Clinical Pharmacy and Therapeutics
- 6th Edition - July 27, 2018
- Imprint: Elsevier
- Editors: Cate Whittlesea, Karen Hodson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 7 0 2 0 - 7 0 1 1 - 2
- Paperback ISBN:9 7 8 - 0 - 7 0 2 0 - 7 0 1 2 - 9
Now fully revised and updated in its sixth edition, Clinical Pharmacy and Therapeutics combines the skills of an interdisciplinary team of clinicians, pharmacists and nurses to pr… Read more
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Request a sales quoteNow fully revised and updated in its sixth edition, Clinical Pharmacy and Therapeutics combines the skills of an interdisciplinary team of clinicians, pharmacists and nurses to present an integrated understanding of disease processes, evidence-based clinical pharmacology and optimal drug regimes. Register your StudentConsult PIN for access to the e-book.
- Key points boxes at the beginning of each chapter
- Case-study boxes throughout the chapters
- Each chapter co-written by a pharmacist and a clinician
- In-depth treatment of therapeutics to support pharmaceutical prescribing
- Logical order and format: key points, epidemiology, aetiology, disease, clinical manifestations, investigations and treatment, drugs used in treatment.
- Dosage reference sources given where appropriate, along with useful websites and further reading for each chapter.
- Pharmacy students and postgraduate pharmacists
- Pharmacology
- Medicine (secondary market)
- Non-medical prescribers
- Nurse practitioners (prescribers)
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Acknowledgements
- List of Contributors
- Section 1. General
- 1. Clinical Pharmacy Practice
- Development of clinical practice in pharmacy
- Pharmaceutical care
- Medicines optimisation
- Pharmaceutical consultation
- Clinical pharmacy functions and knowledge
- Case study
- 2. Prescribing
- Rational and effective prescribing
- Pharmacists as prescribers and the legal framework
- The prescribing process
- Medication review
- Factors that influence prescribers
- Strategies to influence prescribing
- Conclusion
- 3. Practical Pharmacokinetics
- General applications
- Application to therapeutic drug monitoring
- Basic concepts
- Clinical applications
- Case studies
- 4. Drug Interactions
- Definition
- Epidemiology
- Mechanisms of drug interactions
- Conclusion
- Case studies
- 5. Adverse Drug Reactions
- Introduction
- Assessing the safety of drugs
- Definitions
- Classification of adverse drug reactions
- Factors that affect susceptibility to adverse drug reactions
- Immunological reactions
- Formulation issues that contribute to adverse drug reactions
- Epidemiology of adverse drug reactions
- Pharmacovigilance and epidemiological methods in adverse drug reaction detection
- Roles of health professionals
- Case studies
- 6. Laboratory Data
- Haematology data
- Urea and electrolytes
- Liver profile and associated tests
- Calcium and phosphate
- Inflammatory markers
- Special tests
- Creatine kinase
- Immunoglobulins
- Uric acid
- Iron, transferrin and iron binding
- Tumour markers
- Arterial blood gases
- Case studies
- 7. Parenteral Nutrition
- Introduction
- Components of a parenteral nutrition regimen
- Administration of parenteral nutrition
- Pharmaceutical issues
- Nutritional assessment and monitoring
- Complications
- Specific disease states
- Paediatric parenteral nutrition
- Case studies
- 8. Pharmacoeconomics
- Terms used in health economics
- Types of health economic evaluations
- Costs and consequences
- Conclusion
- Section 2. Life Stages
- 9. Neonates
- Drug disposition
- Major clinical disorders
- Principles and goals of therapy
- Case studies
- 10. Paediatrics
- Demography
- The normal child
- Drug disposition
- Drug therapy in children
- Medicines optimisation
- Monitoring parameters
- Adverse drug reactions
- Licensing medicines for children
- Case studies
- 11. Geriatrics
- Pharmacokinetics
- Pharmacodynamics
- Common clinical disorders
- Principles and goals of drug therapy in older people
- Conclusion
- Case studies
- Section 3. Therapeutics
- 12. Dyspepsia, Peptic Ulcer Disease and Gastro-Oesophageal Reflux Disease
- Epidemiology
- Pathophysiology
- Patient assessment and clinical manifestations
- Treatment
- Drugs for dyspepsia
- Case studies
- Acknowledgment
- 13. Inflammatory Bowel Disease
- Introduction
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestation
- Investigations
- Treatment of inflammatory bowel disease
