Comprehensive Clinical Nephrology
- 8th Edition - December 1, 2026
- Latest edition
- Editors: Marcello Tonelli, Richard J. Johnson, Jurgen Floege, Anupam Agarwal
- Language: English
Ideal for board preparation or as a concise, authoritative resource in clinical practice, Comprehensive Clinical Nephrology, 8th Edition, remains the reference of choice for fello… Read more
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Description
Description
Ideal for board preparation or as a concise, authoritative resource in clinical practice, Comprehensive Clinical Nephrology, 8th Edition, remains the reference of choice for fellows, practicing nephrologists, and internists who treat patients with disorders affecting the kidney. Global leaders in nephrology offer a practical approach to this complex field, supported by underlying scientific facts and pathophysiology. You’ll find current information on the full spectrum of clinical procedures and conditions, including new and updated content throughout—all in a single, convenient volume.
Key features
Key features
- Covers everything from fluid and electrolyte disorders to hypertension, diabetes, dialysis, transplantation, and more, providing just the right amount of basic science and practical clinical guidance to help you make efficient and informed decisions
- Contains a new section on women and kidney health addressing sex-specific considerations in kidney disease diagnosis and management, and a new section on climate, environment, and the kidney examining the impact of environmental factors and climate change on renal health
- Provides outstanding visual guidance with more than 1,500 full-color illustrations, as well as more color-coded algorithms for diagnosis, treatment, and management: yellow boxes for general information, green boxes for therapeutic intervention, and blue boxes for necessary investigations
- Covers key topics such as SGLT2 inhibitors and GLP-1 agonists in CKD management; IgA nephropathy and new therapies; focal segmental glomerulosclerosis; complement-mediated kidney diseases; cardiorenal syndrome; acute kidney injury prevention and management; kidney disease in pregnancy; dialysis access; and much more
- Includes quick-reference boxes with links to clinical guidelines in all relevant chapters, plus hundreds of self-assessment questions, videos, and downloadable images online
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish after the publication date
Readership
Readership
Practicing nephrologists, fellows
Table of contents
Table of contents
SECTION I: Essential Kidney Anatomy and Physiology
1 Kidney Anatomy
2 Renal Physiology
SECTION II: Investigation of Kidney Disease
3 Assessment of Glomerular Filtration Rate
4 Urinalysis
5 Ultrasound by the Nephrologist
6 Radiologic and Nuclear Imaging in Nephrology
7 Kidney Biopsy
SECTION III: Fluid and Electrolyte Disorders
8 Disorders of Extracellular Volume
9 Disorders of Water Metabolism
10 Disorders of Potassium Metabolism
11 Disorders of Calcium, Phosphate, and Magnesium Metabolism
12 Normal Acid-Base Balance
13 Metabolic Acidosis
14 Metabolic Alkalosis
15 Respiratory Acidosis, Respiratory Alkalosis, and Mixed Acid-Base Disorders
SECTION IV: Glomerular Diseases
16 Introduction to Glomerular Disease: Clinical Presentations
17 Introduction to Glomerular Disease: Histologic Classification and Pathogenesis
18 Minimal Change Disease
19 Primary and Secondary (Nongenetic) Causes of Focal and Segmental Glomerulosclerosis
20 Inherited Causes of Nephrotic Syndrome
21 Membranous Nephropathy
22 Immunoglobulin-Mediated Glomerulonephritis With a Membranoproliferative Pattern of Injury and Cryoglobulinemic Glomerulonephritis
23 Glomerulonephritis Associated With Complement Disorders
24 Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura)
25 Anti–Glomerular Basement Membrane Disease and Goodpasture Disease
26 Renal and Systemic Vasculitis
27 Lupus Nephritis
28 Monoclonal Immunoglobulin–Related Glomerular Diseases and Renal Amyloidosis
29 Rare Glomerular Disorders
30 Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome
SECTION V: Diabetic Kidney Disease
