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Comprehensive Review of Infectious Diseases
- 1st Edition - December 20, 2019
- Authors: Andrej Spec, Gerome Escota, Courtney Chrisler, Bethany Davies
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 5 6 8 6 6 - 1
Perfect for board review or quick reference in clinical practice, Comprehensive Review of Infectious Diseases is a balanced, high-yield resource covering the full range of infect… Read more
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Request a sales quotePerfect for board review or quick reference in clinical practice, Comprehensive Review of Infectious Diseases is a balanced, high-yield resource covering the full range of infectious disease topics. Whether you’re preparing for examinations or are looking for a concise resource to support your practice, this unique review contains precisely the information you need – from common infectious diseases concepts and conditions to hundreds of up-to-date review questions and answers for self-assessment and exam preparation.
- Covers the most frequently encountered concepts and conditions in infectious diseases.
- Covers challenging areas frequently covered on the boards: clinically-relevant microbiology and ID pharmacology, HIV and antiretroviral therapy, infections in immunocompromised hosts, dermatologic manifestations of ID, infection mimics, infection control and prevention, and more.
- Includes new and emerging topics such as neglected tropical diseases, bioterrorism, and emerging and re-emerging infections.
- Provides 450 case-based, board-style multiple-choice questions and answers for test prep and self-assessment.
- Facilitates quick review and maximum retention of information by including hundreds of high-quality illustrations, tables, high-yield boxes, and bulleted lists.
- Contains practical tips for taking the boards, buzzwords and memory aids for board questions, and clinical and board pearls.
- Edited and written by rising stars in the field of infectious diseases – authors who have recently taken the boards and excelled, and who understand the challenges posed by this complex field of study and practice.
- Includes an Expert Consult™ eBook version with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Infectious Disease trainees and fellows and practitioners
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- Foreword
- Preface
- List of Contributors
- Introduction to the Board Exam
- Abbreviations
- Section 1. High Yield Microbiology
- 1. Bacteriology
- Definitions
- Gram Stain
- Blood Cultures
- Specimens for Bacteriology Culture
- Pathogen Associations
- Gastrointestinal Infections
- Identification Methods
- Antimicrobial Susceptibility Testing (AST) – Methods
- Antimicrobial Susceptibility Testing – Interpretation
- Antimicrobial Resistance Patterns – Intrinsic Resistance (Table 1.12)
- Acquired Resistance Mechanisms
- Potential Treatment Options for Resistant Bacteria
- Antimicrobials with Poor CSF Penetration
- Antimicrobials with Anaerobic Coverage
- Aerobic Actinomycetes (not to be confused with Actinomyces)
- Bacteria That Do Not Grow on Routine Culture Media (Table 1.14)
- Acid-Fast Bacilli (AFB)/Mycobacteria (see Chapters 32 and 33)
- Diagnostic Methods – All Mycobacterium spp
- Pathology Stains (Table 1.16)
- 2. Mycology
- Classification of Medically Important Fungi
- Definitions
- Yeast and Yeast-Like Organisms (Table 2.1)
- Differences among Candida spp
- Thermally Dimorphic Molds (Table 2.2)
- Zygomycetes Molds
- Hyaline Hyphomycetes (Table 2.3)
- Dematiaceous Molds (Table 2.4)
- Amphotericin-Resistant Fungi
- Diagnostic Methods
- 3. Virology
- Definitions
