Clinical Neurophysiology
Nerve Conduction, Electromyography, Evoked Potentials
- 5th Edition - July 15, 2026
- Latest edition
- Authors: Usha Kant Misra, Jayantee Kalita
- Language: English
This book focuses on the neurobiology, techniques of various electrodiagnostic tests,interpretation and application of electrodiagnosis. Nerve conduction test helps to identify the… Read more
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Description
Description
This book focuses on the neurobiology, techniques of various electrodiagnostic tests,
interpretation and application of electrodiagnosis. Nerve conduction test helps to identify the
exact location and extent of nerve compression, degeneration, or disease; electromyography
test investigates the health of the muscles and the motor neurons that control them; and
evoked potentials test helps to measure the activity of the brain assessing the speed and
function of sensory, motor, auditory, visual and cognitive pathways, and emphasizes on precise
technique, common pitfalls, and accurate interpretation of the results.
interpretation and application of electrodiagnosis. Nerve conduction test helps to identify the
exact location and extent of nerve compression, degeneration, or disease; electromyography
test investigates the health of the muscles and the motor neurons that control them; and
evoked potentials test helps to measure the activity of the brain assessing the speed and
function of sensory, motor, auditory, visual and cognitive pathways, and emphasizes on precise
technique, common pitfalls, and accurate interpretation of the results.
Key features
Key features
New to This Edition
Significantly revised on the basis of recent developments bridging scientific advances with
clinical application.
Addition of new chapter on Artificial Intelligence in Electrodiagnosis.
Inclusion of new topics on COVID 19, West Nile Encephalitis, Zika virus, role of ultrasonography
in the evaluation of peripheral nerve diseases especially in carpal tunnel syndrome in the
relevant chapters.
High-quality illustrations in the form of line diagrams and clinical photographs to explain
complex structures and processes.
Provides up-to-date review of relevant clinical and electrophysiological literature, and
histopathological and genetic correlation with electrodiagnostic tests.
Additional Features in eBooks+
Complimentary access to videos along with the full eBook.
Significantly revised on the basis of recent developments bridging scientific advances with
clinical application.
Addition of new chapter on Artificial Intelligence in Electrodiagnosis.
Inclusion of new topics on COVID 19, West Nile Encephalitis, Zika virus, role of ultrasonography
in the evaluation of peripheral nerve diseases especially in carpal tunnel syndrome in the
relevant chapters.
High-quality illustrations in the form of line diagrams and clinical photographs to explain
complex structures and processes.
Provides up-to-date review of relevant clinical and electrophysiological literature, and
histopathological and genetic correlation with electrodiagnostic tests.
Additional Features in eBooks+
Complimentary access to videos along with the full eBook.
Readership
Readership
Ideal for DM and DNB students in Neurology; Electrodiagnostic Laboratories; Neurologists and MD students in Physiology, Psychiatry and Medicine
Table of contents
Table of contents
Memorial
Preface to the Fifth Edition
Preface to the First Edition
Acknowledgements
1 History of Clinical Neurophysiology
Classic Electrodiagnosis
Electromyography and Nerve Stimulation Technique
Evoked Potentials
Miscellaneous
2 An Introduction to Electrodiagnostic Signals and their Measurements
Biophysics
Electrodes
Filter
Amplifier
Averager
Display
Gain and Sweep Time
Signal Trigger and Delay Line
Stimulator
Referral Process
3 Nerve Conduction Study
3.1 Principles of Nerve Conduction Study
Anatomy and Physiology
Axonal Transport
Impulse Propagation
Principles of Motor Nerve Conduction