- Patient care
- Case studies
- 14. Constipation and Diarrhoea
- Constipation
- Diarrhoea
- Case studies
- 15. Adverse Effects of Drugs on the Liver
- Epidemiology
- Risk factors
- Aetiology/pathophysiology/clinical manifestation
- Investigations
- Treatment
- Case studies
- 16. Liver Disease
- Acute liver disease
- Chronic liver disease
- Causes of liver disease
- Clinical manifestations of liver disease
- Investigation of liver disease
- Patient care
- Disease-specific therapies
- Case studies
- 17. Acute Kidney Injury
- Definition and incidence
- Classification and causes
- Clinical manifestations
- Diagnosis and clinical evaluation
- Course and prognosis
- Management
- Non-dialysis treatment of established acute kidney injury
- Renal replacement therapy
- Case studies
- 18. Chronic Kidney Disease and End-Stage Renal Disease
- Renin–angiotensin–aldosterone system
- Measurement of renal function
- Significance of chronic kidney disease
- Causes of chronic kidney disease
- Clinical manifestations
- Diagnosis, investigations and monitoring
- Prognosis
- Treatment
- Renal transplantation
- Implementation of regular dialysis treatment
- Case studies
- 19. Hypertension
- Epidemiology
- Regulation of blood pressure
- Clinical presentation
- Management of hypertension
- Treatment
- Case studies
- 20. Coronary Heart Disease
- Epidemiology
- Aetiology
- Modification of risk factors
- Clinical syndromes
- Acute coronary syndrome
- Patient care
- Case studies
- 21. Chronic Heart Failure
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestations
- Investigations
- Treatment of heart failure
- Patient care
- Case studies
- 22. Arrhythmias
- Normal cardiac electrophysiology
- Arrhythmia mechanisms
- Diagnosis
- Management
- Drug therapy
- Patient care
- Case studies
- 23. Thrombosis
- Venous thromboembolism
- Arterial thromboembolism
- Case studies
- 24. Dyslipidaemia
- Epidemiology
- Lipid transport and lipoprotein metabolism
- Aetiology
- Cardiovascular risk assessment
- Treatment
- Lipid-lowering therapy
- Case studies
- 25. Asthma
- Introduction
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical signs and symptoms
- Investigations
- Treatment
- Patient care
- Case studies
- 26. Chronic Obstructive Pulmonary Disease
- Definitions
- Epidemiology
- Aetiology
- Pathology and pathophysiology
- Clinical manifestations
- Investigations
- Classification
- Treatment
- Patient care
- Palliative care
- Case studies
- 27. Insomnia
- Definitions and epidemiology
- Pathophysiology
- Aetiology and clinical manifestations
- Investigations and differential diagnosis
- Treatment
- Potential adverse effects of hypnotic use
- Patient care
- Case studies
- 28. Anxiety Disorders
- Definitions and epidemiology
- Pathophysiology
- Aetiology and clinical manifestations
- Investigations and differential diagnosis
- Treatment
- Case studies
- 29. Affective Disorders
- Classification
- Epidemiology
- Aetiology
- Clinical manifestations
- Investigations
- Treatment
- Patient care
- Case studies
- 30. Schizophrenia
- Classification
- Symptoms and diagnosis
- Causes of schizophrenia
- Pharmacological treatment
- Case studies
- 31. Epilepsy
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestations
- Diagnosis
- Treatment
- Recent and future evidence for antiepileptic drugs
- Case studies
- 32. Parkinson’s Disease
- Background
- Aetiology
- Pathophysiology
- Clinical features
- Differential diagnosis
- Investigations
- Treatment
- Patient care
- Case studies
- 33. Dementia
- Definition
- Epidemiology
- Clinical manifestations
- Diagnosis of the dementias
- Classification of dementias
- Treatment of dementia
- Patient care
- Case studies
- 34. Pain
- Aetiology and neurophysiology
- Assessment of pain
- Management
- Analgesic ladder
- Analgesic drugs
- Adjuvant medicines
- Treatment of selected pain syndromes
- Case studies
- 35. Nausea and Vomiting
- Epidemiology
- Pathophysiology
- Patient management
- Antiemetic drugs
- Drug treatment in selected circumstances
- Conclusion
- Case studies
- 36. Respiratory Infections
- Upper respiratory tract infections
- Lower respiratory tract infections
- Case studies
- 37. Urinary Tract Infections
- Epidemiology
- Aetiology and risk factors
- Pathogenesis
- Clinical manifestations
- Investigations
- Treatment
- Prevention and prophylaxis
- Case studies
- 38. Gastro-Intestinal Infections
- Epidemiology and aetiology
- Pathophysiology
- Clinical manifestations
- Investigations
- Treatment