- Useful Information About Viruses
- Respiratory Viruses (Table 3.2)
- Viral Gastroenteritis (Table 3.4)
- Arboviruses (Table 3.5)
- Hemorrhagic Fever Viruses
- Herpesviruses (Table 3.6)
- Hepatitis Viruses (Table 3.8)
- Retroviruses (Table 3.11)
- Other Viral Agents of Clinical Significance (Table 3.12)
- 4. Parasitology
- Overview of Parasitology
- Protozoa (Tables 4.1–4.3)
- Intestinal and Urogenital Amebae, Flagellates, and Ciliates
- Intestinal Coccidia and Microsporidia
- Free-Living Amebae (Table 4.8)
- Blood and Tissue Protozoa
- Helminths
- Nematodes (Roundworms)
- Trematodes
- Cestodes (Tapeworms)
- Identification of Intestinal Pathogens
- Specimens and Methods for Diagnosis
- Section 2. Antimicrobial Agents
- 5. Antibacterials
- Antibacterial Classes and Mechanism of Action
- Antibacterial Agents
- Protein Synthesis Inhibitors
- Nucleic Acid Synthesis Inhibitors
- Antimetabolites
- Summary Tables
- 6. Antimycobacterial Agents
- Introduction
- Antimycobacterial Agents
- Bedaquiline
- Capreomycin
- Carbapenems
- Cefoxitin
- Clofazimine
- Cycloserine
- Dapsone
- Delamanid
- Ethambutol
- Ethionamide
- 7. Antifungal Agents
- Antifungal Pharmacokinetic and Pharmacodynamic Principles
- Antifungal Classes
- Polyenes
- Nucleoside Analogs
- Azoles (Imidazoles and Triazoles)
- Echinocandins
- 8. Antivirals
- Antiviral Drugs Against the Herpesviruses (Herpes Simplex Virus, Varicella-Zoster Virus, and Cytomegalovirus)
- Antiviral Drugs Against Influenza A and B and Other Respiratory Viruses
- Other Antivirals
- 9. Antiparasitic Agents
- Antiparasitic Agents
- Antimalarial Drugs
- Agents for Leishmania and Trypanosomiasis
- Agents for Other Protozoa
- Antihelminth Agents
- Section 3. Select Syndromes and Conditions by Body System or Pathogen
- 10. Fevers and Sepsis
- Fevers
- Epidemiology
- Clinical Approach to Fever
- Clinical Approach to a Fever of Unknown Origin (FUO)
- Sepsis
- Epidemiology
- Clinical Approach to Sepsis
- 11. Head and Neck Infections
- Ophthalmic Infections
- Anatomy
- Conjunctivitis
- Keratitis
- Uveitis
- Endophthalmitis
- Infections of the Head and Neck
- Parotitis
- Peritonsillar Abscess
- Ludwig’s Angina
- Vincent’s Angina
- Lemierre Syndrome
- Septic Cavernous Sinus Thrombosis
- Cervicofacial Actinomycosis
- Deep Neck Space Infections
- Osteomyelitis of the Jaw
- 12. Central Nervous System Infections
- Meningitis
- Acute Bacterial Meningitis
- Acute Viral Meningitis
- Chronic Meningitis
- Neurosurgical Infections
- Other CNS Infections
- Brain Abscess
- Subdural Empyema
- Epidural Abscesses
- Toxin-Mediated Infection
- Transmissible Spongiform Encephalopathies (TSEs)
- 13. Respiratory Infections
- Upper Respiratory Tract Infections
- Epiglottitis
- Sinusitis
- Bronchitis
- Pertussis
- Otitis Media
- community Respiratory Viruses
- Influenza
- Respiratory Syncytial Virus (RSV)
- Parainfluenza Virus (PIV)
- Adenovirus (AdV)
- Human Metapneumovirus (HMPV)
- Coronavirus
- Lower Respiratory Tract Infections
- Nosocomial Pneumonia
- Chronic Pneumonia
- Mycobacterial Pneumonia
- Pleural Infections
- 14. Bacteremia and Central Line-Associated Bloodstream Infections
- Definitions
- Epidemiology
- Gram-Positive BSI
- Gram-Negative BSI
- Clinical Presentation and Initial Assessment
- Treatment
- Central Line-Associated Bloodstream Infections (CLABSI)
- 15. Cardiac and Cardiac Device Infections
- Infections Involving Cardiac Structures
- Pericarditis
- Myocarditis
- Rheumatic Fever
- Cardiac Device-Related Infection
- Mechanical Circulatory Support Device-Related Infections
- Infection Involving the Mediastinum
- 16. Gastrointestinal Infections
- Gastroenteritis
- Risk Factors for Gastroenteritis