31 Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease
32 Prevention and Treatment of Diabetic Kidney Disease
33 Management of Patients With Diabetes and Chronic Kidney Disease
SECTION VI: Hypertension
34 Normal Blood Pressure Control and the Evaluation of Hypertension
35 Primary Hypertension
36 Nonpharmacologic Prevention and Treatment of Hypertension
37 Therapeutic Interventions for Hypertension
38 Evaluation and Treatment of Hypertensive Emergencies and Urgencies
39 Endocrine Causes of Hypertension: Aldosterone
40 Other Endocrine Causes of Hypertension
41 Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury
42 Blood Pressure Management in the Dialysis Patient
SECTION VII: Renovascular Disease
43 Renovascular Hypertension, Atherosclerotic Renal Vascular Disease, and Thromboembolic Kidney Disease
SECTION VIII: Women and Kidney Health
44 Kidney Physiology and Complications in Normal Pregnancy
45 Pregnancy With Preexisting Kidney Disease
46 Clinically Relevant Sex Differences in Kidney Health and Disease
SECTION IX: Hereditary and Congenital Diseases of the Kidney
47 Autosomal Dominant Polycystic Kidney Disease
48 Other Cystic Kidney Diseases
49 Alport Syndrome and Other Familial Glomerular Syndromes
50 Inherited Disorders of Sodium and Water Handling
51 Fanconi Syndrome and Other Proximal Tubule Disorders
52 Sickle Cell Diseases and the Kidney
53 Congenital Anomalies of the Kidney and Urinary Tract
SECTION X: Infectious Disease and the Kidney
54 Urinary Tract Infections in Adults
55 Tuberculosis of the Urinary Tract
56 Fungal Infections of the Urinary Tract
57 Parasitic Diseases Associated With Glomerulonephritis and Tubulointerstitial Disease
58 Glomerular Diseases Associated With Bacterial Infection
59 Human Immunodeficiency Virus and Other Viral Infections of the Kidney
SECTION XI: Urologic Disorders
60 Nephrolithiasis and Nephrocalcinosis
61 Urinary Tract Obstruction
62 Primary Vesicoureteral Reflux and Reflux Nephropathy
63 Urologic Issues for the Nephrologist
SECTION XII: Tubulointerstitial and Vascular Diseases
64 Acute Interstitial Nephritis
65 Chronic Interstitial Nephritis
66 Endemic Nephropathies
SECTION XIII: Climate, Environment, and the Kidney
67 Climate Change and Environmental Toxins Affecting the Kidney
68 Green Nephrology
SECTION XIV: Renal Disease and Cancer
69 Oncology: Kidney Disease in Cancer Patients
70 Myeloma and the Kidney
SECTION XV: Acute Kidney Injury
71 Pathophysiology and Etiology of Acute Kidney Injury
72 Acute Kidney Injury in the Tropics
73 Diagnosis and Clinical Evaluation of Acute Kidney Injury
74 Epidemiology and Prognostic Impact of Acute Kidney Injury and Acute Kidney Disease
75 Prevention and Nondialytic Management of Acute Kidney Injury
76 Extracorporeal Therapies for Acute Kidney Injury and Heart Failure
77 Hepatorenal Syndrome
SECTION XVI: Drug Therapy in Kidney Disease
78 Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Kidney Replacement Therapy
79 Common Issues in Prescribing in Kidney Disease and Kidney Replacement Therapy
80 Herbal and Over-the-Counter Medicines and the Kidney
SECTION XVII: Chronic Kidney Disease and Uremic Syndrome
81 Epidemiology of Chronic Kidney Disease and Dialysis
82 Slowing the Progression of Kidney Disease
83 Pathogenesis and Risk of Cardiovascular Disease in Chronic Kidney Disease
84 Practical Management of Cardiovascular Disease in Chronic Kidney Disease
85 Anemia in Chronic Kidney Disease
86 Other Blood and Immune Disorders in Chronic Kidney Disease
87 Bone and Mineral Disorders in Chronic Kidney Disease
88 Cognitive and Neurologic Complications in Chronic Kidney Disease
89 Nutrition and Gastrointestinal Disease in Chronic Kidney Disease
90 Dermatologic Manifestations of Chronic Kidney Disease
91 Acquired Cystic Kidney Disease and Malignant Neoplasms
SECTION XVIII: Geriatric and Palliative Nephrology
92 Geriatric Nephrology
93 Palliative Nephrology
SECTION XIX: Dialytic Therapies
94 Approach to Kidney Replacement Therapy
95 Vascular Access for Hemodialysis
96 Diagnostic and Interventional Nephrology
97 Hemodialysis: Principles and Techniques
98 Hemodialysis: Dialysis Prescription and Adequacy