- Patient care
- Case studies
- 39. Infective Meningitis
- Aetiology and epidemiology
- Pathophysiology
- Clinical manifestations
- Diagnosis
- Drug treatment
- Patient care
- Case studies
- 40. Surgical Site Infection and Antimicrobial Prophylaxis
- Epidemiology
- Surveillance
- Risk factors
- Pathogenesis
- Prevention of surgical site infection
- Case studies
- 41. Tuberculosis
- Introduction
- Epidemiology
- Aetiology
- Clinical features
- Diagnosis
- Public health action
- Bacille Calmette-Guérin Vaccination
- Treatment
- Case studies
- 42. HIV Infection
- Epidemiology
- Pathogenesis
- Clinical manifestations
- Investigations and monitoring
- Drug treatment
- Opportunistic infections
- Impact of antiretroviral therapy and clinical infections
- Case studies
- 43. Fungal Infections
- Introduction
- Superficial infection
- Deep-seated fungal infections
- Fungal infections in the compromised host
- Case studies
- 44. Thyroid and Parathyroid Disorders
- Thyroid physiology
- Hypothyroidism
- Hyperthyroidism/thyrotoxicosis
- Drugs and the thyroid
- Calcium and parathyroid hormone
- Case studies
- 45. Diabetes Mellitus
- Introduction
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestations
- Diagnosis
- Diabetic emergencies
- Long-term diabetes complications
- Treatment of diabetes
- Patient care
- Case studies
- 46. Menstrual Cycle Disorders
- Premenstrual syndrome
- Dysmenorrhoea
- Heavy menstrual bleeding
- Endometriosis
- Case studies
- 47. Menopause
- Menopause
- Management
- Treatment with hormone replacement therapy
- Alternatives to hormone replacement therapy
- Case studies
- 48. Drugs in Pregnancy and Lactation
- Drugs in pregnancy
- Drugs as teratogens
- Drugs in lactation
- Case studies
- 49. Prostate Disease
- Benign prostatic hyperplasia
- Pathophysiology
- Symptoms
- Examination and investigations
- Treatment
- Prostate cancer
- Pathophysiology
- Screening
- Symptoms
- Examination and investigation
- Treatment
- Patient care
- Prostatitis
- Pathophysiology
- Symptoms
- Examination and investigations
- Treatment
- Patient care
- Case studies
- 50. Anaemia
- Epidemiology
- Aetiology
- Iron-deficiency anaemia
- Anaemia of chronic disease
- Sideroblastic anaemias
- Megaloblastic anaemias
- Haemolytic anaemias
- Case studies
- 51. Leukaemia
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestations
- Investigations
- Treatment
- Patient care
- Case studies
- 52. Lymphomas
- Hodgkin’s lymphoma
- Non-Hodgkin’s lymphoma
- Patient care
- Case studies
- 53. Solid Tumours
- Epidemiology
- Aetiology
- Screening and prevention
- Cancer at the cellular level
- Patient management
- Cytotoxic chemotherapy
- Targeted therapies
- Management of patients receiving cytotoxic chemotherapy
- Case studies
- 54. Rheumatoid Arthritis and Osteoarthritis
- Rheumatoid arthritis
- Epidemiology
- Aetiology and pathophysiology
- Clinical manifestations
- Diagnosis
- Investigations
- Treatment
- Osteoarthritis
- Epidemiology
- Pathophysiology
- Aetiology
- Diagnosis
- Management
- Patient Care
- Case studies
- 55. Gout and Hyperuricaemia
- Epidemiology
- Pathophysiology
- Risk factors
- Presentation and diagnosis
- Course of disease
- Treatment
- Patient care
- Case studies
- 56. Glaucoma
- Epidemiology
- Aetiology
- Pathophysiology
- Clinical manifestations
- Investigations
- Treatment
- Drug treatment
- Patient care
- Case studies
- 57. Drug-induced Skin Disorders
- Diagnosis
- Drug-induced skin disorders
- Patient care
- Case studies
- 58. Eczema and Psoriasis
- Eczema
- Pathology and clinical features
- Clinical types
- Treatment
- Patient care
- Psoriasis
- Pathology and clinical features
- Clinical types
- Treatment
- Patient care
- Case studies
- 59. Wounds
- Structure of the skin
- Wound healing
- Diabetic foot ulcers
- Leg ulcers
- Pressure ulcers
- Principles of wound management
- Case studies
- Section 4. Appendices
- Appendix 1. Medical Abbreviations
- Appendix 2. Glossary
- Index
- Edition: 6
- Published: July 27, 2018
- Imprint: Elsevier
- No. of pages: 1112
- Language: English
- Paperback ISBN: 9780702070112
- Paperback ISBN: 9780702070129
CW
Cate Whittlesea
Affiliations and expertise
Professor of Pharmacy Practice and Associate Director Clinical Examination, UCL School of Pharmacy, University College London, London, UKKH
Karen Hodson
Affiliations and expertise
Director MSc in Clinical Pharmacy and Pharmacist Independent Prescribing Programmes, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.