Congress Proceedings

Preface

Editors Acknowledgments

Acknowledgments

Officers

Program Committee

Award Lectures 1

Ontario Cancer Treatment and Research Foundation Richards Award

Potential for Proton Beams in Clinical Radiation Oncology

North American Hyperthermia Group J. Eugene Robinson Award

An Engineer Looks at Hyperthermia

International Association of Radiation Research Henry S. Kaplan Distinguished Science Award

From Bedside to Bench and Back

Radiation Chemistry

Congress Lecture

Electron Transfer in Biology. Some General Aspects, and Specific Contributions by Radiation Chemistry

Congress Lecture

Dynamics of Localization and Solvation of Electrons in Finite Clusters and Bulk Media

Congress Lecture

Ultrafast Dynamics of Electron Solvation

SYmposium: Early Radiation Chemistry: Femtoseconds to Nanoseconds

Concept Design of Electron Femtosecond Pulse Radiolysis

Studies of Ion Solvation Using Pulse Radiolysis

Geminate Ion Recombination in Neat Alkane Liquids Studied by Picosecond Pulse Radiolysis

Symposium: Electron Transfer in Proteins and Peptides

Protein to Protein Electron Transfer

Effects of Structure on Long-Range Electron Transfer in Peptides

Applications of Pulse Radiolysis to Studies on Metalloproteins

Symposium: Radiation Chemistry at the DNA/Water Interface

Charge Migration in Hydrated DNA

Role of Hydration in Influencing Radiation-Induced Damage of DNA at Early Times

Mechanisms of Radiation-Induced Damage of DNA in the Presence of Oxygen and Thiols

Symposium: Radiation Chemistry of Microheterogeneous Media

Radiation-Induced Processes in Microheterogeneous Media

Charge Effects on Photoionization Near Vesicle Interfaces

Radiation-Induced Growth of Micro Crystallites

Electrical Double Layer Effects on Electron Transfer Reactions at Colloidal Metal Oxide-Aqueous Solution Interfaces

DNA and Chromosomal Damage and Repair

Congress Lecture

DNA Repair-Deficient Human Diseases

Symposium: Molecular Biology of the Interphase Nucleus

Chromatin Structure and Gene Expression in Drosophila

Chromatin and Nuclear Structural Factors Which Modify the Radiosensitivity of DNA

Genomic Heterogeneity of UV-Induced Repair: Relationship to Higher-Order Chromatin Structure and Transcriptional Activity

Subnuclear Structure in Radiation and Heat Response

Symposium: Evaluation of New Approaches Used to Measure Radiation Damage in Humans

Molecular Cytogenetic Approaches to Biological Dosimetry and to Characterization of Specific Genetic Changes in Human Tumors

Biodosimetry of Ionizing Radiation in Humans Using the Glycophorin A Genotoxicity Assay

Evaluation of Four Somatic Mutation Assays as Biological Dosimeter in Humans

Experience with the "Cytochalasin-B Method" for Quantifying Radiation-Induced Micronuclei in Human Lymphocytes

Symposium: Mechanisms of Formation of Radiation-Induced Chromosomal Aberrations

Breaks and Intrachanges

The Potential Role of Chromatin Organization in the Induction and Repair of Chromosome Aberrations

The Role of Unrepaired Lesions in the Fixation of Chromosome Damage

Restriction Enzyme-Induced DNA Double-Strand Breaks as a Model to Study the Mechanisms of Chromosomal Aberration Formation

Damage Selectivity in Chromosomes

Congress Lecture

Mapping the Organizational and Functional Topography of the Cell Nucleus

Symposium: Genes Controlling DNA Repair

Genes Controlling DNA Repair

Molecular Analysis of Group A Xeroderma Pigmentosum Gene and Its Product

Genes Controlling Nucleotide Excision Repair in Mammalian Cells

Conservation of Structure and Function of DNA Repair Genes between Yeast and Human

Multiplicity of Mammalian DNA Ligases

Recent Progress in Characterizing Human DNA Repair Genes Cloned Using Rodent Cell Lines

Symposium: Enzymology of DNA Repair

Structure-Function Analyses of Uvr Proteins Catalyzing Nucleotide Excision

Base Excision Repair of Radiation Damage in Escherichia coli

Role of Human DNA Deoxyribophosphodiesterase in Excision Repair of Ionising Radiation-Induced DNA Damage

