Section 1: Forwards – ICCIDD and WHOSection 2: Analytical TechniquesChapter 1Determination of Iodine in Seawater: Methods and ApplicationsHua-Bin Li, Xaing-Rong Xu, and Feng ChinChapter 2 Assay of Iodine in Foodstuffs: Methods and ApplicationsJane KučeraChapter 3Determination of Iodine in-vivo and in-vitro by X-Ray Fluorescence Analysis: Methodology and ApplicationsMarie Hansson, Gertrud Berg, and Mats IsakssonChapter 4Plasma Analytes for Determination of Thyroid StatusRuth M. Ayling and Jinny JeffreyChapter 5Interpretation of Thyroid Function Tests and Their Relationship to Iodine Nutrition: Changes in TSH, Free T4 and Free T3 Resulting From Iodine Deficiency and Iodine ExcessColin M. Dayan and Vijay PanickerChapter 6Thyroglobulin as an Indicator of Iodine IntakeRadovan Bílek and Václav ZamrazilChapter 7Computer Systems for Monitoring Effects of Iodine/Thyroid Status in PopulationsInge Bülow Pederson, Peter LaurbergSection 3: General Aspects of Iodine Sources and Intakes in the Diet, Main Routes of Iodine Metabolism and Metabolic RolesSection 3.1: Iodine Cycle and ChemistryChapter 8Iodine in the AirRussell W. Saunders and Alfonso Saiz-Lopez Chapter 9Iodine and Iodine Species in Sea Water: Speciation, distribution and dynamicsKazuaki Ito and Takeshi HirokawaChapter 10Geochemical Cycling of Iodine Species in SoilsQinhong Hu, Jean E. Moran, and Van BlackwoodChapter 11Transfers of Iodine in the Soil-Plant-Air System: Solid-Liquid Partitioning, Migration, Plant Uptake and VolatilisationDaniel J. AshworthChapter 12Iodine in the Ecosystem: An OverviewAnthony J. Yun, Patrick Y. Lee, Kimberly A. Bazar, Stephanie M. Daniel, and John D. DouxChapter 13The Nature of Iodine in Drinking WaterStig Andersen and Peter Laurberg Chapter 14Application of Iodine Water Purification Tablets: Iodine's Efficacy Against Cryptosporidium ParvumJeffrey A. StarkeChapter 15Iodine Speciation in Foodstuff, Tissues and Environmental Samples: Iodine species and analytical methodXiaolin HouChapter 16Iodine in Farm AnimalsF. Schöne and Rajkumar RajendramChapter 17Radiochemistry of Iodine: relevance to health and diseaseC.C. Lin and J.H. ChaoSection 3.2: Physiology, Metabolism and BiochemistryChapter 18Retention of Iodine in the Body: Biological Half-Life of Iodine in the Human BodyGary H. KramerChapter 19Mathematical Models of Human Iodine Metabolism, Including Assessment of Human Total Body Iodine ContentMarguerite HaysChapter 20Iodine Transfer Through Mother's Milk: The Influence of BromideStanislav PavelkaChapter 21Cellular Iodine Transport: Body Distribution of the Human Sodium Iodide SymporterMatthew J. Provenzano and Frederick DomannChapter 22Sodium-Iodide Symporter (NIS) in Gastric Mucosa: Gastric Iodide SecretionMalin Josefsson and Eva EkbladChapter 23Regulation and Enhancement of Sodium Iodide Symporter (NIS) Expression: NIS Regulatory Pathways in Thyroid and Breast CancerTakahiko Kogai and Gregory A. BrentChapter 24Pendred's Syndrome: Deficiency in Iodide TransportPeter Kopp, Sabine Schnyder, Liuska PesceChapter 25Autoregulation of Thyroid Growth and Function by Iodine: TSH-independent regulation of the thyroid gland by iodocompoundsRoland GärtnerChapter 26Is Iodine an Antioxidant and Antiproliferative Agent for the Mammary and Prostate Glands?Carmen Aceves and Brenda AnguianoChapter 27Uncertainty of Iodine Particulate Deposition in the Respiratory TractRichard P. HarveyChapter 28The relationship Between Thiocyanate and IodinePeter Laurberg, Inge Bülow Pedersen, Allan Carlé, Stig Andersen, Nils Knudsen, and Jesper KarmisholtChapter 29Environmental Perchlorate and the