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Elsevier

Comprehensive Natural Products III

  • 3rd Edition - July 22, 2020
  • Latest edition
  • Editors: Hung-wen Liu, Tadhg Begley
  • Language: English

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structura… Read more

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Description

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community.

Key features

  • Covers the complete arc of natural-products science in one authoritative reference: isolation and structure elucidation, biosynthetic pathways and enzyme mechanisms, chemical ecology, synthetic biology, and modern discovery methods.
  • Captures the decade’s defining advances: genome mining, biosynthetic gene clusters, mass spectrometry and metabolomics, biosynthetic pathway engineering, and the bioinformatics and AI tools that link genes to molecules.
  • Bridges chemistry and biology for a multidisciplinary readership: chemists, biochemists, synthetic and molecular biologists, pharmacologists, microbiologists, and drug-discovery researchers in academia and industry.
  • Structured for fast, flexible access: from indepth overviews for students and newcomers to critical, forward-looking chapters for specialists.
  • Connects fundamental science to real-world impact across medicine, agriculture, and biotechnology.

Readership

Advanced graduate students, postdoctoral researchers, and academic and industrial R&D scientists in natural products chemistry, chemical biology, biosynthesis, and drug discovery.

Institutional: An essential reference for university libraries and for pharmaceutical, biotechnology, and agricultural and food research organisations — offering authoritative insight into how bioactive molecules are discovered, biosynthesised, engineered, and applied.

Table of contents

1. Structural Diversity of Natural Products and Secondary Metabolites
a. Major natural products families and biosynthesis

2. Structural Diversity of Natural Products and Secondary Metabolites
b. Terrestrial, marine, and prokaryotic sources of natural products and chemical biology
(Producing organisms, structural analyses, and biosynthetic pathways. To be split across two volumes for a comprehensive review covering all recent discoveries and advances.)

3. Amino Acids, Peptides and Proteins

4. Carbohydrates, Nucleosides and Nucleic Acids

5. Enzymes and Enzyme Mechanisms
(Radical SAM enzymes, metalloenzymes, Lewis acid/base versus radical-mediated mechanisms, etc.)

6. Development and Modification of Biological Molecules and Pathways
(Synthetic biology, systems biology, biological pathway engineering, protein engineering, etc.)

7. Modern Methods for the Study of Natural Products and Their Biosynthesis
(Analytical, chemical and genetic methods and new bioinformatics tools)

8. Index

Review quotes

Reviews for the second edition:
"A marvelous and monumental piece of work."—Journal of the American Chemical Society
"This work is essential for libraries at institutions where natural product research is seriously pursued or contemplated."—Choice

Product details

  • Edition: 3
  • Latest edition
  • Published: July 22, 2020
  • Language: English

About the editors

HL

Hung-wen Liu

Editor-in-Chief of the previous edition of Comprehensive Natural Products in 2010 (with Professor Lew Mander, now retired), Hung-Wen (Ben) is a Professor of Medicinal Chemistry, College of Pharmacy, and Professor of Chemistry, College of Natural Sciences, University of Texas as well as the George H. Hitchings Regents Chair in Drug Design. His research lies at the crossroads of chemistry and biology and he is currently working on Enzyme Mechanism and Inhibitor Design, Metabolic Pathway Engineering, and Protein Function Regulation. Fellow of the American Association for the Advancement of Science, American Academy of Microbiology, Japan Society for the Promotion of Science, American Chemical Society and former Chair of the American Chemical Society Biological Division. Advisory Board member of the Institute of Chemistry Academia Sinica, Institute of Biological Chemistry Academia Sinica, Genomic Research Center, Academia Sinica, and the Alberta Glycomic Centre and member of the Advisory Committee of the National Health Research Institutes, Institute of Biotechnology & Pharmaceutical Research in Taiwan. He’s on the Editorial Board of Chemical Record (Chemical Society of Japan) and Perspectives in Medicinal Chemistry, the Editorial Advisory Board of Letters in Organic Chemistry, Bioorganic Chemistry, Biochemistry, Journal of Chinese Chemical Society and Synthetic and Systems Biotechnology and an Associate Editor for Organic Letters (ACS).
Affiliations and expertise
Professor of Medicinal Chemistry, College of Pharmacy, and Professor of Chemistry, College of Natural Sciences, University of Texas and George H. Hitchings Regents Chair in Drug Design

TB

Tadhg Begley

Distinguished Professor Tadhg Begley is Robert A. Welch Foundation Chair and Derek Barton Professor in Chemistry at Texas A&M University. He is currently on sabbatical as Newton Abraham Visiting Professor at Oxford University. Professor Begley’s research is focused on the mechanistic enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. He also has a strong interest in the development of chemical biology and has helped organize several major conferences and is the co-organizer of the NIH sponsored Young faculty mentoring workshop. He is the recipient of the Merck Faculty Development Award, the Camille and Henry Dreyfus Teacher-Scholar Award and the ACS Repligen Award in Chemistry of Biological Processes for outstanding contributions to the understanding of biological processes with particular emphasis on structure, function and mechanism. He is co-author of The Organic Chemistry of Biological Pathways (2005) and the editor of Wiley’s 4-volume Encyclopedia of Chemical Biology, as well as a section editor for the previous editor of Comprehensive Natural Products in 2010. Professor Begley is a member of the editorial boards for Molecular Biosystems, Vitamins and Hormones, Bioorganic Chemistry, Chemical Biology and Drug Design and Journal of Biological Chemistry. He has an h-index of 49.
Affiliations and expertise
Robert A. Welch Foundation Chair and Derek Barton Professor in Chemistry, Texas A&M University

View book on ScienceDirect

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