Clinical Cancer Genomic Medicine
- 1st Edition - March 1, 2027
- Latest edition
- Editors: Eamonn Maher, Claire Morgan, Mark Davies, Dhavendra Kumar
- Language: English
Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomics in cancer development, diagnosis, and management, and their use in the… Read more
Description
Description
Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomics in cancer development, diagnosis, and management, and their use in the clinical setting. The book explores not only the genetic basis of cancer, but also the role genomics plays in understanding the molecular basis of disease and how it can aid in diagnosis and treatment. Sections discuss the basics of oncogenomic and emerging technologies and specific cancer types, such as breast, gastrointestinal, ocular, skin, and pediatric. The book also includes knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications.
This is a valuable resource for oncologists, clinicians, researchers, healthcare workers, and members of the biomedical field who need to understand more about the benefits of genetics and genomics for cancer and their applications in the clinical setting.
This is a valuable resource for oncologists, clinicians, researchers, healthcare workers, and members of the biomedical field who need to understand more about the benefits of genetics and genomics for cancer and their applications in the clinical setting.
Key features
Key features
- Presents comprehensive information on applied and translational cancer genetics and genomics
- Discusses current, evidence-based clinical practice in cancer genomic medicine
- Provides readers with updated information on molecular genetics and genomics to raise awareness and improve treatment outcomes
Readership
Readership
Clinical and medical oncologists, cancer researchers, Cancer geneticists, clinical geneticists, graduate students
Table of contents
Table of contents
Section I: Fundamentals of Cancer genetics and genomics
1. The human genome- organisation & function
2. Introduction to cancer genetics
3. Oncogenes and tumour suppressor genes
4. Cancer epigenomics
5. Cancer and the microbiome- the Oncobiome
6. Cancer immunogenomics
7. Cancer pharmacogenomics
8. Genomic Technologies for Tumour Profiling
9. New emerging technologies- The liquid biopsy
10. Gene and genome editing
11. Bioinformatics for Cancer Genome Analysis
Section II: Clinical cancer genetics and genomics
12. Classification and epidemiology of the genetic and inherited cancer – hereditary cancer family syndromes
13. Breast and ovarian cancer including endometrial cancer
14. Gastrointestinal malignancies – oesophagus, colo-rectal, hepato-biliary and pancreatic
15. Central nervous system tumours
16. Neoplasia of endocrine system (solitary and multiple)
17. Ocular tumours – retinoblastoma
18. Hematological cancer and lympho-reticular malignancy
19. Oro-pharyngeal and lung cancers
20. Malignant melanoma and related skin neoplasia
21. Childhood tumours and paediatric malignant neoplasia disorders
22. Malformation syndromes with neoplasia
Section III: Clinical cancer genomic medicine
23. Integration of cancer genomics in clinical medicine
24. Cancer genetic counselling
25. Diagnostic cancer genomic laboratory – organization & function / cancer database
26. Targeted therapy and screening in cancer genomic / precision medicine
27. Surgical approaches in clinical cancer genetics and genomics
28. Ethical, legal and social implications of cancer genomic testing
29. The future of cancer in the context of the genomics era
1. The human genome- organisation & function
2. Introduction to cancer genetics
3. Oncogenes and tumour suppressor genes
4. Cancer epigenomics
5. Cancer and the microbiome- the Oncobiome
6. Cancer immunogenomics
7. Cancer pharmacogenomics
8. Genomic Technologies for Tumour Profiling
9. New emerging technologies- The liquid biopsy
10. Gene and genome editing
11. Bioinformatics for Cancer Genome Analysis
Section II: Clinical cancer genetics and genomics
12. Classification and epidemiology of the genetic and inherited cancer – hereditary cancer family syndromes
13. Breast and ovarian cancer including endometrial cancer
14. Gastrointestinal malignancies – oesophagus, colo-rectal, hepato-biliary and pancreatic
15. Central nervous system tumours
16. Neoplasia of endocrine system (solitary and multiple)
17. Ocular tumours – retinoblastoma
18. Hematological cancer and lympho-reticular malignancy
19. Oro-pharyngeal and lung cancers
20. Malignant melanoma and related skin neoplasia
21. Childhood tumours and paediatric malignant neoplasia disorders
22. Malformation syndromes with neoplasia
Section III: Clinical cancer genomic medicine
23. Integration of cancer genomics in clinical medicine
24. Cancer genetic counselling
25. Diagnostic cancer genomic laboratory – organization & function / cancer database
26. Targeted therapy and screening in cancer genomic / precision medicine
27. Surgical approaches in clinical cancer genetics and genomics
28. Ethical, legal and social implications of cancer genomic testing
29. The future of cancer in the context of the genomics era
Product details
Product details
- Edition: 1
- Latest edition
- Published: March 1, 2027
- Language: English
About the editors
About the editors
EM
Eamonn Maher
Professor Maher is an international authority in clinical cancer genetics and genomics. His vast experience and in-depth knowledge of basic genetics and molecular biology in key cancer family syndromes are unparallel. He would closely supervise and guide on the development of this important volume in the series.
Affiliations and expertise
Professor of Cancer Genetics and Honorary Consultant in Cancer Genetics, Department of Medical Genetics, Cambridge University School of Medicine, Addenbrooke’s Hospital, CambridgeCM
Claire Morgan
Dr. Claire Morgan is Associate Professor in cancer genetics and the Programme Director for the MSc Genomic Medicine course. As the Programme Director, established and leads the first fully NHS-supported Genomic Medicine course in Wales; serves as an invited member of Genomics Partnership Wales and Wales Gene Park Strategic Advisory group and the Genomic Medicine UK advisory Group.
In addition, Programme Director for the BSc Genetics and Medical Genetics degree schemes and teaches on all the UG degree schemes including the Genetics/ Medical Genetics/Applied Medical Sciences and Population Health and Medical Sciences BSc degree schemes in the School of Medicine.
Affiliations and expertise
Associate Professor of Cancer Genetics, MSc Genomic Medicine Programme Director, BSc Medical Genetics/Genetics, Swansea University Medical School, UKMD
Mark Davies
Mark Davies trained at The London Hospital Medical College. Having spent two years in research at the Royal Free Hospital, London he completed his higher surgical training in Cardiff, Swansea & Manchester. He was appointed as a Consultant Surgeon in Swansea in 2007 where he has developed an expertise in inflammatory bowel disease and colorectal cancer. Mr. Davies has a busy clinical practice in the broader aspects of colorectal surgery including minimal access surgery, colorectal cancer and proctology. He is a senior clinical tutor at Swansea University, Chair of the Colorectal Cancer National Specialty Advisory Group and a member of The Court of Examiners of The Royal College of Surgeons of England. He has extensively published and remains a committed surgical trainer and educator. Clinical interests Inflammatory bowel disease Colorectal cancer Abdominal wall hernias Minimal access surgery Proctology (Haemorrhoids, Fissure, Fistula etc) Research interests Colorectal Cancer Quality of life after surgery.
Affiliations and expertise
Singleton Hospital, Sketty Lane, Sketty, Swansea, SA2 8QA, Wales, UKDK
Dhavendra Kumar
Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature.
Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George’s Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).
In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George’s Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.
Affiliations and expertise
Honorary Clinical Professor, William Harvey Research Institute, Queen Mary University of London, UK