Clinical Bioenergetics
From Pathophysiology to Clinical Translation
- 1st Edition - November 12, 2020
- Latest edition
- Editor: Sergej M. Ostojic
- Language: English
Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-de… Read more
Description
Description
Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth.
Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others.
Key features
Key features
- Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics
- Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders
- Features chapter contributions from international leaders in translational bioenergetics research and clinical practice
Readership
Readership
Active researchers in biochemistry, molecular biology, cell biology, oncology, pharmacology; clinician scientists
Table of contents
Table of contents
Part I: Foundational aspects of bioenergetics and disease
1. Tissue specificity of energy metabolism in mitochondria
2. Impaired mitochondrial bioenergetics and signaling pathways: an overview
Part II: Disease-specific case studies
3. Abnormal mitochondrial metabolism in obesity and insulin resistance
4. Impaired mitochondrial energy metabolism: etiologies and implications in neurodegenerative disease
5. Mitochondrial dysfunction in kidney diseases
6. Mitochondrial role in NAFLD as a chronic disease
7. Decreased bioenergetics in traumatic brain injury
8. Impaired mitochondrial bioenergetics in psychiatric disorders
Part III: Modes of analysis in clinical bioenergetics
9. Monitoring mitochondrial oxygenation in clinical environment
10. Assessing metabolic flexibility and mitochondrial bioenergetics
11. Assessing the real-time metabolism and bioenergetics of single cells using fluorescence biosensors
12. Bioenergetic profiling in the skin
13. Evaluating tissue bioenergetics by phosphorous-31 magnetic resonance spectroscopy
14. Targeting respiratory complex Idmolecular mechanism and drug design
Part IV: Theraputic opportunities for impaired bioenergetics
15. Targeting Alzheimer’s disease neuronal mitochondria as a therapeutic approach
16. Mitochondria replacement as an innovative treatment to tackle impaired bioenergetics in clinical medicine
17. Mitochondrial drug delivery systems: therapeutic application for clinical bioenergetics in neurodegenerative disease
18. Dietary interventions for patients with obesity and impaired bioenergetics
19. Novel nutraceuticals to tackle brain and muscle bioenergetics
20. Therapeutic targeting of cardiolipin composition in injury and disease using TPP-conjugated compounds
21. NEET proteins as novel drug targets for mitochondrial dysfunction
22. Translation of bioenergetics therapies: challenges from bench to bedside
23. New therapeutics to modulate mitochondrial energy metabolism in neurodegenerative disorders: the example of mitochondrial disorders
24. Targeting impaired bioenergetics in heart failure
25. Exploring vulnerabilities of quiescent tumor cells by targeting mitochondrial bioenergetics
26. Modulation of the mitochondrial function with polyphenols and other natural bioactive compounds to treat obesity
27. Antioxidants and natural-derived products in the modulation of mitochondrial bioenergetics and dysfunction in chronic kidney disease models
28. Transcranial and systemic photobiomodulation for the enhancement of mitochondrial metabolism in depression
29. Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments
Product details
Product details
- Edition: 1
- Latest edition
- Published: November 12, 2020
- Language: English
About the editor
About the editor
Sergej M. Ostojic
Sergej M. Ostojic, MD, PhD, FACP, is a Professor in the Department of Nutritional Sciences at Texas Tech University, USA, and Executive Director of the Nutrition and Metabolic Health Initiative. He is also affiliated with the Faculty of Health Sciences at the University of Pécs, Hungary. A physician-scientist with extensive international experience, his research focuses on human nutrition, metabolic health, and bioenergetics, with particular emphasis on how dietary factors influence physiological development, metabolic resilience, healthy aging, and disease risk across the lifespan. His work integrates clinical trials, nutritional epidemiology, and translational research to investigate the relationships between nutrient intake, cellular energetics, and individual and population health trajectories. Dr. Ostojic has authored or coauthored over 400 peer-reviewed scientific articles in leading journals, including The Lancet, Nature, The BMJ, Advances in Nutrition, Clinical Nutrition, and The American Journal of Clinical Nutrition. Recognized among the world's top 2% of scientists by Stanford University for eight consecutive years, he serves as Editor-in-Chief of Clinical Bioenergetics and Series Editor of Translational and Applied Bioenergetics (Elsevier). His research has attracted competitive international and industry funding, and he holds eleven patents and patent applications across multiple jurisdictions.