Congress Lecture

Induction of Gene Expression by Radiation

Congress Lecture

Carcinogenesis and DNA Repair in Transgenic Mice

Radiation Effects on Development

Symposium: Radiation Effects on Development

Effects after Irradiation during the Preimplantation Period

Experimental Studies on Brain Development after Prenatal Irradiation

Effects on the Development of the Human Brain after Prenatal Radiation

Uptake and Distribution of Radionuclides in the Embryo and Fetus—Implications for Dosimetry

Radiation Mutagenesis and Oncogenesis

Symposium: Cellular and Molecular Mechanisms of Radiation-Induced Mutagenesis

Mutagenesis of E. coli by Ionizing Radiation

Molecular and Cellular Basis of Radiation-Induced Base Substitutions and Genome Rearrangements in Cultured Mammalian Cells

In Vivo Mutations in Human T-Cells after Ionizing Radiation Exposures

Symposium: Mechanisms in Cellular Neoplastic Transformation

Cancer and Aging in Rodents versus Humans

Multistep Nature of Radiation-Induced Neoplastic Transformation in Syrian Golden Hamster Embryo Cells

Tumor Suppressor Gene Inactivation and Radiation-Induced Neoplastic Transformation In Vitro: Model Studies Using Human Hybrid Cells

Symposium: Radiation Carcinogenesis In Vivo: Cellular and Molecular Mechanisms

Cellular and Molecular Events Underlying Radiation and Chemical Carcinogenesis of the Rat Mammary Gland

ras Oncogene Activation in Gamma- and Neutron-Radiation-Induced Murine Thymic Lymphomas

Molecular Aspects of Ionizing Radiation-Induced Skin Carcinogenesis

Alteration of the Retinoblastoma Gene Locus in Radium-Exposed Individuals

Congress Lecture

Molecular and Cell Biology of Lung Cancer

Symposium: Radiation, Oncogenes and Human Cancer

Gene Induction by Ionizing Radiation

Oncogene Activation during Radiation Transformation In Vitro

Oncogene Activation in Ultraviolet-Induced Skin Tumors from Normal Individuals and Xeroderma Pigmentosum Patients

Mechanism of Radioresistance in Oncogene Transfected Cell Lines

Congress Lecture

Genetics of Tumor Progression

Radiation Exposure, Dosimetry and Risks

Symposium: Energy Deposition in Sub Microscopic Volumes

Techniques for Measurement of Energy Deposition in Nanometer Volumes

Variance-Covariance: A Practical Method for Microdosimetry in Submicroscopic Volumes

Energy Deposition in Sub-microscopic Volumes

Restricted LET Determines the Yield of Intratrack Pairwise Lesion Interaction

Energy Transfer Mechanisms in DNA: Relationship to Energy Deposition in Sub-microscopic Volumes

Symposium: Radioecology

Estimation of Dose to Human Tissues from Ingestion of Foods Exposed to Fallout from Nuclear Weapons Tests in Nevada

Radioecological and Dosimetric Models Used for Retrospective Predictive Assessment of Human Exposure after the Chernobyl Accident

Agricultural Countermeasures Taken in the Chernobyl Region and Evaluation of the Results

Validation of Radioecological Models Using Chernobyl Data

Radioecological Measurements after the Goiania Accident

Position of Radioecology in View of Radiation Protection: Facts and Trends

Symposium: Hazards of Radon

An Overview of the Radon Problem: Does In Vitro Research Have a Role to Play?

A Review of Experimental Animal Radon Health Effects Data

Symposium: Radiation Effects in Space: Humans and Chips

Radiation Effects in Space: Research Needs

Human Exposure to Galactic Cosmic Rays in Space

Heavy Ion Radiobiology of the Nematode Caenorhabditis elegans

Problems of Risk Estimation on the Basis of Accelerator Experiments

Radiation Risk in Space: Implications of In Vitro Heavy Ion Mutation Experiments

Potential Enhanced Risk for Space-Station Astronauts Exposed to Highly Fractionated Doses of Fast Protons