Principles of Sensory Nerve Conduction
Variables Affecting the Nerve Conduction Study
3.2 Median Nerve
Anatomy
Nerve Conduction Study
Median Nerve Entrapment Syndromes
3.3 Ulnar Nerve
Anatomy
Nerve Conduction Study
Ulnar Neuropathy
3.4 Radial Nerve
Anatomy
Nerve Conduction Study
Radial Neuropathy
3.5 Brachial Plexus
Anatomy
Brachial Plexopathy
Neurophysiological Assessment of Brachial Plexus Lesions
Thoracic Outlet Obstruction
Brachial Neuritis
Radiation-Induced Plexopathy
Obstetric Brachial Plexopathy
3.6 Cervical Radiculopathy
Anatomy
Motor and Sensory Nerve Conduction
F Wave
Somatosensory Evoked Potentials
Nerve Root Stimulation
Needle Electromyography
Cervical Radiculopathy
3.7 Lumbar Plexus and its Terminal Branches
Anatomy
Lumbosacral Plexopathy
Neurophysiological Evaluation
3.8 Sacral Plexus and its Terminal Nerve Branches
Anatomy
3.9 Lumbosacral Radiculopathy
Anatomy
L2, L3, and L4 Radiculopathies
L5 Radiculopathy
S1 and S2 Radiculopathy
Multiple Lumbosacral Radiculopathies
Diagnostic Utility of EMG and MRI in Radiculopathy
3.10 Anomalous Innervation of the Extremities
Median to Ulnar Nerve Communication (Martin–Gruber Anastomosis)
Ulnar to Median Nerve Communication
Variations in the Innervation of Intrinsic Hand Muscles
Accessory Deep Peroneal Nerve
Tibial and Peroneal Nerve Communication
3.11 Nerve Conduction of Non-Limb Nerves
Phrenic Nerve
Facial Nerve
Hypoglossal Nerve
Great Auricular Nerve
3.12 Late Response
H Reflex
F Wave
Axon Reflex
3.13 Autonomic Nervous System Testing
Anatomical and Functional Basis
Autonomic Function Tests
4 Electromyography
4.1 Introduction to Electromyography
Anatomy of Muscle
Types of EMG Needle Electrodes
Recording Technique
4.2 Technique of Electromyography
Muscles of Hands
Muscles of Forearm
Muscles of Arm
Muscles of Shoulder Girdle and Trunk
Muscles of the Foot
Muscles of Leg
Muscles of Thigh
Muscles of Pelvic Girdle
Muscles of Face, Head, and Neck
5 Clinical Application of EMG and Nerve Conduction
5.1 Electromyographic Findings in Neurological Disorders
Neurogenic Disorders
Myopathic Disorders
5.2 Nerve Conduction and EMG Studies in Polyneuropathies
Pathophysiological Basis of Nerve Conduction Study
Conduction Block and Temporal Dispersion
Neurophysiological Classification of Polyneuropathy
Limitation of Nerve Conduction Studies
Hereditary Neuropathies
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Subacute Idiopathic Demyelinating Polyradiculoneuropathy
Motor Neuropathy with Multifocal Conduction
Block or Multifocal Motor Neuropathy
Neuropathy Associated with AIDS
Leprosy
Diphtheritic Neuropathy
Metabolic Neuropathy
Carcinomatous Neuropathy
Nutritional Neuropathy
Critical Care Neuropathy
Toxic Neuropathy
Drug-Induced Neuropathy
Ischaemic Neuropathy
Neuropathy Associated with Connective Tissue Disorder
Overview of Investigations in Neuropathy
6 Repetitive Nerve Stimulation
Neuromuscular Junction
Physiology of RNS Test
Variables Influencing Neuromuscular Transmission
Technique of RNS
Measurement
Interpretation of RNS Test
Clinical Application of RNS Study
7 Single-Fibre Electromyography
Introduction
Method of SFEMG
SFEMG in Neurologic Diseases
Neuromuscular Transmission Disorders
SFEMG in Neurogenic Disorders
SFEMG in Myopathies
Macro-EMG
8 Visual Evoked Potential
Anatomical Basis of VEP
Methods of Visual Evoked Potential
Variables Influencing VEP
Multifocal VEP
Clinical Applications of VEP
Flash VEP
9 Brainstem Auditory Evoked Potential
Anatomical and Physiological Basis of BAEP
Brainstem Electrical Activity and its Correlation with BAEP
Patient-Related Variables Affecting BAEP
Method
Normal BAEP, Potential Field Distribution
Waveform Recognition, and Normal Values
Abnormal BAEP
Clinical Neurophysiological Correlation
10 Somatosensory Evoked Potentials
Anatomical and Physiological Basis of SEP
Methods
Normal Median SEP
Tibial SEPS
Reproducibility of SEP
Patient-Related Factors
Clinical Application of SEP
Surgical Monitoring
11 Motor Evoked Potential