ThyroidLewis E. BravermanChapter 30Iodate and Perchlorate in Bottled Water: Methods for Discovery and Impact to HumansShane A. Snyder, Brett J. Vanderford, and Fernando L. Rosario-OrtizChapter 31Dioxins, PCBs and Iodine: Effects on Synthesis and Metabolism of the Iodine Containing Thyroid HormonesVeerle Bruggeman and Veerle DarrasChapter 32Iodide Effects on the Thyroid: Biochemical, Physiological, Pharmacological and Clinical Effects of Iodide in the ThyroidValerie Panneels, Guillermo Juvenal, Jean-Marie Boeynaems, Jacques E. Dumont, and Jacqueline Van SandeChapter 33Influences of Iodine on the Immunogenicity of ThyroglobulinGeorge Carayanniotis and Yi-chi M. Kong Chapter 34Goiter in the Elderly: The Role of IodineShakaib U. Rehman, Mohammed M. Ahmed, and Florence N. HutchisonSection 3.3: Nutrition and Dietary Aspects Chapter 35Iodine Intake and Food ChoiceLone B. Rasmussen, Stig Andersen, Lars Ovesen, and Peter LaurbergChapter 36Iodine Mineral Water and Its Therapeutic Use in Health Resorts: Iodine consumption from natural mineral waters and its effect on the bodyManfred Klieber, Rudolf Winkler, and Rajaventhan SrirajaskanthanChapter 37The Iodine Content of Foods and Diets: Norwegian PerspectivesLisbeth Dahl and Helle Margrete MeltzerChapter 38Correlation between Soy Phytoestrogens and Thyroid Laboratory Parameters: Implications for Iodine Richard Hampl, Daniela Ostatníková, Peter Celec, Zdeněk Putz, Radovan Bílek, Oldřich Lapčik, Petr MatuchaChapter 39Knowledge of Iodine NutritionPieter L. JoosteChapter 40Iodine Metabolism and Parenteral NutritionRobert Hume and Fiona L.R. WilliamsChapter 41 Iodine Content of Standard Infant Formula and Specialized Enteral PreparationsRobert Hume, Karen Lang, and Fiona L.R. WilliamsSection 3.4: Iodine MetabolismChapter 42Trimester-Specific Changes in Maternal Thyroid Hormones: Implications for Iodine NutritionOffie P. Soldin and Danielle SoldinChapter 43The Relationship between Population Iodine Statistics to Iodine Status of Individuals: A possible approach for more comprehensive characterization of iodine nutritional statusVolker F.H. Brauer and Ralf PaschkeChapter 44Variation in Iodine Excretion in Healthy IndividualsStig Andersen, Jesper Karmisholt and Peter LaurbergChapter 45Assessment of Iodine Intake and Iodine Status in VegansHelen J. LightowlerChapter 46Isotopes of Iodine in Thyroid Tissue and Urine: source, application, level and distributionXiaolin Hou and Wenjun DingChapter 47The U-shaped Curve of Iodine Intake and Thyroid DisordersPeter Laurberg, Inge Bülow Pedersen, Allan Carlé, Nils Knudsen, Stig Andersen, Lars Ovesen, and Lone B. RasmussenSection 4: Pathological Aspects of Iodine DeficiencySection 4.1: General Aspects of PathologyChapter 48Iodine Deficiency: The Extent of the ProblemBruno de Benoist, Erin McLean, and Maria AnderssonChapter 49Iodine Deficiency in Pregnancy: Iodine deficiency and supplementation in pregnancyJohn H. Lazarus and Peter PA Smyth Chapter 50Iodine Nutrition and Iodine Deficiency in Term and Pre-Term Newborns Susana Ares, José Quero, and Gabriella Morreale de EscobarChapter 51Oxidative Damage in Iodine DeficiencyFiliz HincalChapter 52Iodine Deficiency in Relation to Iron Deficiency and Parasitosis: Effect of iron status and parasites on iodine deficiency disordersEdgar M. Vásquez-Garibay and Enrique Romero VelardeChapter 53Iodine Deficiency and Thyroid Cancers: Effect of Iodine Prophylaxis on Thyroid Cancer MorphologyH. Rubén HarachChapter 54Iodine Deficiency in Vegetarian and Vegan Diets: Evidence-Based Review of the World's Literature on Iodine Content in Vegetarian DietsCheryl