Single-Event Upsets in Microelectronics

Radiation Safety during Soviet Cosmonauts' Flights. Principles and Realization

Congress Lecture

Radiation Protection: The Basis of New Recommendations on Limits of Exposure

Radiotherapy

Congress Lecture

Radiosurgery in the Management of Intracranial Lesions: A Radiation Oncology Perspective

Congress Lecture

Clinical Experience with a Fully Three-Dimensional Treatment Planning System

Symposium: Altered Fractionation in Radiation Therapy

Introduction to Modified Fractionation

Time Factor in Radiotherapy: Repopulation and Repair Kinetics

Concomitant Boost Radiotherapy in the Treatment of Head and Neck Cancers

Continuous, Hyperfractionated, Accelerated Radiation Therapy (CHART)

RTOG Altered Fractionation Trials

Symposium: Sensitizers in Clinical Trials

The Danish Head and Neck Cancer Study Group (DAHANCA) Randomized Trials with Hypoxie Radiosensitizers in Carcinoma of the Larynx and Pharynx

Intratumoral Strategies for Clinical Radiosensitization

Radiotherapy, Carcinoma of the Cervix and the Radiosensitizer Ro 03-8799 (Pimonidazole)

European Etanidazole Phase III Trial (Progress Report)

Clinical Trials of Etanidazole (SR 2508): RTOG and Joint Center for Radiation Therapy Trials

Rationale for and Experience with Clinical Trials of Halogenated Pyrimidines in Malignant Gliomas: The UCSF/NCOG Experience

S-Phase Specific Radiosensitizers: New Experimental and Clinical Approaches to Overcome Tumor Cell Repopulation

Symposium: High-LET Radiotherapy

An Evaluation of Fast-Neutron Therapy

Boron Neutron Capture Therapy: A Means of Increasing the Effectiveness of Fast Neutron Radiotherapy

Boron Neutron Capture Therapy of Cancer: New Developments

The European High-LET Research Programs in 1991

High-LET Charged Particle Radiotherapy

High-LET Charged-Particle Radiotherapy Research Facility in Japan

Symposium: Radiolabeled Antibodies in Cancer Therapy

Strategies to Improve the Efficacy of Radioimmunotherapy: Radiobiological and Dosimetric Considerations

External-Beam and Radioimmunotherapy Dosimetry Comparison of Colorectal Xenografts

Radioimmunotherapy Studies in Breast Cancer

Symposium: Photodynamic Therapy

Second-Generation Photosensitizers for Photodynamic Therapy of Cancer

Molecular and Biochemical Analysis of Photooxidative Stress Induced by Photodynamic Therapy

Optical and Photobiological Dosimetry for Photodynamic Therapy of Solid Tumors

Approaches to Improve Photochemotherapy of Cancer

Photodynamic Therapy: Current Status and Directions for Future Research

Congress Lecture

Is Selection the Key to Success in Combining Radiotherapy and Chemotherapy?

Symposium: Validity of in Vitro Assays of Cell Survival in Predicting Outcome of Radiotherapy

In Vitro Radiosensitivity of Tumor Cells and Local Tumor Control by Radiotherapy

In Vitro Radiosensitivity and Calculated Cell Growth Fraction in Primary Cultures from Head and Neck Cancers and Cervical Carcinomas: Preliminary Correlations with Treatment Outcome

Surviving Fraction at 2 Gy versus Control of Human Cervical Carcinoma—Update of the Manchester Study

Radiosensitivity Testing in Gynecological Tumors and Malignant Gliomas

Evaluation of Different In Vitro Assays of Inherent Sensitivity as Predictors of Radiotherapy Response

The Biology of Radiation Responses

Congress Lecture

Tumor Hypoxia, Its Clinical Detection and Relevance

Symposium: Radiobiology of Human Tumor Cells

The Nature of Differences in Radiosensitivity among Human Tumor Cells

Are Human Melanoma Cells More Radioresistant In Vivo Than In Vitro!

Prospects for Modifying the Radiosensitivity of Oxic Tumor Cells

Where Do Radioresistant Cells Come From?