Anatomy and Physiology of Corticospinal Tract
Physiological Basis of Motor Evoked Potential
Method of Motor Evoked Potential
Measurement of CMCT
CMCT Abnormalities and their Basis
Comparison of Electrical and Magnetic Stimulation
Safety of Transcranial Electrical and Magnetic Stimulation
Clinical Applications
12 Cognitive Evoked Potential
P3
Waveform Identification and Measurement
Variables Affecting P3
Generators of P3
Clinical Application
13 Electrodiagnosis in Paediatric Practice
13.1 Nerve Conduction and Electromyography
Nerve Conduction Studies
Sensory NCS
Needle EMG
Repetitive Nerve Stimulation
13.2 Visual Evoked Potential in Paediatric Practice
Methodology
Maturation of VEP
Measurement of VEP
Clinical Application
13.3 Brainstem Auditory Evoked Potential in Paediatric Practice
Methodological Considerations
Maturation of BAEP
Clinical Application of BAEP in Paediatrics
13.4 Somatosensory Evoked Potentials in Paediatric Practice
Methodological Considerations
Maturational Changes
Clinical Applications
14 Role of Clinical Neurophysiology in the Prognosis of Neuromuscular Disorders
Amyotrophic Lateral Sclerosis
Radiculopathy
Traumatic Nerve Injury
Polyneuropathy
Diseases of Neuromuscular Junction
Myopathy
15 Artificial Intelligence in Electrodiagnosis
Introduction
Deep Learning Neural Networks
Neuromuscular Junction Disorders
Index
ONLINE RESOURCE
List of Videos
VIDEO 1 Insertional Activity
VIDEO 2 Positive Sharp Waves and Fibrillations
VIDEO 3 Myotonic Discharges
VIDEO 4 Complex Repetitive Discharge (CRD)
VIDEO 5 Fibrillations and Fasciculations
VIDEO 6 Myopathic Motor Unit Potentials
VIDEO 7 Neurogenic Motor Unit Potentials
Preface to the Fifth Edition
Preface to the First Edition
Acknowledgements
1 History of Clinical Neurophysiology
Classic Electrodiagnosis
Electromyography and Nerve Stimulation Technique
Evoked Potentials
Miscellaneous
2 An Introduction to Electrodiagnostic Signals and their Measurements
Biophysics
Electrodes
Filter
Amplifier
Averager
Display
Gain and Sweep Time
Signal Trigger and Delay Line
Stimulator
Referral Process
3 Nerve Conduction Study
3.1 Principles of Nerve Conduction Study
Anatomy and Physiology
Axonal Transport
Impulse Propagation
Principles of Motor Nerve Conduction
Principles of Sensory Nerve Conduction
Variables Affecting the Nerve Conduction Study
3.2 Median Nerve
Anatomy
Nerve Conduction Study
Median Nerve Entrapment Syndromes
3.3 Ulnar Nerve
Anatomy
Nerve Conduction Study
Ulnar Neuropathy
3.4 Radial Nerve
Anatomy
Nerve Conduction Study
Radial Neuropathy
3.5 Brachial Plexus
Anatomy
Brachial Plexopathy
Neurophysiological Assessment of Brachial Plexus Lesions
Thoracic Outlet Obstruction
Brachial Neuritis
Radiation-Induced Plexopathy
Obstetric Brachial Plexopathy
3.6 Cervical Radiculopathy
Anatomy
Motor and Sensory Nerve Conduction
F Wave
Somatosensory Evoked Potentials
Nerve Root Stimulation
Needle Electromyography
Cervical Radiculopathy
3.7 Lumbar Plexus and its Terminal Branches
Anatomy
Lumbosacral Plexopathy
Neurophysiological Evaluation
3.8 Sacral Plexus and its Terminal Nerve Branches
Anatomy
3.9 Lumbosacral Radiculopathy
Anatomy
L2, L3, and L4 Radiculopathies
L5 Radiculopathy
S1 and S2 Radiculopathy
Multiple Lumbosacral Radiculopathies
Diagnostic Utility of EMG and MRI in Radiculopathy
3.10 Anomalous Innervation of the Extremities
Median to Ulnar Nerve Communication (Martin–Gruber Anastomosis)
Ulnar to Median Nerve Communication
Variations in the Innervation of Intrinsic Hand Muscles
Accessory Deep Peroneal Nerve
Tibial and Peroneal Nerve Communication
3.11 Nerve Conduction of Non-Limb Nerves
Phrenic Nerve
Facial Nerve
Hypoglossal Nerve
Great Auricular Nerve
3.12 Late Response
H Reflex
F Wave
Axon Reflex
3.13 Autonomic Nervous System Testing
Anatomical and Functional Basis
Autonomic Function Tests
4 Electromyography
4.1 Introduction to Electromyography
Anatomy of Muscle
Types of EMG Needle Electrodes
Recording Technique
4.2 Technique of Electromyography
Muscles of Hands