Fields and Jonathan BorakChapter 55Relationship between Iodine Intake and Thyroid SizeLone B. Rasmussen, Peter Laurberg, and Lars OvesenChapter 56Thyroid Peroxidase (TPO) Deficiency and Total Iodide Organification DefectLaura FugazzolaChapter 57Iodine Deficiency, Antioxidant Response and Mutagenesis in the Thyroid GlandKnut Krohn and Ralf PaschkeChapter 58Adaptation to Iodine Deficiency: experimental aspectsGabriella Morreale de Escobar, Maria-Jesus Obregon, Pablo-Enrique Pedraza, Rosa Calvo, and Francisco Escobar del ReyChapter 59Iodine and ExercisePeter PA Smyth, Derek F. Smith, George C. Cloughley, Robert A. Burns, and L.H. DuntasChapter 60Antibodies to Thyroid Peroxidase and Thyroglobulin in Iodine DeficienciesInge Bülow Pedersen and Peter LaurbergChapter 61Bromide Interference with Iodine Metabolism: Goitrogenic and Whole-Body Effects of Excessive Inorganic Bromide in the Rat Stanislav PavelkaSection 4.2: The Effects on the Brain and Neurological AspectsChapter 62Iodine Deficiency and the Brain: an overviewBasil S. HetzelChapter 63Iodine-Deficient Gestation and Neuro-Development of 3 Year-Old ChildrenM. Francisco Rivas-Crespo, Isolina Riaño Galán, Paloma Sánchez Martínez, and María Pilar Mosteiro DíazChapter 64Experimental Models of Iodine Deficiency and Cretinism During Development: The Role of the MotherMaria-Jesus Obregon, Rosa Maria Calvo, Francisco Escobar del Rey, and Gabriella Morreale de EscobarChapter 65The Effects of Hypothyroidism Due to Iodine Deficiency in Neonatal Brain: The Changes in Brain Metabolites Detected by Magnetic Resonance SpectroscopyAyşehan Akinci and Hakki Muammer KarakaşChapter 66The DI02 (Deiodinase Type 2) Gene and Mental Retardation in Iodine-DeficiencyTing-wei Guo, David St. Clair, and Lin HeChapter 67DNA Damage in Brain and Thyroid Gland Cells Due to High Fluoride and Low IodineJundong Wang, Yaming Ge, Hongmei Ning, and Ruiyan NiuChapter 68Attention Deficit and Hyperactivity Disorders Due to Iodine Deficiency: A Novel Iodine Deficiency Disorder Affecting the Offspring of Hypothyroxinemic MothersFrancesco Vermiglio, Mariacarla Moleti, and Francisco TrimarchiChapter 69Brain Iodine and Other Halogens of Control and Alzheimer's Diseased Patients: brain iodine deficiency in Alzheimer’s diseaseE. Andrasi and N. PáliChapter 70A Novel Iodine Deficient Disorder: Gestational Hypothyroxinemia. How Safe is it for Progeny?Maricarla Moleti, Francisco Trimarchi, and Francesco VermiglioChapter 71Iodine, Selenium Deficiency and Kashin-Beck DiseaseRodrigo Moreno-ReyesChapter 72Iodine, Thyroid Diseases and Neuromuscular DysfunctionHuy A. TranChapter 73Reduced Iodine Intake and Iodine Prophylaxis in Pregnancy: Importance of Hypothyroxinemia in the First Trimester of GestationRicardo V. Garcia-Mayor, Antonia Rego-Iraeta, and Montserrat RiosSection 5: Treatment of Iodine Deficiency DisordersChapter 74The Role of the ICCIDD in the Global Program for the Elimination of Brain Damage Due to Iodine Deficiency Basil S. HetzelChapter 75Iodine Fortification: Some Industrial Initiatives and ConcernsRuchika Mehra and Kalyan SrinivasanChapter 76Labelling Techniques Using Iodine-123: Applications to Clincial SettingsValerie Ardisson and Nicolas LepareurChapter 77Effect of Iodine Restriction on Thyroid Function in Patients with Hashimoto's ThyroiditisKyung Rae and Chul Sik KimChapter 78Effect of Lifelong Iodine SupplementationGertrud Berg and Ernst NyströmChapter 79Evaluating the Efficiency of Iodisation Programmes: Impact of Iodine Prophylaxis on Different Aspects of Life and SocietyAmar K. ChandraChapter 80Net Benefits of the Active Iodine