99 Acute Complications During Hemodialysis
100 Peritoneal Dialysis: Principles, Techniques, and Adequacy
101 Complications of Peritoneal Dialysis
102 Extracorporeal Therapies for Drug Overdose and Poisoning
103 Plasma Exchange
SECTION XX: Transplantation
104 Immunologic Principles and Immunosuppressive Therapy in Kidney Transplantation
105 Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor
106 Kidney Transplantation Surgery
107 Prophylaxis and Treatment of Kidney Transplant Rejection
108 Infections and Malignancies in the Kidney Transplant Recipient
109 Cardiovascular Disease and Metabolic Abnormalities in the Kidney Transplant Recipient
110 Chronic Allograft Injury
111 Recurrent Disease in Kidney Transplantation
112 Outcomes of Kidney Transplantation: Identification, Measures, and Evaluation
113 Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation
Index
1 Kidney Anatomy
2 Renal Physiology
SECTION II: Investigation of Kidney Disease
3 Assessment of Glomerular Filtration Rate
4 Urinalysis
5 Ultrasound by the Nephrologist
6 Radiologic and Nuclear Imaging in Nephrology
7 Kidney Biopsy
SECTION III: Fluid and Electrolyte Disorders
8 Disorders of Extracellular Volume
9 Disorders of Water Metabolism
10 Disorders of Potassium Metabolism
11 Disorders of Calcium, Phosphate, and Magnesium Metabolism
12 Normal Acid-Base Balance
13 Metabolic Acidosis
14 Metabolic Alkalosis
15 Respiratory Acidosis, Respiratory Alkalosis, and Mixed Acid-Base Disorders
SECTION IV: Glomerular Diseases
16 Introduction to Glomerular Disease: Clinical Presentations
17 Introduction to Glomerular Disease: Histologic Classification and Pathogenesis
18 Minimal Change Disease
19 Primary and Secondary (Nongenetic) Causes of Focal and Segmental Glomerulosclerosis
20 Inherited Causes of Nephrotic Syndrome
21 Membranous Nephropathy
22 Immunoglobulin-Mediated Glomerulonephritis With a Membranoproliferative Pattern of Injury and Cryoglobulinemic Glomerulonephritis
23 Glomerulonephritis Associated With Complement Disorders
24 Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura)
25 Anti–Glomerular Basement Membrane Disease and Goodpasture Disease
26 Renal and Systemic Vasculitis
27 Lupus Nephritis
28 Monoclonal Immunoglobulin–Related Glomerular Diseases and Renal Amyloidosis
29 Rare Glomerular Disorders
30 Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome
SECTION V: Diabetic Kidney Disease
31 Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease
32 Prevention and Treatment of Diabetic Kidney Disease
33 Management of Patients With Diabetes and Chronic Kidney Disease
SECTION VI: Hypertension
34 Normal Blood Pressure Control and the Evaluation of Hypertension
35 Primary Hypertension
36 Nonpharmacologic Prevention and Treatment of Hypertension
37 Therapeutic Interventions for Hypertension
38 Evaluation and Treatment of Hypertensive Emergencies and Urgencies
39 Endocrine Causes of Hypertension: Aldosterone
40 Other Endocrine Causes of Hypertension
41 Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury
42 Blood Pressure Management in the Dialysis Patient
SECTION VII: Renovascular Disease
43 Renovascular Hypertension, Atherosclerotic Renal Vascular Disease, and Thromboembolic Kidney Disease
SECTION VIII: Women and Kidney Health
44 Kidney Physiology and Complications in Normal Pregnancy
45 Pregnancy With Preexisting Kidney Disease
46 Clinically Relevant Sex Differences in Kidney Health and Disease
SECTION IX: Hereditary and Congenital Diseases of the Kidney
47 Autosomal Dominant Polycystic Kidney Disease
48 Other Cystic Kidney Diseases
49 Alport Syndrome and Other Familial Glomerular Syndromes
50 Inherited Disorders of Sodium and Water Handling
51 Fanconi Syndrome and Other Proximal Tubule Disorders
52 Sickle Cell Diseases and the Kidney
53 Congenital Anomalies of the Kidney and Urinary Tract
SECTION X: Infectious Disease and the Kidney
54 Urinary Tract Infections in Adults
55 Tuberculosis of the Urinary Tract
56 Fungal Infections of the Urinary Tract
57 Parasitic Diseases Associated With Glomerulonephritis and Tubulointerstitial Disease