- Viral Gastroenteritis
- Specific Causes of Viral Gastroenteritis
- Bacterial Gastrointestinal Infections
- Specific Causes of Bacterial Gastroenteritis
- Fresh Water Pathogens
- Parasitic Causes of Diarrhea
- Toxin-Mediated Gastroenteritis
- Specific Causes of Toxin-Mediated Disease
- 17. Peritonitis, Intraabdominal Abscess, Hepatobiliary Infections, Splenic Infections
- Definitions
- Peritonitis
- Inraabdominal Abscesses
- Hepatobiliary Infection
- Pancreatitis
- Splenic Infection
- 18. Obstetric and Gynecologic Infections
- Lower Genital Tract Infections
- Female Pelvic Infections
- Urinary Tract Infections (UTI) during Pregnancy
- Other Infections Complicating Pregnancy
- 19. Genitourinary Tract Infection
- Definitions and Terminology
- Urinary Tract Infection: Pathogenesis
- Urinary Tract Infection in Pregnancy
- Renal Abscess
- Epididymitis, Orchitis, Prostatic Infection
- 20. Infections of Pregnancy
- Complications of Infection in Pregnancy: Overview
- Coxiella burnetii
- Listeriosis
- Streptococcus agalactiae
- Syphilis
- Toxoplasmosis
- Trypanosoma cruzi (Chagas Disease)
- Measles
- Parvovirus B19
- Rubella
- Zika
- Cytomegalovirus (CMV)
- Herpes Simplex Virus (HSV)
- Varicella-Zoster Virus (VZV)
- Hepatitis B (HBV)
- Human Immunodeficiency Virus (HIV)
- Other Infections in Pregnancy with Adverse Maternal Outcome
- 21. Sexually Transmitted Infections
- Definitions
- Approach to the Sexual History
- Inflammatory Infections
- Neisseria gonorrhoeae
- Mycoplasma genitalium
- Bacterial Vaginosis
- Other Causes of Vaginitis
- Genital Ulcers
- Herpes Simplex Virus Type 2 (and Type 1)
- Haemophilus ducreyi (Chancroid)
- Donovanosis (granuloma inguinale)
- Lipschutz Ulcer
- Human Papillomavirus (HPV)
- Other Pathogens Which May be Sexually Transmitted
- Hepatitis B
- Hepatitis C
- Enteric Pathogens
- 22. Hepatitis Viruses
- Clinical Presentation of Hepatitis
- Hepatitis A (HAV)
- Hepatitis B (HBV)
- Hepatitis C (HCV) (Fig. 22.3)
- Hepatitis D
- Hepatitis E (Fig. 22.6)
- Other Infection-related Hepatic Conditions
- 23. Viral Exanthems and Vaccine-Preventable Diseases
- Introduction
- Parvovirus B19
- Enterovirus
- Measles
- Rubella
- Varicella-Zoster Virus (VZV)
- Human Herpes Virus 6 and 7
- Other Viral Exanthems
- 24. Disease Due to Spirochetes, Excluding Syphilis
- Spirochetes
- Endemic Treponematoses
- Leptospirosis
- Relapsing Fevers
- Lyme Borreliosis (Lyme Disease)
- 25. Skin and Soft Tissue Infections and Toxin-Mediated Diseases
- General Principles
- Major Skin and Soft Tissue Infections
- Folliculitis
- Furuncles and Carbuncles
- Erysipelas
- Cellulitis
- Necrotizing Soft Tissue Infection
- Pyomyositis
- Clostridial Myonecrosis
- Skin and Soft Tissue Infections Encountered in Unique Clinical Situations (Table 25.2)
- Animal Bite Infections
- Infections After Traumatic Injury
- Infections Associated With Burn Injury
- Surgical Site Infections
- Other Organism-Specific Skin and Soft Tissue Infections
- Erysipelothrix Infection
- Herpes Zoster
- Dermatophytosis
- Sporotrichosis
- Differential Diagnoses for Organism-Specific Ssti BASED on Skin Lesion Characteristics (Table 25.3)
- 26. Bone and Joint Infections
- Diabetic Foot Infections and Associated Osteomyelitis
- Septic Arthritis
- Vertebral Osteomyelitis
- Prosthetic Joint Infections (PJI)
- 27. Infections Caused by Yeasts and Yeast-Like Fungi
- Cryptococcosis
- Pneumocystis
- Candidiasis
- Other Yeasts
- 28. The Dimorphic Mycoses
- Definitions
- Histoplasma capsulatum, H. duboisii
- Blastomyces dermatitidis
- Coccidioides immitis, C. posadasii
- Paracoccidioides brasiliensis, P. lutzii
- Talaromyces (Penicillium) marneffei
- Sporothrix spp.
- Emmonsia spp.
