

PART 10 Therapeutic Procedures
SECTION 1 Corneal Surgery


142. Management of Corneal Perforations

143. Therapeutic Keratoplasty

144. Surgical Management of Superficial Corneal and Conjunctival Disease

145. Management of Corneal Neovascularization

146. In-Office Corneal Procedures

147. Excimer Laser Phototherapeutic Keratectomy

SECTION 2 Conjunctival Surgery

148. Management of Primary Pterygium

149. Recurrent Pterygium

150. Conjunctival Flaps

151. Indications and Applications of Amniotic Membrane in the Clinic

152. Indications for and Uses of Amniotic Membrane in the Operating Room

SECTION 3 Anterior Segment Surgery

153. Surgical Management and Rehabilitation of Anterior Segment Trauma

154. Iris Reconstruction Surgery

155. Management of Scleral Perforation

PART 11 Collagen Crosslinking

156. Collagen Crosslinking for Keratoconus

157. Corneal Crosslinking in Children

158. Collagen Crosslinking for Corneal Ectasia After Laser Refractive Surgery

159. Collagen Crosslinking for Infectious Keratitis

PART 12 Keratoprosthesis

160. Indications for Keratoprosthesis

161. Boston Keratoprosthesis Type 1: Surgical Technique

162. Postoperative Management of Boston Keratoprosthesis Type 1

163. Complications of Boston Keratoprosthesis Type 1

164. Outcomes of Boston Keratoprosthesis Type 1

165. Boston Keratoprosthesis Type 2 Surgical Techniques, Complications, and Outcomes

166. Osteo-Odonto-Keratoprosthesis

167. Contemporary Approaches to the Biosynthetic Cornea: Overview and Classification

PART 13 Ocular Surface Transplantation

168. Classification and Staging of Ocular Surface Disease

169. Conjunctival Limbal Autograft

170. Living-Related Conjunctival Limbal Allograft

171. Keratolimbal Allograft

172. Cultivated Limbal Epithelial Transplantation

173. Simple Limbal Epithelial Transplantation

174. Perioperative Management of Ocular Surface Transplantation

175. Corneal Transplantation in Ocular Surface Disease

176. Outcomes of Ocular Surface Stem Cell Transplantation

PART 14 Refractive Surgery
SECTION 1 Preoperative Considerations


177. Decision Making in Refractive Surgery

178. Patient Evaluation and Selection in Refractive Surgery

179. Topographic and Tomographic Analysis in Keratorefractive Surgery

SECTION 2 Laser Vision Correction

180. Excimer Laser Surface Treatment: Photorefractive Keratectomy

181. Laser In Situ Keratomileusis (LASIK) Technique

182. LASIK for Myopia

183. Laser In Situ Keratomileusis (LASIK) for Hyperopia

184. LASIK Complications

185. Corneal Ectasia: Prevention, Detection, and Management

186. Keratorefractive Lenticule Extraction

SECTION 3 Additional Refractive Procedures

187. Topography-Guided Photorefractive Keratectomy

188. Intrastromal Corneal Ring Segments

189. Combined Corneal Refractive Techniques

190. Allogeneic Corneal Tissue Addition Surgery (CAIRS – Corneal Allogeneic Intrastromal Ring Segments and BLT – Bowman Layer Transplantation)

191. Incisional Keratotomy

192. Phakic Intraocular Lenses

Product details

  • Edition: 6
  • Latest edition
  • Published: July 24, 2026
  • Language: English

About the editors

MM

Mark J. Mannis

Affiliations and expertise
Professor and Chair, Department of Ophthalmology and Vision Science, UC Davis Health System Eye Center, University of California, Davis, Sacramento, CA, USA

EH

Edward J. Holland

Affiliations and expertise
Professor of Ophthalmology, University of Cincinnati, Director of Cornea Service, Cincinnati Eye Institute, Cincinnati, OH, USA