Prophylaxis Over the Silent Prophylaxis: Policy Implications Based on a Natural ExperimentVenanzio VellaChapter 81Treatment Regimens in Toxic and Diffuse Goiters in Iodine Deficiency: Goiter and Hyperthyroidism in Iodine DeficiencyRudolf HoermannChapter 82Are There Side Effects When Using Supraphysiologic Levels of Iodine in Treatment Regimens?Jack KesslerChapter 83Iodination of Salt in Poland: Past and the FutureWieslaw M. GrzesiukChapter 84Iodine Supplementation Fails to Target the Elderly: Perspectives from AustriaPeter Lind, Susanne Kohlfürst, Isabel Igerc, Martin Heinisch, Hans Jürgen Gallowitsch, and Hartmut AignerChapter 85Healthcare Service Delivery in Achieving Sustained Elimination of Iodine Deficiency Disorders: A Case Study of ChinaMu Li, Zupei Chen, and Creswell J. EastmanChapter 86Evaluation of Iodine Prophylaxis in Czech Republic: Changes of Ioduria, Thyroid Status and AutoimmunityVáclav Zamrazil, Radovan Bilek, Jarmilla Čerovská, Marcela Dvoráková, Petra Hoskovcová, and Ivan ŠterzlChapter 87The Effects of Salt Iodination on Normal Thyroid Physiology and Graves’ Disease in IndiaAjay Sood and Denish MoorthySection 6: Damage and Disease Due to Iodine ToxicityChapter 88Developmental Effects of Toxic Doses of IodineX.F. Sun and X.F. YangChapter 89Thyroiditis and Salt Iodination: Effect of dietary iodine on the prevalence of histological autoimmune thyroiditisH. Rubén HarachChapter 90Detrimental Effects of Increasing Iodine Supply: Iodine-Induced Hyperthyroidism, Following Iodine ProphylaxisAndrzej Lewinski, Dorota Slowinska-Klencka, Mariusz Klencki, Bozena Popowicz, Arkadiusz Zygmunt, and Malgorzata Karbownik-LewinskaChapter 91Experimental Studies on the Effects of Excessive Iodine Supplementation on the Thyroid TissueZhongyan Shan, Weiping P. Teng, and Yaxin LaiChapter 92Frequency, Pathogenesis, Prevention and Treatment of Iodine-Induced HyperthyroidismKatja S. Mühlberg and Ralf Paschke Chapter 93Iodine-Induced Toxic Effects Due to Seaweed ConsumptionKarsten MüssigChapter 94The Toxicology of Iodate: A Literate Survey in View of its Use in Iodized SaltHans Bürgi, Th. Schaffner, and J.P. SeilerChapter 95Iodine-Containing Compounds: Use in Patients with Documented Adverse ReactionsSara D. BrouseChapter 96Influence of Iodine-Containing Pharmaceuticals on Iodine Status and Thyroid Function: Iodine-Induced Hyperthyroidism and HypothyroidismKeigo NobukuniChapter 97Two Unusual Situations of Excess Iodine Ingestion: A Faulty Iodinator and the US Space ProgramLewis E. BravermanSection 7: Radiodine in the Non-Iodine Deficient SubjectChapter 98The Use of 131-Iodine in the Treatment of Graves' Disease in ChildrenScott A. Rivkees and Catherine DinauerChapter 99The Low Iodine Diet Prior to Radioiodine Administration in the Management of Differentiated Thyroid CancerRobin J. Prestwich and Georgina E. GerrardChapter 100Use of 131-Iodine and Risk of Radiation Exposure: Potential Hazards to the Patient and Other PeopleTone Cappelen and Jan Frede UnhjemChapter 101The Sodium Iodide Symporter (NIS): NIS-Mediated Radioiodide TherapyChristine Spitzweg and John C. MorrisChapter 102Using Retinoids to Increase Radio-Iodine Uptake in Thyroid Cancer: Role as Potential Re-Differentiation AgentsWendy Ella and Susan ShortChapter 103The Use of Lithium as an Adjuvant in the Radioactive Iodine Treatment of Thyroid CancerMarina S. Zemskova and Francesco Saverio CeliChapter 104131 Iodine in Thyroid Cancer: Use of 131 I in the Diagnosis and Therapy of Differentiated Thyroid CarcinomasDominick LamonicaSection 8: Other Causes of HypothyroidismChapter 105The Extent of