Co-Transport Systems

Current Topics In Membranes

Dedication

Contributors

Preface

Previous Volumes In Series

Chapter One. Amino Acid Secondary Transporters

1 Classification of Amino Acid Transporters

2 Human SLCs Involved in Amino Acid and Neurotransmitter Transport

3 The Structural APCS: Mechanistic Concepts

4 Ions and Directionality in Amino Acid Transport

5 Regulation in APCS Fold Transporters

Acknowledgments

References

Chapter Two. SLC5 and SLC2 Transporters in Epithelia—Cellular Role and Molecular Mechanisms

1 Introduction

2 Physiological Significance and Molecular Characteristics of Epithelial Sugar Transport

3 Sodium–Glucose Symport as the Basis for Active Transepithelial Glucose Transport

4 Cloning of Transporter cDNAs, Sequence Homologies and Conserved Amino Acids

5 Transporter Domains, Their Arrangement in the Membrane and Their Function

6 Crystal Structures and Homology Models of Members of SLC5 and SLC2

7 Regulation of Transporter Activity

8 Synopsis

References

Chapter Three. SLC4A Transporters

1 Introduction

2 SLC4A Transporters

3 Ion Transport Properties

4 Structure of SLC4A Transporters

5 Interaction with Other Proteins

6 Conclusion

Acknowledgments

References

Chapter Four. The SLC10 Carrier Family

1 Introduction

2 The SLC10 Family

3 The Liver Bile Salt Transporter SLC10A1 (NTCP)

4 The Ileal Bile Salt Transporter ASBT (SLC10A2)

5 Novel Members of the SLC10 Family

6 Conclusion

Abbreviations

References

Chapter Five. H+-Coupled Divalent Metal-Ion Transporter-1

1 Introduction and History

2 Animal Models

3 Mutations in Human DMT1

4 Functional Properties of DMT1

5 Regulation of the Cellular Expression of DMT1

6 Tissue-Specific Roles of DMT1 in Physiology and Pathophysiology

7 Therapeutics and Nutrition

Acknowledgments

References

Chapter Six. Molecular Operation of the Cation Chloride Cotransporters

1 Overview

2 General Structure

3 Ion Binding and Inhibitor Interaction: Structure–Function Studies

4 Homology to High Resolution Structures of Bacterial Transport Proteins

5 Future Perspectives

Acknowledgments

References

Chapter Seven. Sodium-Sulfate/Carboxylate Cotransporters (SLC13)

1 Introduction

2 SLC13 Gene Family

3 NaS Cotransporters

4 NaC Cotransporters

5 Future Perspectives

Acknowledgments

References

Chapter Eight. Recent Advances in Structural Biology of Peptide Transporters

1 Introduction

2 Functional Characteristics of PEPT1 and PEPT2

3 Structures of PEPT1 and PEPT2

4 Essential Amino Acid Residues

5 Future Perspectives

References

Chapter Nine. The SLC16A Family of Monocarboxylate Transporters (MCTs)—Physiology and Function in Cellular Metabolism, pH Homeostasis, and Fluid Transport

1 Introduction

2 Physiology and Function of MCTs 1–4 in Cellular Metabolism

3 Interactions between MCTs and Bicarbonate Transport Mechanisms

4 Physiology and Function of MCTs 1–4 in Epithelial and Endothelial Cells

5 Future Directions

6 Conclusion

Acknowledgments

References

Chapter Ten. Phosphate Transport Kinetics and Structure-Function Relationships of SLC34 and SLC20 Proteins

1 Introduction

2 Transport Kinetics

3 Structure–Function Relationships

4 Future Perspectives

Abbreviations

Acknowledgments

References

Chapter Eleven. Functional and Physiological Role of Vitamin C Transporters

1 Introduction

2 NAT Family

3 Functional Properties of SVCT1 and SVCT2 (SLC23A1 and SLC23A2)

4 Structure, Phosphorylation and N-Glycosylation of Vitamin C Transporters

5 Physiological Significance

6 Regulation

7 Polymorphisms and Pathological Relevance

8 Outlook

Acknowledgments

References

Index