Colorectal Cancer, An Issue of Hematology/Oncology Clinics of North America

1st Edition, Volume 36-3 - May 30, 2022
Editors: Kimmie Ng, Benjamin L. Schlechter
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 0 0 1 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 0 0 2 - 5

In this issue of Hematology/Oncology Clinics, guest editors Drs. Kimmie Ng and Benjamin L. Schlechter bring their considerable expertise to the topic of Colorectal Cancer. Despite… Read more

Colorectal Cancer, An Issue of Hematology/Oncology Clinics of North America

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In this issue of Hematology/Oncology Clinics, guest editors Drs. Kimmie Ng and Benjamin L. Schlechter bring their considerable expertise to the topic of Colorectal Cancer. Despite tremendous progress in the management of this disease, many questions and controversies remain regarding screening, adjuvant therapy for resected colon cancers, targeted therapies and immunotherapy for patients with advanced disease, surgical management, and more. In this issue, top experts in the field address provide clinicians with the tools to individualize management and optimize care for this growing patient population.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Screening for Colorectal Cancer
Key points
Pathogenesis and natural history
Epidemiology
Rationale and evidence base to support screening
Randomized Trials
Observational Studies
Modeling Studies
Evidence gaps and opportunities
Summary
Clinics care points
Racial and Ethnic Disparities in Colorectal Cancer Screening and Outcomes
Key points
Introduction
Social determinants of health as precursors to health disparities
Colorectal cancer in Black individuals
Colorectal cancer in American Indian/Alaskan Native individuals
Colorectal cancer in Latino individuals
Colorectal cancer in Asian and Pacific Islander indivdiuals
Other sources of disparities in colorectal cancer screening and outcomes
Evidence-based interventions to reduce colorectal cancer disparities
Summary
Clinics care points
Hereditary Colorectal Cancer
Key points
Introduction/history/Definitions/background
Discussion
Clinics care points
Colorectal Cancer in Younger Adults
Key points
Introduction
Epidemiology of early-onset colorectal cancer
Genetic and familial risk
Clinicopathologic features
Risk factors
Treatment and survival
Surveillance and survivorship
Prevention and early recognition
Summary
Grant support
Impact of Diet and Exercise on Colorectal Cancer
Key points
Introduction
Discussion
Summary
Clinics care points
The Gut Microbiome in Colorectal Cancer
Key points
Introduction
Discussion
Research considerations
Summary
Disclosure
New Insights into Adjuvant Therapy for Localized Colon Cancer
Key points
Introduction
Summary
Clinics care points
Management of Rectal Cancer
Key points
Background on rectal cancer
Development of conventional management of rectal cancer
Modern approaches to stage II and III rectal cancer
Summary
Clinics care points
Nonoperative Management for Rectal Cancer
Key points
Introduction
Neoadjuvant therapy for rectal cancer: overview
Tumor response after neoadjuvant treatment
Nonoperative management approach
Assessment of response to neoadjuvant therapy
Strategies to optimize tumor response
Long-term follow-up
Summary and future directions
Clinics care points
Local Therapies in Advanced Colorectal Cancer
Key points
Introduction
Local therapy for liver metastasis
Local therapy for lung metastasis
Other sites
Local therapy for multiple sites
Discussion
Summary
Clinics care points
Disclosure
Management of Peritoneal Disease in Colorectal Cancer
Key points
Introduction
Summary
Clinics care points
Evolving Role of Circulating Tumor DNA and Emerging Targeted Therapy in Colorectal Cancer
Key points
Introduction
Clinical and research applications
Limitations of circulating tumor DNA
Targeted therapy
Gene fusions
Summary
Clinics care points
Immunotherapy for Colorectal Cancer
Key points
Background
Summary
Clinics care points

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Colorectal Cancer, An Issue of Hematology/Oncology Clinics of North America

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Kimmie Ng

Benjamin L. Schlechter