Hypothyroidism in the United StatesHenry G. Fein and David S. CooperChapter 106Hypothyroidism in the Middle Aged and Elderly: Clinical AspectsJuan J. Diez and Pedro IglesiasChapter 107Hypothyroidism in the Middle Aged and Elderly: Therapeutical AspectsJuan J. Diez and Pedro IglesiasChapter 108Brain Damage in Clinical Hypothyroidism in ChildhoodJunko Arii and Yuzo TanabeChapter 109Hypertension and Hypothyroidism: A Thyroid Dysfunction Frequently Associated with an Abnormal Dietary Iodine IntakeGiorgio Iervasi and Enza FommeiChapter 110Heart Failure, Iodine Intake and Thyroid HormonesGiorgio Iervasi and Alessandro PingitoreChapter 111Skeletal Muscle Changes in HypothyroidismCarlos B. Mantilla, Douglas E. Dow, and Gary C. SieckChapter 112Ocular Aspects of Hypothyroidism: Neuro-Ophthalmological Dysfunction in Relation to Thyroid Disease and IodineA. Seah and Y.L. LoChapter 113Pregnancy and Hypothyroidism: Autoimmune Thyroiditis and Iodine Deficiency Complicating Mother and FetusMarcos Abalovich and Daniel GlinoerChapter 114How the Public and Private Sector Have Successfully Come Together in Efforts to Universally Iodize SaltZahra Popatia, Barbara Macdonald, and Rajan SankarChapter 115Iodine Status Reflected by Urinary Concentrations: Comparison with USA and Other CountriesOffie P. SoldinChapter 116Iodine Intake in European ElderlyAgnes N. Pedersen and Lone B. RasmussenChapter 117Iodine Deficiency in Pregnant Women in EnglandMohammed S. KibirigeChapter 118Epidemiology of Thyroid Disorders in GermanyHenry Völzke and Michael ThammChapter 119Surveillance of Thyroid Disorders and Iodine Intake in the Danish Population Before and After Mandatory Iodide Fortification of Salt: The DanThyr ProgramPeter Laurberg, Torben Jørgensen, Hans Perrild, Lars Ovesen, Nils Knudsen, Inge Bülow Pedersen, Lone B. Rasmussen, Allan Carlé, and Pernille VejbjergChapter 120Iodine Nutrition in Bulgaria: Results from the National Strategy for Elimination of Iodine Deficiency Disorders in Bulgaria-Epidemiologic Studies on Risk Population GroupsPenka Dimitrova Gatseva and Mariana Dimitrova ArgirovaChapter 121Iodine Status in Individuals: An Italian PerspectiveGiuseppe CostanteChapter 122Dietary Iodine Intake in Ukraine Kunio Shiraishi, Susumu Ko, Pavlo V. Zamostyan, Nikolay Y. Tsigankov, Ivan P. Los, and Vitaly N. KorzunChapter 123Iodine Status in Individuals: An Argentine PerspectiveHugo Niepomniszcze, Daniel Bernatené, and Gerardo SartorioChapter 124Iodization of Salt: The Control of Iodine Deficiency Disorders in BrazilMargarete Nimer, José Armando Ansaloni, and Marcelo Eustáquio SilvaChapter 125Effects of Excessive Iodine Intake on Thyroid Diseases: An Epidemiological Study from ChinaWeiping P. Teng, Zhongyan Shan, and Xiaochun TengChapter 126Iodine Deficiency Disorders in ThailandSangsom SinawatChapter 127The Current State of Iodine Deficiency Disorders (IDD) in Australia and the Pacific StatesCreswell J. Eastman and Mu LiChapter 128History of Iodine Deficiency in School Children in Tasmania, AustraliaKristen L. Hynes, C. Leigh Blizzard, Petr Otahal, Judy A. Seal, Alison J. Venn, Terence Dwyer, John R. Burgess, and RoscoeTaylorChapter 129Iodine Deficiency Disorders in New ZealandChristine D. Thomson and Sheila A. SkeaffChapter 130Iodine Nutrition in Pregnancy: Meeting Iodine Requirements in the Diets of Pregnant WomenSheila A. SkeaffChapter 131Iodine Deficiency Disorders in MaliAbdel Kader Traoré and Liv Elin TorheimChapter 132Nutritional, Endocrine and Pathological Aspects of Iodine Deficiency Disorders in IndiaArijit Chakrabarty, Chandrakant S. Pandav, N. Tandon, and M.G. Karmarkar