58 Glomerular Diseases Associated With Bacterial Infection
59 Human Immunodeficiency Virus and Other Viral Infections of the Kidney
SECTION XI: Urologic Disorders
60 Nephrolithiasis and Nephrocalcinosis
61 Urinary Tract Obstruction
62 Primary Vesicoureteral Reflux and Reflux Nephropathy
63 Urologic Issues for the Nephrologist
SECTION XII: Tubulointerstitial and Vascular Diseases
64 Acute Interstitial Nephritis
65 Chronic Interstitial Nephritis
66 Endemic Nephropathies
SECTION XIII: Climate, Environment, and the Kidney
67 Climate Change and Environmental Toxins Affecting the Kidney
68 Green Nephrology
SECTION XIV: Renal Disease and Cancer
69 Oncology: Kidney Disease in Cancer Patients
70 Myeloma and the Kidney
SECTION XV: Acute Kidney Injury
71 Pathophysiology and Etiology of Acute Kidney Injury
72 Acute Kidney Injury in the Tropics
73 Diagnosis and Clinical Evaluation of Acute Kidney Injury
74 Epidemiology and Prognostic Impact of Acute Kidney Injury and Acute Kidney Disease
75 Prevention and Nondialytic Management of Acute Kidney Injury
76 Extracorporeal Therapies for Acute Kidney Injury and Heart Failure
77 Hepatorenal Syndrome
SECTION XVI: Drug Therapy in Kidney Disease
78 Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Kidney Replacement Therapy
79 Common Issues in Prescribing in Kidney Disease and Kidney Replacement Therapy
80 Herbal and Over-the-Counter Medicines and the Kidney
SECTION XVII: Chronic Kidney Disease and Uremic Syndrome
81 Epidemiology of Chronic Kidney Disease and Dialysis
82 Slowing the Progression of Kidney Disease
83 Pathogenesis and Risk of Cardiovascular Disease in Chronic Kidney Disease
84 Practical Management of Cardiovascular Disease in Chronic Kidney Disease
85 Anemia in Chronic Kidney Disease
86 Other Blood and Immune Disorders in Chronic Kidney Disease
87 Bone and Mineral Disorders in Chronic Kidney Disease
88 Cognitive and Neurologic Complications in Chronic Kidney Disease
89 Nutrition and Gastrointestinal Disease in Chronic Kidney Disease
90 Dermatologic Manifestations of Chronic Kidney Disease
91 Acquired Cystic Kidney Disease and Malignant Neoplasms
SECTION XVIII: Geriatric and Palliative Nephrology
92 Geriatric Nephrology
93 Palliative Nephrology
SECTION XIX: Dialytic Therapies
94 Approach to Kidney Replacement Therapy
95 Vascular Access for Hemodialysis
96 Diagnostic and Interventional Nephrology
97 Hemodialysis: Principles and Techniques
98 Hemodialysis: Dialysis Prescription and Adequacy
99 Acute Complications During Hemodialysis
100 Peritoneal Dialysis: Principles, Techniques, and Adequacy
101 Complications of Peritoneal Dialysis
102 Extracorporeal Therapies for Drug Overdose and Poisoning
103 Plasma Exchange
SECTION XX: Transplantation
104 Immunologic Principles and Immunosuppressive Therapy in Kidney Transplantation
105 Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor
106 Kidney Transplantation Surgery
107 Prophylaxis and Treatment of Kidney Transplant Rejection
108 Infections and Malignancies in the Kidney Transplant Recipient
109 Cardiovascular Disease and Metabolic Abnormalities in the Kidney Transplant Recipient
110 Chronic Allograft Injury
111 Recurrent Disease in Kidney Transplantation
112 Outcomes of Kidney Transplantation: Identification, Measures, and Evaluation
113 Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation
Index
Product details
Product details
- Edition: 8
- Latest edition
- Published: December 1, 2026
- Language: English
About the editors
About the editors
Marcello Tonelli
Editor
Affiliations and expertise
Associate Vice President of Health Research, University of Calgary, Senior Associate Dean of Clinical Research, Cumming School of Medicine, Professor of Medicine, University of Calgary, Calgary, Alberta, CanadaRichard J. Johnson
Editor
Affiliations and expertise
Professor of Medicine, Division Chief, Tomas Berl Professor of Nephrology, University of Colorado–Denver, Denver, Colorado, USAJurgen Floege
Editor
Affiliations and expertise
Professor of Medicine, Director, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, GermanyAnupam Agarwal
Editor
Affiliations and expertise
Heersink School of Medicine, USA