Variation in Radiosensitivity among Human Tumors and Human Fibroblasts

Symposium: Physiological Characteristics of Tumor Microenvironments

Microregional Heterogeneity in Tumour Perfusion

Interstitial Hypertension in Experimental and Human Tumors: Etiology and Therapeutic Implications

Oxygenation and Bioenergetic Status of Human Tumors

The pH of Human Tumors: Facts and Problems

Symposium: New Drugs Exploiting Tumor Physiology

Prospect for Improved Nitroazole Radiosensitizers

Preclinical Studies with New Mitomycin Analogs

DNA-Binding Nitroheterocycles as Hypoxia-Selective Cytotoxins

Bioreductive Drugs—Dual Function Agents and Related Compounds

Fractionation Increases the Antitumor Effect of Adding a Hypoxie Cytotoxin to Irradiation

Prospects for Drugs Exploiting Lower Tumor pH

Symposium: Growth Factors/Cytokines in Radiation Responses

The Role of TGF-ßl in the Pathogenesis of Radiation-Induced Hepatic Fibrosis

Regulatory Polypeptide Factors, Signal Transduction and Radiation Response

Role of Cytokines in Innate and LPS-Enhanced Radioresistance

Therapeutic Potential of Cytokines and Peptides in Irradiation-Induced Myelosuppression

Imaging

Congress Lecture

Metabolic Imaging of Tumors Using Emission Tomography and Nuclear Magnetic Resonance

Congress Lecture

Digital Imaging Techniques in Biology

Symposium: Synchrotoron Radiation Microimaging in Biology

Progress and Prospects in X-Ray Microscopy Imaging for Biological Sciences

Non-Ionizing Radiation

Congress Lecture

Interactions of Extremely-Low-Frequency Electromagnetic Fields with Humans

Congress Lecture

Biophysics and Biological Effects of Ultrasound

Hyperthermia

Congress Lecture

Hyperthermia 1991: A Critical Review

Congress Lecture

Aspects of Non-Invasive Thermometry

Symposium: Superficial and Deep-Heating Techniques

Superficial Hyperthermia with Microwaves

Electromagnetic Techniques for Bulky and Deep-Seated Tumors

Interstitial Hyperthermia—Evolving Technologies

Symposium: Site-Specific Clinical Trials for Thermal Radiotherapy

The Current Clinical Trials in the Thermoradiotherapy of Head and Neck Tumors

The Role of Hyperthermia in the Treatment of Local-Regional Recurrences of Breast Cancer: Influence of Pretreatment and Treatment Factors

Hyperthermia of Brain Tumors

Site-Specific Clinical Trials Using Deep Hyperthermia

Thermoradiotherapy in the USSR

Symposium: Predictors for Human Tumor Response to Hyperthermia

Thermotolerance in Human Subjects: Clinical Significance and Methods of Determination

Physiological, Glycolytic, and Cytogenetic Parameters as Predictors for Heat Treatment

Prognostic Value of Tumor Tissue pH for Tumor Response to Hyperthermia

MRI and MRS for Prognostic Evaluation and Therapy Monitoring in Soft Tissue Sarcomas Treated with Hyperthermia and Radiotherapy

Congress Lecture

Function and Regulation of the Universally Conserved Heat-Shock

Symposium: Heat-Shock Response, Regulation and Functions of HSP

Regulation and Function of hsp27 during Hypothermia

Regulation and Function of Collagen-Binding Heat-Shock Protein: hsp-47

The Expression and Function of hsp-70

The 110 kDa Heat-Shock Protein and the 170 kDa Glucose Regulated Protein

Congress Lecture

Protein Denaturation: Its Role in Thermal Killing

Symposium: Biology of Hyperthermia and Its Interaction with Radiation and Anti-Cancer Agents (In Vitro)

Hyperthermia and Radiation: Mechanisms of Interaction

Cytotoxicity In Vitro and In Vivo/In Vitro of Cw-diamminedichloroplatinum(II) (CDDP), Etanidazole, and SR-4233 under Various Conditions of pH, Oxygénation and Temperature ± Radiation

Proteins, Thermotolerance, and Heat-Induced Cell Death

Symposium: Biology of Hyperthermia: Interaction with Radiation and Drugs (In Vivo)

Radiobiological Approaches to Enhancement of Thermoradiotherapy Efficacy

Studies on Combined Treatment with X Rays, Hyperthermia and Hypoxie Cell Sensitizers on Tumors

Preclinical and Clinical Results with Chemotherapy/Hyperthermia/Radiation

Interaction of Hyperthermia and Radiation in Solid Tumors In Vivo

Indexes

Author Index

Subject Index