- 29. Monomorphic Mold Infections
- Microbiology
- Invasive Pulmonary Mycoses
- Chronic Pulmonary Aspergillosis
- Allergic Bronchopulmonary Aspergillosis
- Ocular Disease
- Invasive Fungal Sinusitis
- Allergic Fungal Rhinosinusitis
- Central Nervous System Infection
- Dermatophytosis
- Other Cutaneous Mold Infection
- 30. Arthropod-Borne Diseases
- Major Arthropod-Borne Diseases in the United States
- Human Granulocytic Anaplasmosis (HGA)
- Human Monocytic Ehrlichiosis (HME)
- Babesiosis
- Rocky Mountain Spotted Fever
- Rickettsialpox
- Spotted Fever Associated with R. parkeri
- STARI (Southern Tick-Associated Rash Illness)
- Tick Paralysis
- Tickborne Relapsing Fever
- Trench Fever
- Typhus Fevers
- Major Arthropod-Borne Diseases in the United States Transmitted by Mosquitoes (Table 30.4)
- Arthropod-Borne Illnesses Acquired Abroad
- Chagas Disease
- African Sleeping Sickness
- Oroya Fever
- African Tick Bite Fever
- Other Travel-Related Vectorborne Spotted Fevers
- 31. Infections Associated with Animal Exposure
- Leptospirosis
- Bartonellosis
- Brucellosis
- Q Fever
- Tularemia
- Other Important Infections
- 32. Tuberculosis
- Etiology
- Epidemiology
- Natural History
- TB Infection
- TB Disease: Clinical Syndromes
- TB Diagnosis
- Treatment
- 33. Nontuberculous Mycobacterial Infections
- Introduction
- Clinically Important Nontuberculous Mycobacteria
- Other Clinically Relevant Nontuberculous Mycobacteria Species
- 34. Protozoa
- Introduction
- Blood and Tissue Protozoa
- American Trypanosomiasis: Chagas Disease
- African Trypanosomiasis: Sleeping Sickness
- Babesiosis
- Leishmaniasis
- Toxoplasmosis
- Intestinal Protozoa
- Neobalantidiasis
- Cryptosporidiosis
- Cyclosporiasis
- Cystoisosporiasis (formerly Isosporiasis)
- Amebiasis
- Giardiasis
- A Few More Notable Intestinal Organisms
- Intestinal Pathogens: Summary
- Free-Living Ameba
- Naegleria
- Balamuthia
- Acanthamoeba
- Sappinia
- 35. Helminths
- Soil-Transmitted Helminths
- Ascaris Lumbricoides (Roundworm)
- Trichuris Trichiura (Whipworm)
- Necator americanus and Ancylostoma duodenale (Hookworm)
- Other Nematode Roundworms
- Tissue Nematodes
- Dracunculiasis: Dracunculus medinensis (Guinea Worm)
- Lymphatic Filariasis: Wuchereria bancrofti and Brugia malayi
- Loiasis: Loa loa (African Eye Worm)
- Onchocerciasis: Onchocerca volvulus (River Blindness)
- Other Important Tissue Nematodes
- Schistosomes and Other Flukes (Trematode Flatworms)
- Foodborne Trematodes (Fluke Infections)
- Clonorchis sinensis (and Opisthorchis spp.): Chinese Liver Fluke
- Paragonimiasis (Lung Fluke)
- Fasciolopsiasis (Intestinal Trematode); Fasciolopsis Buski
- Cestodes
- Echinococcosis
- Key Features: Summary (see Table 35.1)
- Section 4. Infections in the Immunocompromised Host
- 36. Natural History of HIV
- Epidemiology
- Pathogenesis
- Transmission
- Acute/Early HIV Infection
- Long Term Nonprogressor HIV Infection
- Diagnostics
- Prevention
- 37. Noninfectious Complications of HIV
- Neurologic Complications
- Dermatologic Manifestations
- Endocrinopathy
- Hematologic Manifestations
- Kidney Complications
- Cardiovascular Complications
- Pulmonary Complications
- Gastrointestinal Manifestations
- Malignancies
- Summary of Common HIV-Associated Conditions
- 38. Antiretroviral Therapy
- Antiretroviral Agents
- What, When, and Why of Antiretroviral Therapy
- Drug–Drug Interactions
- Special Considerations
- 39. Opportunistic Infections in HIV
- Definitions
- Epidemiology
- Diagnostic Approach
- Treatment
- Prevention
- Overview Of Key Opportunistic Infections
- Bacterial Infections
- Protozoal Infections
- Viral Infections
- HIV-Associated Malignancies
- 40. Infections in Patients with Cancer and Immunosuppressive Therapy
- Febrile Neutropenia (FN)
- Bloodstream Infections
- Neutropenic Colitis
- Pneumonia
- Invasive Mold Infections (see Chapter 29)
- Unique Infection Risks in Patients With Hematologic Malignancies
- Infections Associated With Other Chemotherapy Agents