Muscles of Forearm
Muscles of Arm
Muscles of Shoulder Girdle and Trunk
Muscles of the Foot
Muscles of Leg
Muscles of Thigh
Muscles of Pelvic Girdle
Muscles of Face, Head, and Neck
5 Clinical Application of EMG and Nerve Conduction
5.1 Electromyographic Findings in Neurological Disorders
Neurogenic Disorders
Myopathic Disorders
5.2 Nerve Conduction and EMG Studies in Polyneuropathies
Pathophysiological Basis of Nerve Conduction Study
Conduction Block and Temporal Dispersion
Neurophysiological Classification of Polyneuropathy
Limitation of Nerve Conduction Studies
Hereditary Neuropathies
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Subacute Idiopathic Demyelinating Polyradiculoneuropathy
Motor Neuropathy with Multifocal Conduction
Block or Multifocal Motor Neuropathy
Neuropathy Associated with AIDS
Leprosy
Diphtheritic Neuropathy
Metabolic Neuropathy
Carcinomatous Neuropathy
Nutritional Neuropathy
Critical Care Neuropathy
Toxic Neuropathy
Drug-Induced Neuropathy
Ischaemic Neuropathy
Neuropathy Associated with Connective Tissue Disorder
Overview of Investigations in Neuropathy
6 Repetitive Nerve Stimulation
Neuromuscular Junction
Physiology of RNS Test
Variables Influencing Neuromuscular Transmission
Technique of RNS
Measurement
Interpretation of RNS Test
Clinical Application of RNS Study
7 Single-Fibre Electromyography
Introduction
Method of SFEMG
SFEMG in Neurologic Diseases
Neuromuscular Transmission Disorders
SFEMG in Neurogenic Disorders
SFEMG in Myopathies
Macro-EMG
8 Visual Evoked Potential
Anatomical Basis of VEP
Methods of Visual Evoked Potential
Variables Influencing VEP
Multifocal VEP
Clinical Applications of VEP
Flash VEP
9 Brainstem Auditory Evoked Potential
Anatomical and Physiological Basis of BAEP
Brainstem Electrical Activity and its Correlation with BAEP
Patient-Related Variables Affecting BAEP
Method
Normal BAEP, Potential Field Distribution
Waveform Recognition, and Normal Values
Abnormal BAEP
Clinical Neurophysiological Correlation
10 Somatosensory Evoked Potentials
Anatomical and Physiological Basis of SEP
Methods
Normal Median SEP
Tibial SEPS
Reproducibility of SEP
Patient-Related Factors
Clinical Application of SEP
Surgical Monitoring
11 Motor Evoked Potential
Anatomy and Physiology of Corticospinal Tract
Physiological Basis of Motor Evoked Potential
Method of Motor Evoked Potential
Measurement of CMCT
CMCT Abnormalities and their Basis
Comparison of Electrical and Magnetic Stimulation
Safety of Transcranial Electrical and Magnetic Stimulation
Clinical Applications
12 Cognitive Evoked Potential
P3
Waveform Identification and Measurement
Variables Affecting P3
Generators of P3
Clinical Application
13 Electrodiagnosis in Paediatric Practice
13.1 Nerve Conduction and Electromyography
Nerve Conduction Studies
Sensory NCS
Needle EMG
Repetitive Nerve Stimulation
13.2 Visual Evoked Potential in Paediatric Practice
Methodology
Maturation of VEP
Measurement of VEP
Clinical Application
13.3 Brainstem Auditory Evoked Potential in Paediatric Practice
Methodological Considerations
Maturation of BAEP
Clinical Application of BAEP in Paediatrics
13.4 Somatosensory Evoked Potentials in Paediatric Practice
Methodological Considerations
Maturational Changes
Clinical Applications
14 Role of Clinical Neurophysiology in the Prognosis of Neuromuscular Disorders
Amyotrophic Lateral Sclerosis
Radiculopathy
Traumatic Nerve Injury
Polyneuropathy
Diseases of Neuromuscular Junction
Myopathy
15 Artificial Intelligence in Electrodiagnosis
Introduction
Deep Learning Neural Networks
Neuromuscular Junction Disorders
Index
ONLINE RESOURCE
List of Videos
VIDEO 1 Insertional Activity
VIDEO 2 Positive Sharp Waves and Fibrillations
VIDEO 3 Myotonic Discharges
VIDEO 4 Complex Repetitive Discharge (CRD)
VIDEO 5 Fibrillations and Fasciculations
VIDEO 6 Myopathic Motor Unit Potentials
VIDEO 7 Neurogenic Motor Unit Potentials
Product details
Product details
- Edition: 5
- Latest edition
- Published: July 15, 2026
- Language: English