- Infections Associated With Immunosuppressants
- 41. Infections in Solid Organ Transplant Recipients
- Introduction
- Risk Assessment for Infectious Disease
- Donor and Recipient Screening
- Vaccinations
- Timely Diagnosis and Management of Infectious Complications
- 42. Infections in Bone Marrow Transplant Recipients
- Definitions
- Epidemiology
- Infections Encountered After HCT
- Clinical Presentation
- 43. Primary Immunodeficiency Disorders
- Definition
- Presentation
- Assessment
- Treatment
- Section 5. Specialty Topics
- 44. Infection Control and Prevention
- Definitions
- Outbreak Investigation
- Infection Prevention Programs
- Surveillance for HAIs
- Employee Health
- Antimicrobial Stewardship
- 45. Adult Immunization
- Definitions
- Vaccines Used in Adults
- Bacille Calmette–Guérin (BCG) Immunization against Tuberculosis
- Haemophilus influenzae Type b (Hib) Immunization
- Hepatitis A Virus (HAV) Immunization
- Hepatitis B Virus (HBV) Immunization
- Herpes Zoster Immunization
- Human Papilloma Virus (HPV) Immunization
- Influenza Immunization
- Tetanus, Diphtheria, Acellular Pertussis, and Inactivated Polio Immunization
- Measles, Mumps, and Rubella (MMR) Immunization
- Meningococcal Immunization
- Pneumococcal Immunization
- Immunization Recommendations Summary
- 46. General Principles of Travel Medicine
- Pretravel Consultation
- Travelers With Special Health Needs
- Posttravel Evaluation
- 47. Bioterrorism
- Background
- Syndromic Awareness
- Categorization of Biological Agents
- Category A Organisms
- Category B Organisms
- 48. Syndromes that Mimic Infectious Diseases
- Introduction
- Fever as Principal Feature
- Vasculitis
- Neoplastic Disorders
- Autoinflammatory Diseases
- Fever and Rash
- Fever, Muscular Rigidity, Mental Status Change
- Fever and Cytopenia
- Pneumonia Mimics
- Lymphadenopathy
- Gastrointestinal Syndromes
- Cellulitis Mimics
- Osteomyelitis Mimics
- Other ID Mimics
- 49. High Yield Biostatistics
- Introduction
- Definitions
- Common Study Designs in Infectious Diseases
- Types of Statistical Tests for Independent Samples
- Evaluation of Diagnostic Tests
- 50. Commonly Encountered Skin Manifestations in Infectious Disease
- Bacterial Skin Diseases
- Mycobacterial Skin Diseases
- Fungal Skin Diseases
- Dimorphic Mycoses (see Chapter 28)
- viral Skin Diseases
- Herpes Simplex Virus (HSV)
- Human Papilloma Virus (HPV)
- Hand, Foot, and Mouth Disease (HFMD) (see Chapter 23)
- Associated with HIV/AIDS (see Chapters 37 and 39)
- Parasitic Skin Diseases
- Cutaneous Helminthiasis
- Infestations
- Summary of Cutaneous Manifestations of Infection
- 51. ID Memory Aids
- A–Z of Zoonoses
- Food Associations
- Environmental Exposures
- ‘I say…, you say…’
- Disease Associations
- Clinical Clues
- Hematology Hints
- Micro Triggers
- Pathology Prompts
- Radiological Reminders
- Where in the World?
- Miscellaneous Mishmash
- Key Antimicrobials-Associated Adverse Events
- Acronyms
- Section 6. Self-Assessment
- Quiz 1
- Quiz 2
- Quiz 3
- Quiz 4
- Quiz 5
- Quiz 6
- Quiz 7
- Quiz 8
- Quiz 9
- Section 7. Self-Assessment Answers
- Answers 1
- Answers 2
- Answers 3
- Answers 4
- Answers 5
- Answers 6
- Answers 7
- Quiz 8 Answers
- Answers 9
- Index
- No. of pages: 776
- Language: English
- Edition: 1
- Published: December 20, 2019
- Imprint: Elsevier
- Hardback ISBN: 9780323568661
AS
Andrej Spec
Affiliations and expertise
Assistant Professor, Infectious Disease, Associate Director, Infectious Disease-Clinical Research Unit, Division of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St Louis, MissouriGE
Gerome Escota
Affiliations and expertise
Associate Professor of Medicine, Co-Director, Infectious Diseases Fellowship Program, Director of the Internal Medicine Clerkship, Division of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St Louis, MissouriBD
Bethany Davies
Affiliations and expertise
Senior Lecturer in Infection, Brighton and Sussex Medical School Falmer, Brighton, UK